 | 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]- | IC50 | 25.0 [1], 79.43 [2] |
| 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]- | Ki | 41.69 [1] |
 | CID 24883277 | IC50 | 5.01 [1] |
| CID 24883277 | Ki | 7.94 [1] |
 | 5-(5-Ethynyl-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine | IC50 | 12.59 [1] |
| 5-(5-Ethynyl-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine | Ki | 11.48 [1] |
 | 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]ethanol | IC50 | 15.85 [1] |
| 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]ethanol | Ki | 16.6 [1] |
 | 3-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-1-ol | IC50 | 63.1 [1] |
| 3-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-1-ol | Ki | 64.57 [1] |
 | 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-1-ol | IC50 | 15.85 [1] |
| 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-1-ol | Ki | 15.49 [1] |
 | 1-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-2-ol | IC50 | 25.12 [1] |
| 1-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-2-ol | Ki | 26.92 [1] |
 | 3-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propane-1,2-diol | IC50 | 31.62 [1] |
| 3-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propane-1,2-diol | Ki | 30.9 [1] |
 | 2-[[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]methyl]propane-1,3-diol | IC50 | 31.62 [1] |
| 2-[[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]methyl]propane-1,3-diol | Ki | 35.48 [1] |
 | 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]-2-methylpropan-1-ol | IC50 | 794.33 [1] |
| 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]-2-methylpropan-1-ol | Ki | 851.14 [1] |
 | Tert-butyl (3S)-3-[[6-(4-chloro-2-cyanophenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-(6-methoxypyridin-3-yl)propanoate | IC50 | 10000.0 [1] |
 | N-[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]-2-methylpropanamide | IC50 | 39.81 [1] |
 | 4-(2,4-Diamino-pyrimidin-5-yloxy)-2-ethynyl-5-isopropyl-phenol | IC50 | 10.23 [1] |
 | 2-[4-[(6-Methoxypyridin-3-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 9.0 [1], 27.0 [2] |
 | 2-[4-(Imidazo[1,2-a]pyridin-7-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 18.0 [1], 33.0 [2] |
 | 2-[4-(1,3-Benzoxazol-5-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 15.0 [1], 45.0 [2] |
 | 5-Methyl-2-[4-[(2-methylpyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 12.0 [1], 82.0 [2] |
 | 5-Methyl-2-[4-[[4-methyl-3-(1,2,4-triazol-1-yl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 21.0 [1], 92.0 [2] |
 | (3R)-3-[[6-(2-Cyano-4-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-(6-methoxypyridin-3-yl)propanoic acid | IC50 | 207.0 [1], 1676.0 [2] |
 | (3R)-3-[[6-(2-Cyano-4-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-(6-methoxypyridin-3-yl)propanamide | IC50 | 26.0 [1], 174.0 [2] |
 | (3R)-3-[[6-(2-Cyano-4-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-(6-methoxypyridin-3-yl)-N,N-dimethylpropanamide | IC50 | 302.0 [1], 2211.0 [2] |
 | 5-Chloro-2-[4-(imidazo[1,2-a]pyridin-7-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 122.0 [1], 753.0 [2] |
 | 5-Chloro-2-[4-[(2-methylpyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 28.0 [1], 246.0 [2] |
 | 2-[4-[[(1S)-2-Hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 21.0 [1], 71.0 [2] |
 | 5-Chloro-2-[4-[[(1S)-2-hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 54.0 [1], 671.0 [2] |
 | 2-[4-[(3-Fluoro-4-methylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 89.0 [1], 124.0 [2] |
 | 5-Methyl-2-[4-[(4-methyl-3-methylsulfanylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 474.0 [1], 925.0 [2] |
