 | Rolipram | IC50 | 162.0 [1] |
| Rolipram | Ki | 7940.0 [1] |
 | 4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine | IC50 | 4.2 [1] |
| 4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine | Ki | 4.0 [1] |
 | Cilomilast | IC50 | 150.0 [1] |
 | Unii-G6gso9sdnj | IC50 | 1.0 [1], 1.4 [2] |
 | 2-[5-[(1S)-1-[3-Cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol | IC50 | 0.4 [1], 0.5 [2] |
| 2-[5-[(1S)-1-[3-Cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol | Ki | 0.43 [1] |
 | 2-[4-[1-[3,4-Bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol | IC50 | 4.2 [1], 670.0 [2] |
 | 4-[8-(2,1,3-Benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acid | IC50 | 290.0 [1], 602.0 [2] |
 | (R)-(-)-Rolipram | IC50 | 162.0 [1], 550.0 [2], 4000.0 [3] |
 | 2-[4-[1-[3,4-Bis(difluoromethoxy)phenyl]-2-(3-methyl-1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol | IC50 | 1.3 [1], 23.0 [2] |
 | 4-[8-(3-Nitrophenyl)-1,7-naphthyridin-6-yl]benzoic Acid | IC50 | 29.0 [1], 88.0 [2] |
 | Roflumilast | IC50 | 0.35 [1], 0.59 [2] |
 | Ibudilast | IC50 | 54.0 [1], 1300.0 [2] |
 | Piclamilast | IC50 | 1.6 [1], 4.0 [2] |
 | Unii-K4kac9xcco | IC50 | 5.1 [1], 6.7 [2] |
 | 2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine | IC50 | 5000.0 [1] |
 | 4-Imino-7-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-3(4H)-amine | IC50 | 757000.0 [1], 1760000.0 [2] |
 | 8-(3-Methoxyphenyl)-6-(pyridin-4-ylmethyl)quinoline | IC50 | 1.5 [1] |
 | 6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 24.0 [1], 46.0 [2] |
 | 2-[5-[(1R)-1-[3-Cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol | IC50 | 48.0 [1], 56.0 [2] |
 | 5,5-Dimethyl-3-(piperazin-1-ylmethyl)imidazolidine-2,4-dione | IC50 | 1380000.0 [1], 4269000.0 [2] |
 | 2-[5-[1-[3,4-Bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]pyridin-2-yl]propan-2-ol | IC50 | 40.0 [1], 520.0 [2] |
 | 1-[5-[1-[3,4-Bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]pyridin-2-yl]-1-phenylethanol | IC50 | 1.0 [1], 2.1 [2] |
 | 4-[8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl]cyclohexane-1-carboxylic Acid | IC50 | 123.0 [1] |
 | N-(3,4-Dimethoxyphenyl)-4-morpholin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide | IC50 | 100.0 [1], 678.0 [2] |
 | 4-(3,4-Dimethoxyphenyl)-N-pyridin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide | IC50 | 98.0 [1], 152.0 [2] |
 | N-(3,5-Dichloropyridin-4-yl)-4-(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamide | IC50 | 89.0 [1], 281.0 [2] |
 | N-(3,4-Dimethoxyphenyl)-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide | IC50 | 45.0 [1], 756.0 [2] |
 | 4-[2-(4-Chlorophenyl)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]ethyl]pyridine | IC50 | 2.8 [1], 12000.0 [2] |
 | 4-[2-(4-Chlorophenyl)-2-[2-fluoro-4-methoxy-5-(cyclopentyloxy)phenyl]ethyl]pyridine | IC50 | 13.0 [1], 25000.0 [2] |
 | 4-[2-(4-Chlorophenyl)-2-[2-fluoro-3-(cyclopentyloxy)-4-methoxyphenyl]ethyl]pyridine | IC50 | 110.0 [1], 98000.0 [2] |
 | 4-[2-(4-Chlorophenyl)-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine | IC50 | 11.0 [1], 4500.0 [2] |
 | N-[4-[1-[3,4-Bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]sulfonyl-2-methylbenzamide | IC50 | 3.1 [1], 75000.0 [2] |
 | 4-[2-(4-Carboxyphenyl)-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide | IC50 | 24.0 [1], 77000.0 [2] |
 | 4-[2-[4-(1-Hydroxycyclopropyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide | IC50 | 16.0 [1], 1700.0 [2] |
 | 4-[2-[4-(1-Hydroxycyclobutyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide | IC50 | 7.5 [1], 380.0 [2] |
 | 4-[2-[4-(1-Hydroxy-1-methylethyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide | IC50 | 9.6 [1], 360.0 [2] |
 | 4-[2-[4-(1-Hydroxyethyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide | IC50 | 45.0 [1], 510.0 [2] |
 | 2-[3-[4-[1-[3,4-Bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]phenyl]-2-methylpropanoic acid | IC50 | 2.2 [1], 6500.0 [2] |
 | 4-[2-[4-(Hydroxymethyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide | IC50 | 44.0 [1], 470.0 [2] |
 | 4-[2-[4-(Dimethylaminocarbonyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide | IC50 | 8.6 [1], 1000.0 [2] |
 | 4-[2-[4-(2-Oxo-2-hydroxyethyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide | IC50 | 53.0 [1], 58000.0 [2] |
