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Phospholipase A2 group 1B Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
VarespladibIC50228.0 [1], 750.0 [2]
IndoxamIC503.0 [1], 6.0 [2], 700.0 [3]
N,N-Diethylhexadecane-1,2-diamineIC509500.0 [1], 11000.0 [2]
2-(Ethylamino)-1-hexadecanolIC506100.0 [1], 6200.0 [2]
2-[3-[(2-Benzylphenyl)methyl]-2-ethyl-1-oxamoylindolizin-8-yl]oxyacetic acidIC501.3 [1], 6.0 [2]
Me-indoxamIC50364.0 [1], 3300.0 [2]
((3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)acetic acidIC50761.0 [1], 2500.0 [2]
[[1-(1,2-Dioxo-2-aminoethyl)-2-methyl-3-benzylindolizin-8-yl]oxy]acetic acidIC503.0 [1], 8.0 [2]
2-[2-Ethyl-3-[(2-nitrophenyl)methyl]-1-oxamoylindolizin-8-yl]oxyacetic acidIC5036.0 [1], 120.0 [2]
(3-Biphenyl-2-ylmethyl-1-carbamoylmethyl-2-ethyl-indolizin-8-yloxy)-acetic acidIC5014.0 [1]
2-[2-Ethyl-3-(naphthalen-2-ylmethyl)-1-oxamoylindolizin-8-yl]oxyacetic acidIC507.3 [1], 17.0 [2]
2-(3-Benzyl-2-cyclopropyl-1-oxamoylindolizin-8-yl)oxyacetic acidIC5046.0 [1], 49.0 [2]
2-[3-(Cycloheptylmethyl)-2-ethyl-1-oxamoylindolizin-8-yl]oxyacetic acidIC5023.0 [1], 100.0 [2]
2-[2-Methoxy-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-8-yl]oxyacetic acidIC5013.0 [1], 15.0 [2]
2-[2-Ethyl-1-oxamoyl-3-(thiophen-2-ylmethyl)indolizin-8-yl]oxyacetic acidIC5011.0 [1], 13.0 [2]
Methyl 2-[2-ethyl-1-oxamoyl-3-[(3-phenylphenyl)methyl]indolizin-8-yl]oxyacetateIC504.2 [1], 9.0 [2]
2-[3-(Cyclopentylmethyl)-2-methyl-1-oxamoylindolizin-8-yl]oxyacetic acidIC5014.0 [1], 22.0 [2]
2-[3-(Cyclopentylmethyl)-2-cyclopropyl-1-oxamoylindolizin-8-yl]oxyacetic acidIC5029.0 [1], 88.0 [2]
2-[3-(Cyclohexylmethyl)-2-ethyl-1-oxamoylindolizin-8-yl]oxyacetic acidIC5021.0 [1], 30.0 [2]
(3-Biphenyl-2-ylmethyl-1-carbamoylmethyl-2-cyclopropyl-indolizin-8-yloxy)-acetic acidIC5013.0 [1], 26.0 [2]
4-[2-Ethyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-8-yl]oxybutanoic acidIC5080.0 [1], 210.0 [2]
2-[3-(Cyclopentylmethyl)-2-ethyl-1-oxamoylindolizin-8-yl]oxyacetic acidIC5019.0 [1]
Methyl 2-[2-ethyl-1-oxamoyl-3-[(E)-3-phenylprop-2-enyl]indolizin-8-yl]oxyacetateIC5038.0 [1], 80.0 [2]
Methyl 2-[2-methyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-8-yl]oxyacetateIC501.4 [1], 8.0 [2]
2-[3-[(4-Butylphenyl)methyl]-2-ethyl-1-oxamoylindolizin-8-yl]oxyacetic acidIC505.0 [1], 11.0 [2]
2-[2-Ethyl-1-oxamoyl-3-[(4-phenylphenyl)methyl]indolizin-8-yl]oxyacetic acidIC5013.0 [1], 18.0 [2]
2-[3-(Cyclohexylmethyl)-2-methyl-1-oxamoylindolizin-8-yl]oxyacetic acidIC5010.0 [1], 15.0 [2]
Methyl 2-[3-(cyclohexylmethyl)-2-cyclopropyl-1-oxamoylindolizin-8-yl]oxyacetateIC5043.0 [1], 160.0 [2]
