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Perforin-1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
(1Z)-1-(1-Benzothiophen-3-ylmethylidene)-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC50970.0 [1]
(5E)-5-[[5-(1-Oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]methylidene]-2-sulfanylideneimidazolidin-4-oneIC50780.0 [1]
(5E)-5-[(5-Pyridin-3-ylthiophen-2-yl)methylidene]-2-sulfanylideneimidazolidin-4-oneIC5012890.0 [1]
2,4-Difluoro-N-[5-[5-(2-methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]pyridin-3-yl]benzenesulfonamideIC501170.0 [1]
2-[4-(1-Amino-2,4-dicyanopyrido[1,2-a]benzimidazol-3-yl)phenoxy]acetamideIC505190.0 [1]
2,4-Difluoro-N-[5-[5-(1H-indol-5-yl)thiophen-2-yl]pyridin-3-yl]benzenesulfonamideIC505800.0 [1]
5-(5-Phenylthiophen-2-yl)-3H-2-benzofuran-1-oneIC5020000.0 [1]
5-[5-(2-Methylphenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
5-[5-(3-Methylphenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
5-[5-(4-Methylphenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
5-[5-(2-Chlorophenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
5-[5-(3-Chlorophenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
2-Amino-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzoic acidIC505840.0 [1]
2-Hydroxy-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC50670.0 [1]
2-Hydroxy-N-(2-morpholin-4-ylethyl)-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC5012750.0 [1]
N-[2-(Dimethylamino)ethyl]-2-hydroxy-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC5020000.0 [1]
2-Hydroxy-N-(2-hydroxyethyl)-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC503310.0 [1]
2-Hydroxy-N-(2-hydroxypropyl)-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC5020000.0 [1]
N-[3-(Dimethylamino)propyl]-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC5020000.0 [1]
Ethyl 4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzoateIC5010970.0 [1]
Ethyl 2-hydroxy-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzoateIC5020000.0 [1]
5-[5-(2-Methoxyphenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
5-[5-(3-Methoxyphenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
5-[5-(4-Methoxyphenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC509360.0 [1]
5-[5-(3-Aminophenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5013970.0 [1]
5-[5-(4-Aminophenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5011820.0 [1]
5-[5-(3-Hydroxyphenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC505890.0 [1]
5-[5-(4-Hydroxyphenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
N-(2-Amino-2-oxoethyl)-2-hydroxy-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC502650.0 [1]
N-(3-Amino-3-oxopropyl)-2-hydroxy-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC507120.0 [1]
2-Amino-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC501200.0 [1]
2-Amino-N-(2-morpholin-4-ylethyl)-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC5014710.0 [1]
2-Amino-N-[2-(dimethylamino)ethyl]-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC5020000.0 [1]
5-[5-(4-Methylsulfanylphenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
5-[5-[4-(Hydroxymethyl)phenyl]thiophen-2-yl]-3H-2-benzofuran-1-oneIC50900.0 [1]
4-[5-(1-Oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzonitrileIC506870.0 [1]
3-[5-(1-Oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC502970.0 [1]
4-[5-(1-Oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC50180.0 [1]
4-[5-(1-Oxo-2,3-dihydroisoindol-5-yl)thiophen-2-yl]benzamideIC506040.0 [1]
