 | Nutlin-3A | IC50 | 90.0 [1] |
| Nutlin-3A | Ki | 6.4 [1], 40.0 [2], 90.0 [3], 121.0 [4], 140.0 [5] |
 | 2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acid | IC50 | 0.1 [1] |
 | MI-773 (Sar405838) | IC50 | 13.3 [1], 100.0 [2] |
| MI-773 (Sar405838) | Ki | 0.88 [1], 10.0 [2] |
 | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 5.6 [1], 6.8 [2], 11.1 [3], 100.0 [4] |
| (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 0.44 [1], 0.97 [2] |
 | (2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-5-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 44.6 [1], 162.0 [2], 180.0 [3] |
| (2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-5-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 5.0 [1], 10.5 [2], 23.5 [3] |
 | 2-[(3R,5R,6S)-1-[(2S)-1-Tert-butylsulfonylbutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acid | IC50 | 0.1 [1], 1.1 [2] |
 | DI-Chloro-benzo-diazepine | IC50 | 200.0 [1], 420.0 [2], 38000.0 [3], 128000.0 [4] |
 | (2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 28.3 [1], 280.0 [2], 18000.0 [3] |
| (2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 3.0 [1] |
 | 6-Chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid | Ki | 916.0 [1], 920.0 [2] |
 | (3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-[3-(4-methylpiperazin-1-yl)propyl]-3H-1,4-benzodiazepine-2,5-dione | IC50 | 546.0 [1], 704.0 [2], 800.0 [3], 8000.0 [4] |
 | (3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-(2-morpholin-4-ylethyl)-3H-1,4-benzodiazepine-2,5-dione | IC50 | 367.0 [1], 790.0 [2], 1300.0 [3], 10000.0 [4] |
 | 5-[(3S)-3-(4-Chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 700.0 [1], 856.0 [2], 7000.0 [3], 67000.0 [4] |
 | 2-[(3S,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid | IC50 | 76.0 [1], 1100.0 [2], 7100.0 [3], 25200.0 [4] |
 | 2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid | IC50 | 34.0 [1], 360.0 [2], 3400.0 [3], 18100.0 [4] |
 | 2-[(2R,5R,6R)-4-[(2S)-1-Tert-butylsulfonylbutan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid | IC50 | 0.5 [1], 2.0 [2], 240.0 [3] |
 | (3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-[2-(2-methoxyethoxy)ethyl]-3H-1,4-benzodiazepine-2,5-dione | IC50 | 394.0 [1], 700.0 [2], 1100.0 [3], 57000.0 [4] |
 | (2R)-2-[(2S,3R,6S)-2,3-Bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid | IC50 | 86.0 [1], 2900.0 [2], 5900.0 [3], 20700.0 [4] |
 | 2-[(2S,5R,6S)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acid | IC50 | 300.0 [1], 4500.0 [2], 5700.0 [3], 29400.0 [4] |
 | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxycyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 7.1 [1], 8.2 [2] |
| (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxycyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 0.61 [1], 1.1 [2] |
 | (2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 41.4 [1], 1000.0 [2] |
 | Apomorphine | IC50 | 195.0 [1], 215.0 [2], 30000.0 [3] |
 | Nutlin-3 | IC50 | 104.5 [1], 180.0 [2] |
| Nutlin-3 | Ki | 30.0 [1] |
 | Mdm2 inhibitor amg-232 | IC50 | 0.6 [1], 0.63 [2], 47.0 [3] |
 | [(4S,5R)-4,5-Bis(4-bromophenyl)-2-(2-ethoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]-[4-(2-hydroxyethyl)piperazin-1-yl]methanone | IC50 | 140.0 [1] |
 | 5-[(3S)-3-(4-Chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-7-ethynyl-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 710.0 [1], 10300.0 [2], 69000.0 [3] |
 | 2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetamide | IC50 | 0.1 [1], 0.17 [2], 1.8 [3] |
 | 3-[2-(Tert-butylamino)-1-[[4-[(4-chlorophenyl)methoxy]phenyl]methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylic acid | Ki | 600.0 [1] |
 | (3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-1-(2-morpholin-4-ylethyl)-7-prop-1-ynyl-3H-1,4-benzodiazepine-2,5-dione | IC50 | 787.0 [1], 1700.0 [2], 10000.0 [3] |
