 | Rolipram | IC50 | 741.0 [1] |
| Rolipram | Ki | 220.0 [1], 221.0 [2], 223.87 [3], 1470.0 [4] |
 | Roflumilast | IC50 | 0.8 [1] |
| Roflumilast | Ki | 0.4 [1] |
 | Cilomilast | IC50 | 84.0 [1] |
 | Piclamilast | IC50 | 0.04 [1], 0.2 [2], 1.0 [3], 2.0 [4], 3.0 [5] |
 | (R)-(-)-Rolipram | IC50 | 39.81 [1], 231.0 [2], 500.0 [3] |
 | N,N,2-Trimethyl-5-nitrobenzenesulfonamide | IC50 | 1800.0 [1], 175000.0 [2] |
 | Unii-G6gso9sdnj | IC50 | 0.5 [1], 1.0 [2] |
 | 4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one | IC50 | 520.0 [1] |
 | 4-[8-(2,1,3-Benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acid | IC50 | 34.0 [1] |
 | 3-[7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one | IC50 | 42.0 [1], 70.0 [2] |
 | (4As,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one | IC50 | 0.5 [1], 0.63 [2] |
| (4As,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one | Ki | 0.63 [1] |
 | 3-Isobutyl-1-methylxanthine | IC50 | 28200.0 [1] |
 | Ibudilast | IC50 | 65.0 [1], 5000.0 [2] |
 | Crisaborole | IC50 | 55.0 [1] |
 | 6-(3-(Dimethylcarbamoyl)phenylsulfonyl)-4-(3-methoxyphenylamino)-8-methylquinoline-3-carboxamide | IC50 | 0.01 [1] |
 | 2-[5-[(1S)-1-[3-Cyclopropyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-3-yl)ethyl]-1,3-thiazol-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol | IC50 | 0.4 [1] |
 | 3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-[1,2,4]triazolo[4,3-b]pyridazine | IC50 | 2.9 [1], 4.1 [2] |
 | 3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 37.2 [1], 48.2 [2] |
 | (4-{[2-(5-Chlorothiophen-2-Yl)-5-Ethyl-6-Methylpyrimidin-4-Yl]amino}phenyl)acetic Acid | IC50 | 15.0 [1], 55.0 [2] |
 | 8-(3-Methoxyphenyl)-6-(pyridin-4-ylmethyl)quinoline | IC50 | 2.3 [1] |
 | 4-[(3-Methoxyphenyl)amino]-6-(methylsulfonyl)quinoline-3-carboxamide | IC50 | 3.98 [1] |
 | 6-(Benzenesulfonyl)-4-(3-methoxyanilino)quinoline-3-carboxamide | IC50 | 1.58 [1] |
 | 2-(Cyclopentylamino)-3-ethylthieno[3,2-d]pyrimidin-4-one | IC50 | 4900.0 [1] |
 | (5Z)-5-[(3-Cyclopentyloxy-4-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one | IC50 | 310.0 [1] |
 | 3-(2,5-Dimethoxyphenyl)-6-[4-methoxy-3-[(3R)-oxolan-3-yl]oxyphenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | IC50 | 1.6 [1], 2.3 [2] |
 | 5-(3-(Cyclopentyloxy)-4-methoxybenzylidene)-2-thioxothiazolidin-4-one | IC50 | 890.0 [1] |
 | 1-(2-Hydroxyethyl)-3-(2-methylbutan-2-yl)-5-[4-(2-methylimidazol-1-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-one | IC50 | 378.0 [1] |
 | 2-[4-[(2-Phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetic acid | IC50 | 29.0 [1], 210.0 [2] |
 | 2-[4-[(5,5-Dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetic acid | IC50 | 25.0 [1], 150.0 [2] |
 | 3-Tert-butyl-1-(2-hydroxyethyl)-5-[4-methoxy-3-(2-methoxypyrimidin-5-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-one | IC50 | 562.0 [1] |
 | N-Butyl-2-[4-[(5,5-dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetamide | IC50 | 22.0 [1], 70.0 [2] |
 | 4-[8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl]cyclohexane-1-carboxylic Acid | IC50 | 34.0 [1] |
 | N-((3-(6-(2-Cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl)-N-(4-(methylsulfonyl)phenyl)benzamide | IC50 | 0.1 [1], 80.0 [2] |
 | N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]cyclopropanecarboxamide | IC50 | 0.6 [1], 800.0 [2] |
