Probable protein-cysteine N-palmitoyltransferase porcupine Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide	IC50	0.4 [1]
	2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide	IC50	0.07 [1], 1.0 [2]
	2-[5-Methyl-6-(6-methylpyridin-3-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	0.38 [1], 0.57 [2]
	CID 2155128	IC50	157.0 [1]
	N-[2-[(6-Methoxy-1,3-benzothiazol-2-yl)amino]-2-oxoethyl]-3-(4-methoxyphenyl)-4-oxophthalazine-1-carboxamide	IC50	60.0 [1]
	2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide	IC50	2.9 [1]
	(2R)-1-(4-Imidazol-1-ylphenyl)-N-(4-phenylphenyl)pyrrolidine-2-carboxamide	IC50	33000.0 [1]
	2-[4-(1,3-Oxazol-5-yl)phenoxy]-N-(4-phenylphenyl)acetamide	IC50	42.0 [1]
	N-(4-Phenylphenyl)-2-[4-(1H-pyrazol-5-yl)phenoxy]acetamide	IC50	50000.0 [1]
	(2S)-1-(4-Imidazol-1-ylphenyl)-N-(4-phenylphenyl)pyrrolidine-2-carboxamide	IC50	40.0 [1]
	(2S)-2-[[6-(2-Methylpyrazol-3-yl)pyridin-3-yl]amino]-N-(6-pyridin-3-ylpyridin-3-yl)propanamide	IC50	10.0 [1]
	2-[4-(2-Methylpyrazol-3-yl)phenoxy]-N-(4-phenylphenyl)acetamide	IC50	4.0 [1]
	2-(6-Cyclopropyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-[6-(6-methylpyridin-3-yl)pyridazin-3-yl]acetamide	IC50	12.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-[6-(6-methylpyridin-3-yl)pyridazin-3-yl]acetamide	IC50	29.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(4-phenylphenyl)acetamide	IC50	12.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(5-phenylpyridin-2-yl)acetamide	IC50	1.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(4-pyridin-2-ylphenyl)acetamide	IC50	67.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(4-pyridin-3-ylphenyl)acetamide	IC50	8.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(6-pyridin-3-ylpyridazin-3-yl)acetamide	IC50	29.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-[4-(1,3-thiazol-2-yl)phenyl]acetamide	IC50	15.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(6-phenylpyridazin-3-yl)acetamide	IC50	1.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(4-pyridin-4-ylphenyl)acetamide	IC50	72.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(6-pyridin-3-ylpyridin-3-yl)acetamide	IC50	11.0 [1]
	2-(6-Cyclopropyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-[6-(5-fluoropyridin-3-yl)pyridazin-3-yl]acetamide	IC50	11.0 [1]
	N-[6-(5-Fluoropyridin-3-yl)pyridazin-3-yl]-2-(6-methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)acetamide	IC50	9.0 [1]
	[4-(2-Methylpyridin-4-yl)phenyl] N-(4-phenylphenyl)carbamate	IC50	5.0 [1]
	[4-(2-Methylpyridin-4-yl)phenyl] N-(4-pyridin-3-ylphenyl)carbamate	IC50	2.2 [1]
	[4-(2-Methylpyridin-4-yl)phenyl] N-(5-pyrazin-2-ylpyridin-2-yl)carbamate	IC50	0.23 [1]
	2-[3-(2-Methylpyridin-4-yl)phenoxy]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	188.0 [1]
	2-[3-(2-Methylpyridin-4-yl)anilino]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	164.0 [1]
	2-[3-(2-Methylpyridin-4-yl)phenyl]sulfanyl-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	40.0 [1]
	2-Isoquinolin-7-yloxy-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	30.0 [1]
	2-Naphthalen-2-yloxy-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	1000.0 [1]
	2-(1H-Indazol-5-yloxy)-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	1000.0 [1]
	2-(1H-Indazol-5-ylamino)-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	1000.0 [1]
	2-(1-Methylindazol-5-yl)oxy-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	1000.0 [1]
	2-[(1-Methylindazol-5-yl)amino]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	1000.0 [1]
	2-[(3-Amino-1,2-benzoxazol-5-yl)oxy]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	1000.0 [1]
