 | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | IC50 | 420.0 [1] |
 | Tgx-221 | IC50 | 22.0 [1] |
 | Idelalisib | IC50 | 562.0 [1] |
 | 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine | IC50 | 15.2 [1] |
 | PI-103 | IC50 | 12.0 [1] |
 | Dactolisib | IC50 | 35.9 [1] |
 | Pictilisib | IC50 | 33.0 [1] |
 | (2S)-1-N-[5-(2-Tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide | IC50 | 2010.0 [1] |
 | 2-[(1-Methyl-1h-Benzimidazol-2-Yl)methyl]-6-Morpholin-4-Ylpyrimidin-4(3h)-One | IC50 | 86.0 [1] |
 | Alpelisib | IC50 | 1200.0 [1], 2200.0 [2] |
 | 8-[(3,5-Difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 7.0 [1], 10.0 [2], 35.0 [3] |
 | 2-Methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-7-morpholin-4-ylimidazo[1,2-a]pyrimidin-5-one | IC50 | 1.0 [1], 1.3 [2], 78.0 [3], 29000.0 [4] |
 | 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one | IC50 | 16000.0 [1], 75000.0 [2], 200000.0 [3] |
 | 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid | IC50 | 10.0 [1], 40.0 [2] |
 | 1-[4-[4-[5-Amino-6-(benzotriazol-1-yl)pyrazin-2-yl]pyrazol-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone | IC50 | 900.0 [1], 13000.0 [2] |
 | 1-[4-[3-[6-(6-Methoxypyridin-3-yl)quinazolin-4-yl]benzoyl]piperazin-1-yl]ethanone | IC50 | 3570.0 [1], 4840.0 [2] |
 | 5-{4-[3-(4-Acetylpiperazine-1-Carbonyl)phenyl]quinazolin-6-Yl}-2-Methoxypyridine-3-Carbonitrile | IC50 | 1650.0 [1], 6530.0 [2] |
 | 8-(1-Anilinoethyl)-6-methyl-2-morpholin-4-ylchromen-4-one | IC50 | 3.0 [1], 28.0 [2], 57.0 [3] |
 | Wortmannin | IC50 | 10.0 [1], 14.0 [2], 15.0 [3] |
 | (S)-2-(2-(2-Methylindolin-1-yl)-2-oxoethyl)-6-morpholinopyrimidin-4(3H)-one | IC50 | 23.0 [1], 49.0 [2], 60.0 [3] |
 | (2S)-N1-[5-(2-Tert-butyl-4-thiazolyl)-4-methyl-2-thiazolyl]pyrrolidine-1,2-dicarboxamide | IC50 | 6500.0 [1], 10000.0 [2] |
 | 3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol;hydrochloride | IC50 | 16.0 [1] |
 | 9-(1-Anilinoethyl)-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide | IC50 | 11.0 [1], 68.0 [2], 156.0 [3] |
 | 9-(1-Anilinoethyl)-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide | IC50 | 8.0 [1], 35.0 [2] |
 | 2-N-[2-Chloro-4-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide | IC50 | 22.0 [1], 60.0 [2] |
| 2-N-[2-Chloro-4-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide | Ki | 19.0 [1] |
 | (2S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-3-phenylpropan-1-one | IC50 | 63.0 [1], 74.0 [2], 6000.0 [3] |
 | (2S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]propan-1-one | IC50 | 31.0 [1], 62.0 [2], 890.0 [3] |
 | 8-[(6-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 9.0 [1], 10.0 [2], 37.0 [3] |
 | 8-[(8-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 8.0 [1], 10.0 [2], 12.0 [3] |
 | 8-[(6-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide | IC50 | 3.0 [1], 7.0 [2], 10.0 [3] |
 | 8-[(8-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide | IC50 | 2.0 [1], 7.0 [2], 10.0 [3] |
 | 8-[(6,8-Difluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 6.0 [1], 9.0 [2], 10.0 [3] |
 | 8-[(3,5-Difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide | IC50 | 2.0 [1], 7.0 [2], 10.0 [3] |
 | 8-[(6,8-Difluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide | IC50 | 3.0 [1], 6.0 [2], 10.0 [3] |
