Prolactin-releasing peptide receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-Fluoro-4-[3-methoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	IC50	34.0 [1]
	3-Fluoro-4-[3-methoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	Ki	15.0 [1]
	4-[3-(Dimethylamino)-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile	IC50	46.0 [1]
	4-[3-(Dimethylamino)-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile	Ki	8.0 [1]
	6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	204.0 [1]
	6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	28.0 [1]
	6-(4-Chlorobenzoyl)-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	378.0 [1]
	6-(4-Chlorobenzoyl)-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	29.0 [1]
	6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-prop-2-ynyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	1722.0 [1]
	6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-prop-2-ynyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	42.0 [1]
	3-But-2-ynyl-6-(4-imidazol-1-ylbenzoyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	99.0 [1]
	3-But-2-ynyl-6-(4-imidazol-1-ylbenzoyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	6.0 [1]
	4-[3-But-2-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile	IC50	78.0 [1]
	4-[3-But-2-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile	Ki	2.0 [1]
	3-But-2-ynyl-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	665.0 [1]
	3-But-2-ynyl-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	10.0 [1]
	3-But-2-ynyl-6-(pyrazolo[1,5-a]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	776.0 [1]
	3-But-2-ynyl-6-(pyrazolo[1,5-a]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	20.0 [1]
	3-But-2-ynyl-6-(quinoline-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	3350.0 [1]
	3-But-2-ynyl-6-(quinoline-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	24.0 [1]
	6-(4-Chlorobenzoyl)-2-[[1-(4-chlorophenyl)-2-methylpropyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	4494.0 [1]
	6-(4-Chlorobenzoyl)-2-[[1-(4-chlorophenyl)-2-methylpropyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	37.0 [1]
	3-But-2-ynyl-6-(quinoline-3-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	2794.0 [1]
	3-But-2-ynyl-6-(quinoline-3-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	28.0 [1]
	4-[3-But-3-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile	IC50	68.0 [1]
	4-[3-But-3-ynyl-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile	Ki	2.0 [1]
	6-[2-(4-Chlorophenyl)iminoacetyl]-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	5793.0 [1]
	6-[2-(4-Chlorophenyl)iminoacetyl]-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	12.0 [1]
	6-[2-(4-Chlorophenoxy)acetyl]-2-[2-(4-chlorophenyl)-2-methylhydrazinyl]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	3600.0 [1]
	6-[2-(4-Chlorophenoxy)acetyl]-2-[2-(4-chlorophenyl)-2-methylhydrazinyl]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	207.0 [1]
	4-[2-[2-Methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-3-morpholin-4-yl-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	IC50	238.0 [1]
	4-[2-[2-Methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-3-morpholin-4-yl-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	Ki	36.0 [1]
	4-[3-But-3-ynyl-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	IC50	62.0 [1]
	4-[3-But-3-ynyl-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	Ki	5.0 [1]
	3-But-3-ynyl-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	26.0 [1]
	3-(Dimethylamino)-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-6-(2,4,6-trifluorobenzoyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	216.0 [1]
	3-(Dimethylamino)-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-6-(2,4,6-trifluorobenzoyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	6.0 [1]
	3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	686.0 [1]
	3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	16.0 [1]
	6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	3710.0 [1]
	6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	25.0 [1]
	4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	IC50	156.0 [1]
	4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	Ki	11.0 [1]
	4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile	IC50	227.0 [1]
	4-[3-Ethoxy-4-oxo-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile	Ki	5.0 [1]
	3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	158.0 [1]
	3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	20.0 [1]
	3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	1684.0 [1]
	3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	17.0 [1]
	4-[4-Oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	IC50	648.0 [1]
	4-[4-Oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	Ki	10.0 [1]
	3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	IC50	298.0 [1]
	3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	Ki	6.0 [1]
	6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride	IC50	187.0 [1]
	6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride	Ki	17.0 [1]
	6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride	IC50	253.0 [1]
	6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride	Ki	25.0 [1]
	6-(4-Chlorobenzoyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride	IC50	140.0 [1]
	6-(4-Chlorobenzoyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride	Ki	17.0 [1]
	3-Fluoro-4-[4-oxo-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile;hydrochloride	IC50	42.0 [1]
	3-Fluoro-4-[4-oxo-3-prop-2-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile;hydrochloride	Ki	5.0 [1]
	6-[2-(4-Chlorophenoxy)acetyl]-2-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	1183.0 [1]
	6-[2-(4-Chlorophenoxy)acetyl]-2-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	15.0 [1]
	6-(4-Chlorobenzoyl)-3-methoxy-2-[2-[4-(trifluoromethyl)phenyl]pyrrolidin-1-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	34.0 [1]
	6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	3710.0 [1]
	6-(4-Chlorobenzoyl)-3-ethoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	25.0 [1]
	3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	686.0 [1]
	3-Methoxy-6-[4-(trifluoromethoxy)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	16.0 [1]
	4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	IC50	156.0 [1]
	4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	Ki	11.0 [1]
	4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile	IC50	227.0 [1]
	4-[3-Ethoxy-4-oxo-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile	Ki	5.0 [1]
	3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	158.0 [1]
	3-Ethoxy-6-[4-(1,3-oxazol-5-yl)benzoyl]-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	20.0 [1]
	3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	1684.0 [1]
	3-Ethoxy-6-(thieno[2,3-b]pyridine-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	17.0 [1]
	3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	IC50	298.0 [1]
	3-Fluoro-4-[4-oxo-3-pyrrolidin-1-yl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]benzonitrile	Ki	6.0 [1]
	6-[2-(4-Chlorophenyl)sulfanylacetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	1140.0 [1]
	6-[2-(4-Chlorophenyl)sulfanylacetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	8.0 [1]
	6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	824.0 [1]
	6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	12.0 [1]
	3-Methoxy-6-(5-methylthiophene-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	1128.0 [1]
	3-Methoxy-6-(5-methylthiophene-2-carbonyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	10.0 [1]
	6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	253.0 [1]
	6-(4-Chlorobenzoyl)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-3-(dimethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	25.0 [1]
	6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	187.0 [1]
	6-(4-Chlorobenzoyl)-3-(dimethylamino)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	17.0 [1]
	6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	824.0 [1]
	6-(5-Chloro-1-benzofuran-2-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	12.0 [1]
	6-(2,6-Dimethoxypyridine-3-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	228.0 [1]
	6-(2,6-Dimethoxypyridine-3-carbonyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	7.0 [1]
	6-(4-Chlorobenzoyl)-2-[1-(4-chlorophenyl)propylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	1570.0 [1]
	6-(4-Chlorobenzoyl)-2-[1-(4-chlorophenyl)propylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	44.0 [1]
	6-[2-(4-Chlorophenoxy)acetyl]-2-[1-(4-chlorophenyl)ethylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	1183.0 [1]
	6-[2-(4-Chlorophenoxy)acetyl]-2-[1-(4-chlorophenyl)ethylamino]-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	15.0 [1]
	6-(4-Ethoxybenzoyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	1285.0 [1]
	6-(4-Ethoxybenzoyl)-3-methoxy-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	9.0 [1]
	6-[2-(4-Chlorophenoxy)acetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	IC50	678.0 [1]
	6-[2-(4-Chlorophenoxy)acetyl]-3-methoxy-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one	Ki	8.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Prolactin-releasing peptide receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/prolactin-releasing-peptide-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Prolactin-releasing peptide receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/prolactin-releasing-peptide-receptor-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan