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Phosphodiesterase 6A Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Unii-7eis09YY11IC5010000.0 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC509.8 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5011.3 [1]
3-[2-(2-Hydroxyethylamino)ethylamino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC50272.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC5061.8 [1]
CID 45486504IC504.7 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC5015.3 [1]
3-(2-Aminoethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC501210.0 [1]
1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazineIC5010000.0 [1]
2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-3-yl]amino]-N,N-dimethylacetamideIC5086.6 [1]
3-(2-Hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5026.3 [1]
3-(3-Hydroxypropylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5013.8 [1]
3-(2-Ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC509.3 [1]
2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-3-yl]amino]acetic acidIC5045.5 [1]
3-[2-(Dimethylamino)ethylamino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC50261.0 [1]
3-[[(2R)-2-Hydroxypropyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5015.1 [1]
3-[[(2S)-2-Hydroxypropyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5015.3 [1]
3-[[(2R)-1-Hydroxypropan-2-yl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5017.7 [1]
3-[[(2R)-1-Hydroxybutan-2-yl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5023.2 [1]
3-[[(2S)-1-Hydroxypropan-2-yl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5017.9 [1]
2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-3-yl]amino]-N-methylacetamideIC5015.2 [1]
7-(6-Methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(pyridin-2-ylmethylamino)pyrido[3,4-b]pyrazin-2-oneIC5010.8 [1]
7-(6-Methoxypyridin-3-yl)-3-(oxolan-2-ylmethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC508.6 [1]
2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3-yl]amino]-N,N-dimethylacetamideIC50398.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(oxan-4-ylmethylamino)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC5031.4 [1]
7-(6-Methoxypyridin-3-yl)-3-[(2-morpholin-4-yl-2-oxoethyl)amino]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5016.1 [1]
2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3-yl]amino]-N-methylacetamideIC50115.0 [1]
7-(6-Methoxypyridin-3-yl)-3-[(2-morpholin-4-yl-2-oxoethyl)amino]-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC50114.0 [1]
3-[[2-(4-Ethylpiperazin-1-yl)-2-oxoethyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5055.9 [1]
7-(6-Methoxypyridin-3-yl)-3-[(2-oxo-2-pyrrolidin-1-ylethyl)amino]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5039.5 [1]
7-(6-Methoxypyridin-3-yl)-3-[(2-oxo-2-piperazin-1-ylethyl)amino]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC50100.0 [1]
7-(6-Methoxypyridin-3-yl)-3-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5014.7 [1]
3-[[2-(4-Hydroxypiperidin-1-yl)-2-oxoethyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC5024.6 [1]
PDE5 Inhibitor C2IC5058.0 [1]
3-(2-Hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC50114.0 [1]
3-(2-Ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC5057.4 [1]
7-(6-Methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(pyrazin-2-ylmethylamino)pyrido[2,3-b]pyrazin-2-oneIC5023.6 [1]
3-[[2-(4-Ethylpiperazin-1-yl)-2-oxoethyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC5098.9 [1]
3-[[(2S)-1-Hydroxypropan-2-yl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC5068.2 [1]
3-(3-Hydroxypropylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC50124.0 [1]
3-(2-Aminoethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC502000.0 [1]
2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3-yl]amino]acetamideIC50398.0 [1]
2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-3-yl]amino]acetamideIC5086.6 [1]
2-[[7-(6-Methoxypyridin-3-yl)-2-oxo-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3-yl]amino]acetic acidIC50576.0 [1]
3-[[(2S)-2-Hydroxypropyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC5051.8 [1]
3-[[(2R)-2-Hydroxypropyl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC5049.7 [1]
3-[2-(Dimethylamino)ethylamino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC501590.0 [1]
7-(6-Methoxypyridin-3-yl)-3-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC5080.2 [1]
3-[[(2R)-1-Hydroxypropan-2-yl]amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[2,3-b]pyrazin-2-oneIC5063.2 [1]
7-(6-Methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(pyridin-2-ylmethylamino)pyrido[2,3-b]pyrazin-2-oneIC5034.5 [1]
4-[3-[1-(2-Methoxyethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholineIC5010000.0 [1]
4-[3-(3,4,5-Trimethoxyphenyl)imidazo[1,2-a]pyrazin-8-yl]morpholineIC501000.0 [1]
1-[(1S)-6-Chloro-2,3-dihydro-1H-inden-1-yl]-5,6-dimethoxyisoquinolineIC5029500.0 [1]
Items per page: 1 - 10 of 53
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 6A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-6a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Phosphodiesterase 6A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-6a-inhibitors-ic50-ki.
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