Methyl 2-[2-cyclopropyl-3-(naphthalen-1-ylmethyl)-1-oxamoylindolizin-8-yl]oxyacetateIC5023.0 [1], 200.0 [2]
(3-Benzyl-1-carbamoylmethyl-2-ethyl-indolizin-8-yloxy)-acetic acidIC5013.0 [1], 28.0 [2]
[1-Carbamoylmethyl-3-(3-chloro-benzyl)-2-ethyl-indolizin-8-yloxy]-acetic acidIC5015.0 [1], 52.0 [2]
2-[2-Ethyl-3-[(3-methoxyphenyl)methyl]-1-oxamoylindolizin-8-yl]oxyacetic acidIC5021.0 [1], 30.0 [2]
2-[[(3Z)-1-(2-Amino-2-oxoethyl)-2-ethyl-3-(naphthalen-1-ylmethylidene)-2H-indolizin-8-yl]oxy]acetic acidIC5025000.0 [1], 130000.0 [2]
2-[2-Ethyl-3-(2-methylpentyl)-1-oxamoylindolizin-8-yl]oxyacetic acidIC5017.0 [1], 78.0 [2]
2-[[(3Z)-1-(2-Amino-2-oxoethyl)-2-ethyl-3-[(2-phenylphenyl)methylidene]-2H-indolizin-8-yl]oxy]acetic acidIC50100000.0 [1], 420000.0 [2]
2-[2-Ethyl-3-[(2-phenylphenyl)methyl]-8-(tetrazol-2-ylmethoxy)indolizin-1-yl]-2-oxoacetamideIC507000.0 [1]
2-[3-[(3-Chlorophenyl)methyl]-2-ethyl-8-(tetrazol-2-ylmethoxy)indolizin-1-yl]-2-oxoacetamideIC5030000.0 [1], 45000.0 [2]
(1-Carbamoyl-2-ethyl-3-naphthalen-1-ylmethyl-indolizin-8-yloxy)-acetic acidIC5030.0 [1], 135.0 [2]
2-[2-Ethyl-1-oxamoyl-3-[[(3S)-3-pentylcyclohexyl]methyl]indolizin-8-yl]oxyacetic acidIC5020.0 [1], 25.0 [2]
2-[2-Ethyl-1-oxamoyl-3-[(5-thiophen-2-ylthiophen-3-yl)methyl]indolizin-8-yl]oxyacetic acidIC5010.0 [1], 11.0 [2]
[[1-(1,2-Dioxo-2-aminoethyl)-2-ethyl-3-(3-chlorobenzyl)indolizin-8-yl]oxy]acetic acidIC503.0 [1], 6.0 [2]
[[1-(1,2-Dioxo-2-aminoethyl)-2-ethyl-3-[(1-naphthyl)methyl]indolizin-8-yl]oxy]acetic acidIC505.0 [1], 24.0 [2]
[[1-(1,2-Dioxo-2-aminoethyl)-2-ethyl-3-[3-(trifluoromethyl)benzyl]indolizin-8-yl]oxy]acetic acidIC503.0 [1], 9.0 [2]
2-[2-Cyclopropyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-8-yl]oxyacetic acidIC506.0 [1], 9.0 [2]
3-[2-Ethyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-8-yl]oxypropanoic acidIC5044.0 [1], 130.0 [2]
2-(3-Benzyl-2-ethyl-1-oxamoylindolizin-8-yl)oxyacetic acidIC505.0 [1], 8.0 [2]
QuercetinIC502000.0 [1]
Oleanolic acidIC503000.0 [1]
ManoalideIC503900.0 [1]
Petrosaspongiolide mIC501600.0 [1]
Abyssinone VIC506000.0 [1]
ErycristagallinIC503000.0 [1]
2-(3-(2-Amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)propanoic acidIC5080.0 [1]
3-[(3R,4Ar,4bS,6aS,7S,10aR,10bS,12aS)-1-hydroxy-7-(hydroxymethyl)-4b,7,10a-trimethyl-1,3,4,4a,5,6,6a,8,9,10,10b,11,12,12a-tetradecahydronaphtho[2,1-f]isochromen-3-yl]-2-hydroxy-2H-furan-5-oneIC503800.0 [1]
2-[2-Ethyl-3-oxamoyl-1-(phenylmethyl)benzo[g]indol-4-yl]oxyacetic acidIC5084.0 [1]
2-[4-[2-(Benzenesulfonamido)-2-oxoethoxy]-1-benzyl-2-(2-methylpropyl)indol-3-yl]-2-oxoacetamideIC501600.0 [1]