	2-(6-Methoxynaphthalen-2-yl)oxy-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	1000.0 [1]
	2-(6-Cyanonaphthalen-2-yl)oxy-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	2.7 [1]
	2-(4-Cyanophenoxy)-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	485.0 [1]
	2-[(2-Acetyl-3,4-dihydro-1H-isoquinolin-7-yl)oxy]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	24.0 [1]
	2-[4-(4-Acetylpiperazin-1-yl)phenoxy]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	483.0 [1]
	2-[4-(2-Methylpyridin-4-yl)anilino]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	0.96 [1]
	2-[N-Methyl-4-(2-methylpyridin-4-yl)anilino]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	0.67 [1]
	2-[4-(2-Methylpyridin-4-yl)phenyl]sulfanyl-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide	IC50	0.53 [1]
	3-[4-(2-Methylpyridin-4-yl)phenyl]-N-(5-pyrazin-2-ylpyridin-2-yl)propanamide	IC50	0.19 [1]
	2-[4-(2-Methylpyridin-4-yl)phenoxy]-N-(5-pyrazin-2-ylpyridin-2-yl)propanamide	IC50	0.11 [1]
	2-[[3-(4-Fluoro-2-methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide	IC50	27.0 [1]
	2-[(8S)-2,4-Dimethyl-1,3-dioxo-7,8-dihydro-6H-purino[7,8-a]pyrrol-8-yl]-N-(6-phenylpyridazin-3-yl)acetamide	IC50	5.0 [1]
	(2R)-2-(4-Imidazol-1-ylphenoxy)-N-(4-phenylphenyl)propanamide	IC50	130.0 [1]
	(2S)-2-(4-Imidazol-1-ylanilino)-N-(5-phenylpyridin-2-yl)propanamide	IC50	5.0 [1]
	(2R)-2-(4-Imidazol-1-ylanilino)-N-(5-phenylpyridin-2-yl)propanamide	IC50	689.0 [1]
	(2S)-2-(4-Imidazol-1-ylphenoxy)-N-(4-phenylphenyl)propanamide	IC50	7.0 [1]
	(2S)-2-[[6-(2-Methylpyrazol-3-yl)pyridin-3-yl]amino]-N-(5-phenylpyridin-2-yl)propanamide	IC50	1.0 [1]
	2-(6-Methyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(6-phenylpyridin-3-yl)acetamide	IC50	6.0 [1]
	2-(2-Methyl-1,3-dioxoisoindol-4-yl)-N-[4-(1,3-thiazol-2-yl)phenyl]acetamide	IC50	15.0 [1]
	N-(6-Methoxy-1,3-benzothiazol-2-yl)-2-[[3-(4-methoxyphenyl)-4-oxophthalazin-1-yl]methylamino]acetamide	IC50	60.0 [1]
	2-(4-Imidazol-1-ylanilino)-N-(4-phenylphenyl)acetamide	IC50	30.0 [1]
	2,4-Dimethyl-1,3-dioxo-N-[4-(1,3-thiazol-2-yl)phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrrole-8-carboxamide	IC50	42.0 [1]
	2-[[3-[(4-Methoxyphenyl)methyl]-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-[6-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetamide	IC50	710.0 [1]
	N-{[1,1'-Biphenyl]-4-yl}-2-[4-(1H-imidazol-1-yl)phenoxy]acetamide	IC50	15.0 [1]
	(2S)-2-[[6-(2-Methylpyrazol-3-yl)pyridin-3-yl]amino]-N-(5-pyridin-3-ylpyridin-2-yl)propanamide	IC50	1.0 [1]
	2-[4-(2-Methylimidazol-1-yl)phenoxy]-N-(4-phenylphenyl)acetamide	IC50	2.0 [1]
	N-(4-Phenylphenyl)-2-(4-pyrrol-1-ylphenoxy)acetamide	IC50	50000.0 [1]
	(2R)-2-(1,3-Dimethyl-2,6-dioxopurin-7-yl)-N-(4-thiophen-3-ylphenyl)propanamide	IC50	5400.0 [1]
	2-(1,3-Dimethyl-2,6-dioxopurin-7-yl)-N-(4-thiophen-3-ylphenyl)acetamide	IC50	0.4 [1]
	2-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)-N-[4-(1,3-thiazol-2-yl)phenyl]acetamide	IC50	24.0 [1]
	2-(6-Cyclopropyl-5,7-dioxo-3,4-dihydro-2H-pyrrolo[3,4-b]pyridin-1-yl)-N-(6-pyridin-3-ylpyridazin-3-yl)acetamide	IC50	12.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 69 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Probable protein-cysteine N-palmitoyltransferase porcupine Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/probable-protein-cysteine-n-palmitoyltransferase-porcupine-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Probable protein-cysteine N-palmitoyltransferase porcupine Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/probable-protein-cysteine-n-palmitoyltransferase-porcupine-inhibitors-ic50-ki.
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