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Orexin receptor 2 Inhibitors (IC50, Ki)
Structure
Compound Name
Standard Type
Standard Values (in nM)
SuvorexantIC500.4 [1], 56.0 [2], 138.0 [3]
SuvorexantKi0.35 [1], 0.4 [2], 11.8 [3]
[5-Methyl-2-(triazol-2-yl)phenyl]-(4-quinazolin-2-yl-1,4-diazepan-1-yl)methanoneIC5027.0 [1]
[5-Methyl-2-(triazol-2-yl)phenyl]-(4-quinazolin-2-yl-1,4-diazepan-1-yl)methanoneKi0.59 [1], 0.6 [2]
[(7R)-4-(6-Fluoroquinazolin-2-yl)-7-methyl-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanoneIC5027.0 [1]

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References
This online resource may be cited as follows
MLA
"Quest Database™ Orexin receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 31 Dec. 2025, https://www.aatbio.com/data-sets/orexin-receptor-2-inhibitors-ic50-ki.
APA
AAT Bioquest, Inc. (2025, December 31). Quest Database™ Orexin receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/orexin-receptor-2-inhibitors-ic50-ki.
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