 | 1-[[3-[6-(2-Cyanopropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylurea | IC50 | 0.1 [1], 140.0 [2] |
 | N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]pyridine-3-carboxamide | IC50 | 0.7 [1], 210.0 [2] |
 | Isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl(4-(methylsulfonyl)phenyl)carbamate | IC50 | 0.3 [1], 80.0 [2] |
 | 2-[8-[3-[[N-[(4-Fluorophenyl)methyl]-4-methylsulfonylanilino]methyl]phenyl]quinolin-6-yl]-2-methylpropanenitrile | IC50 | 0.1 [1], 1800.0 [2] |
 | N-[[3-[6-(2-Cyanopropan-2-yl)quinolin-8-yl]phenyl]methyl]-5-methyl-N-(4-methylsulfonylphenyl)-1,2-oxazole-3-carboxamide | IC50 | 0.1 [1], 30.0 [2] |
 | 1-[[2-Fluoro-5-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylurea | IC50 | 0.3 [1], 50.0 [2] |
 | 4-Fluoro-N-(4-methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]benzamide | IC50 | 0.6 [1], 560.0 [2] |
 | N-(4-Methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]acetamide | IC50 | 4.2 [1], 2000.0 [2] |
 | 1-((3-(6-(2-Cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl)-1-(4-(methylsulfonyl)phenyl)-3-phenylurea | IC50 | 0.03 [1], 40.0 [2] |
 | 4-(2-Hydroxypropan-2-yl)-N-(4-methylsulfonylphenyl)-N-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]benzamide | IC50 | 0.4 [1], 270.0 [2] |
 | trans-3-(3-Cyclopentoxy-4-methoxyphenyl)-1-methoxycarbonyl-4-(methylcarbonyl)pyrrolidine | IC50 | 320.0 [1] |
| trans-3-(3-Cyclopentoxy-4-methoxyphenyl)-1-methoxycarbonyl-4-(methylcarbonyl)pyrrolidine | Ki | 30.0 [1] |
 | N-(3,4-Dimethoxyphenyl)-4-morpholin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide | IC50 | 67.0 [1] |
 | 4-(3,4-Dimethoxyphenyl)-N-pyridin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide | IC50 | 15.0 [1] |
 | N-(3,5-Dichloropyridin-4-yl)-4-(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamide | IC50 | 44.0 [1] |
 | N-(3,4-Dimethoxyphenyl)-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide | IC50 | 31.0 [1] |
 | N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide | IC50 | 61.0 [1] |
 | (R)-2-(4-Fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamide | IC50 | 185.0 [1], 925.0 [2] |
 | 3-(6-(2-(Methylsulfonyl)propan-2-yl)quinolin-8-yl)-N-(pyridin-4-yl)benzamide | IC50 | 0.9 [1], 200.0 [2] |
 | 1-[[2-Chloro-5-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-1-(4-methylsulfonylphenyl)-3-propan-2-ylurea | IC50 | 4.4 [1], 4000.0 [2] |
 | 1-(4-Methylsulfonylphenyl)-1-[1-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethyl]-3-propan-2-ylurea | IC50 | 0.7 [1], 400.0 [2] |
 | N-(3,5-Dichloropyridin-4-yl)-3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)benzamide | IC50 | 0.4 [1], 90.0 [2] |
 | N-(4-(Methylsulfonyl)phenyl)-3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)benzamide | IC50 | 0.5 [1], 140.0 [2] |
 | 4-Methylsulfonyl-N-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]benzamide | IC50 | 1.2 [1], 1000.0 [2] |
 | 1-(4-Methylsulfonylphenyl)-1-[[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]methyl]-3-propan-2-ylurea | IC50 | 0.1 [1], 100.0 [2] |
 | 3-(6-(2-(Methylsulfonyl)propan-2-yl)quinolin-8-yl)-N-phenylbenzamide | IC50 | 5.9 [1], 7000.0 [2] |
 | [4-[3-[(4-Phenylpyridazino[4,5-b]indolizin-1-yl)amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | IC50 | 6700.0 [1] |
| [4-[3-[(4-Phenylpyridazino[4,5-b]indolizin-1-yl)amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | Ki | 41.0 [1] |
