 | PI-103 | IC50 | 8.7 [1] |
 | Pictilisib | IC50 | 3.0 [1] |
| Pictilisib | Ki | 2.6 [1], 10.2 [2] |
 | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | IC50 | 600.0 [1] |
| 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | Ki | 6000.0 [1] |
 | 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine | IC50 | 16.0 [1] |
 | Dactolisib | IC50 | 16.4 [1] |
 | Idelalisib | IC50 | 800.0 [1] |
 | Buparlisib | IC50 | 30.0 [1] |
| Buparlisib | Ki | 20.0 [1] |
 | Wortmannin | IC50 | 12.0 [1] |
| Wortmannin | Ki | 120.0 [1] |
 | Alpelisib | IC50 | 5.0 [1] |
 | Tgx-221 | IC50 | 5700.0 [1] |
 | (2S)-1-N-[5-(2-Tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide | IC50 | 20.0 [1] |
 | N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide | IC50 | 0.9 [1] |
 | 6-(2-Aminopyrimidin-5-yl)-N-(2-methoxyethyl)-3-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide | IC50 | 0.9 [1], 13.0 [2] |
| 6-(2-Aminopyrimidin-5-yl)-N-(2-methoxyethyl)-3-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide | Ki | 1.9 [1], 2.3 [2], 2.4 [3], 3.1 [4] |
 | PF-04691502 | IC50 | 3.3 [1], 4.85 [2], 8.33 [3] |
| PF-04691502 | Ki | 0.57 [1] |
 | Gedatolisib | IC50 | 0.4 [1], 0.6 [2] |
 | Taselisib | IC50 | 0.7 [1], 4.0 [2], 31.0 [3] |
| Taselisib | Ki | 0.29 [1], 0.3 [2] |
 | (2S)-N1-[5-(2-Tert-butyl-4-thiazolyl)-4-methyl-2-thiazolyl]pyrrolidine-1,2-dicarboxamide | IC50 | 15.0 [1], 32.0 [2], 200.0 [3] |
 | N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonamide | IC50 | 0.8 [1], 1.3 [2], 49.0 [3], 82.0 [4] |
 | N-{6-[6-Amino-5-(Trifluoromethyl)pyridin-3-Yl]imidazo[1,2-A]pyridin-2-Yl}acetamide | IC50 | 3.6 [1], 4.0 [2], 5.9 [3], 12.0 [4] |
 | 2-(Difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazol-4-ol | IC50 | 0.12 [1], 0.53 [2], 0.83 [3], 1.3 [4], 2.9 [5] |
 | 2-(Difluoromethyl)-3-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-7-methoxybenzimidazol-5-amine | IC50 | 0.95 [1], 1.0 [2], 3.1 [3], 4.8 [4], 8.8 [5] |
 | 4-[4-[4-(Difluoromethoxy)-2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine | IC50 | 3.0 [1], 4.7 [2], 8.5 [3], 418.0 [4], 427.0 [5] |
 | 2-(Difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-5-methoxybenzimidazol-4-ol | IC50 | 49.0 [1], 70.0 [2], 158.0 [3], 378.0 [4], 583.0 [5] |
 | 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one | IC50 | 100000.0 [1], 200000.0 [2], 255000.0 [3] |
 | Omipalisib | IC50 | 0.04 [1], 0.55 [2], 0.63 [3], 1.1 [4] |
 | N-[6-[6-Chloro-5-[[(4-fluorophenyl)sulfonyl]amino]-3-pyridinyl]-1,3-benzothiazol-2-yl]acetamide | IC50 | 6.3 [1] |
| N-[6-[6-Chloro-5-[[(4-fluorophenyl)sulfonyl]amino]-3-pyridinyl]-1,3-benzothiazol-2-yl]acetamide | Ki | 1.2 [1] |
 | CID 46927938 | IC50 | 8.3 [1] |
| CID 46927938 | Ki | 1.77 [1], 1.89 [2], 2.33 [3] |
 | (3-(9-(1-Benzylpiperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanol | IC50 | 45.0 [1], 63.0 [2] |
 | N-(2-Chlorophenyl)-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2-carboxamide | IC50 | 16.0 [1], 1000.0 [2] |
| N-(2-Chlorophenyl)-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2-carboxamide | Ki | 16.0 [1], 16.3 [2] |
