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Phosphodiesterase 8B Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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RolipramIC5016000.0 [1]
(2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-olIC5016000.0 [1]
PF-04447943IC5010000.0 [1]
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
Unii-7eis09YY11IC5010000.0 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
(4As,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-oneIC503981.07 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501000.0 [1]
1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazineIC5010000.0 [1]
5-Methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-7H-furo[2,3-f]indole-7-carboxamideIC5016000.0 [1]
3-Isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC5010000.0 [1]
3-Propan-2-yl-5-[[(1S,2R)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl]-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-[[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]amino]-4-(trifluoromethyl)pyrimidine-5-carboxylic acidIC501000.0 [1]
2-[(7-Amino-5-cyclopropyltriazolo[4,5-d]pyrimidin-3-yl)methyl]-3H-quinazolin-4-oneIC5043.9 [1]
(R)-2-(4-Fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamideIC5016000.0 [1]
3-[(4-Benzylmorpholin-2-yl)methyl]-5-cyclopropyltriazolo[4,5-d]pyrimidin-7-amineIC5041.0 [1]
3-[[(2R)-4-(Pyridin-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amineIC501.6 [1]
5-Cyclopropyl-3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]triazolo[4,5-d]pyrimidin-7-amineIC500.9 [1]
5-Methyl-3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]triazolo[4,5-d]pyrimidin-7-amineIC501.3 [1]
3-[[(2R)-4-[(4-Ethyl-1,3-thiazol-2-yl)methyl]morpholin-2-yl]methyl]-5-methyltriazolo[4,5-d]pyrimidin-7-amineIC504.2 [1]
3-[[(2R)-4-[(3,5-Difluorophenyl)methyl]morpholin-2-yl]methyl]-5-methyltriazolo[4,5-d]pyrimidin-7-amineIC5019.0 [1]
(3R,5S)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-5-phenylpiperidine-3-carboxamideIC500.9 [1]
(3R,5S)-N-[(6-Aminopyridin-2-yl)methyl]-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-5-phenylpiperidine-3-carboxamideIC500.12 [1]
(3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC5065.0 [1]
(3R,5R)-5-Methyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC5040.0 [1]
(3R,5R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-5-propylpiperidine-3-carboxamideIC506.0 [1]
(3R,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC502000.0 [1]
(3R,5R)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC502.91 [1]
(3R,5R)-5-Hydroxy-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC502700.0 [1]
(3R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC50166.0 [1]
(3R,5R)-5-(5-Methyl-1,3,4-oxadiazol-2-yl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC5066.0 [1]
(3S,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC504.3 [1]
(3R,5S)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC50675.0 [1]
4-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-1,1-dioxo-1,4-thiazinane-2-carboxamideIC502400.0 [1]
[(3R,5R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-5-[(6-methylpyridin-2-yl)methylcarbamoyl]piperidin-3-yl] acetateIC507.0 [1]
(3S,5S)-5-(3-Methyl-1,2,4-oxadiazol-5-yl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC503.86 [1]
(3R,5R)-5-Ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamideIC50168.0 [1]
(3R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC50284.0 [1]
1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC50240.0 [1]
(3R,4R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-4-(trifluoromethyl)pyrrolidine-3-carboxamideIC501700.0 [1]
(3R,5R)-5-Butyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC5015.0 [1]
(3R,5R)-N-[(6-Aminopyridin-2-yl)methyl]-5-ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]piperidine-3-carboxamideIC5016.5 [1]
1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamideIC50516.0 [1]
(3R,5R)-5-Ethyl-1-[(5-methyl-2-pyrimidin-4-yl-1H-imidazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC5026.2 [1]
(3R,5R)-5-Ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC50707.0 [1]
(3R,5S)-N-[(6-Aminopyridin-2-yl)methyl]-5-ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]piperidine-3-carboxamideIC502000.0 [1]
(3R,5S)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamideIC502000.0 [1]
(3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamideIC5044.1 [1]
4-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]morpholine-2-carboxamideIC5010000.0 [1]
(3R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]pyrrolidine-3-carboxamideIC5010000.0 [1]
(3R,5R)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC506.0 [1]
(3R,5R)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamideIC507.3 [1]
(3S,5S)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC500.95 [1]
(3R,5S)-5-Ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamideIC5010000.0 [1]
4-Fluoro-2-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-1,3-dihydroisoquinoline-4-carboxamideIC50370.0 [1]
