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Potassium channel subfamily K member 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
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▼
2-Methoxy-N-(3-(3-methylbenzamido)phenyl)benzamideIC504.0 [1], 16.0 [2]
PK-ThppIC50300.0 [1]
N-(3-Benzamidophenyl)benzamideIC5021.0 [1], 240.0 [2]
N-(3-Benzoylamino-phenyl)-3-methyl-benzamideIC5027.0 [1], 75.0 [2]
2-Methoxy-N-[3-[(2-methoxybenzoyl)amino]phenyl]benzamideIC5010.0 [1], 30.0 [2]
N-[3-(3-Methylbenzamido)phenyl]pyridine-4-carboxamideIC5095.0 [1], 2140.0 [2]
3-Methyl-N-[3-[[3-(trifluoromethyl)benzoyl]amino]phenyl]benzamideIC5010.0 [1], 370.0 [2]
2-Ethoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamideIC509.0 [1], 11.0 [2]
N-[3-[(3-Methylbenzoyl)amino]phenyl]-2-(trifluoromethoxy)benzamideIC5029.0 [1], 60.0 [2]
N-[3-[(2-Ethoxybenzoyl)amino]phenyl]-2-(trifluoromethyl)benzamideIC502.0 [1], 10.0 [2]
PropafenoneIC505100.0 [1]
MexiletineIC5097300.0 [1]
N-[(2,4-Difluorophenyl)methyl]-2-[2-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]phenyl]benzamideIC507.0 [1]
N-(3-Benzamidophenyl)pyridine-3-carboxamideIC501290.0 [1]
2-Methoxy-N-{3-[(2-methylbenzoyl)amino]phenyl}benzamideIC5073.0 [1]
3-Fluoro-N-{3-[(phenylcarbonyl)amino]phenyl}benzamideIC5045.0 [1]
N-{3-[(Phenylcarbonyl)amino]phenyl}furan-2-carboxamideIC5037.0 [1]
3-Chloro-N-(3-(3-methylbenzamido)phenyl)benzamideIC503.0 [1]
N-[3-[(4-Tert-butylbenzoyl)amino]phenyl]-3-methylbenzamideIC50190.0 [1]
N-(3-Benzamidophenyl)-2-chlorobenzamideIC50500.0 [1]
2,5-Dimethoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamideIC50150.0 [1]
N-[3-[(3-Methylbenzoyl)amino]phenyl]-2-propan-2-yloxybenzamideIC50210.0 [1]
2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]pyridine-4-carboxamideIC50180.0 [1]
N-(3-Benzamidophenyl)-4-tert-butylbenzamideIC503000.0 [1]
N-(3-Benzamidophenyl)-4-(trifluoromethyl)benzamideIC503000.0 [1]
N-(3-Benzamidophenyl)-2-methylbenzamideIC50100.0 [1]
N-(3-Benzamidophenyl)-4-methoxybenzamideIC503000.0 [1]
N-(3-Benzamidophenyl)-4-methylbenzamideIC503000.0 [1]
N-(3-Benzamidophenyl)pyridine-4-carboxamideIC50250.0 [1]
N-[3-(Cyclohexanecarbonylamino)phenyl]benzamideIC5079.0 [1]
N-(3-Benzamidophenyl)-2-methoxybenzamideIC50220.0 [1]
N-(3-Benzamidophenyl)-4-chlorobenzamideIC503000.0 [1]
N-[3-[(3-Methylbenzoyl)amino]phenyl]thiophene-2-carboxamideIC505.0 [1]
2-Methyl-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamideIC5091.0 [1]
N-(3-Benzamidophenyl)-4-fluorobenzamideIC50310.0 [1]
N-[3-[(3-Fluorobenzoyl)amino]phenyl]-3-methylbenzamideIC5025.0 [1]
N-(3-Benzamidophenyl)-3-(trifluoromethyl)benzamideIC50160.0 [1]
N-[3-[(4-Methoxybenzoyl)amino]phenyl]-3-methylbenzamideIC501300.0 [1]
3-Methyl-N-[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]benzamideIC503000.0 [1]
2-Chloro-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamideIC5023.0 [1]
N-[3-[(3-Methoxybenzoyl)amino]phenyl]-3-methylbenzamideIC5031.0 [1]
N-(3-Benzamidophenyl)-4-(dimethylamino)benzamideIC50260.0 [1]
N-(3-Benzamidophenyl)furan-3-carboxamideIC50800.0 [1]
N-[3-[(3-Methylbenzoyl)amino]phenyl]-2-(trifluoromethyl)benzamideIC5014.0 [1]
N-(3-Benzamidophenyl)thiophene-3-carboxamideIC50160.0 [1]
N-(3-Benzamidophenyl)-2-(trifluoromethyl)benzamideIC50130.0 [1]
