Platelet activating factor receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Apafant	IC50	40.0 [1], 50.0 [2], 200.0 [3]
	2-[3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylethanol	IC50	6.0 [1]
	2-[3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylethanol	Ki	3.2 [1], 6.0 [2], 6.1 [3], 6.3 [4]
	(2R,5R)-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane	IC50	13.0 [1]
	(2R,5R)-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane	Ki	9.0 [1], 14.3 [2]
	5-(4-Methoxyphenyl)-N-(1-methyl-4-(3-pyridinyl)butyl)-2,4-decadienamide	IC50	40.0 [1]
	Loratadine	IC50	50000.0 [1], 135000.0 [2]
	Modipafant racemate	IC50	13.0 [1], 31.3 [2]
	Respatadine	IC50	610.0 [1], 840.0 [2]
	5-[4-[2-(3,4,5-Trimethoxyphenyl)ethyl]phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline	IC50	40.0 [1], 60.0 [2]
	(2R,5R)-2,5-Bis(3,4,5-trimethoxyphenyl)oxolane	IC50	1500.0 [1]
	(2R,5R)-2,5-Bis(3,4,5-trimethoxyphenyl)oxolane	Ki	103.0 [1]
	2-[3-Methoxy-2-propoxy-5-[5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylethanol	Ki	59.0 [1], 116.0 [2]
	4-(2-Chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine	IC50	370.0 [1]
	1-Iphtf	Ki	1.85 [1], 2.9 [2]
	Potassium;3-[3-(2-oxopropylsulfonyl)-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenoxy]propyl hydrogen phosphate	Ki	110.0 [1], 174.0 [2]
	(4R)-5-[3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonyl-4-methylpentan-1-ol	Ki	3.72 [1], 5.26 [2]
	(4S)-5-[3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonyl-4-methylpentan-1-ol	Ki	2.86 [1], 3.7 [2]
	N-Cyclohexyl-N-methyl-4-[(2-methylbenzimidazol-1-yl)methyl]benzenesulfonamide	IC50	300.0 [1]
	(5S)-2-[4-[2-(Benzenesulfonyl)ethoxy]-3-methoxy-5-propylsulfonylphenyl]-5-(3,4,5-trimethoxyphenyl)oxolane	IC50	1.0 [1]
	(5S)-2-[4-[2-(Benzenesulfonyl)ethoxy]-3-methoxy-5-propylsulfonylphenyl]-5-(3,4,5-trimethoxyphenyl)oxolane	Ki	1.0 [1]
	Clotrimazole	Ki	22635.0 [1]
	Chlorpheniramine	IC50	50000.0 [1]
	Ginkgolide-B	IC50	128.0 [1]
	Brotizolam	IC50	300.0 [1]
	Cilostamide	Ki	1917.0 [1]
	Rupatadine	IC50	3700.0 [1]
	Azatadine	IC50	50000.0 [1]
	Lexipafant	Ki	0.38 [1]
	5-[3-[7-(2-Chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-4-yl]prop-2-ynyl]phenanthridin-6-one	IC50	13.0 [1]
	Tulopafantum	IC50	11.0 [1]
	Orvepitant	Ki	2270.0 [1]
	(2r)-2-(Acetyloxy)-3-(Hexadecyloxy)propyl 2-(Trimethylammonio)ethyl Phosphate	IC50	0.28 [1]
	3-[[2-[2-(4-Chlorophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]methyl]-1-hydroxy-1-methylurea	IC50	10.0 [1]
	[4-(3-Phenylpropyl)piperazin-1-yl]-[(4R)-2-pyridin-3-yl-1,3-thiazolidin-4-yl]methanone	IC50	2.3 [1]
	CID 46897162	IC50	5000.0 [1]
	1-[4-(13-Chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]butan-1-one	IC50	33000.0 [1]
	1-[4-(13-Chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]propan-1-one	IC50	2400.0 [1]
	N-(4-1H-Imidazol-1-yl)butyl-2-(1-methylethyl)-11-oxo-11H-pyrido(2,1b)quinazoline-8-carboxamide	IC50	3500.0 [1]
	ABT-491 free base	Ki	0.57 [1]
	(2R,3R,4R,5S)-2,5-Bis-(3,4-dimethoxy-phenyl)-3,4-dimethyl-tetrahydro-furan	Ki	1000.0 [1]
	N-[(2S)-1-Ethoxy-4-methylpentan-2-yl]-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzenesulfonamide	IC50	0.01 [1]
	5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	5700.0 [1]
	11-Oxo-2-propan-2-yl-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	350.0 [1]
	2-Methyl-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	500.0 [1]
	2-Methoxy-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	1000.0 [1]
	11-Oxo-2-propan-2-yloxy-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	600.0 [1]
	11-Oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	1800.0 [1]
	2-Bromo-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	700.0 [1]
	2-Hydroxy-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	1200.0 [1]
	11-Oxo-2-propan-2-yl-N-(4-pyridin-2-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	5000.0 [1]
	11-Oxo-2-propan-2-yl-N-(7-pyridin-3-ylheptyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	1000.0 [1]
	11-Oxo-2-propan-2-yl-N-(4-pyrimidin-5-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	450.0 [1]
	3-Methoxy-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	370.0 [1]
	3-Chloro-11-oxo-N-(4-pyridin-3-ylbutyl)pyrido[2,1-b]quinazoline-8-carboxamide	IC50	1000.0 [1]
	N-(2-Methyl-5-pyridin-3-ylpentan-2-yl)-11-oxo-2-propan-2-ylpyrido[2,1-b]quinazoline-8-carboxamide	IC50	1200.0 [1]
	N-Formyl Desloratadine	IC50	13000.0 [1]
	1-[4-(13-Methoxy-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]ethanone	IC50	3400.0 [1]
