 | Papaverine | IC50 | 40.0 [1] |
 | Mardepodect | IC50 | 1.34 [1] |
 | 2-[[4-[4-Pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline | IC50 | 0.3 [1], 1.0 [2], 1.41 [3] |
 | 2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine | IC50 | 7.0 [1], 7.28 [2], 7.3 [3], 32.0 [4] |
 | Sildenafil | IC50 | 3100.0 [1], 5400.0 [2], 6800.0 [3], 10000.0 [4] |
 | 6,7-Dimethoxy-4-[(3R)-3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline | IC50 | 16.0 [1], 64.0 [2] |
| 6,7-Dimethoxy-4-[(3R)-3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline | Ki | 3981071.71 [1] |
 | Tadalafil | IC50 | 10000.0 [1] |
 | (2R)-2-[[3-Cyano-2-[4-(2-ethoxyphenyl)phenyl]-6-fluoroquinolin-4-yl]amino]propanoic acid | IC50 | 6.0 [1], 8.0 [2] |
 | 1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-2-quinazolinyl)methyl)- | Ki | 1000.0 [1], 1900.0 [2] |
 | 4-Methoxy-2-[2-[3-(4-methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]isoindole-1,3-dione | Ki | 2.0 [1] |
 | 5,8-Dimethyl-2-(2-phenylimidazo[1,2-a]pyridin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 0.1 [1], 37.0 [2] |
 | N-[cis-3-(2-Methoxy-3h-Imidazo[4,5-B]pyridin-3-Yl)cyclobutyl]-1,3-Benzothiazol-2-Amine | IC50 | 0.8 [1], 2.2 [2], 3.4 [3] |
 | Vardenafil | IC50 | 790.0 [1], 880.0 [2] |
 | 5-(6,7-Dimethoxycinnolin-4-yl)-3-methyl-N-propan-2-ylpyridin-2-amine | IC50 | 1.9 [1], 2.0 [2] |
 | CID 46239428 | Ki | 5.0 [1] |
 | 5-(1h-Benzimidazol-2-Ylmethylsulfanyl)-2-Methyl-[1,2,4]triazolo[1,5-C]quinazoline | IC50 | 12.0 [1] |
 | N-(12-Methoxy-5-methyl-3-propyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-7-yl)methanesulfonamide | IC50 | 7.0 [1], 7.16 [2] |
 | 3-(2-Chlorophenyl)-12-methoxy-5-methyl-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 13.1 [1], 21.0 [2] |
 | 1h-Benzimidazol-2-Yl(4-{[3-(Morpholin-4-Yl)pyrazin-2-Yl]oxy}phenyl)methanone | IC50 | 4.5 [1] |
 | 1-[4-[3-[4-(1H-Benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperazin-1-yl]ethanone | IC50 | 5.1 [1] |
 | N-[4-(3-Morpholin-4-ylpyrazin-2-yl)oxyphenyl]-1H-benzimidazol-2-amine | IC50 | 1.1 [1], 25.0 [2] |
 | [1-[3-[4-(1,3-Benzothiazol-2-ylamino)phenoxy]pyrazin-2-yl]piperidin-4-yl]methanol | IC50 | 0.2 [1], 200.0 [2] |
 | 4-[5-(8,9-Dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]morpholine | IC50 | 10.0 [1] |
| 4-[5-(8,9-Dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]morpholine | Ki | 26.0 [1] |
 | 2-Methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl)pyrazolo[1,5-c]quinazoline | IC50 | 50.0 [1] |
 | 2-(2'-Ethoxybiphenyl-4-Yl)-4-Hydroxy-1,6-Naphthyridine-3-Carbonitrile | IC50 | 12.0 [1] |
 | N-Methyl-N-[4-(quinolin-2-ylmethoxy)phenyl]-1,3-benzothiazole-6-carboxamide | IC50 | 31.0 [1] |
 | N-Methyl-N-[4-(quinolin-2-ylmethoxy)phenyl]pyridine-4-carboxamide | IC50 | 250.0 [1] |
 | N-Methyl-3-pyridin-2-yl-N-[4-(quinolin-2-ylmethoxy)phenyl]-1H-pyrazole-5-carboxamide | IC50 | 12.0 [1] |