4-[5-(2-Methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]benzamideIC5020000.0 [1]
N-Methyl-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC5010700.0 [1]
N,N-Dimethyl-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzamideIC5020000.0 [1]
5-[5-(4-Methylsulfonylphenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
N-Tert-butyl-4-[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzenesulfonamideIC506090.0 [1]
N-[4-[5-(1-Oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]phenyl]methanesulfonamideIC501090.0 [1]
5-[5-(1-Oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]pyridine-2-carboxamideIC50920.0 [1]
5-(5-Pyridin-4-ylthiophen-2-yl)-3H-2-benzofuran-1-oneIC504530.0 [1]
5-[5-(1-Oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC506240.0 [1]
3-[5-(1-Oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzenesulfonamideIC504850.0 [1]
5-[5-(4-Chlorophenyl)thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
3-[5-(1-Oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]benzonitrileIC5020000.0 [1]
5-[5-[4-(4-Methylpiperazine-1-carbonyl)phenyl]thiophen-2-yl]-3H-2-benzofuran-1-oneIC5020000.0 [1]
(5E)-5-[[4-(1-Oxo-3H-2-benzofuran-5-yl)-1,3-thiazol-2-yl]methylidene]-2-sulfanylideneimidazolidin-4-oneIC501410.0 [1]
(5E)-5-[[3-(1-Oxo-3H-2-benzofuran-5-yl)-1,2-oxazol-5-yl]methylidene]-2-sulfanylideneimidazolidin-4-oneIC501300.0 [1]
(5E)-5-[[3-(1-Oxo-3H-2-benzofuran-5-yl)-1,2-thiazol-5-yl]methylidene]-2-sulfanylideneimidazolidin-4-oneIC501440.0 [1]
5-[(2Z)-2-[(5-Hydroxy-2-sulfanylidene-1,3-dihydroimidazol-4-yl)methylidene]indol-6-yl]-3H-2-benzofuran-1-oneIC50360.0 [1]
5-[(2Z)-2-[(5-Hydroxy-2-sulfanylidene-1,3-dihydroimidazol-4-yl)methylidene]indol-5-yl]-3H-2-benzofuran-1-oneIC50820.0 [1]
5-[(2E)-2-[(5-Hydroxy-2-sulfanylidene-1,3-dihydroimidazol-4-yl)methylidene]indol-5-yl]-2,3-dihydroisoindol-1-oneIC502500.0 [1]
6-[(2E)-2-[(5-Hydroxy-2-sulfanylidene-1,3-dihydroimidazol-4-yl)methylidene]indol-6-yl]-3,4-dihydro-2H-isoquinolin-1-oneIC501660.0 [1]
6-[(2Z)-2-[(5-Hydroxy-2-sulfanylidene-1,3-dihydroimidazol-4-yl)methylidene]indol-5-yl]-3,4-dihydro-2H-isoquinolin-1-oneIC501450.0 [1]
5-[(2E)-2-[(5-Hydroxy-2-sulfanylidene-1,3-dihydroimidazol-4-yl)methylidene]indol-6-yl]-2,3-dihydroisoindol-1-oneIC501580.0 [1]
(5E)-2-Imino-1-methyl-5-[[5-(1-oxo-3H-2-benzofuran-5-yl)thiophen-2-yl]methylidene]imidazolidin-4-oneIC502750.0 [1]
2,4-Difluoro-N-[5-[5-(2-methyl-1-oxo-3H-isoindol-5-yl)furan-2-yl]pyridin-3-yl]benzenesulfonamideIC5015000.0 [1]
2,4-Difluoro-N-[5-[2-(2-methyl-1-oxo-3H-isoindol-5-yl)-1,3-thiazol-4-yl]pyridin-3-yl]benzenesulfonamideIC5020000.0 [1]
4-Methyl-N-[5-[5-(2-methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]pyridin-3-yl]-1,3-thiazole-5-sulfonamideIC5011600.0 [1]
N-[5-[5-(2-Methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]pyridin-3-yl]-4-methylsulfonylbenzenesulfonamideIC5020000.0 [1]
4-Methyl-3-[5-(2-methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]-N-pyridin-2-ylbenzenesulfonamideIC5020000.0 [1]
N-[4-Fluoro-3-[5-(2-methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]phenyl]pyridine-2-sulfonamideIC5020000.0 [1]
N-[5-[5-(2-Methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]pyridin-3-yl]-2,3-dihydro-1,4-benzodioxine-6-sulfonamideIC5020000.0 [1]
3-Cyano-N-[5-[5-(2-methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]pyridin-3-yl]benzenesulfonamideIC5020000.0 [1]
N-[5-[5-(2-Methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]pyridin-3-yl]-3,5-bis(trifluoromethyl)benzenesulfonamideIC5020000.0 [1]
