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PRMT5/MEP50 complex Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
(E)-3-[5-(2-Nitrophenyl)furan-2-yl]-1-phenylprop-2-en-1-oneIC5023000.0 [1], 169000.0 [2]
2-({[2-(Benzyloxy)naphthalen-1-yl]methyl}amino)-1-phenylethanolIC502800.0 [1]
3-[(4-Methylphenoxy)methyl]-6-pyridin-3-yl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoleIC5026000.0 [1], 200000.0 [2]
2-[({2-[(2-Fluorobenzyl)oxy]-1-naphthyl}methyl)amino]ethanolIC5018000.0 [1], 172000.0 [2]
Methyl 2-{[(1H-benzimidazol-2-ylsulfanyl)acetyl]amino}benzoateIC508100.0 [1], 24000.0 [2]
S-Adenosyl-L-homocysteineIC50600.0 [1]
CID 56962336IC5020000.0 [1]
CID 90241673IC5022.0 [1]
2-[(5-Methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-(2-methoxyphenyl)acetamideIC5019000.0 [1]
2-[(5-Methoxy-1H-benzimidazol-2-yl)thio]-N-phenylacetamideIC5033000.0 [1]
2-[(6-Methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-(2-methylphenyl)acetamideIC50200000.0 [1]
({[5-(4-Chlorophenyl)furan-2-yl]methylidene}amino)ureaIC50570.0 [1]
CID 122669401IC5022.0 [1]
Methyl 4-({[(5-methoxy-1H-benzimidazol-2-yl)thio]acetyl}amino)benzoateIC50100000.0 [1]
1-[(4-Chlorophenyl)methoxy]-3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-2-olIC501001.0 [1]
N-(2-Chlorophenyl)-2-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetamideIC5047000.0 [1]
PRMT5 Inhibitor C17IC50330.0 [1]
2-Hydroxy-5-{[4-(4-methoxy-3-methylphenyl)-1,3-thiazol-2-yl]amino}benzoic acidIC5014000.0 [1]
1-[2-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylureaIC5037000.0 [1]
Chembl4127276IC5044000.0 [1]
Methyl 2-({[(5-ethoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl}amino)benzoateIC50350.0 [1]
Methyl 2-({[(6-methyl-1H-benzimidazol-2-yl)sulfanyl]acetyl}amino)benzoateIC501400.0 [1]
Methyl 2-[[2-[(4-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC50100000.0 [1]
Methyl 2-[[2-[[6-(dimethylamino)-1H-benzimidazol-2-yl]sulfanyl]acetyl]amino]benzoateIC50330.0 [1]
2-[[2-[(6-Methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]-N,N-dimethylbenzamideIC50200000.0 [1]
(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(S)-hydroxy(phenyl)methyl]oxolane-3,4-diolIC501074.0 [1]
Methyl 2-[[2-[(6-propan-2-yloxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC502800.0 [1]
Methyl 2-[[2-[(6-fluoro-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC503300.0 [1]
2-[[2-[(6-Methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]-N-methylbenzamideIC50200000.0 [1]
Methyl 2-[[2-[(6-amino-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC5040000.0 [1]
N-(2,5-Dihydro-1,3-thiazol-5-yl)-2,4-dimethoxybenzamideIC5027000.0 [1]
Methyl 2-[[2-[(4-chloro-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC50100000.0 [1]
Methyl 2-[[2-(3H-imidazo[4,5-c]pyridin-2-ylsulfanyl)acetyl]amino]benzoateIC5087000.0 [1]
Methyl 2-[[2-[(6-propoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC50530.0 [1]
Methyl 2-[[2-[(6-hydroxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC50100000.0 [1]
Methyl 2-[[2-[(5-methoxy-1H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]acetyl]amino]benzoateIC508400.0 [1]
N-[2-(Dimethylamino)phenyl]-2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetamideIC5025000.0 [1]
Methyl 2-[[2-[[6-(methylamino)-1H-benzimidazol-2-yl]sulfanyl]acetyl]amino]benzoateIC501600.0 [1]
Methyl 2-[[2-[(4-methyl-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC50100000.0 [1]
Methyl 3-[[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]pyridine-4-carboxylateIC502400.0 [1]
1-(3,4-Dichlorophenyl)-N-(piperidin-4-ylmethyl)methanamineIC5027000.0 [1]
2-[(E)-{[3-(1H-Benzimidazol-2-yl)phenyl]imino}methyl]-3,4-dibromo-6-methoxyphenolIC5048000.0 [1]
Methyl 2-[[2-[(6-bromo-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC50340.0 [1]
2-[({2-[(4-Chlorobenzyl)oxy]-1-naphthyl}methyl)amino]ethanolIC5035600.0 [1]
N-[3-(Diethylamino)propyl]-4-methoxy-3-nitrobenzamideIC5042000.0 [1]
2-[[2-[(6-Methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoic acidIC50100000.0 [1]
Ethyl 2-[[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC501900.0 [1]
1-(Benzyloxy)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-olIC5010001.0 [1]
Methyl 2-({[(6-nitro-1H-benzimidazol-2-yl)sulfanyl]acetyl}amino)benzoateIC50830.0 [1]
3,3'-(1,4-Phenylenebis(oxy))bis(1-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol)IC50101.0 [1]
Methyl 3-[[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoateIC5052000.0 [1]
N-(2-Acetylphenyl)-2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetamideIC502900.0 [1]
Chembl4128780IC5035000.0 [1]
5-{[4-(4-Fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acidIC5022000.0 [1]
Methyl 2-{2-[(5-chloro-1H-1,3-benzodiazol-2-yl)sulfanyl]acetamido}benzoateIC50500.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[1-(1-methylpiperidin-4-yl)indazol-6-yl]oxyacetamideIC50100.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[2-(4-methylsulfonylpiperazin-1-yl)phenoxy]acetamideIC50101.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-(2-piperazin-1-ylsulfonylphenoxy)acetamideIC50100.0 [1]