N-[3-[(4-Chlorobenzoyl)amino]phenyl]-3-methylbenzamideIC50150.0 [1]
N-(3-Benzamidophenyl)pyridine-2-carboxamideIC5086.0 [1]
N-[3-[[4-(Dimethylamino)benzoyl]amino]phenyl]-3-methylbenzamideIC50150.0 [1]
N-[3-[(3-Methylbenzoyl)amino]phenyl]-2-propan-2-ylbenzamideIC50330.0 [1]
2-Methoxy-N-[3-[[2-(trifluoromethoxy)benzoyl]amino]phenyl]benzamideIC504.0 [1]
N-[3-[(2-Ethoxybenzoyl)amino]phenyl]-2-methoxybenzamideIC502.0 [1]
N-[3-[(2-Methoxybenzoyl)amino]phenyl]-2-propan-2-ylbenzamideIC507.0 [1]
2-Propan-2-yl-N-[3-[[2-(trifluoromethoxy)benzoyl]amino]phenyl]benzamideIC5011.0 [1]
2-Propan-2-yloxy-N-[3-[[2-(trifluoromethoxy)benzoyl]amino]phenyl]benzamideIC501.0 [1]
3-Methyl-N-{3-[(3-methylbenzoyl)amino]phenyl}benzamideIC5030.0 [1]
N-[3-[(3-Methylbenzoyl)amino]phenyl]furan-2-carboxamideIC50140.0 [1]
N-(3-Benzamidophenyl)-3-methoxybenzamideIC50330.0 [1]
N-{3-[(Phenylcarbonyl)amino]phenyl}thiophene-2-carboxamideIC5029.0 [1]
N-(3-Benzamidophenyl)-3-chlorobenzamideIC5052.0 [1]
1-[3-(3-Chlorophenyl)-1-[(1R,2R)-4,6-difluoro-2-methoxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50446.0 [1]
6-N-[(1R)-1-(2,4-Difluorophenyl)propyl]-8-N-(1-pyrazin-2-ylethyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxamideIC50430.0 [1]
6-N-[(1R)-1-(2-Methoxypyridin-3-yl)propyl]-8-N-[(1R)-1-phenylpropyl]-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxamideIC50240.0 [1]
N-[(1R)-1-(2-Chlorophenyl)-2-methylpropyl]-6-[(2S)-2-methylpyrrolidine-1-carbonyl]-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxamideIC5064.0 [1]
[8-[[[(1R)-1-(2,2-Difluoro-1,3-benzodioxol-5-yl)propyl]amino]methyl]-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazin-6-yl]-[(2S)-2-methylpyrrolidin-1-yl]methanoneIC50200.0 [1]
N-[(1R)-1-(2-Chlorophenyl)propyl]-6-(pyrrolidine-1-carbonyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxamideIC50210.0 [1]
6-(Morpholine-4-carbonyl)-N-[(1R)-1-phenylpropyl]-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxamideIC501700.0 [1]
6-N-Ethyl-6-N-[(2-methyltetrazol-5-yl)methyl]-8-N-[(1R)-1-phenylpropyl]-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxamideIC50450.0 [1]
6-N-[1-[3-(Dimethylsulfamoyl)phenyl]ethyl]-8-N-[(1R)-1-phenylpropyl]-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxamideIC501100.0 [1]
6-N-[(3-Isocyanophenyl)methyl]-8-N-[(1R)-1-phenylpropyl]-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxamideIC50250.0 [1]
8-N-[(1S)-1-(5-Methoxypyrazin-2-yl)propyl]-6-N-[(1R)-1-phenylethyl]-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxamideIC50190.0 [1]
6-N-[(1R)-1-(6-Isocyanopyridin-3-yl)propyl]-8-N-[(1R)-1-phenylpropyl]-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxamideIC501000.0 [1]
N-[(1R)-1-(6-Isocyanopyridin-3-yl)propyl]-8-[(2S)-2-methylpyrrolidine-1-carbonyl]-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carboxamideIC502000.0 [1]
3-[5-Acetyl-1-[(2,4-difluorophenyl)methyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC5095.0 [1]
3-[5-Acetyl-1-[(1R,2R)-6-chloro-4-fluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC50439.0 [1]
3-[1-[(2,4-Difluorophenyl)methyl]-5-(2-methylpropanoyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC5019.0 [1]
3-[1-[(1R,2R)-4,6-Difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-propanoyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC5070.0 [1]
