 | Sildenafil | IC50 | 3.6 [1] |
| Sildenafil | Ki | 1.6 [1], 1.87 [2], 1.91 [3], 10.0 [4] |
 | Tadalafil | IC50 | 4.0 [1] |
| Tadalafil | Ki | 5.2 [1], 10.0 [2] |
 | Zaprinast | IC50 | 1000.0 [1] |
| Zaprinast | Ki | 130.0 [1] |
 | Vardenafil | IC50 | 0.7 [1] |
| Vardenafil | Ki | 0.7 [1], 1.0 [2] |
 | Rolipram | IC50 | 16000.0 [1] |
| Rolipram | Ki | 200000.0 [1] |
 | 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | IC50 | 26.92 [1], 27.0 [2], 40.0 [3] |
 | 1-(1,3-Benzodioxol-5-yl)-2-[5-(3,4-dimethoxyphenyl)pyrimidin-2-yl]-3,9-dihydro-1H-pyrido[3,4-b]indol-4-one | Ki | 8.0 [1], 8.86 [2] |
 | Sildenafil citrate | IC50 | 2.2 [1], 3.5 [2], 5.1 [3] |
 | Milrinone | IC50 | 740.0 [1], 100000.0 [2], 110000.0 [3] |
 | 1-(3-Chlorophenylamino)-4-phenylphthalazine | IC50 | 500.0 [1], 1800.0 [2], 5000.0 [3] |
 | (11R,15S)-4-Benzyl-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 19.0 [1], 39.0 [2] |
 | (10S,15R)-13-Butyl-10-(4-methoxyphenyl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione | IC50 | 5.0 [1], 5.01 [2] |
 | 1-(2,3-Dihydro-1-benzofuran-5-yl)-2-(5-pyridin-2-ylpyridin-2-yl)-1,3,4,9-tetrahydropyrido[3,4-b]indole | Ki | 4.0 [1] |
 | 2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one | IC50 | 5.0 [1], 5.01 [2] |
 | N-Desmethylvardenafil | IC50 | 0.6 [1], 2.0 [2] |
 | 11-Benzyl-7,13-dimethyl-4-phenyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 160.0 [1] |
 | 5-(2-Ethoxyphenyl)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | IC50 | 316.23 [1], 330.0 [2], 331.13 [3] |
 | 4-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxycyclohexane-1-carboxamide | IC50 | 53.0 [1], 146.0 [2], 190.0 [3] |
 | 3-[[4-Ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclobutane-1-carboxamide | IC50 | 34.0 [1], 45.0 [2], 60.0 [3] |
 | Dipyridamole | IC50 | 520.0 [1], 574.0 [2] |
 | Hydroxyhomosildenafil | IC50 | 1.91 [1], 19.0 [2] |
 | Desmethylsildenafil | IC50 | 5.7 [1], 5.75 [2] |
 | Avanafil | IC50 | 6.99 [1] |
| Avanafil | Ki | 5.0 [1] |
 | Sodium;1-[4-(1,3-benzodioxol-5-ylmethylamino)-6-chloroquinazolin-2-yl]piperidine-4-carboxylate | IC50 | 3.7 [1], 8.6 [2] |
 | Perlolyrine | IC50 | 9300.0 [1] |
 | Cipamfylline | IC50 | 71000.0 [1] |
| Cipamfylline | Ki | 7500.0 [1] |
 | 6H-Purin-6-one, 1,7-dihydro-2-(2-propoxyphenyl)- | IC50 | 80.0 [1], 1000.0 [2] |
 | 2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine | IC50 | 919.0 [1], 920.0 [2] |
 | 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 0.2 [1] |
 | (7R,8S)-2-Benzyl-5-methyl-7,8-propano-7,8-dihydro-3H-imidazo[2,1-b]purin-4(5H)-one | IC50 | 80.0 [1] |
 | 3-(4-Hydroxybenzyl)-1-(Thiophen-2-Yl)chromeno[2,3-C]pyrrol-9(2h)-One | IC50 | 17.0 [1] |
 | 3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 0.05 [1] |
 | 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 0.07 [1] |
 | (11R,15S)-5-[(3-Bromo-4-hydroxyphenyl)methyl]-8-ethyl-4-methoxy-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 1.58 [1], 1.6 [2] |
 | (7R)-7-Benzyl-3-[(3-chloro-4-hydroxyphenyl)methyl]-5-ethyl-2-phenylmethoxy-7,8-dihydroimidazo[2,1-b]purin-4-one | IC50 | 2.09 [1], 2.1 [2] |
 | (7R)-7-Benzyl-3-[(3-chloro-4-hydroxyphenyl)methyl]-5-ethyl-2-methoxy-7,8-dihydroimidazo[2,1-b]purin-4-one | IC50 | 1.9 [1], 1.91 [2] |
 | 5-[[(7R)-7-Benzyl-5-ethyl-2-methoxy-4-oxo-7,8-dihydroimidazo[2,1-b]purin-3-yl]methyl]-2-methoxybenzonitrile | IC50 | 10.96 [1], 11.0 [2] |
 | (7R)-7-Benzyl-3-[(3-bromo-4-hydroxyphenyl)methyl]-5-ethyl-2-methoxy-7,8-dihydroimidazo[2,1-b]purin-4-one | IC50 | 1.29 [1], 1.3 [2] |
