Peroxisome proliferator-activated receptor alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Rosiglitazone	IC50	10000.0 [1], 15000.0 [2], 50000.0 [3], 100000.0 [4]
	Rosiglitazone	Ki	33300.0 [1]
	Fenofibric acid	IC50	10000.0 [1], 24000.0 [2], 35000.0 [3]
	Fenofibric acid	Ki	35000.0 [1]
	Endurobol	IC50	463.0 [1], 1995.26 [2]
	2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-phenoxy-propionic acid	IC50	42.0 [1]
	Farglitazar	IC50	2870.0 [1]
	Farglitazar	Ki	489.78 [1], 490.0 [2]
	5-[3-[3-(4-Phenoxy-2-propylphenoxy)propoxy]phenyl]-1,3-thiazolidine-2,4-dione	IC50	28.0 [1]
	5-[3-[3-(4-Phenoxy-2-propylphenoxy)propoxy]phenyl]-1,3-thiazolidine-2,4-dione	Ki	30.0 [1]
	F3MethylAA	IC50	280.0 [1], 310.0 [2]
	(2S)-2-(4-[2-(3-[2,4-Difluorophenyl]-1-heptylureido)ethyl]phenoxy)-2-methylbutyric acid	IC50	348.0 [1], 538.0 [2], 740.0 [3]
	(2S)-2-Methyl-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acid	IC50	21.0 [1]
	2-Methyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenoxy}-3-phenyl-propionic acid	IC50	678.0 [1], 680.0 [2]
	(2R)-2-Methyl-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acid	IC50	1545.25 [1], 1546.0 [2]
	(R)-3-(4-(3-(2-Benzoyl-4-ethylphenoxy)butoxy)-2-methylphenyl)propanoic acid	IC50	4257.0 [1]
	(S)-3-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-pyrrol-1-yl-propionic acid	IC50	697.0 [1]
	(S)-3-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-pyrrol-1-yl-propionic acid	Ki	560.0 [1]
	2-[3-[2-[[Cyclopropanecarbonyl(ethyl)amino]methyl]-4-(6-ethoxypyridin-3-yl)phenyl]-4-methoxyphenyl]acetic acid	IC50	250000.0 [1]
	Arachidonic acid	IC50	1200.0 [1]
	Oleic acid	IC50	600.0 [1]
	Linoleic acid	IC50	1100.0 [1]
	Eicosapentaenoic acid	IC50	1100.0 [1]
	Linolenic acid	IC50	1200.0 [1]
	Dihomo-gamma-linolenic acid	IC50	1400.0 [1]
	Pirinixic acid	IC50	10110.0 [1], 36300.0 [2]
	gamma-Linolenic acid	IC50	270.0 [1]
	Palmitoleic acid	IC50	1700.0 [1]
	Muraglitazar	IC50	190.0 [1], 250.0 [2]
	Erucic acid	IC50	30000.0 [1]
	GW7647	IC50	0.46 [1]
	GW7647	Ki	0.05 [1]
	Tesaglitazar	IC50	3800.0 [1]
	Tesaglitazar	Ki	1000.0 [1]
	Ragaglitazar	IC50	980.0 [1]
	Ragaglitazar	Ki	980.0 [1]
	5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide	IC50	914.0 [1]
	5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide	Ki	230.0 [1]
	LY-518674	IC50	23.99 [1], 24.0 [2]
	Naveglitazar	IC50	2710.19 [1], 2711.0 [2]
	Benzeneacetic acid, 3-chloro-4-((3-((3-phenyl-7-propyl-6-benzofuranyl)oxy)propyl)thio)-	IC50	53.95 [1], 54.0 [2]
	CID 9890319	IC50	174.0 [1]
	CID 9890319	Ki	170.0 [1]
	(2S)-2-Methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acid	IC50	28.0 [1]
	CID 9889841	IC50	570.0 [1], 570.16 [2]
	2-Methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acid	IC50	45.0 [1]
	2-Methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acid	Ki	4.0 [1]
	2-{5-[3-(6-Benzoyl-1-propylnaphthalen-2-yloxy)propoxy]indol-1-YL}ethanoic acid	IC50	112.98 [1], 113.0 [2]
	4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide	IC50	25118.86 [1]
	(2R)-7-(3-(2-Chloro-4-(4-fluorophenoxy)phenoxy)propoxy)-2-ethylchromane-2-carboxylic acid	IC50	60.0 [1]