3-[5-(Cyclopropanecarbonyl)-1-[(1R,2R)-4,6-difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC5083.1 [1]
1-[1-[(1R,2R)-4,6-Difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[3-(trifluoromethoxy)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50171.0 [1]
1-[3-(3-Chlorophenyl)-1-[(1S,2S)-4,6-difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC501185.0 [1]
1-[1-[(1R,2R)-4,6-Difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-(2-fluoro-5-methoxyphenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50204.0 [1]
3-[5-Acetyl-1-[(1R,2R)-4-bromo-6-fluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC50226.0 [1]
3-[5-Acetyl-1-[(1R,2R)-6-fluoro-2-hydroxy-4-methyl-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC50231.0 [1]
1-[1-[(1R,2R)-4,6-Difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[6-(trifluoromethyl)pyridin-2-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50239.0 [1]
3-[1-[(1R,2R)-4,6-Difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-(2-methylpropanoyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC50250.0 [1]
Methyl 3-(3-cyanophenyl)-1-[(1R,2R)-4,6-difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxylateIC50260.0 [1]
1-[1-[(1R,2R)-4,6-Difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50270.0 [1]
3-[5-Acetyl-1-[(1R,2R)-4,6-dichloro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC50350.0 [1]
1-[1-[(1S,2S)-4,6-Difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50773.0 [1]
3-[5-Acetyl-1-[(1R,2R)-4-chloro-6-fluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC50393.0 [1]
1-[1-[(1R,2R)-4,6-Difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-(3-methoxyphenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50442.0 [1]
1-[1-[(1S)-2,3-Dihydro-1H-inden-1-yl]-3-(4-fluorophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50479.0 [1]
1-[1-[(1R,2R)-4,6-Difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-(4-fluorophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50495.0 [1]
3-[5-Acetyl-1-[(1R,2R)-4-cyclopropyl-6-fluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC50500.0 [1]
1-[1-[(1R,2R)-4,6-Dichloro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[6-(trifluoromethyl)pyridin-2-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50518.0 [1]
1-[1-[(1R,2R)-6-Chloro-4-fluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-(4-fluorophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50568.0 [1]
3-[5-Acetyl-1-[(1S,2S)-4,6-difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC50881.0 [1]
3-[5-Acetyl-1-[(1R,2R)-6-chloro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrileIC50685.0 [1]
1-[1-[(1R)-2,3-Dihydro-1H-inden-1-yl]-3-(4-fluorophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50712.0 [1]
1-[1-[(1R,2R)-4,6-Difluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50773.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Potassium channel subfamily K member 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/potassium-channel-subfamily-k-member-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Potassium channel subfamily K member 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/potassium-channel-subfamily-k-member-3-inhibitors-ic50-ki.
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