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PI4-kinase beta subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-[2-(morpholin-4-yl)ethyl]pyrazolo[1,5-a]pyrimidin-7-amineIC508.0 [1], 60.0 [2], 137.0 [3], 2000.0 [4]
(3S)-4-(6-Amino-1-methylpyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamideIC505.0 [1], 11.0 [2], 37.0 [3]
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamideIC5019.0 [1], 28.0 [2]
pi4KIII beta inhibitor 3IC505.0 [1], 19.0 [2]
1-[4-(5-Amino-2-pyridin-3-yl-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-chlorophenoxy)ethanoneIC5010.0 [1], 16.0 [2]
(3R)-4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamideIC50316.0 [1], 472.0 [2]
8-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)-3,8-diazabicyclo[3.2.1]octane-3-carboxamideIC50635.0 [1], 981.0 [2]
(3S,5R)-4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)-3,5-dimethylpiperazine-1-carboxamideIC50543.0 [1], 1412.0 [2]
(3S)-4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)-3-methylpiperazine-1-carboxamideIC508.0 [1], 31.0 [2]
(3S)-4-(2-Aminothieno[2,3-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamideIC507.0 [1], 13.0 [2]
[4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-imidazo[1,2-a]pyridin-2-ylmethanoneIC50946.0 [1], 8795.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)-2,3-dimethylpiperazine-1-carboxamideIC502583.0 [1], 2712.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methylphenyl)piperazine-1-carboxamideIC5085.0 [1], 145.0 [2]
(2R,5S)-4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)-2,5-dimethylpiperazine-1-carboxamideIC50275.0 [1], 381.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)-3-methylpiperazine-1-carboxamideIC5018.0 [1], 23.0 [2]
(3S)-4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(6-methoxy-2-methylpyridin-3-yl)-3-methylpiperazine-1-carboxamideIC5020.0 [1], 60.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)-2-methylpiperazine-1-carboxamideIC501500.0 [1], 10000.0 [2]
[4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-(1H-benzimidazol-2-yl)methanoneIC506138.0 [1], 10000.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-[(4-methoxyphenyl)methyl]piperazine-1-carboxamideIC501764.0 [1], 1946.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-[4-(trifluoromethoxy)phenyl]piperazine-1-carboxamideIC50331.0 [1], 548.0 [2]
4-(5-Amino-2-phenyl-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)piperazine-1-carboxamideIC5011.0 [1], 32.0 [2]
(3S)-4-(2-Amino-9-methylpurin-6-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamideIC508.0 [1], 53.0 [2]
[4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-(1H-indol-2-yl)methanoneIC5010000.0 [1]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-pyridin-3-ylpiperazine-1-carboxamideIC503387.0 [1], 5000.0 [2]
1-[4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(3,4-dimethoxyphenyl)ethanoneIC505743.0 [1], 10000.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(6-methoxy-2-methylpyridin-3-yl)piperazine-1-carboxamideIC50173.0 [1], 195.0 [2]
3-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)-3,8-diazabicyclo[3.2.1]octane-8-carboxamideIC501768.0 [1], 2577.0 [2]
(2S)-N-[4-[4-Chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-5-methyl-1H-imidazol-2-yl]-2-(4-chlorophenyl)propanamideIC5042.0 [1], 71.0 [2]
4-(5-Amino-2-pyridin-3-yl-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)piperazine-1-carboxamideIC502.0 [1], 4.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-phenylpiperazine-1-carboxamideIC50380.0 [1], 517.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(6-methoxy-4-methylpyridin-3-yl)piperazine-1-carboxamideIC50414.0 [1], 656.0 [2]
(3S)-4-(6-Amino-[1,2]thiazolo[5,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamideIC507.0 [1], 47.0 [2]
(3S)-4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamideIC504.0 [1], 8.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(2-methylphenyl)piperazine-1-carboxamideIC50114.0 [1], 150.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(3-methylphenyl)piperazine-1-carboxamideIC50115.0 [1], 312.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxy-2-methylphenyl)piperazine-1-carboxamideIC509.0 [1], 35.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxyphenyl)piperazine-1-carboxamideIC5051.0 [1], 53.0 [2]
1-[4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl]-2-(4-chlorophenoxy)ethanoneIC50216.0 [1], 635.0 [2]
4-(5-Amino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(6-methoxypyridin-3-yl)piperazine-1-carboxamideIC50424.0 [1], 611.0 [2]
(3R)-4-(6-Amino-1-methylpyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamideIC501000.0 [1], 3000.0 [2]
4-[4-Chloro-3-(methylcarbamoyl)phenyl]-N-[(3-pyrazol-1-ylphenyl)methyl]pyridine-2-carboxamideIC504.0 [1], 18.0 [2]
