Platelet-derived growth factor receptor beta Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Sunitinib	IC50	83.1 [1]
	Sunitinib	Ki	8.0 [1]
	Semaxanib	IC50	2400.0 [1]
	3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one	IC50	3750.0 [1]
	Erlotinib	IC50	12200.0 [1]
	Staurosporine	IC50	0.6 [1], 0.76 [2], 4.3 [3], 4.7 [4], 204.7 [5]
	Sorafenib	IC50	10.0 [1], 18.4 [2], 37.0 [3], 57.0 [4]
	Nintedanib	IC50	1.8 [1], 2.0 [2], 3.5 [3], 3.7 [4], 65.0 [5]
	Orantinib	IC50	50.0 [1], 60.0 [2], 100.0 [3], 16500.0 [4]
	Imatinib	IC50	72.0 [1], 240.0 [2], 386.0 [3]
	3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone	IC50	510.0 [1], 28400.0 [2], 60900.0 [3]
	6,7-Dimethyl-2-phenylquinoxaline	IC50	6200.0 [1], 6500.0 [2]
	PDGF Receptor Tyrosine Kinase Inhibitor III	IC50	80.0 [1], 130.0 [2]
	4-N-(3-Bromophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	50000.0 [1]
	4-N-(3-Bromophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	8900.0 [1], 8920.0 [2], 300000.0 [3]
	(5-Hydroxy-1H-indol-2-yl)-(1H-indol-2-yl)methanone	IC50	90.0 [1], 200.0 [2], 600.0 [3], 3200.0 [4]
	4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamide	IC50	240.0 [1], 700.0 [2]
	Glycine, N,N-dimethyl-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester	IC50	100.0 [1], 1300.0 [2], 3500.0 [3]
	Crizotinib	IC50	1000.0 [1], 10000.0 [2]
	Vatalanib	IC50	490.0 [1], 600.0 [2]
	Tandutinib	IC50	26.0 [1], 36.0 [2], 200.0 [3]
	Linifanib	IC50	60.0 [1], 66.0 [2]
	PDGF Receptor Tyrosine Kinase Inhibitor IV	IC50	3.0 [1], 4.2 [2]
	5-[(Z)-(5-Chloro-2-oxo-1H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide	IC50	3.0 [1], 3000.0 [2]
	7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine	IC50	15.0 [1]
	7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine	Ki	2090.0 [1]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	680.0 [1], 1867.0 [2]
	N4-(3-Bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	50000.0 [1], 300000.0 [2]
	2-Benzyl-N4-(3-bromophenyl)-1H-indole-4,6-diamine	IC50	50000.0 [1]
	4-[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]-N-(4-phenoxyphenyl)piperazine-1-carboxamide	IC50	10.0 [1], 40.0 [2], 525.0 [3]
	N-(4-Cyanophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide	IC50	450.0 [1], 850.0 [2]
	Acetic acid, methoxy-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester	IC50	20.0 [1], 100.0 [2], 4200.0 [3]
	4-[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide	IC50	200.0 [1], 216.0 [2], 420.0 [3]
	4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[(6-methylpyridin-3-yl)methyl]piperazine-1-carbothioamide	IC50	90.0 [1], 140.0 [2]
	N-(4-Cyanophenyl)-4-[6-methoxy-7-[3-(2-methylpiperidin-1-yl)propoxy]quinazolin-4-yl]piperazine-1-carboxamide	IC50	4.0 [1], 29.0 [2], 150.0 [3]
	4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[(5-methylpyrazin-2-yl)methyl]piperazine-1-carbothioamide	IC50	50.0 [1], 140.0 [2], 1350.0 [3]
	N-[(6-Chloropyridin-3-yl)methyl]-4-[6-methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]piperazine-1-carbothioamide	IC50	50.0 [1], 80.0 [2], 1010.0 [3]
	N-(4-Isopropoxyphenyl)-4-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)piperazine-1-carboxamide	IC50	20.0 [1], 60.0 [2], 100.0 [3]
	4-[6-Methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide	IC50	4.0 [1], 39.0 [2], 51.0 [3]
	N-(4-Cyanophenyl)-4-[6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinazolin-4-yl]piperazine-1-carboxamide	IC50	4.0 [1], 22.0 [2], 73.0 [3]
	4-[6-Methoxy-7-[3-(2-methylpiperidin-1-yl)propoxy]quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide	IC50	4.0 [1], 35.0 [2], 74.0 [3]
	4-[6-Methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-N-pyridin-4-ylpiperazine-1-carbothioamide	IC50	240.0 [1], 400.0 [2], 980.0 [3]
	4-[6-Methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]piperazine-1-carbothioamide	IC50	90.0 [1], 150.0 [2], 1030.0 [3]
	4-[3-Cyano-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]piperazine-1-carbothioamide	IC50	3.0 [1], 10.0 [2]
	N-[[2-Chloro-6-(trifluoromethyl)pyridin-3-yl]methyl]-4-[6-methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]piperazine-1-carbothioamide	IC50	100.0 [1], 1130.0 [2], 1400.0 [3]
	N-(6-Chloropyridin-3-yl)-4-[6-methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]piperazine-1-carbothioamide	IC50	360.0 [1], 510.0 [2], 890.0 [3]
	4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(6-phenylpyridin-3-yl)piperazine-1-carbothioamide	IC50	100.0 [1], 270.0 [2], 360.0 [3]
	4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[(5-methylfuran-2-yl)methyl]piperazine-1-carbothioamide	IC50	80.0 [1], 90.0 [2]
	4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-pyridin-4-ylpiperazine-1-carbothioamide	IC50	60.0 [1], 220.0 [2], 580.0 [3]