	2-Methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}propionic Acid	IC50	1445.0 [1], 1736.0 [2]
	{3-Chloro-4-[3-(3-hydroxy-4-propionyl-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-acetic acid	IC50	599.79 [1], 600.0 [2]
	3-[4-[3-[(1R)-1-[(5-Chloro-1,3-dimethylindole-2-carbonyl)amino]ethyl]-5-fluorophenoxy]-2-ethylphenyl]propanoic acid	IC50	10256.52 [1], 10257.0 [2]
	2-[4-[3-[2-Chloro-4-(4-fluorophenoxy)phenoxy]propoxy]phenoxy]-2-methylpropanoic acid	IC50	30.0 [1]
	{4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-3-chloro-phenyl}-acetic acid	IC50	7396.05 [1], 7400.0 [2]
	{3-Chloro-4-[3-(3-ethyl-7-propyl-benzofuran-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid	IC50	1730.0 [1]
	2-{5-[3-(7-Propyl-3-trifluoromethylbenzo[D]isoxazol-6-yloxy)propoxy]indol-1-YL}ethanoic acid	IC50	495.45 [1], 496.0 [2]
	(2S)-2-Methoxy-3-{4-[5-(4-phenoxy-phenoxy)-pent-1-ynyl]-phenyl}-propionic acid	IC50	769.13 [1], 770.0 [2]
	2-[4-[3-[1-[(3,4-Dimethylphenyl)methyl]-4-methyl-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid	IC50	11.99 [1], 12.0 [2]
	(2R)-7-(3-(2-Chloro-4-cyclopentylphenoxy)propoxy)-2-methylchromane-2-carboxylic Acid	IC50	39.99 [1], 40.0 [2]
	(S)-2-Ethoxy-3-{4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-propionic acid	IC50	1686.0 [1], 1686.55 [2]
	3-{4-[2-(2-Biphenyl-4-yl-5-methyl-oxazol-4-yl)ethoxy]-phenyl}-2-methyl-2-phenoxypropionic acid	IC50	503.0 [1]
	3-{4-[2-(2-Biphenyl-3-yl-5-methyl-oxazol-4-yl)ethoxy]-phenyl}-2-methyl-2-phenoxypropionic acid	IC50	167.0 [1]
	(S)-2-Methoxy-3-{4-[4-(4-phenoxy-phenoxy)-but-1-ynyl]-phenyl}-propionic acid	IC50	1153.45 [1], 1154.0 [2]
	(R)-7-[3-(2-Chloro-4-isobutyl-phenoxy)-propoxy]-2-methyl-chroman-2-carboxylic acid	IC50	16.0 [1]
	2-[4-[3-[1-[(4-Tert-butylphenyl)methyl]-4-methyl-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid	IC50	15.0 [1]
	2-(4-(4-(4-(Trifluoromethyl)benzyloxy)benzylthio)-5-methoxy-2-methylphenoxy)acetic acid	IC50	4.7 [1]
	2-[4-[3-[1-[(3-Methoxyphenyl)methyl]-5-oxo-4-propyl-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid	IC50	19.0 [1], 19.01 [2]
	(R)-7-[3-(2-Chloro-4-trifluoromethyl-phenoxy)-propoxy]-2-ethyl-chroman-2-carboxylic acid	IC50	89.95 [1], 90.0 [2]
	(S)-3-{4-[3-(Biphenyl-4-yloxy)-propoxy]-phenyl}-2-methoxy-propionic acid	IC50	567.54 [1], 568.0 [2]
	(S)-3-{4-[3-(4-Benzoyl-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid	IC50	469.89 [1], 470.0 [2]
	(S)-2-Methoxy-3-{3-methoxy-4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-propionic acid	IC50	1349.0 [1]
	3-[2-Ethyl-4-[(3R)-3-(4-ethyl-2-pyridin-2-ylphenoxy)butoxy]phenyl]propanoic acid	IC50	7345.14 [1], 7350.0 [2]
	3-[4-[(3R)-3-(4-Ethyl-2-pyridin-2-ylphenoxy)butoxy]-2-methylphenyl]propanoic acid	IC50	8290.0 [1], 8298.51 [2]
	(2S)-3-[4-[2-(2-Cyclohexyl-5-methyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-methyl-2-phenoxypropanoic acid	IC50	17.99 [1], 18.0 [2]
	3-[4-[(3R)-3-[4-Ethyl-2-(1,3-oxazol-2-yl)phenoxy]butoxy]-2-methylphenyl]propanoic acid	IC50	10399.2 [1], 10400.0 [2]
	2-[5-[3-(6-Benzoylnaphthalen-2-yl)oxypropoxy]indol-1-yl]acetic acid	IC50	484.0 [1], 484.17 [2]