IdelalisibIC5010000.0 [1]
PictilisibIC5010000.0 [1]
BuparlisibIC5025000.0 [1]
Torin 1IC506680.0 [1]
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-olIC50408.0 [1]
ApitolisibIC5010000.0 [1]
Torin 2IC5018.3 [1]
1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5060.0 [1]
LeniolisibIC509100.0 [1]
4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC505200.0 [1]
N6-(6-Methoxypyridin-3-yl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamineIC505000.0 [1]
CID 44814409IC509100.0 [1]
1-Isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC507400.0 [1]
3-[4-Amino-1-(1-Methylethyl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]phenolIC502600.0 [1]
Tert-Butyl {4-[4-Amino-1-(Propan-2-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]-2-Methoxyphenyl}carbamateIC506370.0 [1]
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amineIC509100.0 [1]
1-Isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC503000.0 [1]
1-Isopropyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC505900.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC509100.0 [1]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC509100.0 [1]
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenolIC501600.0 [1]
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenolIC50210.0 [1]
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-3-methylphenolIC502600.0 [1]
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2,5-difluorophenolIC50470.0 [1]
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenolIC50870.0 [1]
6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)naphthalen-2-olIC507400.0 [1]
Chmfl-PI3KD-317IC50300.2 [1]
N-(5-Methyl-1,2-oxazol-3-yl)-3-[[4-methyl-5-(4-pyrazol-1-ylphenyl)-1,3-thiazol-2-yl]carbamoylamino]propanamideIC5040.0 [1]
5-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-bromophenolIC5017.0 [1]
1-(1-Methylethyl)-3-Quinolin-6-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-AmineIC508.0 [1]
1-Cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5099.0 [1]
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-dihydrothiazol-2-yl)benzamideIC505700.0 [1]
1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)ethanoneIC503400.0 [1]
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-3-methylthiophene-2-carbaldehydeIC501700.0 [1]
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)furan-3-carbaldehydeIC502800.0 [1]
N-[3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]-methanesulfonamideIC504900.0 [1]
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzonitrileIC507200.0 [1]
N-[4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]-methanesulfonamideIC502000.0 [1]
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-benzenesulfonamideIC504900.0 [1]
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[b]thiophene-5-carbaldehydeIC5012000.0 [1]
3-(Benzo[c][1,2,5]oxadiazol-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5014000.0 [1]
2-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetonitrileIC503500.0 [1]
2-(3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetonitrileIC504400.0 [1]
1-Isopropyl-3-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC508200.0 [1]
1-Isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5014000.0 [1]
1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50100000.0 [1]
3-(4-Fluoro-3-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5013000.0 [1]
3-(2,5-Difluoro-4-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC503500.0 [1]
1-Isopropyl-3-(2,3-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC503600.0 [1]
1-Isopropyl-3-(2,4-dimethoxypyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC504900.0 [1]
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenolIC502780.0 [1]
3-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenolIC504020.0 [1]
1-Cyclopentyl-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC507390.0 [1]
3-(4-Amino-3-methoxyphenyl)-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50530.0 [1]
3-(3-Bromo-5-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50100000.0 [1]
Tert-butyl 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indole-1-carboxylateIC5013000.0 [1]
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-5-bromophenolIC504090.0 [1]
Tert-butyl 5-(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indole-1-carboxylateIC50100000.0 [1]
3-(1H-Indol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC504100.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ PI4-kinase beta subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/pi4-kinase-beta-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ PI4-kinase beta subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pi4-kinase-beta-subunit-inhibitors-ic50-ki.
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