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Phosphodiesterase 3B Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
TadalafilIC5010000.0 [1], 50000.0 [2]
PapaverineIC501030.0 [1]
PapaverineKi417.0 [1]
VesnarinoneIC5013200.0 [1], 14540.0 [2]
CilostamideIC5018.0 [1], 69.07 [2]
6,7-Dimethoxy-4-[(3R)-3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazolineKi273.0 [1]
6,7-Dimethoxy-4-[(3r)-3-(2-Naphthyloxy)pyrrolidin-1-Yl]quinazolineKi463.0 [1]
6,7-Dimethoxy-4-[(3R)-3-[2-(trifluoromethyl)phenoxy]pyrrolidin-1-yl]quinazolineKi100.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(2-methoxyphenoxy)pyrrolidin-1-yl]quinazolineKi100.0 [1]
2-{[(3R)-1-(6,7-Dimethoxyquinazolin-4-yl)pyrrolidin-3-yl]oxy}benzonitrileKi100.0 [1]
4-[(3R)-3-(4-Ethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi328.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(3-phenylphenoxy)pyrrolidin-1-yl]quinazolineKi280.0 [1]
(R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazolineKi237.0 [1]
(R)-4-[3-(5-Chloro-pyrimidin-2-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazolineKi332.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(pyridin-2-yloxy)pyrrolidin-1-yl]quinazolineKi207.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(pyridin-4-yloxy)pyrrolidin-1-yl]quinazolineKi685.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(naphthalen-1-yloxy)pyrrolidin-1-yl]quinazolineKi56.0 [1]
6,7-Dimethoxy-4-[(3R)-3-[(7-methoxynaphthalen-2-yl)oxy]pyrrolidin-1-yl]quinazolineKi305.0 [1]
6,7-Dimethoxy-4-[(3R)-3-[(2-methylquinolin-6-yl)oxy]pyrrolidin-1-yl]quinazolineKi223.0 [1]
4-[(3R)-3-(Isoquinolin-3-yloxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi196.0 [1]
(R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)-quinazolineKi100.0 [1]
4-[(3R)-3-(2-Chlorophenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi100.0 [1]
4-{[(3R)-1-(6,7-Dimethoxyquinazolin-4-yl)pyrrolidin-3-yl]oxy}benzonitrileKi471.0 [1]
4-[(3R)-3-(4-Tert-butylphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi1890.0 [1]
4-[(3R)-3-(3-Ethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi88.0 [1]
4-[(3R)-3-(3,4-Dimethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazolineKi260.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(pyridin-3-yloxy)pyrrolidin-1-yl]quinazolineKi748.0 [1]
6,7-Dimethoxy-4-[(3R)-3-[(6-methoxynaphthalen-2-yl)oxy]pyrrolidin-1-yl]quinazolineKi280.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(quinolin-6-yloxy)pyrrolidin-1-yl]quinazolineKi201.0 [1]
6,7-Dimethoxy-4-[(3R)-3-(quinolin-7-yloxy)pyrrolidin-1-yl]quinazolineKi240.0 [1]
(2R,8R)-2-(2,4-Dichlorophenyl)-6-ethyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dioneIC5050000.0 [1]
(10R,15S)-10-(2,4-Dichlorophenyl)-13-ethyl-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5050000.0 [1]
(10R,15R)-10-(2,4-Dichlorophenyl)-13-ethyl-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5050000.0 [1]
MilrinoneIC50280.0 [1]
2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanolIC505360.0 [1]
(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinoneIC5037.0 [1]
3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-[1,2,4]triazolo[4,3-b]pyridazineIC502300.0 [1]
3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC50720.0 [1]
6-{(1S)-1-[6-(1-Methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinolineIC50150.0 [1]
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
4-[[1-(2-Chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholineIC5010000.0 [1]
3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC504600.0 [1]
1-(5-Butoxypyridin-3-Yl)-4-Methyl-8-(Morpholin-4-Ylmethyl)[1,2,4]triazolo[4,3-A]quinoxalineIC5010000.0 [1]
Pde2/pde10-IN-1IC5010000.0 [1]
(11R,15S)-5-Anilino-4-[[4-(6-fluoropyridin-2-yl)phenyl]methyl]-8-methyl-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one;phosphoric acidKi3100.0 [1]
CID 73211886IC5024000.0 [1]
(4R)-3-[4-[(2-Benzyl-3-oxocyclohexen-1-yl)amino]phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-oneIC500.19 [1]
3-[[2-[4-(4,4-Dimethyl-5-oxo-1H-pyrazol-3-yl)-2,3-difluoroanilino]-6-oxocyclohexen-1-yl]methyl]benzonitrileIC500.33 [1]
3-[2-Fluoro-4-[[2-[(3-nitrophenyl)methyl]-3-oxocyclohexen-1-yl]amino]phenyl]-4,4-dimethyl-1H-pyrazol-5-oneIC504.5 [1]
3-{4-[(2-Benzyl-3-oxocyclohex-1-en-1-yl)amino]phenyl}-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-oneIC5010.0 [1]
3-[4-[(2-Benzyl-3-oxocyclohexen-1-yl)amino]-2-fluorophenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-oneIC500.24 [1]
