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Phosphodiesterase 3A Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
PapaverineIC50284.0 [1], 917.0 [2]
PapaverineKi279.0 [1]
MilrinoneIC50440.0 [1], 3600.0 [2], 11400.0 [3]
3-[7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-oneIC50360.0 [1], 2380.0 [2]
VesnarinoneIC5010700.0 [1], 11210.0 [2]
CilostamideIC5016.0 [1], 18.1 [2]
6,7-Dimethoxy-4-[(3R)-3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazolineKi211.0 [1]
2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazineIC503700.0 [1], 5000.0 [2]
2-Amino-4-(3-benzyl-2-ethylsulfanylimidazol-4-yl)-6-(4-bromophenyl)pyridine-3-carbonitrileIC503.76 [1]
6,7-Dimethoxy-4-[(3r)-3-(2-Naphthyloxy)pyrrolidin-1-Yl]quinazolineKi283.0 [1]
6,7-Dimethoxy-4-[(3R)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl]quinazolineKi100.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(2-methoxyphenoxy)pyrrolidin-1-yl]quinazolineKi100.0 [1]
2-{[(3R)-1-(6,7-Dimethoxyquinazolin-4-yl)pyrrolidin-3-yl]oxy}benzonitrileKi100.0 [1]
4-[(3R)-3-(4-Ethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi161.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(3-phenylphenoxy)pyrrolidin-1-yl]quinazolineKi271.0 [1]
(R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazolineKi141.0 [1]
(R)-4-[3-(5-Chloro-pyrimidin-2-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazolineKi162.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(pyridin-2-yloxy)pyrrolidin-1-yl]quinazolineKi77.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(pyridin-4-yloxy)pyrrolidin-1-yl]quinazolineKi226.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(naphthalen-1-yloxy)pyrrolidin-1-yl]quinazolineKi48.0 [1]
6,7-Dimethoxy-4-[(3R)-3-[(7-methoxynaphthalen-2-yl)oxy]pyrrolidin-1-yl]quinazolineKi273.0 [1]
6,7-Dimethoxy-4-[(3R)-3-[(2-methylquinolin-6-yl)oxy]pyrrolidin-1-yl]quinazolineKi152.0 [1]
4-[(3R)-3-(Isoquinolin-3-yloxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi151.0 [1]
(R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)-quinazolineKi100.0 [1]
4-[(3R)-3-(2-Chlorophenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi100.0 [1]
4-{[(3R)-1-(6,7-Dimethoxyquinazolin-4-yl)pyrrolidin-3-yl]oxy}benzonitrileKi214.0 [1]
4-[(3R)-3-(4-Tert-butylphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi720.0 [1]
4-[(3R)-3-(3-Ethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi61.0 [1]
4-[(3R)-3-(3,4-Dimethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi121.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(pyridin-3-yloxy)pyrrolidin-1-yl]quinazolineKi302.0 [1]
6,7-Dimethoxy-4-[(3R)-3-[(6-methoxynaphthalen-2-yl)oxy]pyrrolidin-1-yl]quinazolineKi199.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(quinolin-6-yloxy)pyrrolidin-1-yl]quinazolineKi104.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(quinolin-7-yloxy)pyrrolidin-1-yl]quinazolineKi209.0 [1]
5-(3-(Cyclopentyloxy)-4-methoxybenzylidene)-2-thioxothiazolidin-4-oneIC5010830.0 [1]
2-Amino-4-(4-ethoxyphenyl)-6-thiophen-3-ylpyridine-3-carbonitrileIC5013300.0 [1], 13500.0 [2]
Chembl4127641IC50101000.0 [1], 369000.0 [2]
SildenafilIC5026000.0 [1]
3-Isobutyl-1-methylxanthineIC507000.0 [1]
RoflumilastIC50100000.0 [1]
IbudilastIC50299000.0 [1]
2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanolIC5010000.0 [1]
(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinoneIC5096.0 [1]
6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acidIC5014000.0 [1]
PF-04447943IC5010000.0 [1]
8-[(4-Chlorophenyl)methyl]-10-thia-3,5,6,8-tetrazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(9),2,4,11(16)-tetraen-7-oneIC5010000.0 [1]
4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-olIC5029000.0 [1]
3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC501700.0 [1]
6-{(1S)-1-[6-(1-Methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinolineIC503530.0 [1]
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
5-(4-Ethoxy-3-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-oneIC509460.0 [1]
Unii-7eis09YY11IC5030000.0 [1]
(3S)-3-(7-Methoxy-1-methylbenzotriazol-5-yl)-3-[4-methyl-3-[[(4R)-4-methyl-1,1-dioxo-3,4-dihydro-5,1lambda6,2-benzoxathiazepin-2-yl]methyl]phenyl]propanoic acidIC5010000.0 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
CID 46239428Ki10000.0 [1]
5-(1h-Benzimidazol-2-Ylmethylsulfanyl)-2-Methyl-[1,2,4]triazolo[1,5-C]quinazolineIC5010000.0 [1]
