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Nuclear receptor ROR-alpha Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideIC502000.0 [1], 5011.87 [2], 11000.0 [3], 20000.0 [4]
N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideKi132.0 [1]
CID 44241473Ki172.0 [1]
5-Butyl-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC507200.0 [1], 9800.0 [2]
N-[4-[Hydroxy(dimethyl)silyl]phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideIC5030000.0 [1], 53000.0 [2]
4-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]pyridine-2-carboxamideIC5030000.0 [1]
2-Acetamido-N-[4-(5-cyano-3-fluoro-2-methoxyphenyl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5019000.0 [1], 33000.0 [2]
N-[4-[5-Cyano-2-(2,2,2-trifluoroethoxy)pyridin-3-yl]thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC506200.0 [1], 33000.0 [2]
2-(4-Ethylsulfonylphenyl)-N-[4-[2-[4-(trifluoromethoxy)phenoxy]pyridin-3-yl]thiophen-2-yl]acetamideIC5033000.0 [1]
2-Acetamido-N-[4-[5-cyano-2-(2,2,2-trifluoroethoxy)pyridin-3-yl]thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC50600.0 [1], 33000.0 [2]
2-(4-Ethylsulfonylphenyl)-N-[4-[2-[[4-(trifluoromethoxy)phenyl]methoxy]pyridin-3-yl]thiophen-2-yl]acetamideIC5033000.0 [1]
(2R)-2-Acetamido-2-(4-ethylsulfonylphenyl)-N-[4-[2-[[4-(trifluoromethoxy)phenyl]methoxy]pyridin-3-yl]thiophen-2-yl]acetamideIC509400.0 [1], 33000.0 [2]
4-Cyano-N-[3-[1-(cyclohexanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]pyridine-2-carboxamideIC5030000.0 [1]
3-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]benzamideIC5030000.0 [1]
3-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1H-indol-5-yl]benzamideIC5030000.0 [1]
7-KetocholesterolKi12.0 [1]
7alpha-HydroxycholesterolKi12.0 [1]
7beta-HydroxycholesterolKi12.0 [1]
Ethyl 2-[2-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoateIC5033000.0 [1]
CID 118622692IC5030000.0 [1]
N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-thiophenesulfonamideKi220.0 [1]
Ethyl 2-[(2-{[(furan-2-ylmethyl)carbamoyl]methyl}-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoateIC5033000.0 [1]
Ethyl 2-[2-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoateIC5033000.0 [1]
N-[5-(2-Chlorobenzoyl)-4-(3-chlorophenyl)-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC505011.87 [1]
5-Butylphenanthridin-6(5H)-oneIC5010200.0 [1]
Ethyl 2-((2-(2-((4-fluorobenzyl)amino)-2-oxoethyl)-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy)propanoateIC501680.0 [1]
Ethyl 2-[(2-{[(4-ethoxyphenyl)carbamoyl]methyl}-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoateIC5022600.0 [1]
Ethyl 2-[(1-oxo-2-{[(2-phenylethyl)carbamoyl]methyl}-1,2-dihydroisoquinolin-5-yl)oxy]propanoateIC5033000.0 [1]
5-Butyl-2-methylphenanthridin-6(5H)-oneIC5017600.0 [1]
5-Butyl-2-ethylphenanthridin-6(5H)-oneIC509000.0 [1]
5-Butyl-2-hydroxymethylphenanthridin-6(5H)-oneIC5020000.0 [1]
Ethyl 2-({2-[(benzylcarbamoyl)methyl]-1-oxo-1,2-dihydroisoquinolin-5-yl}oxy)propanoateIC503220.0 [1]
2-(5-Butoxy-1-oxo-2-isoquinolinyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamideIC5021500.0 [1]
N-(5-Benzoyl-4-phenyl-1,3-thiazol-2-yl)-2-(4-ethylsulfonylphenyl)acetamideIC505011.87 [1]
5-Nonyl-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC5020000.0 [1]
5-Butyl-2-tert-butylphenanthridin-6(5H)-oneIC5011800.0 [1]
5-Ethyl-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC5020000.0 [1]
5-Hexyl-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC507600.0 [1]
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-5-methylphenanthridin-6-oneIC5020000.0 [1]
5-(2,2,2-Trifluoroethyl)-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC509900.0 [1]
5-(Cyclohexylmethyl)-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC5010300.0 [1]
5-Butyl-2-isopropyl-phenanthridin-6-oneIC5016700.0 [1]
5-Butyl-3-methoxy-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC507800.0 [1]
5-Butyl-4-methoxy-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC5010000.0 [1]
5-Butyl-9-methoxy-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC505300.0 [1]
5-Butyl-10-methoxy-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC509100.0 [1]
N-(2,4-Difluorophenyl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamideIC5010000.0 [1]
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-5H-phenanthridin-6-oneIC5020000.0 [1]
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-5-propylphenanthridin-6-oneIC5010800.0 [1]
[4-[(3R)-4-[5-(Hydroxymethyl)-4-(trifluoromethyl)pyrimidin-2-yl]-3-propan-2-ylpiperazin-1-yl]-2-methylsulfonylphenyl]methanolIC5010000.0 [1]
4-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-ethylindol-5-yl]pyridine-2-carboxamideIC5030000.0 [1]
N-(4-Ethylphenyl)-N-(2-methylpropyl)-3-(methylsulfonimidoyl)-4-(oxan-4-ylmethoxy)benzenesulfonamideIC5010000.0 [1]
N-(4-Ethylphenyl)-N-(2-methylpropyl)-3-(methylsulfonimidoyl)-4-(oxan-4-ylmethoxy)benzenesulfonamideIC5010000.0 [1]