 | 8-[(3,5-Difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 10.0 [1], 25.0 [2], 850.0 [3] |
 | [(3S)-3-[[6-(6-Methoxy-5-methylpyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]oxy]pyrrolidin-1-yl]-(oxan-4-yl)methanone | IC50 | 1940.0 [1], 2037.8 [2], 2038.0 [3], 6490.0 [4] |
 | 2-[4-[2-(2-Propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol | IC50 | 0.5 [1], 16.0 [2], 24.0 [3] |
| 2-[4-[2-(2-Propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol | Ki | 0.27 [1] |
 | 2-[1-(Propan-2-Yl)-1h-1,2,4-Triazol-5-Yl]-4,5-Dihydrothieno[3,2-D][1]benzoxepine-8-Carboxamide | IC50 | 4.0 [1], 155.0 [2] |
 | 1-[4-[3-[6-(6-Methoxypyridin-3-yl)quinazolin-4-yl]benzoyl]piperazin-1-yl]ethanone | IC50 | 418.0 [1], 2120.0 [2] |
 | 5-{4-[3-(4-Acetylpiperazine-1-Carbonyl)phenyl]quinazolin-6-Yl}-2-Methoxypyridine-3-Carbonitrile | IC50 | 262.0 [1], 3440.0 [2] |
 | 5-[5-Chloro-2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine | IC50 | 5.2 [1] |
| 5-[5-Chloro-2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine | Ki | 1.73 [1], 2.77 [2], 3.07 [3] |
 | 5-(6-Morpholin-4-yl-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl)benzene-1,3-diol | IC50 | 5.9 [1], 53.4 [2], 61.3 [3], 139.8 [4] |
 | 2-(Morpholin-4-yl)-benzo[h]chromen-4-one | IC50 | 13000.0 [1] |
 | 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one | IC50 | 130.0 [1], 5000.0 [2] |
 | Apitolisib | IC50 | 4.8 [1], 5.0 [2] |
| Apitolisib | Ki | 5.0 [1] |
 | Pik-75 | IC50 | 0.5 [1], 7.8 [2] |
 | 1-[4-(3-Ethyl-7-morpholin-4-yltriazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea | IC50 | 1.0 [1], 1.4 [2], 2.0 [3] |
 | N-(7,8-Dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide | IC50 | 11.0 [1] |
 | 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | IC50 | 52.0 [1] |
 | Leniolisib | IC50 | 244.0 [1], 262.0 [2], 1670.0 [3] |
 | CID 118502708 | IC50 | 320.0 [1], 1400.0 [2], 1410.0 [3] |
 | CID 46244454 | IC50 | 13000.0 [1], 30000.0 [2] |
 | 5-(2-Morpholin-4-Yl-7-Pyridin-3-Yl-6,7-Dihydro-5h-Pyrrolo[2,3-D]pyrimidin-4-Yl)-Pyrimidin-2-Ylamine | IC50 | 33.0 [1] |
 | 3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol | IC50 | 2.0 [1], 8.0 [2], 41.0 [3] |
 | 1-Methyl-3-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]urea | IC50 | 41.0 [1] |
 | Methyl 4-[6-[4-(methylcarbamoylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate | IC50 | 100.0 [1] |
 | 5-[6-[(4-Methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amine | IC50 | 2.0 [1] |
 | N-[5-(2-Amino-4-methylpyrido[2,3-d]pyrimidin-6-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamide | IC50 | 2.0 [1], 3.59 [2] |
 | 9-(1-Anilinoethyl)-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide | IC50 | 560.0 [1], 2500.0 [2], 9600.0 [3] |
 | 9-(1-Anilinoethyl)-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide | IC50 | 370.0 [1], 2200.0 [2], 2300.0 [3] |
 | 1-[4-[4-[5-Amino-6-(benzotriazol-1-yl)pyrazin-2-yl]pyrazol-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone | IC50 | 16.0 [1], 58.0 [2] |