 | 1-(2-Ethoxyethyl)-3-ethyl-5-(piperazin-1-yl)-N-(pyridin-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine | IC50 | 0.4 [1] |
 | 11-Benzyl-13-methyl-4-phenyl-5,6,8,11,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7,12-pentaen-10-one | IC50 | 180.0 [1] |
 | 3-[2-(2-Hydroxyethylamino)ethylamino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 1.1 [1], 1.12 [2] |
 | 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-one | IC50 | 0.34 [1] |
 | 1-(4-Fluorobenzyl)-6-(3-carbamoyl-6-propoxyphenyl)-1H-imidazo[4,5-g]quinazoline-8(7H)-one | IC50 | 0.48 [1] |
 | 3-Ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-(pyridin-2-ylmethyl)-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 1.3 [1] |
 | 1-Benzyl-6-[3-(4-methylpiperazinosulfonyl)-6-propoxyphenyl]-1H-imidazo[4,5-g]quinazoline-8(7H)-one | IC50 | 5.3 [1] |
 | Ethoxy-[[1-[3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]methyl]phosphinic acid | IC50 | 0.17 [1], 5888436553555.88 [2] |
 | 5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 50.0 [1], 82.0 [2] |
 | 2-(5-(4-Methylpiperazin-1-ylsulfonyl)-2-propoxyphenyl)-9-propyl-1H-purin-6(9H)-one | IC50 | 10.0 [1] |
 | 5-[5-[4-(Diethoxyphosphorylmethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 0.58 [1], 1737800828749.38 [2] |
 | 3-Ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-propoxypyridin-3-yl]-2-(pyridin-2-ylmethyl)-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 1.1 [1] |
 | 2-(2-Propoxyphenyl)-9-propyl-1H-purin-6(9H)-one | IC50 | 10.0 [1] |
 | Ethoxy-[[4-[3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperazin-1-yl]methyl]phosphinic acid | IC50 | 0.18 [1], 5495408738576.25 [2] |
 | Ethoxy-[2-[4-[3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperazin-1-yl]ethyl]phosphinic acid | IC50 | 0.28 [1], 3548133892335.76 [2] |
 | Ethoxy-[1-[3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]phosphinic acid | IC50 | 0.3 [1], 3311311214825.91 [2] |
 | 5-[5-[4-(2-Diethoxyphosphorylethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 1.05 [1], 954992586021.44 [2] |
 | 5-[5-(4-Diethoxyphosphorylpiperidin-1-yl)sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 0.41 [1], 2454708915685.03 [2] |
 | 5-[5-[4-(Diethoxyphosphorylmethyl)piperidin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 0.34 [1], 2951209226666.39 [2] |
 | 2-[4-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperazin-1-yl]ethylphosphonic acid | IC50 | 0.94 [1], 1071519305237.6 [2] |
 | [1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]phosphonic acid | IC50 | 0.7 [1], 1412537544622.76 [2] |
 | [1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]methylphosphonic acid | IC50 | 0.32 [1], 3090295432513.59 [2] |
 | 5-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamide | IC50 | 11.0 [1] |
 | 5-[[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxyfuran-2-carboxamide | IC50 | 3.0 [1] |
 | 5-[[4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-2-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamide | IC50 | 3.0 [1] |
 | 3-(5-Ethylfuran-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 0.53 [1], 0.54 [2] |
 | 3-(5-Ethylthiophen-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | IC50 | 0.6 [1] |
 | 4-(1,3-Benzodioxol-5-ylmethoxy)-6,7,8-trimethoxy-quinazoline | IC50 | 1000.0 [1] |
 | 6-(6-Methoxypyridin-3-yl)-2-(2-morpholin-4-ylethylamino)-4-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3-one | IC50 | 2.4 [1], 2.9 [2] |