 | 5-[(3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 250.0 [1], 16000.0 [2], 80000.0 [3] |
 | 5-[(3S)-4-[(1R)-1-(4-Chlorophenyl)ethyl]-7-iodo-2,5-dioxo-3-[4-(trifluoromethyl)phenyl]-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 980.0 [1], 11000.0 [2], 30000.0 [3] |
 | 5-[(3S)-4-[(1R)-1-(4-Chlorophenyl)ethyl]-7-iodo-2,5-dioxo-3-[4-(trifluoromethoxy)phenyl]-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 1040.0 [1], 19000.0 [2], 67000.0 [3] |
 | 5-[(3S)-3-(4-Chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-2,5-dioxo-7-prop-1-ynyl-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 1110.0 [1], 10700.0 [2], 30000.0 [3] |
 | 5-[4-[Carboxy-(4-chlorophenyl)methyl]-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 510.0 [1], 38000.0 [2], 128000.0 [3] |
 | (3R)-3-(4-Chlorophenyl)-3-[(3S)-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]propanoic acid | IC50 | 540.0 [1], 24000.0 [2], 70000.0 [3] |
 | 5-[[(2S)-2-(4-Chlorophenyl)-2-[(3S)-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]acetyl]amino]pentanoic acid | IC50 | 870.0 [1], 31000.0 [2], 90000.0 [3] |
 | 5-[(3S)-3-(4-Chlorophenyl)-4-[(4-chlorophenyl)methyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 8220.0 [1], 13000.0 [2], 60000.0 [3] |
 | 5-[(3S)-3-(4-Chlorophenyl)-4-[1-(4-chlorophenyl)-2-(diethylamino)-2-oxoethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 2130.0 [1], 9000.0 [2], 37000.0 [3] |
 | 5-[(3S)-3-(4-Chlorophenyl)-4-[1-(4-chlorophenyl)-2-methoxy-2-oxoethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 2820.0 [1], 25000.0 [2], 67000.0 [3] |
 | CID 71020652 | IC50 | 4.4 [1], 20.4 [2], 100.0 [3] |
 | 2-[(2S,5R,6R)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acid | IC50 | 140.0 [1], 2800.0 [2], 15300.0 [3] |
 | 2-[(2R,5R,6R)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acid | IC50 | 290.0 [1], 5000.0 [2], 16700.0 [3] |
 | 6-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]pyridine-3-carboxylic acid | IC50 | 0.1 [1], 0.8 [2], 5.0 [3] |
 | (4S)-4-(4-Chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-2-(2-methoxyphenyl)-3-propan-2-yl-4H-pyrrolo[3,4-c]pyrazol-6-one | IC50 | 0.13 [1], 0.16 [2], 505.8 [3] |
 | 2-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]pyridine-4-carboxylic acid | IC50 | 0.1 [1], 1.4 [2], 47.0 [3] |
 | 3-[2-(2,3,4,4a,5,7,8,8a-Octahydropyrano[4,3-b]pyridin-1-yl)-4-(5-chloropyridin-3-yl)-3-[(4-methylcyclohexyl)methyl]imidazo[4,5-c]pyridin-6-yl]-4H-1,2,4-oxadiazol-5-one | IC50 | 8.0 [1], 10.0 [2] |
 | (2'R,3S,3'S,5'R)-3'-(3-Chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-6-fluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 2742.86 [1], 5000.0 [2] |
 | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 100.0 [1], 260.4 [2], 35400.0 [3] |
 | (2'R,3R,3'S,5'S)-6-Chloro-3'-(2,3-difluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 61.7 [1], 100.0 [2], 272.83 [3] |
 | (2'R,3R,3'S,5'S)-3'-(3-Chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5,6-difluoro-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 70.2 [1], 137.94 [2], 500.0 [3] |
 | (2'R,3R,3'R,5'S)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 20.1 [1], 100.0 [2], 256.02 [3] |
 | (2'R,3R,3'S,5'S)-6-Chloro-3'-(2,3-difluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 27.0 [1], 100.0 [2], 111.52 [3] |
 | (2'R,3R,3'S,5'S)-3'-(3-Chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5,6-difluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 35.0 [1], 100.0 [2], 121.9 [3] |
 | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 89.59 [1], 100.0 [2] |
 | (2'R,3R,3'R,5'S)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 18.0 [1], 85.61 [2], 100.0 [3] |
