Platelet-derived growth factor receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Imatinib	IC50	50.0 [1], 400.0 [2]
	4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol	IC50	68.0 [1], 76.0 [2]
	4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	IC50	10.0 [1]
	3-(3-Thienyl)-6,7-dimethoxyquinoline	IC50	20.0 [1], 461.0 [2]
	N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	IC50	5000.0 [1]
	4-(6,7-Dimethoxyquinoxaline-2-ylamino)cyclohexanecarboxylic acid methyl ester	IC50	28.0 [1], 49.0 [2], 345.0 [3]
	6-(2,6-Dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-D]pyrimidin-7(8H)-one	IC50	45.0 [1], 139.0 [2]
	N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide	IC50	100.0 [1]
	Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-((4-fluorophenyl)amino)-8-methyl-	IC50	47.0 [1], 1250.0 [2]
	N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine	IC50	10000.0 [1]
	2-(3-Methylcyclohexylamino)-6,7-dimethoxyquinoxaline	IC50	41.0 [1]
	2-Cyclohexylamino-6,7-dimethoxyquinoxaline	IC50	124.0 [1]
	5,7-Dimethoxy-3-(4-pyridinyl)quinoline	IC50	80.0 [1]
	5,7-Dimethoxy-3-(4-pyridinyl)quinoline	Ki	14.0 [1]
	N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-acetamide	IC50	50000.0 [1]
	2-(Phenylamino)-6,7-dimethoxyquinoxaline	IC50	6.0 [1]
	2-Methoxy-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	IC50	300.0 [1]
	N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]naphthalene-2-carboxamide	IC50	50.0 [1]
	4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	IC50	10.0 [1]
	Staurosporine	IC50	2.0 [1]
	Sunitinib	IC50	80.0 [1]
	N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	10000.0 [1]
	N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	10000.0 [1]
	Canertinib	IC50	50000.0 [1]
	Lfm-a13	IC50	500000.0 [1]
	6,7-Dimethyl-2-phenylquinoxaline	IC50	0.0 [1]
	Pyridone 6	IC50	1490.0 [1]
	6-(2,6-Dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one	IC50	1660.0 [1]
	6-(2,6-Dichlorophenyl)-2-[(4-Fluoro-3-Methylphenyl)amino]-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-One	IC50	1430.0 [1]
	Unii-NA856793UT	IC50	50000.0 [1]
	7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-Amine	IC50	20000.0 [1]
	CID 6918852	Ki	5000.0 [1]
	6-(2,6-Dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one	IC50	636.0 [1]
	9-Hydroxy-4-phenyl-6H-pyrrolo[3,4-C]carbazole-1,3-dione	IC50	50000.0 [1]
	(Z)-3-(3,4-Dimethoxy-phenyl)-2-pyridin-3-yl-acrylonitrile	IC50	3000.0 [1]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	27.54 [1]
	PDGF Receptor Tyrosine Kinase Inhibitor III	IC50	80.0 [1]
	PDGF Receptor Tyrosine Kinase Inhibitor II	IC50	1100.0 [1]
	VEGF Receptor 2 Kinase Inhibitor I	IC50	100000.0 [1]
	1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea	IC50	48.0 [1]
	2-[2-[4-[4-(4-Tert-butylanilino)phenoxy]-6-methoxyquinolin-7-yl]oxyethylamino]ethanol	IC50	480.0 [1]
	1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea	IC50	1250.0 [1]
	N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamide	IC50	10000.0 [1]
	3-(3-Chlorophenyl)-5,7-dimethoxychromen-4-one	IC50	10000.0 [1]
	(5-Hydroxy-1H-indol-2-yl)-(1H-indol-2-yl)methanone	IC50	200.0 [1]
	4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamide	IC50	700.0 [1]
	N-(4-Chlorophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide	IC50	1100.0 [1]
	N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide	IC50	550.0 [1]
	4-[(4-Methyl-1-piperazinyl)methyl]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide	IC50	200.0 [1]
	1,3-Diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	10000.0 [1]
	6-Acetyl-8-cyclopentyl-5-methyl-2-(4-piperazin-1-yl-phenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	IC50	2460.0 [1]
	3-[[5-[6-[(3-Chlorophenyl)amino]pyrazinyl]-3-pyridinyl]amino]-1-propanol	IC50	360.0 [1]
	Glycine, N,N-dimethyl-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester	IC50	100.0 [1]
	Thienopyrimidine deriv. 28	IC50	60.0 [1]
	N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide	IC50	140.0 [1]