2-(3-(2-Amino-2-oxoacetyl)-1-benzyl-2-isobutyl-1H-indol-4-yloxy)acetic acidIC501600.0 [1]
4-[5-[[5-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-2,4-dimethoxy-3,6-dimethylphenyl]methyl]-2,4-dimethoxy-3,6-dimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acidIC5090000000.0 [1]
2-[2-Ethyl-1-oxamoyl-3-(2-phenylethyl)indolizin-8-yl]oxyacetic acidIC5051.0 [1]
2-[1-[(2-Benzylphenyl)methyl]-2-ethyl-3-oxamoylindol-4-yl]oxyacetic acidIC5062.0 [1]
2-(3-(Biphenyl-2-ylmethyl)-8-carbomethoxymethyloxy-2-isopropylindolizin-1-yl)glyoxylamideIC5035.0 [1]
2-[3-Biphenyl-2-ylmethyl-2-ethyl-8-(quinolin-2-ylmethoxy)-indolizin-1-yl]-2-oxo-acetamideIC5055000.0 [1]
2-(2-Ethyl-1-oxamoyl-3-pentylindolizin-8-yl)oxyacetic acidIC5062.0 [1]
Methyl 2-[2-ethyl-1-oxamoyl-3-(2-phenylethyl)indolizin-8-yl]oxyacetateIC5051.0 [1]
4-[4-[5-[3-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-4-methoxyphenyl]sulfonyl-2-methoxybenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acidIC509000000.0 [1]
3-[2-Ethyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-7-yl]oxypropanoic acidIC50240.0 [1]
2-[[1-[1,2-Dioxo-2-(dimethylamino)ethyl]-2-ethyl-3-benzylindolizin-8-yl]oxy]acetic acidIC5050000.0 [1]
2-[3-(1-Adamantylmethyl)-2-methyl-1-oxamoylindolizin-8-yl]oxyacetic acidIC50120.0 [1]
2-[3-[(3,5-Ditert-butylphenyl)methyl]-2-ethyl-1-oxamoylindolizin-8-yl]oxyacetic acidIC506600.0 [1]
2-(2-Methyl-1-octyl-3-oxamoylindol-4-yl)oxyacetic acidIC50780.0 [1]
2-[3-Biphenyl-2-ylmethyl-2-ethyl-8-(pyridin-4-ylmethoxy)-indolizin-1-yl]-2-oxo-acetamideIC5083.0 [1]
Methyl 2-[2-cyclopentyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-8-yl]oxyacetateIC50280.0 [1]
4-[[1-Benzyl-2-ethyl-3-(1,2-dioxo-2-aminoethyl)indolizin-6-yl]oxy]butanoic acidIC501100.0 [1]
2-[2-Methylsulfanyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-8-yl]oxyacetic acidIC5016.0 [1]
4-[2-Ethyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-7-yl]oxybutanoic acidIC50140.0 [1]
Bis[3-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)-carbonyl]-4-methoxyphenyl]etherIC50100000000.0 [1]
2-[3-Biphenyl-2-ylmethyl-2-ethyl-8-(pyridin-2-ylmethoxy)-indolizin-1-yl]-2-oxo-acetamideIC5046.0 [1]
(E)-3-(1-Benzyl-2-methyl-3-oxamoylindol-4-yl)prop-2-enoic acidIC50100000.0 [1]
3-(Carbamoylcarbonyl)-1-benzyl-2-methyl-1H-indole-4-propionic acidIC50100000.0 [1]
2-[[1-[1,2-Dioxo-2-(methylamino)ethyl]-2-ethyl-3-benzylindolizin-8-yl]oxy]acetic acidIC5050000.0 [1]
2-[2-Ethyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-7-yl]oxyacetic acidIC501400.0 [1]
