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Overview of human CD45 isoforms For Human CD45 isoforms - RA, RO, RB, RAB, RBC and RABC
Human CD45 isoform | Description |
|---|---|
| Human CD45RA | CD45RA, which is expressed on naïve T cells, consists of exon 4. After activation CD45RA+ T regulatory cells are converted to CD45RO+ T regulatory cells. |
| Human CD45RO | CD45RO is a low-molecular weight isoform which enhances both T- and B-cell receptor signaling meditated activation. It is typically expressed on activated T cells, memory T cells, some B cell subsets, monocytes and granulocytes. CD45RO contains exons 3, 7 and 8 of the CD45 gene. The RA, RB, and RC exons are not present. |
| Human CD45RB | CD45RB is a 220 kDa glycoprotein expressed on B cells, naïve T cells, thymocytes and dendritic cells. It plays key roles in T- and B- cell receptor signaling. As T cells become activated and mature from naïve to memory cells, CD45RB expression is downregulated. CD45RB contains exon 5. |
| Human CD45RAB | CD45RAB contains exons 4 and 5 of the CD45 gene. |
| Human CD45RBC | CD45RAB contains exons 5 and 6 of the CD45 gene. |
References
This online resource may be cited as follows
MLA | "Quest Database™ Overview of human CD45 isoforms For Human CD45 isoforms - RA, RO, RB, RAB, RBC and RABC." AAT Bioquest, Inc., 24 Feb. 2026, https://www.aatbio.com/data-sets/overview-of-human-cd45-isoforms-for-human-cd45-isoforms-ra-ro-rb-rab-rbc-and-rabc. | |
APA | AAT Bioquest, Inc. (2026, February 24). Quest Database™ Overview of human CD45 isoforms For Human CD45 isoforms - RA, RO, RB, RAB, RBC and RABC. AAT Bioquest. https://www.aatbio.com/data-sets/overview-of-human-cd45-isoforms-for-human-cd45-isoforms-ra-ro-rb-rab-rbc-and-rabc. | |
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