 | 6-Chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methyl-2-(3-quinolin-2-ylpropoxy)pyrimidin-4-amine | Ki | 0.01 [1] |
 | [1-(3-{[1-(Quinolin-2-Yl)azetidin-3-Yl]oxy}pyrazin-2-Yl)piperidin-4-Yl]methanol | IC50 | 2.4 [1], 2400.0 [2] |
 | 6-Methoxy-3-methyl-1-(3-methylpyridin-4-yl)-8-(trifluoromethyl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1.48 [1] |
 | 1-(2-Chlorophenyl)-6,8-Dimethoxy-3-Methylimidazo[5,1-C][1,2,4]benzotriazine | IC50 | 0.28 [1] |
 | 8-Fluoro-1-(3-fluoro-2-methylphenyl)-6-methoxy-3-methylimidazo[5,1-c][1,2,4]benzotriazine | IC50 | 3.55 [1] |
 | N-Methyl-3-phenyl-N-[4-(quinolin-2-ylmethoxy)phenyl]-1H-pyrazole-5-carboxamide | IC50 | 24.0 [1] |
 | 2-{2-[3-(4-Methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione | Ki | 87.0 [1] |
 | 5,8-Dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 1.8 [1], 7.2 [2] |
 | 5,7-Dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyridine | IC50 | 0.32 [1], 17.0 [2] |
 | Unii-ND06tnj6W7 | IC50 | 0.32 [1] |
 | 5,7-Dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidine | IC50 | 12.0 [1], 67.0 [2] |
 | 5,8-Dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine | IC50 | 7.2 [1] |
 | 2-[2-[3-(4-Methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-4-methylisoindole-1,3-dione | Ki | 6.1 [1], 61.0 [2] |
 | 4-Hydroxy-2-[2-[3-(4-methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]isoindole-1,3-dione | Ki | 20.0 [1], 22.0 [2] |
 | 2-[3-[3-(4-Methoxyphenyl)-4-oxoquinazolin-2-yl]propyl]isoindole-1,3-dione | Ki | 219.0 [1] |
 | 2-[2-[3-(4-Methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-4-pyridin-4-ylisoindole-1,3-dione | Ki | 0.07 [1] |
 | 2-[2-[3-(4-Methoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-propan-2-yloxyisoindole-1,3-dione | Ki | 0.37 [1], 0.56 [2] |
 | 2-(6-Chloropyridin-3-yl)-N-(1-methylpyrazol-4-yl)-4-propan-2-yloxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide | Ki | 0.9 [1] |
 | 2-[2-[3-(4-Methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-4-propan-2-yloxyisoindole-1,3-dione | Ki | 0.15 [1] |
 | 2-(6-Chloropyridin-3-yl)-4-propan-2-yloxy-6-pyridin-3-ylsulfonyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine | Ki | 0.63 [1] |
 | [2-(6-Chloropyridin-3-yl)-4-(2-methoxyethoxy)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-pyrazolo[1,5-a]pyridin-3-ylmethanone | Ki | 0.92 [1], 0.93 [2] |
 | [2-(6-Chloropyridin-3-yl)-4-(2-methoxyethoxy)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-imidazo[1,5-a]pyridin-1-ylmethanone | Ki | 0.99 [1], 1.0 [2] |
 | N-(3-Ethylphenyl)-4-(1-methylpiperidin-4-yl)oxy-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide | Ki | 14.0 [1] |
 | 1-[4-[Benzyl(methyl)amino]-2-[5-(1H-pyrazol-4-yl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-3-methylbutan-1-one | Ki | 15.0 [1] |