 | [4-[1-[3,4-Bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]methyl N-ethylcarbamate | IC50 | 4.6 [1], 410.0 [2] |
 | 4-[2-[4-(4-Fluorophenoxymethyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide | IC50 | 0.5 [1], 1900.0 [2] |
 | 5-[1-(4-Chlorophenyl)-2-pyridin-4-ylethyl]-2,3-bis(difluoromethoxy)-1-oxidopyridin-1-ium | IC50 | 32.0 [1], 3800.0 [2] |
 | 4-[2-(4-Chlorophenyl)-2-[3-(cyclopentyloxy)-4-(difluoromethoxy)phenyl]ethyl]pyridine | IC50 | 13.0 [1], 8700.0 [2] |
 | 4-[2-[4-(5-Methyl-2-pyridylcarbonyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide | IC50 | 7.3 [1], 890.0 [2] |
 | Acetic acid;2-[(Z)-1-(3,3-dimethylcyclohexen-1-yl)ethylideneamino]guanidine | IC50 | 790000.0 [1], 1460000.0 [2] |
 | 2-[4-[(3R)-3-Methyl-2-oxo-1,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]guanidine | IC50 | 1320000.0 [1], 2650000.0 [2] |
 | Sildenafil | IC50 | 5000.0 [1] |
 | Chlortetracycline | IC50 | 100000.0 [1] |
 | Tadalafil | IC50 | 10000.0 [1] |
 | Zaprinast | Ki | 50000.0 [1] |
 | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone | IC50 | 4300.0 [1] |
 | Crisaborole | IC50 | 55.0 [1] |
 | Sibenadet | IC50 | 38.0 [1] |
 | 4,5-Dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone | Ki | 50000.0 [1] |
 | 2-(Cyclopentyloxy)-4-[alpha-(4-pyridylmethyl)benzyl]anisole | IC50 | 17.5 [1] |
 | (S)-(+)-Rolipram | IC50 | 4300.0 [1] |
 | (2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol | IC50 | 16000.0 [1] |
 | 2,5-Diphenylfuran | IC50 | 10000.0 [1] |
 | 1-(3-Nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione | IC50 | 22.0 [1] |
 | (R)-5-(6-Cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide | IC50 | 1800.0 [1] |
 | Cipamfylline | IC50 | 1600.0 [1] |
 | 3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-[1,2,4]triazolo[4,3-b]pyridazine | IC50 | 1.5 [1] |
 | 4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-ol | IC50 | 63.7 [1] |
 | 8-(3-Nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline | IC50 | 0.07 [1] |
 | 3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 6.7 [1] |
 | 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
 | 6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 32.0 [1] |
 | 3-(2-Chlorophenyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 26.0 [1] |
 | CID 44142091 | IC50 | 35.0 [1] |
 | 6-[4-Methoxy-3-(oxolan-3-yloxy)phenyl]-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 20.0 [1] |
 | 3-(2-Chlorophenyl)-6-[4-methoxy-3-(3-oxolanyloxy)phenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 9.8 [1] |
 | 6-[4-Methoxy-3-(oxolan-3-yloxy)phenyl]-3-[2-(trifluoromethyl)phenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 7.1 [1] |
 | 3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-(oxolan-3-yloxy)phenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 3.4 [1] |
 | N-Tert-Butyl-6-chloro-N'-methyl-[1,3,5]triazine-2,4-diamine | IC50 | 245.0 [1] |
 | 6-(3-Cyclopentyloxy-4-methoxyphenyl)-3-(2-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 33.0 [1] |
 | CID 44142090 | IC50 | 13.0 [1] |
 | CID 44142093 | IC50 | 21.0 [1] |
 | Triazolothiadiazine, 7 | IC50 | 6.1 [1] |
 | CID 44142095 | IC50 | 35.0 [1] |
 | CID 44142096 | IC50 | 37.0 [1] |
 | CID 44142097 | IC50 | 53.0 [1] |
 | CID 44142098 | IC50 | 11.0 [1] |
 | 3-(2-Fluorophenyl)-6-[4-methoxy-3-(3-oxolanyloxy)phenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 11.0 [1] |
 | 8-(3-Nitrophenyl)-6-(4-pyridylmethyl)pyrido(2,3-d)pyridazin-5-one | IC50 | 340.0 [1] |
 | 4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one | Ki | 1000.0 [1] |
 | ITI214 (free base) | Ki | 62.0 [1] |
 | Tofimilast | IC50 | 23.0 [1] |
 | N-[4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-yl]acetamide | IC50 | 2900.0 [1] |
 | 3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
 | 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
 | 3-Phenyl-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one | IC50 | 100000.0 [1] |
 | 3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione | IC50 | 100000.0 [1] |
 | 4-[[1-(2-Chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine | IC50 | 10000.0 [1] |
 | 4-Chloroquinazoline | IC50 | 162.0 [1] |
 | N-(3-(6-(Pyridin-4-ylmethyl)quinolin-8-yl)phenyl)benzenesulfonamide | IC50 | 5.6 [1] |
Calculator