 | 2-[(1-Methyl-1h-Benzimidazol-2-Yl)methyl]-6-Morpholin-4-Ylpyrimidin-4(3h)-One | IC50 | 10000.0 [1] |
 | 2-N-(2-Chlorophenyl)-2-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide | IC50 | 1.5 [1], 100.0 [2] |
| 2-N-(2-Chlorophenyl)-2-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide | Ki | 1.2 [1] |
 | 6-(1H-Indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)phenoxy)-1H-pyrazolo[3,4-b]pyridine | IC50 | 6.8 [1], 7.0 [2], 187.0 [3] |
 | 2-N-[2-Chloro-4-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide | IC50 | 2.0 [1], 4.6 [2] |
| 2-N-[2-Chloro-4-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide | Ki | 2.0 [1] |
 | N-[5-(1,3-Benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide | IC50 | 769.0 [1] |
| N-[5-(1,3-Benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide | Ki | 12.9 [1], 13.0 [2] |
 | N-[5-(2-Amino-1,3-benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide | IC50 | 44.0 [1] |
| N-[5-(2-Amino-1,3-benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide | Ki | 5.6 [1] |
 | 5,5-Dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one | IC50 | 975.0 [1], 1333.0 [2], 2939.0 [3] |
 | (2S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-3-phenylpropan-1-one | IC50 | 4700.0 [1], 8100.0 [2], 12000.0 [3] |
 | (2S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]propan-1-one | IC50 | 2300.0 [1], 3500.0 [2], 8200.0 [3] |
 | 2-[(3S)-3-(1H-Indol-3-ylmethyl)morpholin-4-yl]-7,7-dimethyl-6,8-dihydro-5H-[1,3]thiazolo[5,4-c]azepin-4-one | IC50 | 59.0 [1], 199.0 [2], 1412.0 [3] |
 | [(3S)-3-[[6-[6-Methoxy-5-(trifluoromethyl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]oxy]pyrrolidin-1-yl]-(oxan-4-yl)methanone | IC50 | 589.0 [1], 590.0 [2], 3550.0 [3] |
 | 1-[(3S)-3-[[6-[6-Methoxy-5-(trifluoromethyl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]oxy]pyrrolidin-1-yl]propan-1-one | IC50 | 791.0 [1], 792.0 [2], 2600.0 [3] |
 | 1-[(3S)-3-[[6-(6-Methoxy-5-methylpyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one | IC50 | 651.0 [1], 7410.0 [2] |
 | [(3S)-3-[[6-(6-Methoxy-5-methylpyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]-(oxan-4-yl)methanone | IC50 | 373.0 [1], 432.0 [2], 6190.0 [3] |
 | [(3S)-3-[[6-[6-Methoxy-5-(trifluoromethyl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]-(oxan-4-yl)methanone | IC50 | 43.0 [1], 44.0 [2], 2150.0 [3] |
 | (2S,3S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-3-methylpentan-1-one | IC50 | 2800.0 [1], 6300.0 [2], 9200.0 [3] |
 | Benzoin | IC50 | 2120000.0 [1] |
 | Nvp-aew541 | IC50 | 9000.0 [1], 9100.0 [2] |
 | Ku-0063794 | IC50 | 8900.0 [1] |
 | Copanlisib | IC50 | 0.5 [1], 0.7 [2] |
 | BGT-226 free base | IC50 | 4.0 [1], 41.91 [2] |
 | 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid | IC50 | 870.0 [1] |
 | AS-252424 | IC50 | 940.0 [1] |
 | Azd-8186 | IC50 | 35.0 [1], 752.0 [2] |
 | CID 44219749 | IC50 | 1026.0 [1] |
 | Liphagal | IC50 | 100.0 [1] |
 | Gne-477 | IC50 | 4.0 [1] |
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