 | 2-[(5-Fluoro-1H-benzimidazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one | IC50 | 30.0 [1], 41.0 [2], 100.0 [3] |
 | 8-[1-(3-Fluoro-5-methylanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 5.0 [1], 15.0 [2], 49.0 [3] |
 | 8-[1-(3-Chloro-4-fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 6.0 [1], 12.0 [2], 16.0 [3] |
 | 8-[1-(2,5-Difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 10.0 [1], 19.0 [2], 60.0 [3] |
 | 8-[1-(3,5-Difluoroanilino)ethyl]-6-(4-hydroxypiperidine-1-carbonyl)-2-morpholin-4-ylchromen-4-one | IC50 | 3.0 [1], 11.0 [2], 17.0 [3] |
 | 8-[1-(3,5-Difluoroanilino)ethyl]-2-morpholin-4-yl-6-(piperidine-1-carbonyl)chromen-4-one | IC50 | 5.0 [1], 12.0 [2], 14.0 [3] |
 | 8-[1-(3,5-Difluoroanilino)ethyl]-N-ethyl-N-methyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 2.0 [1], 7.0 [2], 8.0 [3] |
 | 8-[1-(3-Fluoro-5-methoxyanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 4.0 [1], 10.0 [2], 15.0 [3] |
 | 8-[1-(2,3-Difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 4.0 [1], 13.0 [2], 24.0 [3] |
 | 8-[1-(3,5-Difluoroanilino)ethyl]-N-ethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 5.0 [1], 9.0 [2], 14.0 [3] |
 | 8-[1-(3,5-Difluoroanilino)ethyl]-N-(2-methoxyethyl)-N-methyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 4.0 [1], 11.0 [2], 17.0 [3] |
 | 8-[1-(3,5-Dichloroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 5.0 [1], 10.0 [2], 17.0 [3] |
 | 8-[1-(3,5-Difluoro-N-methylanilino)ethyl]-2-morpholin-4-yl-6-(pyrrolidine-1-carbonyl)chromen-4-one | IC50 | 5.0 [1], 13.0 [2], 100.0 [3] |
 | 8-[1-(3-Chloroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 4.0 [1], 9.0 [2], 10.0 [3] |
 | 8-(1-(3,5-Difluorophenylamino)ethyl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one | IC50 | 5.0 [1], 11.0 [2], 33.0 [3] |
 | 8-[1-(3,5-Difluoroanilino)ethyl]-N-(2-methoxyethyl)-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 4.0 [1], 9.0 [2], 31.0 [3] |
 | 8-[1-(3,5-Difluoroanilino)ethyl]-N-(2-hydroxyethyl)-N-methyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 4.0 [1], 10.0 [2], 15.0 [3] |
 | 8-[1-(3,5-Difluoroanilino)ethyl]-N,N-diethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 4.0 [1], 10.0 [2], 16.0 [3] |
 | 8-[1-(3,5-Difluoroanilino)ethyl]-2-morpholin-4-yl-6-(pyrrolidine-1-carbonyl)chromen-4-one | IC50 | 2.0 [1], 4.0 [2], 9.0 [3] |
 | 8-[1-(4-Fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 7.0 [1], 18.0 [2], 128.0 [3] |
 | 8-[1-(3-Fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide | IC50 | 5.0 [1], 12.0 [2], 32.0 [3] |
 | 2-Methyl-5-(2-methylmorpholin-4-yl)-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-one | IC50 | 0.3 [1], 0.5 [2], 2500.0 [3] |
 | (2S,3S)-2-Amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-3-methylpentan-1-one | IC50 | 67.0 [1], 140.0 [2], 1400.0 [3] |
 | Buparlisib | IC50 | 166.0 [1], 607.0 [2] |
 | Nvp-aew541 | IC50 | 9000.0 [1], 9100.0 [2] |
 | Apitolisib | IC50 | 27.0 [1] |
 | Ku-0063794 | IC50 | 30000.0 [1] |
 | Omipalisib | IC50 | 1.2 [1] |
 | AS-252424 | IC50 | 20000.0 [1] |
 | Azd-8186 | IC50 | 3.0 [1], 4.0 [2] |
 | 1-[4-(3-Ethyl-7-morpholin-4-yltriazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea | IC50 | 7.0 [1] |