4-Methoxy-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinolineIC503850.0 [1]
3-[4-[[2-[(2,6-Dichlorophenyl)methyl]-3-oxocyclohexen-1-yl]amino]-2-fluorophenyl]-4,4-dimethyl-1H-pyrazol-5-oneIC500.13 [1]
6-Fluoro-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5023900.0 [1]
1-[5-(6,7-Dimethoxycinnolin-4-yl)-3-methylpyridin-2-yl]-4-(6-fluoropyridin-3-yl)piperidin-4-olIC506540.0 [1]
(1-Methylbenzimidazol-2-yl)-[4-(3-pyridin-3-ylpyridin-2-yl)oxyphenyl]methanoneIC50234000.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[(4-pyridin-2-ylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi1200.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[(4-phenylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi1500.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi30000.0 [1]
(11R,15S)-5-Anilino-8-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-oneKi42000.0 [1]
4-(4-Methylphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC5016720.0 [1]
4-(3-Chlorophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC505010.0 [1]
4-(4-Chlorophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC503830.0 [1]
4-(2-Chlorophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC505920.0 [1]
5-[1-[4-(4-Fluorophenyl)-2-thiazolyl]-1H-pyrazole-4-yl]-1H-tetrazoleIC502340.0 [1]
4-(3-Fluorophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC504650.0 [1]
4-(2-Fluorophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC504720.0 [1]
4-(4-Nitrophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC507270.0 [1]
4-(3-Nitrophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC508540.0 [1]
4-(2-Nitrophenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC5010210.0 [1]
4-(3-Methylphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC5014490.0 [1]
4-(2-Methylphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC5016620.0 [1]
4-(4-Methoxyphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC5025620.0 [1]
4-(3-Methoxyphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC5025110.0 [1]
4-(2-Methoxyphenyl)-2-[4-(2H-tetrazol-5-yl)pyrazol-1-yl]-1,3-thiazoleIC5028020.0 [1]
3-Cyclopentyloxy-4-(difluoromethoxy)-N-[(4-methoxyphenyl)methyl]benzamideIC50100000.0 [1]
4-Fluoro-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC50103000.0 [1]
4-(Fluoromethyl)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC505680.0 [1]
4-(3-Fluoropropyl)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5019100.0 [1]
4-(2-Fluoroethoxy)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC507760.0 [1]
4-(2-Fluoroethoxymethyl)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC504550.0 [1]
4-[2-(2-Fluoroethoxy)ethoxy]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5016200.0 [1]
4-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5061900.0 [1]
4-[2-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]ethoxy]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5029600.0 [1]
N-(2-Fluoroethyl)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolin-4-amineIC503480.0 [1]
4-[4-(2-Fluoroethyl)triazol-1-yl]-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC503560.0 [1]
3-(2-Fluoroethoxy)-2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5019900.0 [1]
4-(2-Fluoroethoxy)-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC505610.0 [1]
4-(2-Fluoroethoxymethyl)-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC501000000.0 [1]
4-[2-(2-Fluoroethoxy)ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5050100.0 [1]
4-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5051800.0 [1]
4-[2-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]ethoxy]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5028130.0 [1]
N-(2-Fluoroethyl)-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolin-4-amineIC5038300.0 [1]
4-[4-(2-Fluoroethyl)triazol-1-yl]-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC5016200.0 [1]
6-Fluoro-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinolineIC50151000.0 [1]
Benzyl N-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]carbamateIC501.0 [1]
N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamideIC50100000.0 [1]
3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamideIC50100000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 3B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-3b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Phosphodiesterase 3B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-3b-inhibitors-ic50-ki.
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