2-(5,5-Dibutylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-olIC506200.0 [1]
2-(5,5-Dimethylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-olIC509400.0 [1]
2-(5-Butyl-5-methylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-olIC507700.0 [1]
4-[3-[2-Chloranyl-6-(Trifluoromethyl)phenoxy]-5-(Dimethylcarbamoyl)indazol-1-Yl]benzoic AcidIC5010000.0 [1]
4-[3-(2-Chloro-6-methylphenoxy)-5-(dimethylcarbamoyl)indazol-1-yl]benzoic acidIC5010000.0 [1]
Chembl4175305IC5010000.0 [1]
(4S)-4-Benzyl-1-[4-[(5S)-2-(2-cyclopentylethyl)-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thioneIC506000.0 [1]
(4R)-4-Tert-butyl-3-(2-phenylethyl)-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thioneIC5030100.0 [1]
(4S)-4-Benzyl-1-[4-[(5S)-2-[(3-fluorophenyl)methyl]-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thioneIC506800.0 [1]
(4S)-4-Benzyl-3-[2-(2-bicyclo[2.2.1]heptanyl)ethyl]-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thioneIC5013000.0 [1]
(4S)-4-Benzyl-1-[4-[(5S)-2-[(3-methoxyphenyl)methyl]-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thioneIC508000.0 [1]
(4S)-4-Benzyl-3-(2-phenylethyl)-1-[4-[(5S)-2-prop-2-enyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thioneIC5015000.0 [1]
(4S)-3-[2-(2-Adamantyl)ethyl]-4-benzyl-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thioneIC508400.0 [1]
(4S)-4-Benzyl-1-[4-[(5S)-2-[(4-fluorophenyl)methyl]-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thioneIC509900.0 [1]
(4S)-4-Benzyl-3-(2-phenylethyl)-1-[4-[(5S)-2-[(E)-prop-1-enyl]-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thioneIC5012500.0 [1]
(4S)-4-Benzyl-3-(2-phenylethyl)-1-[4-[(5S)-2-(2-phenylpropyl)-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thioneIC507500.0 [1]
(4S)-4-Benzyl-1-[4-[(5S)-2-[(3-methylphenyl)methyl]-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thioneIC506800.0 [1]
(4S)-4-Benzyl-1-[4-[(5S)-2-(cyclohexylmethyl)-4,5-dihydro-1H-imidazol-5-yl]butyl]-3-(2-phenylethyl)imidazolidine-2-thioneIC506400.0 [1]
(4S)-4-Benzyl-3-[(4-methylcyclohexyl)methyl]-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thioneIC5026000.0 [1]
(4S)-4-Butyl-3-(2-phenylethyl)-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thioneIC5011900.0 [1]
(4S)-4-Benzyl-3-(3-cyclopentylpropyl)-1-[4-[(5S)-2-propyl-4,5-dihydro-1H-imidazol-5-yl]butyl]imidazolidine-2-thioneIC505800.0 [1]
2-[4-[[2-(4-Ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(4-fluorophenyl)-2-methylpropanamideIC5010000.0 [1]
N-(4-Cyanopyridin-2-yl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamideIC5010000.0 [1]
N-[3-[1-(Cyclopentanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]benzamideIC5030000.0 [1]
N-Benzyl-N-[4-[hydroxy(dimethyl)silyl]phenyl]benzenesulfonamideIC5030000.0 [1]
N-[4-[Hydroxy(dimethyl)silyl]phenyl]-N-(2-phenylethyl)benzenesulfonamideIC5030000.0 [1]
N-Ethyl-N-[4-[hydroxy(dimethyl)silyl]phenyl]benzenesulfonamideIC5030000.0 [1]
N-Butyl-N-[4-[hydroxy(dimethyl)silyl]phenyl]benzenesulfonamideIC5030000.0 [1]
2-[4-[[2-(4-Ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-N-(4-fluorophenyl)-2-methylpropanamideIC5010000.0 [1]
5,5,8,8-Tetramethyl-N-phenyl-6,7-dihydronaphthalene-2-carboxamideIC5010000.0 [1]
Ethyl 2-[(2-{[(4-ethylphenyl)carbamoyl]methyl}-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoateIC5025000.0 [1]
Ethyl 2-[(2-{[(4-butylphenyl)carbamoyl]methyl}-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoateIC5030700.0 [1]
Ethyl 2-[(2-{[(4-methylphenyl)carbamoyl]methyl}-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoateIC5036500.0 [1]
5-Butyl-2-hexylphenanthridin-6(5H)-oneIC5010300.0 [1]
1,1,4,4-Tetramethyl-N-phenyl-2,3-dihydro-1,4-benzodisiline-6-carboxamideIC501300.0 [1]
5-Butyl-9-chloro-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-oneIC505600.0 [1]
N-[5-(2-Chlorobenzoyl)-4-(2-chlorophenyl)-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC50110.0 [1]
5-(Cyclopropylmethyl)-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-oneIC5013600.0 [1]
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-5-propan-2-ylphenanthridin-6-oneIC5012300.0 [1]
5-Butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-methylphenanthridin-6-oneIC507600.0 [1]
5-Butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-(trifluoromethyl)phenanthridin-6-oneIC505500.0 [1]
5-Butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-hydroxyphenanthridin-6-oneIC506400.0 [1]
Items per page: 1 - 10 of 95
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References

This online tool may be cited as follows

MLA

"Quest Database™ Nuclear receptor ROR-alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/nuclear-receptor-ror-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Nuclear receptor ROR-alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nuclear-receptor-ror-alpha-inhibitors-ic50-ki.
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