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Phospholipase D2 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
HalopemideIC50300.0 [1], 310.0 [2], 1500.0 [3], 6500.0 [4]
N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-naphthamideIC50240.0 [1], 380.0 [2]
CID 25105713IC50933.0 [1], 1800.0 [2]
N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamideIC50110.0 [1], 140.0 [2]
FIPI hydrochlorideIC5017.0 [1], 20.0 [2], 300.0 [3]
N-[2-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1-benzothiophene-2-carboxamideIC50210.0 [1], 340.0 [2], 2000.0 [3]
(1R,2R)-N-[2-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-2-phenylcyclopropane-1-carboxamideIC503900.0 [1], 6800.0 [2]
RaloxifeneIC503400.0 [1], 10000.0 [2]
(Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)-phenyl)-2-phenylbut-1-en-1-yl)phenolIC5044.0 [1], 74000.0 [2]
4-Chloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC50130.0 [1], 140.0 [2]
N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)furan-2-carboxamideIC50450.0 [1], 1400.0 [2]
4-Methoxy-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC501100.0 [1], 20000.0 [2]
3,4-Difluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC50130.0 [1], 560.0 [2]
3,4-Dichloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC50220.0 [1], 250.0 [2]
3,5-Dichloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC501100.0 [1], 1900.0 [2]
4-Methyl-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC50210.0 [1], 1100.0 [2]
N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-4-vinylbenzamideIC501400.0 [1], 1900.0 [2]
3,4,5-Trimethoxy-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC5079.0 [1], 690.0 [2]
9-Oxo-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]fluorene-4-carboxamideIC50600.0 [1], 1000.0 [2]
N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-9H-carbazole-9-carboxamideIC50260.0 [1], 1000.0 [2]
N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-(phenylthio)acetamideIC5020000.0 [1]
N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-pyrrole-2-carboxamideIC50340.0 [1], 1200.0 [2]
4,5-Dibromo-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]furan-2-carboxamideIC50170.0 [1], 220.0 [2]
4-Fluoro-N-(4-fluorobenzoyl)-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamideIC50470.0 [1], 2200.0 [2]
2-Chloro-N-(2-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC5012000.0 [1], 20000.0 [2]
4-Chloro-N-(4-chlorobenzoyl)-N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamideIC501200.0 [1], 2500.0 [2]
(S)-N-(1-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propan-2-yl)-2-naphthamideIC50140.0 [1]
N-(2-(4-(2-Oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)quinoline-3-carboxamideIC5042.0 [1], 600.0 [2]
4-Fluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamideIC50350.0 [1], 6700.0 [2]
N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-2-carboxamideIC5090.0 [1], 500.0 [2]
4-Bromo-N-[(2S)-1-[1-(3-methylphenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamideIC5020.0 [1], 84.0 [2]
N-[2-[1-(3-Fluorophenyl)-2-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamideIC5020.0 [1], 100.0 [2]
(1R,2S)-N-[(2S)-1-[4-(5-Bromo-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-2-phenylcyclopropane-1-carboxamideIC501100.0 [1], 6400.0 [2]
N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamideIC5020.0 [1]
(1R,2R)-N-[(2S)-1-[4-(5-Bromo-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-2-phenylcyclopropane-1-carboxamideIC506400.0 [1]
3,4-Difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamideIC50355.0 [1]
N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)octanamideIC502000.0 [1]
N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-4-(trifluoromethyl)benzamideIC504300.0 [1]
4-Fluoro-N-[2-[1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamideIC50610.0 [1]
4-Fluoro-N-(2-(4-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC501410.0 [1]
N-(2-(4-(2-Oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC501500.0 [1]
N-(2-(4-(5-Bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-4-fluorobenzamideIC5076.0 [1]
N-[2-[1-(4-Chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-4-fluorobenzamideIC505670.0 [1]
N-[2-[1-(4-Bromophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-4-fluorobenzamideIC508000.0 [1]
N-(2-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-4-methylbenzamideIC50240.0 [1]
N-[2-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]thiophene-3-carboxamideIC501000.0 [1]
N-[2-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamideIC5020.0 [1]
4-Chloro-N-[(2S)-1-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamideIC501200.0 [1]
(1R,2R)-N-[(2S)-1-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-2-phenylcyclopropane-1-carboxamideIC501150.0 [1]
N-[(2S)-1-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-3,4-difluorobenzamideIC50730.0 [1]
N-[(2S)-1-[4-(5-Bromo-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-3,4-difluorobenzamideIC50187.0 [1]
N-[(2S)-1-[4-(5-Bromo-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-4-chlorobenzamideIC50890.0 [1]