 | N-(7,8-Dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide | IC50 | 350.0 [1] |
 | 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | IC50 | 1400.0 [1] |
 | Gne-477 | IC50 | 86.0 [1] |
 | Leniolisib | IC50 | 424.0 [1], 2250.0 [2] |
 | 5-(7-(Methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine | IC50 | 120.0 [1] |
 | 5-(2-Amino-8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide | IC50 | 1000.0 [1], 1258.93 [2] |
 | DNA-PK Inhibitor V | IC50 | 3700.0 [1] |
 | 2-((9H-Purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3H)-one | IC50 | 11000.0 [1] |
 | 3-[4-Amino-1-(1-Methylethyl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]phenol | IC50 | 8600.0 [1] |
 | cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenol | IC50 | 230.0 [1] |
 | 7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 9000.0 [1], 9100.0 [2] |
 | 5-Chloro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)ethyl]quinazolin-4-one | IC50 | 77.0 [1] |
 | (2S)-1-N-[5-(3-Fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide | IC50 | 9100.0 [1] |
| (2S)-1-N-[5-(3-Fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide | Ki | 10000.0 [1] |
 | 4-[4-(2-Methylbenzimidazol-1-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine | IC50 | 289.0 [1], 523.0 [2] |
 | 2-[4-(Morpholin-4-Yl)-6-Oxo-1,6-Dihydropyrimidin-2-Yl]-N-Phenylacetamide | IC50 | 42.0 [1] |
 | 2-[2-(2-Methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one | IC50 | 4.0 [1], 6.0 [2] |
 | pi-103 (Hydrochloride) | IC50 | 3.0 [1] |
 | 8-(4-Fluoro-2-methylphenoxy)-2-(morpholin-4-yl)quinolin-4(1H)-one | IC50 | 32.0 [1], 72.0 [2] |
 | 1-Methyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine | IC50 | 16000.0 [1] |
 | 1-(1-Methylethyl)-3-Quinolin-6-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine | IC50 | 240.0 [1] |
 | 1-Cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | IC50 | 130.0 [1] |
 | (2R)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one | IC50 | 27.0 [1], 145.0 [2] |
 | N-[(E)-(5-Cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide | IC50 | 46.0 [1] |
 | 5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide | IC50 | 489.78 [1], 50118723.36 [2] |
 | 1-(4-Amino-6-Methyl-1,3,5-Triazin-2-Yl)-N-(1h-Pyrazol-3-Yl)-1h-Benzimidazol-2-Amine | IC50 | 870.0 [1], 875.0 [2] |
 | 5-Methyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-7-one | IC50 | 0.6 [1], 0.63 [2] |
 | [(4-{2-[(3-Hydroxyphenyl)amino]-1h-Benzimidazol-1-Yl}-1,3,5-Triazin-2-Yl)amino]acetonitrile | IC50 | 380.0 [1] |
| [(4-{2-[(3-Hydroxyphenyl)amino]-1h-Benzimidazol-1-Yl}-1,3,5-Triazin-2-Yl)amino]acetonitrile | Ki | 190.0 [1] |
 | 6-(6-Methoxypyridin-3-yl)benzo[d]thiazol-2-amine | IC50 | 1584.89 [1], 3600.0 [2] |
 | 2-N-[2-Chloro-5-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide | IC50 | 204.0 [1] |
| 2-N-[2-Chloro-5-(dimethylcarbamoyl)phenyl]-2-N,8-N-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide | Ki | 204.0 [1] |
 | [(3S)-3-[[6-(6-Methoxy-5-methylpyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]oxy]pyrrolidin-1-yl]-(oxan-4-yl)methanone | IC50 | 4150.0 [1], 6790.0 [2] |
 | N-{5-[3-Fluoro-4-(methanesulfonyl)phenyl]-4-methyl-1,3-thiazol-2-yl}acetamide | IC50 | 1600.0 [1] |
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