 | N-Phenyl-2-pyridin-4-yl-4-(2-pyridin-2-ylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide | Ki | 47.9 [1] |
 | 5,8-Dimethyl-2-[2-(1-methyl-2-thiophen-2-ylimidazol-4-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 1.0 [1] |
 | 6-Cyclopropyl-N-(2-methyl-5-quinolin-2-ylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | IC50 | 1.0 [1] |
 | 6-Cyclopropyl-N-(2-pyridin-2-yl-1,3-thiazol-5-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | IC50 | 2.0 [1] |
 | 1-[4-[3-(1-Quinolin-2-ylazetidin-3-yl)oxypyrazin-2-yl]piperidin-1-yl]ethanone | IC50 | 29.0 [1], 29000.0 [2] |
 | 6-[3-(1-Quinolin-2-ylazetidin-3-yl)oxypyrazin-2-yl]quinazolin-2-amine | IC50 | 6.8 [1], 6800.0 [2] |
 | (1H-Benzoimidazol-2-yl)-[3-(3-phenyl-pyridin-2-yl)-azetidin-1-yl]-methanone | IC50 | 21.9 [1] |
 | 6-Cyclopropyl-N-[4-(methylcarbamoyl)pyridin-3-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | IC50 | 13.7 [1] |
 | 2-[3-(1H-Benzimidazol-2-yl)propoxy]-6-chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methylpyrimidin-4-amine | Ki | 0.02 [1] |
 | 6-Chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methyl-2-[2-(1,8-naphthyridin-2-yloxy)ethoxy]pyrimidin-4-amine | Ki | 0.04 [1] |
 | 5-Cyclopropyl-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine | Ki | 9.2 [1] |
 | 6-Cyclopropyl-N-[2-(2-methoxyethyl)-5-pyridin-2-ylpyrazol-3-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | IC50 | 1.0 [1] |
 | [1-[4-(1-Quinolin-2-ylazetidin-3-yl)oxypyridin-3-yl]piperidin-4-yl]methanol | IC50 | 4.7 [1], 4700.0 [2] |
 | [1-[3-(1-Quinolin-2-ylpiperidin-4-yl)oxypyrazin-2-yl]piperidin-4-yl]methanol | IC50 | 6.5 [1], 6500.0 [2] |
 | [1-[3-(1-Quinolin-2-ylazetidin-3-yl)oxyquinoxalin-2-yl]piperidin-4-yl]methanol | IC50 | 6.8 [1], 6800.0 [2] |
 | 6-Cyclopropyl-N-[2-(dimethylcarbamoyl)-3-methoxyphenyl]-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamide | IC50 | 12.0 [1], 12.2 [2] |
 | 6-Cyclopropyl-N-[3-(dimethylcarbamoyl)-1-methylpyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | IC50 | 31.5 [1] |
 | 1h-Benzimidazol-2-Yl(4-{[3-(Tetrahydro-2h-Pyran-4-Yl)pyridin-2-Yl]oxy}phenyl)methanone | IC50 | 0.1 [1], 0.17 [2] |
 | 1-[4-[2-[4-(1H-Benzimidazole-2-carbonyl)phenoxy]pyridin-3-yl]piperidin-1-yl]ethanone | IC50 | 0.1 [1], 0.16 [2] |
 | N-[4-(3-Morpholin-4-ylpyridin-2-yl)oxyphenyl]-1,3-benzothiazol-2-amine | IC50 | 0.96 [1] |
 | 2-[2-[2-(Furan-3-yl)-1H-imidazol-5-yl]ethyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 0.27 [1] |
 | 2-[2-[3-[(3S)-3-Fluoropyrrolidin-1-yl]phenyl]imidazo[1,2-a]pyridin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 0.16 [1] |
 | 5,8-Dimethyl-2-(2-pyridin-2-ylimidazo[1,2-a]pyridin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 0.16 [1] |
 | 5,8-Dimethyl-2-[2-(2-thiophen-2-yl-1H-imidazol-5-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 0.34 [1], 0.4 [2] |