	2-[4-[3-[[[2-Fluoro-4-(trifluoromethyl)benzoyl]amino]methyl]-5-methylphenoxy]-2-methylphenoxy]-2-methylpropanoic acid	IC50	313.0 [1], 313.33 [2]
	2-(6-(3-(4-(4-Fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acid	IC50	1047.0 [1], 1047.13 [2]
	2-[4-[3-[4-(2-Hydroxyethyl)-1-[(4-methylphenyl)methyl]-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid	IC50	26.98 [1], 27.0 [2]
	2-Methyl-2-[2-methyl-4-[3-[[[2-methyl-4-(trifluoromethyl)benzoyl]amino]methyl]phenoxy]phenoxy]propanoic acid	IC50	1761.98 [1], 1763.0 [2]
	2-[4-[3-[1-(Cyclohexylmethyl)-5-oxo-4-propyl-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid	IC50	250.0 [1], 250.03 [2]
	3-[2-Ethyl-4-[(3R)-3-[2-pyridin-2-yl-4-(trifluoromethyl)phenoxy]butoxy]phenyl]propanoic acid	IC50	6090.0 [1], 6095.37 [2]
	(2R)-2-Methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acid	IC50	618.0 [1], 618.02 [2]
	3-(1-(3-(7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indol-5-yl)propanoic acid	IC50	449.78 [1], 450.0 [2]
	2-(4-(3-(6-Benzoyl-1-propylnaphthalen-2-yloxy)propoxy)-1H-indol-1-yl)acetic acid	IC50	578.0 [1], 578.1 [2]
	2-(6-(3-(6-Benzoylnaphthalen-2-yloxy)propoxy)-1H-indol-1-yl)acetic acid	IC50	4486.0 [1], 4487.45 [2]
	2-(5-(3-(4-(4-Fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acid	IC50	469.89 [1], 470.0 [2]
	2-(6-(3-(4-(4-Fluorobenzoyl)phenoxy)propoxy)-1H-indol-1-yl)acetic acid	IC50	115.88 [1], 116.0 [2]
	2-(1-(3-(7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indol-5-yl)acetic acid	IC50	400.0 [1]
	2-(6-(3-(6-Benzoyl-1-propylnaphthalen-2-yloxy)propoxy)-1H-indol-1-yl)acetic acid	IC50	4486.0 [1], 4487.45 [2]
	2-(4-(3-(4-(4-Fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acid	IC50	414.0 [1]
	3-[4-[(3R)-3-[4-Ethyl-2-(1,3-thiazol-4-yl)phenoxy]butoxy]-2-methylphenyl]propanoic acid	IC50	4100.0 [1], 4102.04 [2]
	4-[({1-[(E)-{[4-(Morpholin-4-yl)phenyl]imino}methyl]naphthalen-2-yl}oxy)methyl]benzoic acid	IC50	42953.64 [1], 43000.0 [2]
	(R)-3-{4-[3-(4-Ethyl-2-phenoxy-phenoxy)-butoxy]-2-methyl-phenyl}-propionic acid	IC50	3758.0 [1], 3758.37 [2]
	(R)-3-{2-Methyl-4-[3-(2-phenoxy-4-trifluoromethoxy-phenoxy)-butoxy]-phenyl}-propionic acid	IC50	897.0 [1], 897.43 [2]
	(R)-3-{4-[3-(4-Chloro-2-phenoxy-phenoxy)-butoxy]-2-trifluoromethyl-phenyl}-propionic acid	IC50	4385.31 [1], 4386.0 [2]
	2-(4-(3-(2-Benzoyl-4-ethylphenoxy)propoxy)phenoxy)-2-methylpropanoic acid	IC50	1398.0 [1], 1399.59 [2]
	(R)-3-{4-[3-(4-Chloro-2-phenoxy-phenoxy)-butoxy]-2-methyl-phenyl}-propionic acid	IC50	5303.0 [1], 5308.84 [2]
	(R)-3-{2-Methyl-4-[3-(2-phenoxy-4-trifluoromethyl-phenoxy)-butoxy]-phenyl}-propionic acid	IC50	1037.0 [1], 1037.53 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Peroxisome proliferator-activated receptor alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/peroxisome-proliferator-activated-receptor-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Peroxisome proliferator-activated receptor alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/peroxisome-proliferator-activated-receptor-alpha-inhibitors-ic50-ki.
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