 | 2-[4-[[4-Chloro-3-(1,2,4-triazol-4-yl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 31.0 [1], 63.0 [2] |
 | 5-Chloro-2-[4-[[3-(1,2,4-triazol-4-yl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 284.0 [1], 1015.0 [2] |
 | 5-Chloro-2-[4-[[4-chloro-3-(1,2,4-triazol-4-yl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 41.0 [1], 286.0 [2] |
 | 5-Methyl-2-[4-[[3-(1,2,4-triazol-4-yl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 65.0 [1], 324.0 [2] |
 | 2-[4-[(4-Amino-2-methoxypyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 32.0 [1], 62.0 [2] |
 | 2-[4-[(3-Iodo-4-methylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 512.0 [1], 1296.0 [2] |
 | 2-[4-[[(1R)-1-(2-Methoxypyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 10.0 [1], 164.0 [2] |
 | 5-Methyl-2-[4-[(4-methyl-3-methylsulfonylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 16.0 [1], 55.0 [2] |
 | 2-[4-[[(1S)-2-Hydroxy-1-(2-methoxypyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 14.0 [1], 130.0 [2] |
 | 5-Methyl-2-[4-[(2-propan-2-ylpyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 101.0 [1], 1346.0 [2] |
 | 5-Chloro-2-[4-[[(1R)-1-[6-(difluoromethyl)pyridin-3-yl]-3-hydroxypropyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 32.0 [1], 273.0 [2] |
 | 5-Methyl-2-[4-[(4-methyl-3-morpholin-4-ylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 96.0 [1], 1121.0 [2] |
 | 5-Methyl-2-[4-[[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 14.0 [1], 30.0 [2] |
 | 5-Methyl-2-[4-[[(1S)-1-(2-methylpyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 486.0 [1], 3797.0 [2] |
 | 2-[4-[(2-Methoxypyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 13.0 [1], 42.0 [2] |
 | 5-Chloro-2-[4-[(2-methoxypyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 42.0 [1], 224.0 [2] |
 | 2-[4-[[(1S)-1-[6-(Difluoromethyl)pyridin-3-yl]-2-hydroxyethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 7.0 [1], 33.0 [2] |
 | 2-[4-[(4-Chloro-3-methylsulfonylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 37.0 [1], 120.0 [2] |
 | 5-Chloro-2-[4-[[(1S)-1-[6-(difluoromethyl)pyridin-3-yl]-2-hydroxyethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 16.0 [1], 404.0 [2] |
 | 5-Chloro-2-[4-[[(1S)-2-hydroxy-1-(2-methylpyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 15.0 [1], 225.0 [2] |
 | 2-[4-[[(1S)-2-Hydroxy-1-(2-methylpyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 7.0 [1], 61.0 [2] |
 | 5-Chloro-2-[4-[[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 15.0 [1], 180.0 [2] |
 | 5-Chloro-2-[4-[(4-methyl-3-methylsulfonylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 40.0 [1], 241.0 [2] |
 | [(3R)-3-[[6-(2-Cyano-4-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-[6-(trifluoromethyl)pyridin-3-yl]propyl] acetate | IC50 | 130.0 [1], 536.0 [2] |
 | 5-Chloro-2-[4-[[(1S)-2-hydroxy-1-(2-methoxypyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 42.0 [1], 854.0 [2] |
 | 5-Methyl-2-(4-(quinoxalin-6-ylmethylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzonitrile | IC50 | 34.0 [1], 67.0 [2] |
 | 5-Methyl-2-(4-(quinolin-2-ylmethylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzonitrile | IC50 | 156.0 [1], 263.0 [2] |
 | 2-(4-((1H-Indol-6-yl)methylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-5-methylbenzonitrile | IC50 | 423.0 [1], 2163.0 [2] |
 | 2-[4-(1,3-Benzodioxol-5-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 56.0 [1], 310.0 [2] |
 | 2-[4-[1-(1,3-Benzodioxol-5-yl)ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 54.0 [1], 125.0 [2] |
 | 5-Chloro-2-[4-(quinoxalin-6-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 125.0 [1], 478.0 [2] |
 | 5-Methyl-2-[4-(1-pyrazin-2-ylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 37.0 [1], 663.0 [2] |
