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Prolyl endopeptidase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
(2S)-1-(2-Benzyl-3-oxo-1H-isoindole-4-carbonyl)pyrrolidine-2-carbonitrileIC5081.0 [1]
(2S)-1-(2-Benzyl-3-oxo-1H-isoindole-4-carbonyl)pyrrolidine-2-carbonitrileKi23.0 [1]
N-Benzyl-2-[(2S)-2-cyanopyrrolidine-1-carbonyl]benzamideIC5073.0 [1]
2-Benzyl-7-(pyrrolidine-1-carbonyl)-3H-isoindol-1-oneIC50610.0 [1]
TalabostatIC50980.0 [1]
Benzyl N-[(3R,6R,7aS)-3-cyano-5-oxo-3,6,7,7a-tetrahydro-2H-pyrrolo[2,1-b][1,3]thiazol-6-yl]carbamateIC501300.0 [1]
Benzyl N-[(2R)-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]carbamateIC502000.0 [1]
Benzyl N-[2-[(2R)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]carbamateIC50690.0 [1]
Benzyl N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]carbamateIC5095.0 [1]
Benzyl N-[(2S)-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]carbamateIC507.0 [1]
LinagliptinIC50100000.0 [1]
N-(N-(Phenyl)butyryl-L-prolyl)pyrrolidineIC5015.0 [1], 49.0 [2], 190.0 [3]
N-(N-(Phenyl)butyryl-L-prolyl)pyrrolidineKi0.97 [1]
SitagliptinIC50100000.0 [1]
(2s)-1-[1-(4-Phenylbutanoyl)-L-Prolyl]pyrrolidine-2-CarbonitrileKi0.02 [1], 0.92 [2], 0.95 [3]
CID 9929984IC502.0 [1]
CID 9929984Ki1.5 [1]
Py(D)AlaboroProIC50990.0 [1], 13000.0 [2]
Py(D)AlaboroProKi3100.0 [1]
(S)-Benzyl 2-((S)-2-(5-phenylisoxazole-3-carbonyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylateKi0.21 [1], 10.0 [2], 15.0 [3]
(S)-Benzyl 2-((S)-2-(isoxazole-3-carbonyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylateKi36.0 [1], 72.0 [2]
Benzyl (2S)-2-[(2S)-2-[5-(phenylmethoxymethyl)-1,2-oxazole-3-carbonyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylateKi1.25 [1], 4.0 [2], 6.0 [3]
(S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamideIC501800.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50860.0 [1], 83500.0 [2]
5-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC5050000.0 [1]
BaicalinIC5012000.0 [1], 12300.0 [2]
VildagliptinIC5050000.0 [1], 100000.0 [2]
Z-Pro-prolinalIC501.1 [1]
Z-Pro-prolinalKi4.3 [1]
(R)-1-(2-(1-Oxoisoindolin-2-yl)acetyl)pyrrolidin-2-ylboronic acidIC507.2 [1]
(R)-1-(2-(1-Oxoisoindolin-2-yl)acetyl)pyrrolidin-2-ylboronic acidKi2.8 [1]
(R)-1-(2-Acetamidoacetyl)pyrrolidin-2-ylboronic acidKi211.0 [1]
(3S)-1,2,3,4-Tetrahydro-3-[(pyrrolidine-1-yl)carbonyl]-2-(4-phenylbutyryl)isoquinolineIC507.0 [1], 550.0 [2]
(R)-1-(2-(2,5-Dichlorobenzamido)acetyl)pyrrolidin-2-ylboronic acidKi2.2 [1]
(R)-1-((R)-2-Acetamidopropanoyl)pyrrolidin-2-ylboronic acidIC50130.0 [1]
(R)-1-((R)-2-Acetamidopropanoyl)pyrrolidin-2-ylboronic acidKi2705.0 [1]
(2S)-1-[(3As,4R,7aR)-2-benzyl-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindole-4-carbonyl]pyrrolidine-2-carbonitrileKi0.75 [1], 1.0 [2]
Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylateIC5086.0 [1], 600.0 [2]
Benzyl 2-[2-(1,2-thiazole-3-carbonyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylateKi0.26 [1], 16.0 [2]
Benzyl (2S)-2-[(2S)-2-(5-cyano-1,2-oxazole-3-carbonyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylateKi7.5 [1], 38.0 [2]
Benzyl (2S)-2-[(2S)-2-(5-trimethylsilyl-1,2-oxazole-3-carbonyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylateKi0.45 [1], 19.0 [2]
Dimethyl 3-[(2S)-1-[(2S)-1-phenylmethoxycarbonylpyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]-1,2-oxazole-4,5-dicarboxylateKi1000.0 [1]
N-[3-[(3-Acetamidophenoxy)-[1-(pyrrolidine-2-carbonyl)pyrrolidin-2-yl]phosphoryl]oxyphenyl]acetamide;hydrochlorideIC5050000.0 [1], 89000.0 [2]
N-[2-[(2S)-2-Cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamideIC504800.0 [1], 4840.0 [2]
[(2R)-1-[(2S)-3-Methyl-2-(pyridine-3-carbonylamino)butanoyl]pyrrolidin-2-yl]boronic acidIC501.3 [1]
[(2R)-1-[(2S)-3-Methyl-2-(pyridine-3-carbonylamino)butanoyl]pyrrolidin-2-yl]boronic acidKi0.73 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxy-2-methylquinoline-4-carboxamideIC5053600.0 [1]