 | N-[(1-Methylpyrazol-4-yl)methyl]-5-[[(1S,2S)-2-pyridin-2-ylcyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine | Ki | 0.23 [1], 0.32 [2] |
 | 6-Chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methyl-2-[[(1S,2S)-2-pyridin-2-ylcyclopropyl]methoxy]pyrimidin-4-amine | Ki | 0.02 [1], 0.07 [2] |
 | 6-Chloro-5-methyl-N-[(1-methylpyrazol-4-yl)methyl]-2-[[(1S,2S)-2-pyridin-2-ylcyclopropyl]methoxy]pyrimidin-4-amine | Ki | 0.44 [1] |
 | 4-[8-Morpholin-4-yl-2-(3-quinolin-2-ylcyclobutyl)imidazo[1,2-b]pyridazin-3-yl]benzoic acid | IC50 | 1.0 [1], 13.0 [2] |
 | 1-[4-[8-Morpholin-4-yl-2-(3-quinolin-2-ylcyclobutyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]piperidine-4-carboxylic acid | IC50 | 2.0 [1], 93.0 [2] |
 | 4,7-Diacetyl-N-[4-(2-hydroxypropan-2-yl)quinolin-2-yl]-3-methyl-1-benzothiophene-2-carboxamide | IC50 | 2.6 [1], 5.1 [2] |
 | 7-Acetyl-N-[5-(3-methoxyazetidine-1-carbonyl)quinolin-2-yl]-4-(methoxymethyl)-3-methyl-1-benzothiophene-2-carboxamide | IC50 | 0.22 [1], 0.73 [2] |
 | 7-Acetyl-N-[4-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]quinolin-2-yl]-4-(methoxymethyl)-3-methyl-1-benzothiophene-2-carboxamide | IC50 | 0.15 [1], 1.3 [2] |
 | [2-[[7-Acetyl-4-(methoxymethyl)-3-methyl-1-benzothiophene-2-carbonyl]amino]quinolin-5-yl]methyl dihydrogen phosphate | IC50 | 0.6 [1], 0.99 [2] |
 | 7-Acetyl-N-[4-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]quinolin-2-yl]-4-(methoxymethyl)-3-methyl-1-benzothiophene-2-carboxamide | IC50 | 0.23 [1], 0.42 [2] |
 | 1-[5-(4-Chloro-3,5-dimethoxyphenyl)furan-2-yl]-2-ethoxy-2-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]ethanone | IC50 | 0.62 [1] |
 | N-[3-[3-(Oxan-4-yl)pyridin-2-yl]oxycyclobutyl]-1,3-benzothiazol-2-amine | IC50 | 0.75 [1], 3.19 [2] |
 | 5-Methyl-N-[3-[3-(oxan-4-yl)pyridin-2-yl]oxycyclobutyl]pyridin-2-amine | IC50 | 8.25 [1], 17.63 [2] |
 | N-[3-[3-(Oxan-4-yl)pyridin-2-yl]oxycyclobutyl]-1H-benzimidazol-2-amine | IC50 | 1.53 [1], 2.63 [2] |
 | 1-[4-[3-[3-(Quinolin-2-ylamino)cyclobutyl]oxypyrazin-2-yl]piperidin-1-yl]ethanone | IC50 | 4.93 [1], 15.82 [2] |
 | 1-[4-[3-[3-[(5-Methylpyridin-2-yl)amino]cyclobutyl]oxypyrazin-2-yl]piperidin-1-yl]ethanone | IC50 | 66.06 [1], 84.55 [2] |
 | N-[3-[3-(Oxan-4-yl)pyridin-2-yl]oxycyclobutyl]-5-(trifluoromethyl)pyridin-2-amine | IC50 | 106.0 [1], 865.0 [2] |
 | 6-[[3-[3-(Oxan-4-yl)pyridin-2-yl]oxycyclobutyl]amino]pyridine-3-carbonitrile | IC50 | 590.0 [1], 865.0 [2] |
 | 5-Chloro-N-[3-[3-(oxan-4-yl)pyridin-2-yl]oxycyclobutyl]pyridin-2-amine | IC50 | 83.7 [1], 865.0 [2] |
 | 2-[3-[3-(3-Azabicyclo[3.2.2]nonan-3-yl)pyrazin-2-yl]azetidin-1-yl]quinoline | IC50 | 35.0 [1] |
 | 4-[3-(1-Quinolin-2-ylazetidin-3-yl)pyrazin-2-yl]benzamide | IC50 | 1.3 [1] |
 | 2-Fluoro-4-[3-(1-quinolin-2-ylazetidin-3-yl)pyrazin-2-yl]benzamide | IC50 | 2.0 [1], 2.6 [2] |
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