	N-(Furan-2-ylmethyl)-4-[6-methoxy-7-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]piperazine-1-carbothioamide	IC50	160.0 [1], 290.0 [2], 310.0 [3]
	Bis(1H-2-indolyl)methanone deriv. 50	IC50	70.0 [1], 300.0 [2], 4900.0 [3]
	4-[6-Methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-N-[(5-methylpyrazin-2-yl)methyl]piperazine-1-carbothioamide	IC50	50.0 [1], 60.0 [2], 250.0 [3]
	4-[6-Methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide	IC50	170.0 [1], 250.0 [2], 1250.0 [3]
	N-(1,3-Benzodioxol-5-ylmethyl)-4-[6-methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]piperazine-1-carbothioamide	IC50	20.0 [1], 40.0 [2], 120.0 [3]
	4-[6-Methoxy-7-(2-piperidin-1-ylethoxy)quinazolin-4-yl]-N-(4-pyridin-2-ylphenyl)piperazine-1-carbothioamide	IC50	70.0 [1], 150.0 [2], 180.0 [3]
	Lapatinib	IC50	8500.0 [1], 200000.0 [2]
	Nilotinib	IC50	60.11 [1], 71.0 [2]
	Pazopanib	IC50	83.0 [1], 84.0 [2]
	Vandetanib	IC50	477.0 [1], 1100.0 [2]
	Dovitinib	IC50	1.0 [1], 5.0 [2]
	Foretinib	IC50	9.6 [1]
	(3Z)-3-(1H-Imidazol-5-ylmethylene)-5-methoxy-1H-indol-2(3H)-one	IC50	10000.0 [1], 18000.0 [2]
	3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide	IC50	1860.0 [1], 2636.67 [2]
	4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol	IC50	1.1 [1]
	VEGF Receptor 2 Kinase Inhibitor I	IC50	4000.0 [1], 100000.0 [2]
	2-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide	IC50	4.0 [1]
	7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine	IC50	5.9 [1], 6.0 [2]
	(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid	IC50	10.0 [1], 110.0 [2]
	N-(4-Chlorophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide	IC50	1100.0 [1]
	N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide	IC50	90.0 [1], 550.0 [2]
	6-(2-Phenylethyl)-4-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	500000.0 [1]
	2-(2-Chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,6-diamine	IC50	50000.0 [1]
	N-(4-Methoxyphenyl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine	IC50	22.8 [1]
	2-[4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenyl]-N-(1-propan-2-ylpyrazol-4-yl)acetamide	IC50	20.0 [1]
	N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide	IC50	90.0 [1]
	4-(7-Ethoxy-6-methoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide	IC50	10.0 [1]
	4-N-(3-Bromo-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	500000.0 [1]
	N-(4-Bromophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide	IC50	270.0 [1], 530.0 [2]
	4-(6,7-Dimethoxyquinazolin-4-yl)-N-(4-propan-2-ylphenyl)piperazine-1-carboxamide	IC50	20.0 [1], 80.0 [2]
	N-Benzyl-4-(7-ethoxy-6-methoxyquinazolin-4-yl)piperazine-1-carbothioamide	IC50	150.0 [1]
	4-(6-Ethoxy-7-methoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide	IC50	40.0 [1]
	4-(6,7-Dimethoxy-2-methylquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide	IC50	30000.0 [1]
	4-[6-Amino-7-(ethylamino)quinazolin-4-yl]-N-benzylpiperazine-1-carbothioamide	IC50	1440.0 [1]
	4-(2-Chloro-6,7-dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide	IC50	30000.0 [1]
	N-Benzyl-4-quinazolin-4-ylpiperazine-1-carbothioamide	IC50	30000.0 [1]
	4-[7-(Ethylamino)-6-nitroquinazolin-4-yl]-N-(4-phenoxyphenyl)piperazine-1-carboxamide	IC50	200.0 [1]
	N-(4-Phenoxyphenyl)-4-(6,7,8-trimethoxyquinazolin-4-yl)piperazine-1-carboxamide	IC50	30000.0 [1]
	N-Benzyl-4-(6-ethoxy-7-methoxyquinazolin-4-yl)piperazine-1-carbothioamide	IC50	620.0 [1]
	N-Benzyl-4-[7-(ethylamino)-6-nitroquinazolin-4-yl]piperazine-1-carbothioamide	IC50	30000.0 [1]
	4-(7,8-Dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide	IC50	30000.0 [1]
	N-(4-Phenoxyphenyl)-4-quinazolin-4-ylpiperazine-1-carboxamide	IC50	380.0 [1]
	4-(6,7-Dimethoxy-2-morpholin-4-ylquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide	IC50	30000.0 [1]
	(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)-phenyl amine	IC50	9.0 [1], 23.0 [2]
	(5-Methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine	IC50	54.0 [1], 487.0 [2]
	4-Chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol	IC50	2.8 [1]
	4-[[7-(2-Chloro-5-hydroxyphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamide	IC50	1.7 [1]
	(7-Methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine	IC50	9.0 [1], 18.0 [2]
	4-(6,8-Dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide	IC50	10900.0 [1]
	4-N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	90000.0 [1]
	4-N-(3-Bromophenyl)-6-[(2,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	17000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Platelet-derived growth factor receptor beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-beta-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Platelet-derived growth factor receptor beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-beta-inhibitors-ic50-ki.
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