5-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC5016800.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-5-carboxamideIC503400.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-methylquinoline-4-carboxamideIC50640.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamideIC5011300.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-8-carboxamideIC508200.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-6-fluoroquinoline-4-carboxamideIC50610.0 [1]
6-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50840.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-6-(trifluoromethoxy)quinoline-4-carboxamideIC50710.0 [1]
8-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50350.0 [1]
8-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50360.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-6-methoxyquinoline-4-carboxamideIC506100.0 [1]
7-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC501200.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(3,4-dimethoxyphenyl)pyridine-4-carboxamideIC5011800.0 [1]
2-(4-Cyanophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamideIC5029100.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-methyl-1,3-thiazole-5-carboxamideIC507200.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-methyl-1,3-oxazole-5-carboxamideIC5013700.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxyquinoline-4-carboxamideIC5038000.0 [1]
7-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC501400.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]piperidine-4-carboxamideIC505900.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-1,2,4-triazole-5-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-5-phenylquinoline-4-carboxamideIC508700.0 [1], 19400.0 [2]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-pyridin-4-ylacetamideIC502000.0 [1]
N-[(2R)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]quinoline-4-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-5-methylquinoline-4-carboxamideIC509100.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-[1,2,4]triazolo[1,5-a]pyrimidine-7-carboxamideIC5024000.0 [1]
7-Anilino-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC502030.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1,7-naphthyridine-4-carboxamideIC503400.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(1H-imidazol-5-yl)acetamideIC5022000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-phenylpyridine-4-carboxamideIC5014200.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methylimidazole-4-carboxamideIC506600.0 [1]
N-[(2R)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]quinoline-4-carboxamideIC505800.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-7-phenylquinoline-4-carboxamideIC508700.0 [1], 19400.0 [2]
N-[2-[(2S)-2-Cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]-6-methoxyquinoline-4-carboxamideIC508300.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2H-triazole-4-carboxamideIC50100000.0 [1]
QuercetinIC5013000.0 [1]
KaempferolIC50200000.0 [1]
RutinIC50200000.0 [1]
BaicaleinIC5036000.0 [1]
AlogliptinIC50100000.0 [1]
beta-Boswellic acidIC509750.0 [1]
Acetyl-11-keto-beta-boswellic acidIC507890.0 [1]
Berberine chlorideIC50145000.0 [1]
11-Keto-beta-boswellic acidIC5036320.0 [1]
OmarigliptinIC5067000.0 [1]
3,7-DihydroxyflavoneIC50200000.0 [1]
PolyozellinIC502720.0 [1]
GosogliptinIC5030000.0 [1]
Ala-boroProIC501000.0 [1]
Kynapcin-12IC501250.0 [1]
Abt-279Ki30000.0 [1]
(R)-1-(2-Aminoacetyl)pyrrolidin-2-ylboronic acidIC5047000.0 [1]
N-(1-Napthalenecarbonyl)-Gly-boroProIC501.8 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Prolyl endopeptidase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/prolyl-endopeptidase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Prolyl endopeptidase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/prolyl-endopeptidase-inhibitors-ic50-ki.
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