 | (2'R,3R,3'R,5'S)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 61.0 [1], 100.0 [2], 220.41 [3] |
 | Nutlin-3B | IC50 | 108.0 [1], 13600.0 [2] |
 | Nutlin-1 | IC50 | 100.0 [1], 260.0 [2] |
 | CID 57406853 | IC50 | 18.0 [1] |
 | Nutlin-2 | IC50 | 100.0 [1], 140.0 [2] |
 | Nvp-cgm097 | IC50 | 0.8 [1] |
| Nvp-cgm097 | Ki | 1.3 [1] |
 | 2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid | IC50 | 1.1 [1], 4.1 [2] |
 | Siremadlin | IC50 | 0.23 [1] |
| Siremadlin | Ki | 0.21 [1] |
 | (4S)-4-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-2-methylpropanoyl]amino]-3-[4-(phosphonomethyl)phenyl]propanoyl]amino]-3-(6-chloro-1H-indol-3-yl)propanoyl]amino]-5-[[1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]carbamoyl]cyclopropyl]amino]-5-oxopentanoic acid | IC50 | 5.0 [1] |
 | (2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N,N-dimethyl-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 86.0 [1] |
 | 3-(4-Chlorophenyl)-3-(1-hydroxymethylcyclopropylmethoxy)-2-(4-nitrobenzyl)-2,3-dihydroisoindol-1-one | IC50 | 230.0 [1], 298.0 [2] |
 | 2-[(3S,5S,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid | IC50 | 2400.0 [1], 18900.0 [2] |
 | CID 117884873 | IC50 | 149.0 [1] |
| CID 117884873 | Ki | 19.0 [1] |
 | (6R,7S)-6,7-Bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine | IC50 | 50000.0 [1] |
| (6R,7S)-6,7-Bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine | Ki | 1230.0 [1] |
 | [6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-phenylimidazol-4-yl]-1H-indol-2-yl]-[(3S)-3-[3-(dimethylamino)propyl-methylamino]pyrrolidin-1-yl]methanone | IC50 | 190.0 [1] |
| [6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-phenylimidazol-4-yl]-1H-indol-2-yl]-[(3S)-3-[3-(dimethylamino)propyl-methylamino]pyrrolidin-1-yl]methanone | Ki | 109.0 [1] |
 | 3-(4-Chlorophenyl)-3-[(1R,4S)-4-hydroxycyclopent-2-en-1-yl]oxy-2-[(4-methylphenyl)methyl]isoindol-1-one | IC50 | 1400.0 [1] |
 | 4-[[1-(4-Chlorophenyl)-1-[[1-(hydroxymethyl)cyclopropyl]methoxy]-3-oxoisoindol-2-yl]methyl]benzonitrile | IC50 | 1790.0 [1], 1800.0 [2] |
 | 2-[(4-Bromophenyl)methyl]-3-(4-chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]isoindol-1-one | IC50 | 1200.0 [1] |
 | 2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-[cyclopropylsulfonyl(methyl)amino]ethyl]-3-methyl-2-oxopiperidin-3-yl]acetic acid | IC50 | 0.2 [1] |
 | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 9.8 [1] |
| (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 0.86 [1] |
 | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 9.4 [1], 21.3 [2] |
 | CID 70872023 | IC50 | 100.0 [1] |
| CID 70872023 | Ki | 2.9 [1] |
 | 2-[(2R,5R,6R)-4-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid | IC50 | 0.4 [1], 1.8 [2] |
 | 2-[2-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]-1,3-thiazol-5-yl]acetic acid | IC50 | 0.1 [1], 0.8 [2] |
 | (2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 800.0 [1] |
| (2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 13.0 [1] |
 | 2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chloro-2-fluorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acid | IC50 | 0.1 [1], 6.4 [2] |
 | 4-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]benzoic acid | IC50 | 0.18 [1], 0.6 [2] |
 | 4-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]cyclohexane-1-carboxylic acid | IC50 | 0.42 [1], 0.73 [2] |
 | 4-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]bicyclo[2.2.2]octane-1-carboxylic acid | IC50 | 0.1 [1], 0.7 [2] |
 | 3-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]cyclobutane-1-carboxylic acid | IC50 | 0.52 [1], 0.83 [2] |
 | (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-[4-(4-methylphenyl)triazol-1-yl]pentanoic acid | IC50 | 24260.0 [1] |
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