	[4-[(2S)-2-Acetamido-3-[[(2S)-1-[[(2S)-1-(dibutylamino)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate	IC50	77.0 [1]
	20-Ethyl-17,23-dioxa-4,14,20,26-tetrazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dione	IC50	4400.0 [1]
	3-(1H-Indol-3-yl)quinoline	IC50	8000.0 [1]
	2-(3-Aminophenylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one	IC50	24.0 [1]
	N-(4-Bromophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide	IC50	530.0 [1]
	N-(4-Tert-butylphenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide	IC50	30.0 [1]
	4-(6,7-Dimethoxyquinazolin-4-yl)-N-(4-propan-2-ylphenyl)piperazine-1-carboxamide	IC50	80.0 [1]
	N-(4-Chlorophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide	IC50	790.0 [1]
	[3-(2-Imidazol-1-yl-ethoxy)-phenyl]-(4-pyridin-3-yl-pyrimidin-2-yl)-amine	IC50	10000.0 [1]
	3-[5-[3-(2-Methoxyethoxy)prop-1-ynyl]thiophen-3-yl]-7-(1,2,4-triazol-1-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazole	IC50	84.0 [1]
	(3-Imidazol-1-yl-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine	IC50	18000.0 [1]
	(3-Chloro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine	IC50	10000.0 [1]
	2-(Phenylamino)quinoxaline	IC50	5100.0 [1]
	4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-amino)-[1,3,5]triazin-2-ol	IC50	12500.0 [1]
	6-[(4-Methylpiperazin-1-yl)methyl]-3-[5-(3-phenoxyprop-1-ynyl)thiophen-3-yl]-1,4-dihydroindeno[1,2-c]pyrazole	IC50	58.0 [1]
	[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	IC50	50000.0 [1]
	7-((1H-Imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole	IC50	50000.0 [1]
	7-[(4-Methylpiperazin-1-yl)methyl]-3-thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazole	IC50	50000.0 [1]
	2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 46	IC50	500.0 [1]
	2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 50	IC50	76.0 [1]
	2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 51	IC50	82.0 [1]
	1-[2-Amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea	IC50	340.0 [1]
	1-[2-Amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea	IC50	50000.0 [1]
	1-(2-Amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea	IC50	13240.0 [1]
	PD089828 analog 12	IC50	50000.0 [1]
	1-[2-Amino-6-(3,5-diethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea	IC50	50000.0 [1]
	PD089828 analog 31	IC50	50000.0 [1]
	Bis(1H-2-indolyl)methanone 11	IC50	300.0 [1]
	Bis(1H-2-indolyl)methanone 12	IC50	300.0 [1]
	Acetic acid, methoxy-, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester	IC50	200.0 [1]
	3-[[4-[4-[(3-Chlorophenyl)amino]-1,3,5-triazin-2-yl]-2-pyridinyl]amino]-1-Propanol	IC50	10000.0 [1]
	N-(4-Pyridin-4-yl-pyrimidin-2-yl)-benzene-1,3-diamine	IC50	10000.0 [1]
	N-(4-Pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine	IC50	100000.0 [1]
	2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-acetamide	IC50	1000.0 [1]
	6-(2,6-Dichlorophenyl)-8-methyl-2-[4-(4-methylpiperazine-1-carbonyl)anilino]pyrido[2,3-d]pyrimidin-7-one	IC50	14.0 [1]
	6,7-Dimethoxy-3-((E)-styryl)-quinoline	IC50	5.0 [1]
	6,7-Dimethoxy-3-(4-methoxy-3-methyl-phenyl)-quinoline	IC50	400.0 [1]
	6-(2,6-Dichlorophenyl)-2-(4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one	IC50	203.0 [1]
	3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline	IC50	60.0 [1]
	3-[[4-(3-Pyridinyl)-2-pyrimidinyl]amino]benzoic acid	IC50	10000.0 [1]
	3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinoline	IC50	500.0 [1]
	3-(1H-Indol-3-yl)-7,8-dimethoxy-quinoline	IC50	50000.0 [1]
	3-(2,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinoline	IC50	50000.0 [1]
	4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid ethyl ester	IC50	200.0 [1]
	3-Hydroxy-6,7-dimethoxyquinoline	IC50	20000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Platelet-derived growth factor receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Platelet-derived growth factor receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/platelet-derived-growth-factor-receptor-inhibitors-ic50-ki.
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