 | 5-Methyl-2-[4-(1-quinoxalin-6-ylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 75.0 [1], 276.0 [2] |
 | 2-[4-[[(1S)-1-(2-Methoxypyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 481.0 [1], 5363.0 [2] |
 | 2-[4-[1-(4-Chloro-3-methylsulfonylphenyl)ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 19.0 [1], 36.0 [2] |
 | 2-[4-[[(1R)-1-(1,3-Benzodioxol-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 15.0 [1], 19.0 [2] |
 | 2-[4-[[(1S)-1-(1,3-Benzodioxol-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 2206.0 [1], 7074.0 [2] |
 | 5-Methyl-2-[4-[1-(4-methyl-3-methylsulfonylphenyl)ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 23.0 [1], 45.0 [2] |
 | 5-Methyl-2-(4-(quinolin-7-ylmethylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzonitrile | IC50 | 20.0 [1], 24.0 [2] |
 | 2-[4-[[(1R)-1-(4-Chloro-3-methylsulfonylphenyl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 12.0 [1], 17.0 [2] |
 | 2-[4-[[(1S)-1-(4-Chloro-3-methylsulfonylphenyl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 430.0 [1], 4546.0 [2] |
 | 5-Methyl-2-[4-[[(1R)-1-quinoxalin-6-ylethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 15.0 [1], 45.0 [2] |
 | 5-Methyl-2-[4-[[(1S)-1-quinoxalin-6-ylethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 570.0 [1], 10000.0 [2] |
 | 5-Methyl-2-[4-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 19.0 [1], 92.0 [2] |
 | 5-Chloro-2-[4-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 37.0 [1], 842.0 [2] |
 | 5-Bromo-2-[4-[[(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 42.0 [1], 455.0 [2] |
 | 5-Methyl-2-[4-[[(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 22.0 [1], 42.0 [2] |
 | 5-Chloro-2-[4-[[(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 25.0 [1], 383.0 [2] |
 | 5-Fluoro-2-[4-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 85.0 [1], 11432.0 [2] |
 | 2-[4-[[6-(Trifluoromethyl)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 63.0 [1], 1814.0 [2] |
 | 5-Chloro-2-[4-[[2-methyl-6-(trifluoromethyl)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 187.0 [1], 10000.0 [2] |
 | 5-Chloro-2-[4-[[6-(dimethylamino)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 628.0 [1], 1190.0 [2] |
 | 5-Chloro-2-[4-[(6-methoxypyridin-3-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 59.0 [1], 169.0 [2] |
 | 5-Bromo-2-[4-[(6-methoxypyridin-3-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 78.0 [1], 325.0 [2] |
 | 5-Chloro-2-[4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 91.0 [1], 1128.0 [2] |
 | 5-Chloro-2-[4-[[5-(trifluoromethyl)pyridin-2-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 118.0 [1], 4886.0 [2] |
 | (3R)-3-[[6-(4-Chloro-2-cyanophenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-(6-methoxypyridin-3-yl)propanoic acid | IC50 | 1379.0 [1], 10000.0 [2] |
 | 5-Chloro-2-[4-[[(1R)-3-hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]propyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 90.0 [1], 903.0 [2] |
 | 2-[4-[[(1R)-3-Hydroxy-1-(6-methylpyridin-3-yl)propyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 12.0 [1], 31.0 [2] |
 | 2-[4-[[(1R)-1-[6-(Difluoromethyl)pyridin-3-yl]-3-hydroxypropyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 13.0 [1], 43.0 [2] |
 | 2-[4-[[(1S)-2-Hydroxy-1-(6-methoxypyridin-3-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 6.0 [1], 28.0 [2] |
 | 2-[4-[[(1R)-3-Hydroxy-1-(6-methoxypyridin-3-yl)propyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 14.0 [1], 20.0 [2] |
 | 2-[4-[[3-Hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]propyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 55.0 [1], 136.0 [2] |
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