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Poly [ADP-ribose] polymerase-1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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▼
Standard Type
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▼
Standard Values (in nM)
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▼
OlaparibIC506.0 [1]
VeliparibIC5010.0 [1]
VeliparibKi5.0 [1]
3-AminobenzamideIC5030000.0 [1]
3-AminobenzamideKi3100.0 [1]
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-oneIC501200.0 [1]
N~2~,N~2~-Dimethyl-N~1~-(6-oxo-5,6-dihydrophenanthridin-2-YL)glycinamideIC50110.0 [1]
RucaparibIC5026.0 [1]
RucaparibKi1.4 [1]
NiraparibIC5016.7 [1]
6(5H)-PhenanthridinoneIC50350.0 [1]
NicotinamideIC50210000.0 [1]
5-Aminoisoquinolin-1(2H)-oneIC50300.0 [1], 1000.0 [2], 1600.0 [3], 1800.0 [4]
9,19-Diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaene-8,10-dioneIC5036.0 [1]
1H-Benzimidazole-4-carboxamideIC50240.0 [1]
1H-Benzimidazole-4-carboxamideKi95.0 [1], 240.0 [2]
2-Phenylbenzimidazole-4-carboxamideKi15.0 [1], 17.0 [2]
8-Chloro-2-{3-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridin-1-yl]propyl}-3,4-dihydroquinazolin-4-oneIC5013.0 [1]
4-{[3-(Piperazine-1-carbonyl)phenyl]methyl}phthalazin-1(2H)-oneIC502.0 [1], 16.0 [2], 30.5 [3]
BenzamideIC505400.0 [1], 20000.0 [2], 22000.0 [3]
TalazoparibIC500.6 [1], 7.2 [2]
TalazoparibKi1.2 [1]
4-[3-(1,4-Diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-oneIC503.4 [1], 7.0 [2]
4-Benzyl-1(2H)-phthalazinoneIC50770.0 [1]
IWR-1-endoIC5018700.0 [1], 85000.0 [2], 100000.0 [3]
4,4'-OxydibenzamideIC50100000.0 [1]
5-Chloro-2-(3-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)propyl)quinazolin-4(3H)-oneIC5065.0 [1], 682.0 [2]
1H-Benzimidazole-7-carboxamide, 2-[4-(2-pyridinyl)phenyl]-IC5083.0 [1]
1H-Benzimidazole-7-carboxamide, 2-[4-(2-pyridinyl)phenyl]-Ki1.9 [1], 2.0 [2]
2-Methyl-1H-benzo[d]imidazole-4-carboxamideIC501000.0 [1]
2-Methyl-1H-benzo[d]imidazole-4-carboxamideKi99.0 [1]
2-{3-[4-Phenyl-3,6-dihydro-1(2H)-pyridinyl]propyl}-4(3H)-quinazolinoneIC5016.0 [1], 21.0 [2]
2-(3-(4-(4-Fluorophenyl)-5,6-dihydropyridin-1(2H)-yl)propyl)quinazolin-4(3H)-oneIC508.9 [1], 16.0 [2], 304.0 [3]
2-(3-(4-Phenylpiperidin-1-yl)propyl)quinazolin-4(3H)-oneIC5046.0 [1], 79.0 [2]
2-(3-(4-(4-Chlorophenyl)-5,6-dihydropyridin-1(2H)-yl)propyl)quinazolin-4(3H)-oneIC508.9 [1], 23.0 [2]
N-Ethyl-3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamideIC5050.0 [1]
N-{3-[(4-Oxo-3,4-dihydrophthalazin-1-yl)methyl]phenyl}propanamideIC5020.0 [1]
2-(4-Pyridine-3-ylphenyl)-1H-benzimidazole-4-carboxamideIC5022.0 [1]
2-(4-Pyridine-3-ylphenyl)-1H-benzimidazole-4-carboxamideKi0.95 [1], 1.0 [2]
2-Phenyl-2H-indazole-7-carboxamideIC5024.0 [1], 25.0 [2]
2-(4-((Methylamino)methyl)phenyl)-2H-indazole-7-carboxamideIC503.8 [1], 5.0 [2]
INO-1001 free baseIC501.0 [1], 40.0 [2]
4-[[4-Fluoro-3-[4-(4-iodobenzoyl)piperazine-1-carbonyl]phenyl]methyl]-2H-phthalazin-1-oneIC503.3 [1], 7.0 [2], 7.4 [3]
4-[[4-Fluoro-3-[5-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]phenyl]methyl]-2H-phthalazin-1-oneIC500.74 [1], 10.0 [2], 17.33 [3]
4-HydroxyquinazolineIC509500.0 [1], 15800.0 [2]
4-Amino-1,8-naphthalimideIC5026.0 [1], 180.0 [2]
Bmn-673 8R,9SIC501.1 [1], 144.0 [2]
1-HydroxyisoquinolineIC509.0 [1], 7000.0 [2]
2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamideIC503.2 [1]
3,4-Dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinoneIC5053.2 [1], 10820.0 [2]
5-Methyl-3,4-dihydroisoquinolin-1(2H)-oneIC50160.0 [1]
5-Methyl-3,4-dihydroisoquinolin-1(2H)-oneKi70.0 [1]
3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)-N-[(1s)-1-Phenylethyl]propanamideIC503700.0 [1], 6300.0 [2]
Nvp-tnks656IC5019000.0 [1]
2-(4-Methylphenyl)-4H-chromen-4-oneIC507100.0 [1], 25000.0 [2]
1H-Benzimidazole-7-carboxamide, 2-(1-propyl-4-piperidinyl)-Ki8.0 [1]
2-(4-Hydroxyphenyl)-1h-Benzimidazole-4-CarboxamideKi6.0 [1]
