Platelet-derived growth factor receptor alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Imatinib	IC50	18.0 [1]
	Nintedanib	IC50	1.9 [1], 2.3 [2], 4.0 [3], 18.0 [4], 59.0 [5]
	Staurosporine	IC50	0.1 [1], 0.43 [2], 0.45 [3], 0.6 [4]
	Foretinib	IC50	3.6 [1], 6.82 [2]
	N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide	IC50	210.0 [1], 25000.0 [2], 26600.0 [3]
	Imatinib mesylate	IC50	20000.0 [1], 24000.0 [2]
	Dasatinib	IC50	9.9 [1], 63.0 [2]
	Nilotinib	IC50	2.54 [1], 71.0 [2]
	Amuvatinib	IC50	2100.0 [1], 3000.0 [2]
	PDGF Receptor Tyrosine Kinase Inhibitor IV	IC50	45.0 [1]
	4-(6,7-Dimethoxy-9H-pyrimido[4,5-b]indol-4-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]piperazine-1-carbothioamide	IC50	50000.0 [1]
	(4S,6Z)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione	IC50	95.0 [1], 440.0 [2]
	1-(2,2-Diethoxyethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amine	IC50	10000.0 [1], 100000.0 [2]
	N-[[4-(6,7-Dimethoxyquinolin-4-yl)oxyphenyl]carbamoyl]-2-methylbenzamide	IC50	4.0 [1], 7.6 [2]
	4-(4-(5-Benzylpyrimidin-2-yl)piperazin-1-yl)quinazoline	IC50	295.0 [1], 316.0 [2]
	Infigratinib phosphate	IC50	2718.0 [1], 10000.0 [2]
	1-[4-[3-[4-Amino-5-[2-fluoro-5-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone	IC50	5300.0 [1], 10000.0 [2]
	N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxy-9H-pyrimido[4,5-b]indol-4-yl)piperazine-1-carbothioamide	IC50	15500.0 [1], 16000.0 [2]
	N-(1,3-Benzodioxol-5-ylmethyl)-4-(8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-6-yl)piperazine-1-carbothioamide	IC50	50000.0 [1]
	Amuvatinib hydrochloride	IC50	40.0 [1], 81.0 [2]
	N-[4-(Pyrimidin-2-ylsulfamoyl)phenyl]-4-(8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-6-yl)piperazine-1-carbothioamide	IC50	50000.0 [1]
	4-(6,7-Dimethoxyquinazolin-4-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]piperazine-1-carbothioamide	IC50	50000.0 [1]
	Sunitinib	IC50	130.0 [1]
	Lapatinib	IC50	20000.0 [1]
	Crizotinib	IC50	1000.0 [1]
	Pazopanib	IC50	71.0 [1]
	Nintedanib esylate	IC50	59.0 [1]
	Semaxanib	IC50	200.0 [1]
	Cabozantinib	IC50	10000.0 [1]
	Ponatinib	IC50	2.6 [1]
	Ceritinib	IC50	1140.0 [1]
	Saracatinib	IC50	10000.0 [1]
	Doramapimod	IC50	30000.0 [1]
	Elliptinium	IC50	700.0 [1]
	Nvp-aew541	IC50	800.0 [1]
	9-Hydroxyellipticine	IC50	600.0 [1]
	Linifanib	IC50	15.0 [1]
	Tivozanib	IC50	2.26 [1]
	4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid	IC50	794.33 [1]
	Bms-777607	IC50	28.0 [1]
	1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea	IC50	10.0 [1]
	Bemcentinib	IC50	20.0 [1]
	9H-Purine-2,6-diamine, N2-(2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-, cis-	IC50	20000.0 [1]
	1-(Tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	657.0 [1]
	(E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine	IC50	56.0 [1]
	VEGF receptor tyrosine kinase inhibitor III	IC50	970.0 [1]
	Tak-285	IC50	10000.0 [1]
	1-(2,4-Difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl)urea	IC50	67.0 [1]
	3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide	IC50	3120.0 [1]
	MK-2461	IC50	100.0 [1]
	CID 44219749	IC50	50000.0 [1]
	(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione	IC50	2.38 [1]
	Ilorasertib	Ki	0.79 [1]
	Tak-593	IC50	4.3 [1]
	CID 53246941	IC50	956.0 [1]
	PDGF Receptor Tyrosine Kinase Inhibitor III	IC50	50.0 [1]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	943.0 [1]
	Mivavotinib	IC50	45.0 [1]
	1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea	IC50	35.0 [1]
	Flt3-IN-1	IC50	10000.0 [1]
	Cep-11981	IC50	246.0 [1]
	CID 44814409	IC50	10000.0 [1]
	3-((4-(6-Methylpyridin-2-yl)-5-(quinolin-6-yl)-1H-imidazol-2-yl)methyl)benzamide	IC50	3000.0 [1]