3-Bromo-N-[5-[5-(2-methyl-1-oxo-3H-isoindol-5-yl)thiophen-2-yl]pyridin-3-yl]-5-(trifluoromethyl)benzenesulfonamideIC5020000.0 [1]
(Z)-1-(Furan-2-ylmethylene)-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-oneIC504400.0 [1]
(Z)-6-Methyl-1-((5-methylfuran-2-yl)methylene)-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-oneIC502700.0 [1]
(1Z)-6-Methyl-4-sulfanylidene-1-(thiophen-2-ylmethylidene)-5H-furo[3,4-c]pyridin-3-oneIC508600.0 [1]
(1Z)-6-Methyl-1-[(5-phenylthiophen-2-yl)methylidene]-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC503400.0 [1]
(1Z)-1-(1H-Imidazol-2-ylmethylidene)-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC5020000.0 [1]
(1Z)-6-Methyl-1-[(1-methylpyrrol-2-yl)methylidene]-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC5020000.0 [1]
(1Z)-1-[(4-Fluorophenyl)methylidene]-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC5020000.0 [1]
(1Z)-1-[(4-Chlorophenyl)methylidene]-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC5020000.0 [1]
(1Z)-6-Methyl-1-[(4-methylphenyl)methylidene]-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC5020000.0 [1]
(1Z)-6-Methyl-4-sulfanylidene-1-[[4-(trifluoromethyl)phenyl]methylidene]-5H-furo[3,4-c]pyridin-3-oneIC5020000.0 [1]
(1Z)-6-Methyl-4-sulfanylidene-1-[[4-(trifluoromethoxy)phenyl]methylidene]-5H-furo[3,4-c]pyridin-3-oneIC5020000.0 [1]
(1Z)-1-[[4-(Dimethylamino)phenyl]methylidene]-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC5020000.0 [1]
N-[4-[(Z)-(6-Methyl-3-oxo-4-sulfanylidene-5H-furo[3,4-c]pyridin-1-ylidene)methyl]phenyl]acetamideIC5020000.0 [1]
(1Z)-6-Methyl-1-[(5-phenylthiophen-2-yl)methylidene]-5H-furo[3,4-c]pyridine-3,4-dioneIC505000.0 [1]
(1Z)-6-Methyl-1-(1H-pyrrol-2-ylmethylidene)-5H-furo[3,4-c]pyridine-3,4-dioneIC5020000.0 [1]
(1Z)-6-Methyl-1-[(5-methylfuran-2-yl)methylidene]-5H-pyrrolo[3,4-c]pyridine-3,4-dioneIC5020000.0 [1]
(1Z)-6-Methyl-1-[(5-phenylthiophen-2-yl)methylidene]-4-sulfanylidene-5H-pyrrolo[3,4-c]pyridin-3-oneIC5020000.0 [1]
(1Z)-1-(Furan-3-ylmethylidene)-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC5020000.0 [1]
(1Z)-6-Methyl-4-sulfanylidene-1-(thiophen-3-ylmethylidene)-5H-furo[3,4-c]pyridin-3-oneIC5020000.0 [1]
(1Z)-1-(1-Benzofuran-2-ylmethylidene)-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC508200.0 [1]
(1Z)-1-[(4-Methoxy-1-benzofuran-2-yl)methylidene]-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC506700.0 [1]
(1Z)-1-[(6-Methoxy-1-benzofuran-2-yl)methylidene]-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC507200.0 [1]
(1Z)-1-[(7-Methoxy-1-benzofuran-2-yl)methylidene]-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC503000.0 [1]
(1Z)-1-(1-Benzothiophen-2-ylmethylidene)-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC509500.0 [1]
(1Z)-1-[(5-Methoxy-1-benzothiophen-2-yl)methylidene]-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC5013100.0 [1]
(1Z)-1-(1-Benzothiophen-2-ylmethylidene)-6-methyl-5H-furo[3,4-c]pyridine-3,4-dioneIC504600.0 [1]
(1Z)-1-(1H-Indol-2-ylmethylidene)-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC501300.0 [1]
(1Z)-1-[(6-Methoxy-1H-indol-2-yl)methylidene]-6-methyl-4-sulfanylidene-5H-furo[3,4-c]pyridin-3-oneIC503100.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Perforin-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/perforin-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Perforin-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/perforin-1-inhibitors-ic50-ki.
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