2-(4-Methoxyphenyl)-1H-benzimidazole-4-carboxamideIC5060.0 [1]
2-(4-Methoxyphenyl)-1H-benzimidazole-4-carboxamideKi6.8 [1]
1-[2-Fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]phenyl]pyrrolidine-2,5-dioneIC505.0 [1]
(S)-8-Chloro-2-(3-(4-phenylpiperidin-1-yl)cyclopent-1-enyl)quinazolin-4(3H)-oneIC508.7 [1]
5-Chloro-2-methyl-3H-quinazolin-4-oneIC501200.0 [1]
3-(4-Cyanophenyl)quinoxaline-5-carboxamideIC50101.0 [1]
9,19-Diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaen-10-oneIC5010000.0 [1]
9,19-Diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaen-8-oneIC5056.0 [1], 90.0 [2]
2-(4-((Methylamino)methyl)phenyl)-1H-benzo[d]imidazole-4-carboxamideKi3.2 [1], 4.0 [2]
2-(3-(4-Phenyl-5,6-dihydropyridin-1(2H)-yl)propyl)phenanthridin-6(5H)-oneIC5046.0 [1], 119.0 [2]
2-Phenyl-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-oneKi6.0 [1]
4-(4-(4-Phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)phthalazin-1(2H)-oneIC5064.0 [1]
Benzo[c][1,7]naphthyridin-6(5H)-oneIC50169.0 [1]
Benzo[c][1,5]naphthyridin-6(5H)-oneIC50116.0 [1]
2-(4-Aminophenyl)-1H-benzo[d]imidazole-4-carboxamideIC5030.0 [1]
2-(4-Aminophenyl)-1H-benzo[d]imidazole-4-carboxamideKi11.0 [1]
2-[4-[(Dimethylamino)methyl]phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-oneIC505.0 [1]
2-[4-[(Dimethylamino)methyl]phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-oneKi5.0 [1]
3-[(E)-N-Hydroxy-C-methylcarbonimidoyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-oneKi39.0 [1]
3-[(E)-Methoxyiminomethyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-oneKi809.0 [1]
2-(4-Fluorophenyl)-3-[(E)-hydroxyiminomethyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-oneKi6.0 [1]
3-[(E)-Hydroxyiminomethyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-oneKi9.4 [1]
3-(Hydroxymethyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-oneKi79.0 [1]
3-[(Z)-Methoxyiminomethyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-oneKi121.0 [1]
1-[2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)phenyl]-3-phenylpyrrolidine-2,5-dioneIC506.8 [1]
1-(2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)piperidine-2,6-dioneIC504.1 [1]
4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-oneIC505.0 [1], 6.9 [2]
2-(4-Chlorophenyl)-3-[(E)-hydroxyiminomethyl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-oneKi7.5 [1]
2-{3-[4-(4-Fluorophenyl)-3,6-dihydro-1(2H)-pyridinyl]propyl}-8-methyl-4(3H)-quinazolinoneIC508.0 [1], 16.0 [2]
8-Chloro-2-[3-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)propyl]-3,4-dihydroquinazolin-4-oneIC5026.0 [1]
3H-Pyridazino(3,4,5-de)quinazolin-3-one, 8-((1,3-dihydro-2H-isoindol-2-yl)methyl)-1,2-dihydro-IC502.0 [1], 12.0 [2]
5H-Benzo[c][1,6]naphthyridin-6-oneIC50128.0 [1]
2-Nitro-6(5H)-phenanthridinoneIC50156.0 [1], 350.0 [2]
3-Aminobenzo[c][1,5]naphthyridin-6(5H)-oneIC50180.0 [1]
2-[1-(Propan-2-yl)pyrrolidin-3-yl]-1H-1,3-benzodiazole-4-carboxamideKi9.0 [1]
2-(Pyrrolidin-3-yl)-1H-1,3-benzodiazole-4-carboxamideKi4.0 [1]
1-[2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)phenyl]-3-methylpyrrolidine-2,5-dioneIC503.8 [1]
4-(3-(2-Oxopyrrolidin-1-yl)benzyl)phthalazin-1(2H)-oneIC50120.0 [1]
3,4-Dihydropyrrolo(3,2,1-jk)(1,4)benzodiazepin-1(2H)-oneKi105.0 [1]
(R)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamideIC502.4 [1]
2-(Azetidin-3-yl)-1H-benzimidazole-4-carboxamideKi6.0 [1]
2-[(2r)-Pyrrolidin-2-yl]-1h-benzimidazole-4-carboxamideKi7.0 [1]
2-[(2s)-Pyrrolidin-2-yl]-1h-benzimidazole-4-carboxamideKi30.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Poly [ADP-ribose] polymerase-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/poly-adp-ribose-polymerase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Poly [ADP-ribose] polymerase-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/poly-adp-ribose-polymerase-1-inhibitors-ic50-ki.
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