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Phosphodiesterase 7A Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
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▼
N,N,2-Trimethyl-5-nitrobenzenesulfonamideIC5090.0 [1], 2100.0 [2], 2200.0 [3]
SildenafilIC504690.0 [1], 22000.0 [2]
3-Isobutyl-1-methylxanthineIC5085600.0 [1]
RolipramIC50200000.0 [1]
3-Phenyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-oneIC504680.0 [1], 5500.0 [2]
2-(Cyclopentylamino)-3-ethyl-7-pyridin-3-ylthieno[3,2-d]pyrimidin-4-oneIC502.0 [1]
3-Methyl-6-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]-2-(prop-2-enylamino)thieno[3,2-d]pyrimidin-4-oneIC50160.0 [1]
2-(Cyclopentylamino)-3-ethylthieno[3,2-d]pyrimidin-4-oneIC50150.0 [1]
N-(4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-phenyl)-acetamideIC5060.0 [1], 140.0 [2]
(3,4,5-Trimethoxyphenyl)methyl 5-phenylfuran-2-carboxylateIC505170.0 [1]
(3,4,5-Trimethoxyphenyl)methyl 5-phenylfuran-2-carboxylateKi5910.0 [1]
5,8-Dichlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC5010.0 [1]
8-Chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC50170.0 [1]
5-(4-Methyl-2-nitrophenyl)-N-[(3,4,5-trimethoxyphenyl)methyl]furan-2-carboxamideIC503200.0 [1]
5-(4-Methyl-2-nitrophenyl)-N-[(3,4,5-trimethoxyphenyl)methyl]furan-2-carboxamideKi7220.0 [1]
TheophyllineIC50200000.0 [1]
TadalafilIC5010000.0 [1]
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamideIC50200000.0 [1]
CrisaboroleIC50730.0 [1]
Unii-6X97K9I3QNIC508.7 [1]
8-[(4-Chlorophenyl)methyl]-10-thia-3,5,6,8-tetrazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(9),2,4,11(16)-tetraen-7-oneIC5010000.0 [1]
4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-olIC5075000.0 [1]
2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazineIC503345.0 [1]
3-Phenyl-1H-quinazoline-2,4-dithioneIC501040.0 [1]
2-[(2-Nitrophenyl)sulfanyl]anilineIC507600.0 [1]
1-({[5-(Ethoxycarbonyl)-4-methyl-1,3-thiazol-2-yl]amino}carbonyl)propyl N-benzoylleucinateIC50860.0 [1]
2-[(5-Chloro-2-nitrophenyl)thio]pyridineIC507980.0 [1]
N-(4,6-Dimethylpyrimidin-2-yl)-4-[2-(4-methoxy-3-methylphenyl)-5-(4-methylpiperazin-1-yl)-4,5,6,7-tetrahydroindol-1-yl]benzenesulfonamideIC5014.0 [1]
RoflupramIC5050000.0 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
3-Phenyl-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-oneIC50100000.0 [1]
3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dioneIC50100000.0 [1]
CID 46239428Ki10000.0 [1]
4-[[1-(2-Chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholineIC501910.0 [1]
(4As,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-oneIC503162.28 [1]
PDE4 inhibitor intermediate 1Ki7900.0 [1]
1-[(3,4-Dichlorophenyl)-methyl]-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxideIC508000.0 [1]
N,N-Diethyl-3-methyl-1-(2-methylphenyl)-6-thiophen-2-ylpyrazolo[3,4-b]pyridine-4-carboxamideIC5043000.0 [1]
2-Sulfanylidene-3-(2,3,4-trifluorophenyl)-1H-quinazolin-4-oneIC507020.0 [1]
2-[(4-Chloro-2-nitrophenyl)thio]pyridineIC503600.0 [1]
Benzene, 2-chloro-4-nitro-1-(phenylthio)-IC502200.0 [1]
4-Chloro-2-nitro-1-(phenylthio)benzeneIC501500.0 [1]
6,8-Dimethoxy-3,4-dimethyl-1-(3-methylpyridin-4-yl)imidazo[1,5-a]quinoxalineIC5010000.0 [1]
6-Methoxy-3,8-Dimethyl-4-(Morpholin-4-Ylmethyl)-1h-Pyrazolo[3,4-B]quinolineKi10000.0 [1]
1-Cyclohexyl-N-[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]-3-methylthieno[2,3-c]pyrazole-5-carboxamideIC5010.0 [1]
4-[5-(8,9-Dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]morpholineKi2472.0 [1]
[1-(3-{[1-(Quinolin-2-Yl)azetidin-3-Yl]oxy}pyrazin-2-Yl)piperidin-4-Yl]methanolIC5030000.0 [1]
4(3H)-Quinazolinone, 2-(ethylthio)-3-phenyl-IC506900.0 [1]
2-[4-[6,7-Diethoxy-2,3-bis(hydroxymethyl)naphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-oneIC501700.0 [1]
7-(5-Cyclohexylimino-4-methyl-1,3,4-thiadiazol-2-yl)-2-methylquinazolin-4-amineIC503.9 [1]
1-(5-Butoxypyridin-3-Yl)-4-Methyl-8-(Morpholin-4-Ylmethyl)[1,2,4]triazolo[4,3-A]quinoxalineIC5010000.0 [1]
Pde2/pde10-IN-1IC5010000.0 [1]
2-(Benzylthio)-3-phenyl-4(3H)-quinazolinoneIC50600.0 [1]
5-(4-Chlorophenyl)-N-cyclohexyl-3-methyl-1,3,4-thiadiazol-2-imineIC501500.0 [1]