Methyl 2-[2-tert-butyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-8-yl]oxyacetateIC50100.0 [1]
2-Ethyl-3-(3-chlorobenzyl)-8-(2-hydroxybutoxy)indolizine-1-acetamideIC5019000.0 [1]
4-[5-[3-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-4-methoxyphenyl]sulfanyl-2-methoxybenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acidIC50100000000.0 [1]
4-[4-[5-[3-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-4-methoxyphenyl]sulfinyl-2-methoxybenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acidIC5011000000.0 [1]
Thielocin A1IC50135000000.0 [1]
2-(1-Benzyl-2,6-dimethyl-3-oxamoylindol-4-yl)oxyacetic acidIC502000.0 [1]
4-[2-Cyclopropyl-1-oxamoyl-3-[(2-phenylphenyl)methyl]indolizin-8-yl]oxybutanoic acidIC504400.0 [1]
4-[4-[2,4-Dihydroxy-3,6-dimethyl-5-[[(2-oxo-2-phenylmethoxyethyl)amino]methyl]benzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoic acidIC5010000000.0 [1]
4-[4-[2,4-Dihydroxy-3,6-dimethyl-5-[[[(1S)-1-phenylethyl]amino]methyl]benzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoic acidIC5060000000.0 [1]
4-[4-[5-[(2,4-Dimethoxy-3,6-dimethylphenyl)methyl]-2,4-dimethoxy-3,6-dimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acidIC50100000000.0 [1]
3-[4-(3-Phenylmethoxy-2-tetradecoxypropoxy)phenyl]-4H-1,2,4-oxadiazol-5-oneIC50100000.0 [1]
3-[4-(3-Decoxy-2-tetradecoxypropoxy)phenyl]-4H-1,2,4-oxadiazol-5-oneIC5010000.0 [1]
3-[4-[3-(4-Phenylbutoxy)-2-tetradecoxypropoxy]phenyl]-4H-1,2,4-oxadiazol-5-oneIC5015000.0 [1]
3-[4-(3-Benzhydryloxy-2-tetradecoxypropoxy)phenyl]-4H-1,2,4-oxadiazol-5-oneIC5018000.0 [1]
3-[4-(2-Tetradecoxy-3-trityloxypropoxy)phenyl]-4H-1,2,4-oxadiazol-5-oneIC505750.0 [1]
4-[[3-[4-[(5-Oxo-4H-1,2,4-oxadiazol-3-yl)methyl]phenoxy]-2-tetradecoxypropoxy]methyl]benzonitrileIC507600.0 [1]
4-[[2-Octadecoxy-3-[4-[(5-oxo-4H-1,2,4-oxadiazol-3-yl)methyl]phenoxy]propoxy]methyl]benzonitrileIC508700.0 [1]
4-[4-[3-[[5-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-2,4-dihydroxy-3,6-dimethylphenyl]methyl]-2,4-dihydroxy-6-methylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acidIC5018000000.0 [1]
4-[4-[5-[3-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-4-methoxyphenyl]sulfanyl-2-methoxybenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acidIC5055000000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phospholipase A2 group 1B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/phospholipase-a2-group-1b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Phospholipase A2 group 1B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phospholipase-a2-group-1b-inhibitors-ic50-ki.
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