(3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamideIC501.96 [1]
(3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC504.36 [1]
(3R,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC5010000.0 [1]
(3R,5R)-N-[(6-Aminopyridin-2-yl)methyl]-5-ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]piperidine-3-carboxamideIC504.42 [1]
(3R,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-pyrimidin-4-yl-1H-imidazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamideIC5010000.0 [1]
(3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-pyrimidin-4-yl-1H-imidazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamideIC5013.0 [1]
(3R,5R)-5-(3-Methyl-1,2,4-oxadiazol-5-yl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC503.9 [1]
(3R,5R)-5-Ethyl-1-[(5-methyl-2-pyrimidin-4-yl-1H-imidazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC5026.0 [1]
(3R)-N-[(6-Aminopyridin-2-yl)methyl]-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]piperidine-3-carboxamideIC5058.0 [1]
(3R,5S)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC502000.0 [1]
(3R,5R)-5-Ethyl-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC5019.6 [1]
(3R,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC5010000.0 [1]
(3R,5S)-5-Ethyl-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC5010000.0 [1]
(3R,5S)-5-(Methoxymethyl)-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-(oxan-4-ylmethyl)piperidine-3-carboxamideIC5010000.0 [1]
5-(Methoxymethyl)-1-[(5-methyl-2-morpholin-4-yl-1,3-oxazol-4-yl)methyl]-N-[[(2R)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC5010000.0 [1]
2-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]-3,4-dihydro-1H-isoquinoline-4-carboxamideIC505.0 [1]
(3R,5R)-5-(Methoxymethyl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC503.2 [1]
[(3R,5R)-1-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-5-[(6-methylpyridin-2-yl)methylcarbamoyl]piperidin-3-yl] N-ethylcarbamateIC50120.0 [1]
(3S,5S)-5-(5-Methyl-1,3,4-oxadiazol-2-yl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[(6-methylpyridin-2-yl)methyl]piperidine-3-carboxamideIC5065.9 [1]
(3R,5R)-5-(3-Methyl-1,2,4-oxadiazol-5-yl)-1-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-N-[[(2S)-oxolan-2-yl]methyl]piperidine-3-carboxamideIC5035.2 [1]
8-[(4-Hydroxycyclohexyl)amino]-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-oneIC502000.0 [1]
3-[(4-Chlorophenyl)methyl]-5-cyclopropyltriazolo[4,5-d]pyrimidin-7-amineIC5086.0 [1]
5-Cyclopropyl-3-[(2-ethyl-1,3-thiazol-4-yl)methyl]triazolo[4,5-d]pyrimidin-7-amineIC5093.0 [1]
5-Cyclopropyl-3-[[(3R)-1-(1,3-thiazol-2-ylmethyl)pyrrolidin-3-yl]methyl]triazolo[4,5-d]pyrimidin-7-amineIC50206.0 [1]
3-(Oxan-2-ylmethyl)-N-(oxolan-2-ylmethyl)-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amineIC504030.0 [1]
N-(Oxolan-2-ylmethyl)-3-[[(2R)-oxolan-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amineIC5010000.0 [1]
5-(5-Methyl-1,2-oxazol-3-yl)-3-(oxan-2-ylmethyl)triazolo[4,5-d]pyrimidin-7-amineIC50388.0 [1]
5-Cyclopropyl-3-[(8-methylimidazo[1,2-a]pyridin-2-yl)methyl]triazolo[4,5-d]pyrimidin-7-amineIC5053.8 [1]
3-[(3-Tert-butyl-1H-pyrazol-5-yl)methyl]-5-cyclopropyltriazolo[4,5-d]pyrimidin-7-amineIC506.79 [1]
5-Cyclopropyl-3-(oxan-4-ylmethyl)triazolo[4,5-d]pyrimidin-7-amineIC50925.0 [1]
5-Cyclopropyl-3-[(3-cyclopropyl-1H-pyrazol-5-yl)methyl]triazolo[4,5-d]pyrimidin-7-amineIC506.8 [1]
5-Cyclopropyl-3-[[(2R)-4-(pyrimidin-2-ylmethyl)morpholin-2-yl]methyl]triazolo[4,5-d]pyrimidin-7-amineIC5023.0 [1]
N-(1-Methoxypropan-2-yl)-3-[[(2R)-oxolan-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amineIC5010000.0 [1]
N-Cyclopropyl-3-[[(2R)-oxolan-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amineIC5010000.0 [1]
N',N'-Dimethyl-N-[3-[[(2R)-oxolan-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-yl]propane-1,3-diamineIC5010000.0 [1]
5-Butyl-3-(oxan-2-ylmethyl)triazolo[4,5-d]pyrimidin-7-amineIC50228.0 [1]
5-(2-Methyl-1,3-thiazol-4-yl)-3-(oxan-2-ylmethyl)triazolo[4,5-d]pyrimidin-7-amineIC5013.1 [1]
5-[(3-Fluorophenoxy)methyl]-3-(oxolan-2-ylmethyl)triazolo[4,5-d]pyrimidin-7-amineIC5017.1 [1]
5-Cyclopropyl-3-[(3-phenyl-1H-1,2,4-triazol-5-yl)methyl]triazolo[4,5-d]pyrimidin-7-amineIC5055.1 [1]
5-Cyclopropyl-3-[2-(4-methyl-1,3-thiazol-5-yl)ethyl]triazolo[4,5-d]pyrimidin-7-amineIC5079.4 [1]
5-Cyclopropyl-3-[(2-phenyltriazol-4-yl)methyl]triazolo[4,5-d]pyrimidin-7-amineIC5052.4 [1]
3-[(1S)-1-Cyclohexylethyl]-5-cyclopropyltriazolo[4,5-d]pyrimidin-7-amineIC5074.6 [1]
5-Cyclopropyl-3-[2-(furan-2-ylmethylsulfanyl)ethyl]triazolo[4,5-d]pyrimidin-7-amineIC50136.0 [1]
3-(Oxan-2-ylmethyl)triazolo[4,5-d]pyrimidin-7-amineIC501400.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 8B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-8b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Phosphodiesterase 8B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-8b-inhibitors-ic50-ki.
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