	1-[4-(2-Tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)piperidin-1-yl]ethanone	IC50	41000.0 [1]
	2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan	IC50	180.0 [1]
	1-(2,2-Dimethylpropyl)-5-[5-(2-hydroxypropan-2-yl)-2-methylphenyl]-3-methylimidazo[4,5-b]pyridin-2-one	Ki	2000.0 [1]
	SDZ-62-434 free	IC50	7500.0 [1]
	N-[4,6-Dimethoxy-2-(3-morpholin-4-ylpropylamino)pyrimidin-5-yl]-5-[(3,3,6-trimethyl-1,2-dihydroinden-5-yl)oxy]furan-2-carboxamide	Ki	1060.0 [1]
	(E)-3-(1-Butyl-4-methoxynaphthalen-2-yl)-N-[(2S)-5-pyridin-3-ylpentan-2-yl]prop-2-enamide	IC50	1.0 [1]
	5-p-Tolyl-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	5400.0 [1]
	Diallyl-[4-(2,3-dihydro-imidazo[2,1-a]isoquinolin-5-yl)-benzyl]-amine	IC50	9200.0 [1]
	4-[[4-(2,3-Dihydroimidazo[2,1-a]isoquinolin-5-yl)phenyl]methyl]thiomorpholine	IC50	1100.0 [1]
	1-[3-(3-Morpholin-4-ylpropoxy)-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylpropan-2-one	Ki	2.5 [1]
	5-(4-Pyrrolidin-1-ylmethyl-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	59400.0 [1]
	Dicyclohexyl-[4-(2,3-dihydro-imidazo[2,1-a]isoquinolin-5-yl)-benzyl]-amine	IC50	13100.0 [1]
	5-Phenyl-2,3-dihydroimidazo[2,1-a]isoquinoline	IC50	11200.0 [1]
	5-Pyridin-4-yl-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	47900.0 [1]
	5-Thiophen-2-yl-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	15200.0 [1]
	5-(3,4-Dimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	22000.0 [1]
	5-(4-Tert-Butylphenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline	IC50	900.0 [1]
	5-(4-Morpholin-4-ylmethyl-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	2800.0 [1]
	5-Furan-2-yl-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	100000.0 [1]
	5-(4-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	14200.0 [1]
	5-(3,4,5-Trimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	100000.0 [1]
	5-(4-Chloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	37200.0 [1]
	5-Biphenyl-4-yl-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	3400.0 [1]
	5-(2-Chloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	8100.0 [1]
	5-(3-Chloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	5400.0 [1]
	5-(4-Tert-butylphenyl)-9-methyl-2,3-dihydroimidazo[2,1-a]isoquinoline	IC50	31800.0 [1]
	1-[3-(3-Imidazol-1-ylpropoxy)-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylpropan-2-one	Ki	3.0 [1]
	5-(4-Ethyl-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	6300.0 [1]
	5-(4-Tert-butylphenyl)-9-chloro-2,3-dihydroimidazo[2,1-a]isoquinoline	IC50	40400.0 [1]
	5-Pyridin-3-yl-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	100000.0 [1]
	5-(3,4-Dichloro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	17000.0 [1]
	5-(3-Trifluoromethyl-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline	IC50	19200.0 [1]
	3-[2-[2-(3-Bromophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]-1-butyl-1-hydroxyurea	IC50	22.0 [1]
	3-[2-[2-(4-Bromophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]-1-butyl-1-hydroxyurea	IC50	21.0 [1]
	1-Butyl-1-hydroxy-3-[3-methoxy-2-[2-(2,3,5,6-tetrafluorophenyl)sulfanylethoxy]-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]urea	IC50	2.0 [1]
	4-[2-(4-Butylphenyl)ethyl]-7-(2-chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaene	IC50	10.0 [1]
	3-[2-[2-(2-Bromophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]-1-butyl-1-hydroxyurea	IC50	23.0 [1]
	1-Butyl-1-hydroxy-3-[3-methoxy-2-[2-(2,3,5,6-tetrafluorophenyl)sulfonylethoxy]-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]urea	IC50	285.0 [1]
	1-Butyl-3-[[2-[2-(4-chlorophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]methyl]-1-hydroxyurea	IC50	167.0 [1]
	7-(2-Chlorophenyl)-13-methyl-4-[2-[4-(2-methylpropyl)phenyl]ethyl]-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaene	IC50	30.0 [1]
	3-[2-[2-(4-Bromophenyl)sulfonylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]-1-butyl-1-hydroxyurea	IC50	38.0 [1]
	1-Butyl-3-[2-[2-(3,4-dichlorophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]-1-hydroxyurea	IC50	45.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Platelet activating factor receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/platelet-activating-factor-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Platelet activating factor receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/platelet-activating-factor-receptor-inhibitors-ic50-ki.
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