	1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-(4-methoxy-phenyl)-urea	IC50	3.6 [1]
	(E)-1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea	IC50	1110.0 [1]
	4-[5-(6-Methoxynaphthalen-2-yl)-1-methyl-2-(2-methyl-4-methylsulfinylphenyl)imidazol-4-yl]pyridine	IC50	30000.0 [1]
	(5-Hydroxy-1H-indol-2-yl)-(1H-indol-2-yl)methanone	IC50	1000.0 [1]
	N-[4-[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yl)oxypyridine-2-carboxamide	IC50	7.7 [1]
	4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamide	IC50	890.0 [1]
	4-(Chloromethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide	IC50	139.0 [1]
	N-({4-[(6,7-Dimethoxyquinolin-4-Yl)oxy]phenyl}carbamothioyl)-2-Phenylacetamide	IC50	28.0 [1]
	1-Cyclohexyl-3-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]urea	IC50	7.0 [1]
	N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide	IC50	240.0 [1]
	6,6-Dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	402.0 [1]
	1-[4-[4-Amino-7-(1-methylpyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-fluorophenyl)urea	Ki	50.12 [1]
	Glycine, N,N-dimethyl-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester	IC50	100.0 [1]
	cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenol	IC50	900.0 [1]
	7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine	IC50	10000.0 [1]
	2-Amino-N-[3-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]acetamide	IC50	1000.0 [1]
	4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol	IC50	299.0 [1]
	N-(4-Bromophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide	IC50	710.0 [1]
	N-(4-Cyanophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide	IC50	770.0 [1]
	4-(6,7-Dimethoxyquinazolin-4-yl)-N-(4-propan-2-ylphenyl)piperazine-1-carboxamide	IC50	90.0 [1]
	1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluoro-phenyl]-urea	IC50	17.0 [1]
	1-[4-[4-Amino-7-[3-(methylamino)prop-1-ynyl]thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-methylphenyl)urea	Ki	2.51 [1]
	Tert-butyl N-[4-[4-amino-1-[2-[4-(dimethylamino)piperidin-1-yl]ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]carbamate	IC50	10000.0 [1]
	1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanone	IC50	100000.0 [1]
	N-Ethyl-2-hydroxy-N-methyl-3-[C-phenyl-N-[4-(piperidin-1-ylmethyl)phenyl]carbonimidoyl]-1H-indole-6-carboxamide	IC50	890.0 [1]
	Vegfrecine	IC50	3200.0 [1]
	3-{[(1R)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione	IC50	40500.0 [1]
	(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dione	IC50	1000.0 [1]
	N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamide	IC50	4310.0 [1]
	1-[4-[4-Amino-7-(3-amino-3-methylbut-1-ynyl)thieno[3,2-c]pyridin-3-yl]phenyl]-3-(3-methylphenyl)urea	Ki	10000.0 [1]
	N-(1,3-Dimethylpyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yl)oxyphenyl]acetamide	IC50	3.0 [1]
	CID 25207521	IC50	11100.0 [1]
	6H-Pyrido(4,3-b)carbazol-9-ol, 1-((3-(diethylamino)propyl)amino)-5,6,11-trimethyl-, hydrate	IC50	2000.0 [1]
	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-octylbenzo[de]isoquinoline-1,3-dione	IC50	100000.0 [1]
	6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-dodecylbenzo[de]isoquinoline-1,3-dione	IC50	26170.0 [1]
	CID 46864270	IC50	1.3 [1]
	3-[7-[4-[(1S,4S)-5-Methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol	IC50	6560.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Platelet-derived growth factor receptor alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Platelet-derived growth factor receptor alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-alpha-inhibitors-ic50-ki.
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