 | (11R,15S)-4-Benzyl-8-ethyl-5-[(4-hydroxyphenyl)methyl]-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 3.89 [1], 3.9 [2] |
 | (11R,15S)-5-[(3-Bromo-4-methoxyphenyl)methyl]-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 6.46 [1], 6.5 [2] |
 | (11R,15S)-4-Ethoxy-8-ethyl-5-[(4-hydroxyphenyl)methyl]-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 0.89 [1], 0.9 [2] |
 | (11R,15S)-5-[(3-Chloro-4-hydroxyphenyl)methyl]-8-ethyl-4-methoxy-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 2.0 [1] |
 | (11R,15S)-5-[(3-Chloro-4-methoxyphenyl)methyl]-8-ethyl-4-methoxy-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 5.0 [1], 5.01 [2] |
 | (7R)-7-Benzyl-3-[(3-chloro-4-methoxyphenyl)methyl]-5-ethyl-4-oxo-7,8-dihydroimidazo[2,1-b]purine-2-carboxamide | IC50 | 2.8 [1], 2.82 [2] |
 | 3-Benzo[1,3]dioxol-5-ylmethyl-6,7,8-trimethoxy-3H-quinazolin-4-one | IC50 | 530.0 [1] |
 | 3-(1,3-Benzodioxol-5-yl)-2-benzoyl-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one | Ki | 2.49 [1] |
 | (11R,15S)-8-Ethyl-5-[(4-methoxyphenyl)methyl]-7-oxo-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-triene-4-carboxamide | IC50 | 3.98 [1], 4.0 [2] |
 | (11R,15S)-5-[(3-Chloro-4-hydroxyphenyl)methyl]-8-ethyl-N-methyl-7-oxo-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-triene-4-carboxamide | IC50 | 1.29 [1], 1.3 [2] |
 | 5-[[(7R)-7-Benzyl-5-ethyl-2-methoxy-4-oxo-7,8-dihydroimidazo[2,1-b]purin-3-yl]methyl]-2-hydroxybenzonitrile | IC50 | 42.66 [1], 43.0 [2] |
 | (7R)-7-Benzyl-3-[(3-bromo-4-methoxyphenyl)methyl]-5-ethyl-2-methoxy-7,8-dihydroimidazo[2,1-b]purin-4-one | IC50 | 2.19 [1], 2.2 [2] |
 | (11R,15S)-5-[(3-Bromo-4-methoxyphenyl)methyl]-8-ethyl-4-methoxy-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 2.8 [1], 2.82 [2] |
 | (11R,15S)-5-[(3-Chloro-4-hydroxyphenyl)methyl]-4-ethoxy-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 2.09 [1], 2.1 [2] |
 | (11R,15S)-5-[(3-Chloro-4-methoxyphenyl)methyl]-4-ethoxy-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 6.46 [1], 6.5 [2] |
 | (11R,15S)-5-[(3-Bromo-4-methoxyphenyl)methyl]-4-ethoxy-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 5.37 [1], 5.4 [2] |
 | (7R)-2,7-Dibenzyl-5-ethyl-7,8-dihydro-3H-imidazo[2,1-b]purin-4-one | IC50 | 4.5 [1] |
 | (11R,15S)-5-[(4-Chlorophenyl)methyl]-8-ethyl-4-(2-phenylethynyl)-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 5.0 [1], 5.01 [2] |
 | (11R,15S)-5-(1,3-Benzodioxol-5-ylmethyl)-4-benzyl-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 45.71 [1], 46.0 [2] |
 | (11R,15S)-4-Benzyl-5-[(3-chloro-4-methoxyphenyl)methyl]-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 57.54 [1], 58.0 [2] |
 | (11R,15S)-5-[(4-Aminophenyl)methyl]-4-benzyl-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 549.54 [1], 550.0 [2] |
 | (11R,15S)-4-Benzyl-8-ethyl-5-[(4-methoxyphenyl)methyl]-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 19.95 [1], 20.0 [2] |
 | (11R,15S)-4-Benzyl-5-[(4-chlorophenyl)methyl]-8-ethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 158.49 [1], 160.0 [2] |
 | (11R,15S)-4-Benzyl-8-ethyl-5-[(4-methylphenyl)methyl]-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 39.81 [1], 40.0 [2] |
 | (11R,15S)-8-Ethyl-4-ethylsulfanyl-5-[(4-hydroxyphenyl)methyl]-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one | IC50 | 1.8 [1], 1.82 [2] |
 | (11R,15S)-8-Ethyl-5-[(4-hydroxyphenyl)methyl]-7-oxo-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-triene-4-carboxamide | IC50 | 2.09 [1], 2.1 [2] |
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