4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-benzamideIC5060.0 [1]
5-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]-2-fluorobenzoic acidIC50160.0 [1]
8-Chloro-5-[3-(dimethylamino)-2-hydroxypropoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC50400.0 [1]
8-Chloro-6-pyridin-3-ylspiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC5050.0 [1]
Methyl 3-(5-cyclohexylimino-4-methyl-1,3,4-thiadiazol-2-yl)benzoateIC50140.0 [1]
3-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-benzenesulfonamideIC50200.0 [1]
8-Chloro-6-[3-(4-methylpiperazine-1-carbonyl)phenyl]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC5040.0 [1]
4-[(2-Nitro-4-chlorophenyl)thio]pyridineIC50720.0 [1]
2-Bromophenyl 4-chloro-2-nitrophenyl sulfideIC50990.0 [1]
2-Bromophenyl 2-nitro-5-chlorophenyl sulfideIC501010.0 [1]
4-[(3-Chloro-4-nitrophenyl)thio]anilineIC501470.0 [1]
2-(5-Chloro-2-nitrophenylthio)anilineIC505450.0 [1]
2-Bromophenyl 2-chloro-4-nitrophenyl sulfideIC502140.0 [1]
2'-(2-Nitro-5-chlorophenylthio)acetoanilideIC502100.0 [1]
5-[(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxymethyl]furan-2-carboxylic acidIC5010.0 [1]
3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxypropane-1-sulfonic acidIC5010.0 [1]
8-Chloro-6-pyridin-2-ylspiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC5030.0 [1]
8-Chloro-6-pyridin-4-ylspiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-oneIC5030.0 [1]
2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]-3-methylbenzoic acidIC501370.0 [1]
2-[2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyethylamino]acetic acidIC5040.0 [1]
3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)benzoic acidIC5020.0 [1]
5-(4-Chlorophenyl)-3-methyl-N-phenyl-1,3,4-thiadiazol-2-imineIC502950.0 [1]
2,2-Dioxo-1-[(3-phenylphenyl)methyl]-[1]benzothiolo[3,2-c][1,2,6]thiadiazin-4-oneIC5015000.0 [1]
1-[(2-Chlorophenyl)methyl]-2,2-dioxo-[1]benzothiolo[3,2-c][1,2,6]thiadiazin-4-oneIC5028000.0 [1]
3-(4-Chloro-2-nitrophenylthio)anilineIC505690.0 [1]
1-[(2-Nitrophenyl)methyl]-2,2-dioxo-[1]benzothiolo[3,2-c][1,2,6]thiadiazin-4-oneIC5022000.0 [1]
2,2-Dioxo-1-[(4-phenylphenyl)methyl]-[1]benzothiolo[3,2-c][1,2,6]thiadiazin-4-oneIC5013000.0 [1]
2,2-Dioxo-1-[(2-phenylphenyl)methyl]-2lambda6,1,3-benzothiadiazin-4-oneIC5021000.0 [1]
2,2-Dioxo-1-[(2-phenylphenyl)methyl]-[1]benzothiolo[3,2-c][1,2,6]thiadiazin-4-oneIC5014000.0 [1]
(3-Bromo-4-fluorophenyl)-[(5S)-3,3-difluoro-5-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanoneIC5010000.0 [1]
N-(2-Hydroxyethyl)-3-[3-methyl-4-oxo-2-(prop-2-enylamino)thieno[3,2-d]pyrimidin-6-yl]benzamideIC501100.0 [1]
N-[3-(Dimethylamino)propyl]-4-[3-methyl-4-oxo-2-(prop-2-enylamino)thieno[3,2-d]pyrimidin-6-yl]benzamideIC50310.0 [1]
3-Methyl-6-phenyl-2-(prop-2-enylamino)thieno[3,2-d]pyrimidin-4-oneIC506800.0 [1]
3-Methyl-2-(prop-2-enylamino)thieno[3,2-d]pyrimidin-4-oneIC505000.0 [1]
2-(Cyclohexylamino)-3-ethylthieno[3,2-d]pyrimidin-4-oneIC50740.0 [1]
2-(Cyclopentylamino)-3-ethyl-6-methylthieno[3,2-d]pyrimidin-4-oneIC5011000.0 [1]
2-(Cyclopentylamino)-3,6-diethylthieno[3,2-d]pyrimidin-4-oneIC506500.0 [1]
2-(Cyclopentylamino)-3-ethyl-6-[(pyridin-3-ylamino)methyl]thieno[3,2-d]pyrimidin-4-oneIC501000.0 [1]
2-(Cyclopentylamino)-3-ethyl-N-[6-(4-hydroxypiperidin-1-yl)pyridin-3-yl]-4-oxothieno[3,2-d]pyrimidine-6-carboxamideIC502600.0 [1]
2-(Cyclopentylamino)-3-ethyl-7-methylthieno[3,2-d]pyrimidin-4-oneIC5098.0 [1]
2-(Cyclopentylamino)-7-ethenyl-3-ethylthieno[3,2-d]pyrimidin-4-oneIC5030.0 [1]
2-(Cyclopentylamino)-3-Ethyl-7-Ethynylthieno[3,2-D]pyrimidin-4(3h)-OneIC5045.0 [1]
2-(Cyclopentylamino)-3-ethyl-4-oxothieno[3,2-d]pyrimidine-7-carbonitrileIC5067.0 [1]
2-(Cyclopentylamino)-3-ethyl-7-(2-pyridin-3-ylethynyl)thieno[3,2-d]pyrimidin-4-oneIC504.2 [1]
2-(Cyclopentylamino)-3-ethyl-7-(3-morpholin-4-ylprop-1-ynyl)thieno[3,2-d]pyrimidin-4-oneIC5019.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 7A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-7a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Phosphodiesterase 7A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-7a-inhibitors-ic50-ki.
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