2-[2-(4-Acetylpiperazin-1-yl)sulfonylphenoxy]-N-[3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]acetamideIC50101.0 [1]
Tert-butyl N-[2-[2-[[3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]amino]-2-oxoethoxy]phenyl]carbamateIC501001.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[3-(morpholin-4-ylmethyl)phenoxy]acetamideIC50100.0 [1]
N-[(2S)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[2-(2-morpholin-4-ylethoxy)phenoxy]acetamideIC50100.0 [1]
N-[(2R)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[2-[2-(dimethylamino)ethoxy]phenoxy]acetamideIC50101.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[3-(oxan-4-ylamino)phenoxy]acetamideIC50100.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-(1-pyrrolidin-3-ylindazol-5-yl)oxyacetamideIC50100.0 [1]
N-[(2R)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[2-(dimethylamino)quinolin-8-yl]oxyacetamideIC50100.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-(2-morpholin-4-ylsulfonylphenoxy)acetamideIC50100.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-(2-fluorophenoxy)acetamideIC50101.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[6-(oxan-4-ylamino)pyridin-2-yl]oxyacetamideIC501001.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[2-(4-methylpiperazin-1-yl)sulfonylphenoxy]acetamideIC50100.0 [1]
4-[2-[[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]amino]-2-oxoethoxy]benzamideIC501001.0 [1]
N-[(2S)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[7-(morpholin-4-ylmethyl)quinolin-8-yl]oxyacetamideIC50100.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[1-(1-methylpyrrolidin-3-yl)indazol-5-yl]oxyacetamideIC50100.0 [1]
2-Anilino-N-[3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]acetamideIC501001.0 [1]
2-[2-[[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]amino]-2-oxoethoxy]-N-methylbenzamideIC50101.0 [1]
2-[2-[[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]amino]-2-oxoethoxy]benzamideIC50101.0 [1]
N-[(2R)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[2-(2-morpholin-4-ylethoxy)phenoxy]acetamideIC501001.0 [1]
N-[(2S)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[2-[2-(dimethylamino)ethoxy]phenoxy]acetamideIC50100.0 [1]
2-[2-(4-Acetylpiperazin-1-yl)phenoxy]-N-[3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]acetamideIC50100.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[2-(methanesulfonamido)phenoxy]acetamideIC50100.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[(3-methylbenzimidazol-5-yl)amino]acetamideIC50101.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[2-(methanesulfonamido)pyridin-3-yl]oxyacetamideIC5010000.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-(1-piperidin-4-ylindazol-6-yl)oxyacetamideIC50100.0 [1]
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[3-(methanesulfonamido)pyridin-2-yl]oxyacetamideIC501001.0 [1]
2-(5-Acetamidopyridin-3-yl)oxy-N-[3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]acetamideIC5010000.0 [1]
N-[(2S)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-2-[2-(dimethylamino)quinolin-8-yl]oxyacetamideIC50101.0 [1]
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-[3-(3-methyl-6,7-dihydro-4H-imidazo[4,5-c]pyridin-5-yl)phenoxy]propan-2-olIC50101.0 [1]
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-(pyrrolidin-3-ylmethoxy)propan-2-olIC5040000.0 [1]
4-Anilino-1-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridin-2-oneIC50101.0 [1]
(2R)-1-[3-[(Cyclopentylamino)methyl]phenoxy]-3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-2-olIC501001.0 [1]
(2S)-1-[3-[(Cyclopentylamino)methyl]phenoxy]-3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-2-olIC50101.0 [1]
1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethoxy)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-2-olIC50101.0 [1]
1-(1,3-Benzodioxol-5-yloxy)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-2-olIC501001.0 [1]
1-[(2S)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-3-phenylureaIC50101.0 [1]
1-[(2R)-3-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-3-phenylureaIC501001.0 [1]
1-Cyclopentyloxy-3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-2-olIC501001.0 [1]
1-[3-[(Cyclohexylamino)methyl]phenoxy]-3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-2-olIC50101.0 [1]
1-[3-[(Cyclopentylamino)methyl]phenoxy]-3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-2-olIC50101.0 [1]
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-[3-[(oxan-4-ylamino)methyl]phenoxy]propan-2-olIC50101.0 [1]
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-[3-(piperidin-1-ylmethyl)phenoxy]propan-2-olIC501001.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ PRMT5/MEP50 complex Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/prmt5-mep50-complex-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ PRMT5/MEP50 complex Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/prmt5-mep50-complex-inhibitors-ic50-ki.
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