6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
4-[[1-(2-Chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholineIC507760.0 [1]
N-[(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamideIC5030000.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501000.0 [1]
trans CM-414IC501800.0 [1]
5-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamideIC503200.0 [1]
N-(12-Methoxy-5-methyl-3-propyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-7-yl)methanesulfonamideIC501260.0 [1]
3-[8-Methoxy-2-(trifluoromethyl)imidazo[1,2-a]pyridin-5-yl]-4,4-dimethyl-1H-pyrazol-5-oneIC50140.0 [1]
2-Amino-6-(4-bromophenyl)-4-(2-ethoxyphenyl)pyridine-3-carbonitrileIC5027000.0 [1]
6,8-Dimethoxy-3,4-dimethyl-1-(3-methylpyridin-4-yl)imidazo[1,5-a]quinoxalineIC5010000.0 [1]
6-Methoxy-3,8-Dimethyl-4-(Morpholin-4-Ylmethyl)-1h-Pyrazolo[3,4-B]quinolineKi10000.0 [1]
[1-[3-[4-(1,3-Benzothiazol-2-ylamino)phenoxy]pyrazin-2-yl]piperidin-4-yl]methanolIC5030000.0 [1]
4-[5-(8,9-Dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]morpholineKi177.0 [1]
2,9-Dimethyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[1,5-c]quinazolineIC5010000.0 [1]
(3,4,5-Trimethoxyphenyl)methyl 5-phenylfuran-2-carboxylateIC5054600.0 [1]
[1-(3-{[1-(Quinolin-2-Yl)azetidin-3-Yl]oxy}pyrazin-2-Yl)piperidin-4-Yl]methanolIC5030000.0 [1]
1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazineIC5010000.0 [1]
CID 73211886IC5015000.0 [1]
5-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]-2-fluorobenzoic acidIC5016980.0 [1]
8-Chloro-5-[3-(dimethylamino)-2-hydroxypropoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC50101000.0 [1]
8-Chloro-6-pyridin-3-ylspiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC5014800.0 [1]
8-Chloro-6-[3-(4-methylpiperazine-1-carbonyl)phenyl]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC5031600.0 [1]
5-[(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxymethyl]furan-2-carboxylic acidIC5010800.0 [1]
5-Methyl-6-(2-isopropylpyrazolo[1,5-a]pyridine-3-yl)-4,5-dihydropyridazine-3(2H)-oneIC5089000.0 [1]
3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxypropane-1-sulfonic acidIC5012700.0 [1]
8-Chloro-6-pyridin-2-ylspiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC5045100.0 [1]
8-Chloro-6-pyridin-4-ylspiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC5011200.0 [1]
2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]-3-methylbenzoic acidIC5020540.0 [1]
2-[2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyethylamino]acetic acidIC50101000.0 [1]
3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)benzoic acidIC5016700.0 [1]
(4R)-3-[4-[(2-Benzyl-3-oxocyclohexen-1-yl)amino]phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-oneIC501.3 [1]
(R)-6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-oneIC503800.0 [1]
3-[[2-[4-(4,4-Dimethyl-5-oxo-1H-pyrazol-3-yl)-2,3-difluoroanilino]-6-oxocyclohexen-1-yl]methyl]benzonitrileIC507.6 [1]
3-[2-Fluoro-4-[[2-[(3-nitrophenyl)methyl]-3-oxocyclohexen-1-yl]amino]phenyl]-4,4-dimethyl-1H-pyrazol-5-oneIC50150.0 [1]
7-Methoxy-4-(3-phenylpiperidin-1-yl)-6-propoxyquinazolineIC5098.0 [1]
6,7-Dimethoxy-4-(3-phenylpiperidin-1-yl)quinazolineIC508.5 [1]
3-{4-[(2-Benzyl-3-oxocyclohex-1-en-1-yl)amino]phenyl}-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-oneIC5053.0 [1]
3-[4-[(2-Benzyl-3-oxocyclohexen-1-yl)amino]-2-fluorophenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-oneIC501.6 [1]
4-Methoxy-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinolineIC5027500.0 [1]
3-[4-[[2-[(2,6-Dichlorophenyl)methyl]-3-oxocyclohexen-1-yl]amino]-2-fluorophenyl]-4,4-dimethyl-1H-pyrazol-5-oneIC502.2 [1]
6-Fluoro-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5038500.0 [1]
(3-Bromo-4-fluorophenyl)-[(5S)-3,3-difluoro-5-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanoneIC5010000.0 [1]
Methyl 3-[3-ethyl-2-[(3-fluoropyridin-4-yl)amino]-4-oxothieno[3,2-d]pyrimidin-7-yl]piperidine-1-carboxylateIC5029.0 [1]
3-Ethyl-2-[(3-fluoropyridin-4-yl)amino]-7-[1-(3-hydroxy-2,2-dimethylpropanoyl)piperidin-3-yl]thieno[3,2-d]pyrimidin-4-oneIC5037.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 3A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-3a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Phosphodiesterase 3A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-3a-inhibitors-ic50-ki.
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