N-[(2S)-1-[4-(6-Fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]naphthalene-2-carboxamideIC50360.0 [1]
N-[(2S)-1-[4-(5-Bromo-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]naphthalene-2-carboxamideIC503900.0 [1]
(1R,2R)-N-[(2S)-1-[4-(6-Fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-2-phenylcyclopropane-1-carboxamideIC503800.0 [1]
N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-3-phenylpropiolamideIC50730.0 [1]
N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)quinoline-6-carboxamideIC50740.0 [1]
N-[2-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1,4-dihydronaphthalene-2-carboxamideIC50860.0 [1]
6-Fluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-naphthamideIC50850.0 [1]
N-(2-(4-(5-Fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-naphthamideIC50140.0 [1]
4-Chloro-N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC5061.0 [1]
4-Fluoro-N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC50375.0 [1]
N-(2-(4-(5-Bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-4-chlorobenzamideIC5097.0 [1]
4-Chloro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamideIC5042.0 [1]
3,4-Difluoro-N-[2-[4-(6-fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]benzamideIC5014.0 [1]
4-Chloro-N-[(2S)-1-[4-(4-fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamideIC5012000.0 [1]
4-Fluoro-N-[(2S)-1-[4-(4-fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamideIC5010000.0 [1]
3,4-Difluoro-N-[(2S)-1-[4-(4-fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamideIC5014000.0 [1]
N-[(2S)-1-[4-(4-Fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]naphthalene-2-carboxamideIC5013000.0 [1]
(1R,2R)-N-[(2S)-1-[4-(4-Fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-2-phenylcyclopropane-1-carboxamideIC5020000.0 [1]
4-Fluoro-N-[(2S)-1-[4-(5-fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamideIC503100.0 [1]
4-Chloro-N-[(2S)-1-[4-(5-fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamideIC501040.0 [1]
N-[(2S)-1-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-4-fluorobenzamideIC501400.0 [1]
(1S,2S)-N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]-2-phenylcyclopropane-1-carboxamideIC5020000.0 [1]
N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]-3-phenylprop-2-ynamideIC501600.0 [1]
(1S,2S)-N-[(2S)-1-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propan-2-yl]-2-phenylcyclopropane-1-carboxamideIC5030000.0 [1]
(S)-3,4-Difluoro-N-(1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propan-2-yl)benzamideIC50200.0 [1]
N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]-1-benzothiophene-2-carboxamideIC5030.0 [1]
N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamideIC50990.0 [1]
4-Amino-3-methoxy-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]benzamideIC50550.0 [1]
N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)quinoxaline-2-carboxamideIC5020000.0 [1]
(S)-3-Methyl-N-(1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propan-2-yl)benzamideIC5027000.0 [1]
5-Fluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-1H-indole-2-carboxamideIC5025.0 [1]
N-[2-[1-(3-Chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-5-fluoro-1H-indole-2-carboxamideIC5073.0 [1]
N-[2-[1-(3,4-Difluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-5-fluoro-1H-indole-2-carboxamideIC50100.0 [1]
5-Fluoro-N-[2-[1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-1H-indole-2-carboxamideIC5030.0 [1]
N-[2-[1-(4-Chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-5-fluoro-1H-indole-2-carboxamideIC5050.0 [1]
N-[2-[1-(4-Bromophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-5-fluoro-1H-indole-2-carboxamideIC50100.0 [1]
N-[(2S)-1-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]naphthalene-2-carboxamideIC5060.0 [1]
N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamideIC5063.0 [1]
N-[2-[1-(3-Chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamideIC50290.0 [1]
N-[2-[1-(3-Chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamideIC50165.0 [1]
N-[2-[1-(3-Chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-4-fluorobenzamideIC5070.0 [1]
N-[2-[1-(3,4-Difluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamideIC50120.0 [1]
N-[2-[1-(3,4-Difluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamideIC5070.0 [1]
N-[2-[1-(3,4-Difluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-4-fluorobenzamideIC50660.0 [1]
N-[2-[1-(4-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamideIC5080.0 [1]
N-[2-[1-(4-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamideIC5040.0 [1]
N-[2-[1-(4-Chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamideIC50655.0 [1]
N-[2-[1-(4-Chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamideIC50200.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phospholipase D2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/phospholipase-d2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Phospholipase D2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phospholipase-d2-inhibitors-ic50-ki.
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