 | [4-[3-[[4-(3-Nitrophenyl)pyridazino[4,5-b]indolizin-1-yl]amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | IC50 | 389.0 [1] |
| [4-[3-[[4-(3-Nitrophenyl)pyridazino[4,5-b]indolizin-1-yl]amino]propyl]piperazin-1-yl]-pyrazin-2-ylmethanone | Ki | 5.6 [1] |
 | 4-Phenyl-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridazino[4,5-b]indolizin-1-amine | IC50 | 13200.0 [1] |
| 4-Phenyl-N-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propyl]pyridazino[4,5-b]indolizin-1-amine | Ki | 2600.0 [1] |
 | 2-[3-[4-[[(3R,5S)-3,5-Dimethylpiperazin-1-yl]methyl]-2-(morpholin-4-ylmethyl)phenyl]phenoxy]-5-fluoro-N-[4-[(2-hydroxy-5-methylbenzoyl)amino]cyclohexyl]pyridine-3-carboxamide | IC50 | 0.02 [1], 10.0 [2] |
 | N-[4-[[2-[3-[4-[[(3R,5S)-3,5-Dimethylpiperazin-1-yl]methyl]-2-(morpholin-4-ylmethyl)phenyl]phenoxy]-5-fluoropyridine-3-carbonyl]amino]cyclohexyl]-4-methyl-1,3-thiazole-2-carboxamide | IC50 | 0.03 [1], 10.0 [2] |
 | 4-[3-(3-Chlorophenyl)-7-methoxy-2,4-dioxopyrimido[5,4-c]quinolin-1-yl]cyclohexane-1-carboxylic acid | IC50 | 17.0 [1] |
 | 3-Benzo[1,3]dioxol-5-yl-1-cyclopentyl-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 513.0 [1] |
 | 3-(3-Chlorophenyl)-7-methoxy-1-(1-methylsulfonylpiperidin-4-yl)pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 68.0 [1] |
 | 1-Cyclopentyl-3-ethyl-7-propylpyrimido[5,4-c]quinoline-2,4-dione | IC50 | 25000.0 [1] |
 | 3-(3-Chlorophenyl)-7-methoxy-1-[(3S)-1-methylsulfonylpyrrolidin-3-yl]pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 80.0 [1] |
 | 1-Cyclopentyl-3-ethyl-7-propan-2-ylpyrimido[5,4-c]quinoline-2,4-dione | IC50 | 12400.0 [1] |
 | 1-Cyclopentyl-7-methoxy-3-m-tolyl-1H-pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 78.0 [1] |
 | 3-(3-Chlorophenyl)-1-(1-ethylsulfonylpiperidin-4-yl)-7-methoxypyrimido[5,4-c]quinoline-2,4-dione | IC50 | 26.0 [1] |
 | 3-(3-Chlorophenyl)-7-methoxy-1-[1-(methylsulfonylmethylsulfonyl)piperidin-4-yl]pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 39.0 [1] |
 | 1-Cyclopentyl-7-methoxy-3-(4-methyl-thiophen-2-yl)-1H-pyrimido[5,4-c]quinoline-2,4-dione | IC50 | 126.0 [1] |
 | 7-Chloro-1-cyclopentyl-3-ethylpyrimido[5,4-c]quinoline-2,4-dione | IC50 | 17000.0 [1] |
 | N-[4-[3-(3-Chlorophenyl)-7-methoxy-2,4-dioxopyrimido[5,4-c]quinolin-1-yl]cyclohexyl]methanesulfonamide | IC50 | 25.0 [1] |
 | Theophylline | IC50 | 200000.0 [1] |
 | Pentoxifylline | IC50 | 90000.0 [1] |
 | Tadalafil | IC50 | 50000.0 [1] |
 | Zaprinast | Ki | 50000.0 [1] |
 | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone | Ki | 1930.0 [1] |
 | Apremilast | IC50 | 30.0 [1] |
 | 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide | IC50 | 200000.0 [1] |
 | I-Bet151 (gsk1210151A) | IC50 | 3981.07 [1] |
 | Zardaverine | IC50 | 1410.0 [1] |
 | 4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine | IC50 | 1.4 [1] |
 | 4,5-Dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone | Ki | 50000.0 [1] |
 | 1(2H)-Phthalazinone | IC50 | 520.0 [1] |
 | Moracin M | IC50 | 4500.0 [1] |
 | Cartazolate | IC50 | 199.53 [1] |
 | Moracin C | IC50 | 18100.0 [1] |
 | N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide | IC50 | 60.0 [1] |
 | (2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol | IC50 | 16000.0 [1] |
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