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Prostaglandin E synthase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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3-(3-(Tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acidIC502100.0 [1]
2-(9-Chloro-1h-Phenanthro[9,10-D]imidazol-2-Yl)benzene-1,3-DicarbonitrileIC5056.0 [1]
1-(5-Chloro-1,3-benzoxazol-2-yl)-N-[4-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamideIC50383.0 [1]
1-[5-Chloro-6-(4-chlorophenyl)-1,3-benzoxazol-2-yl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamideIC50109.0 [1]
2-Bromo-5-[(2,2-dimethylpropanoylamino)methyl]-N-(1H-imidazol-2-yl)benzamideIC50180.0 [1]
LicofeloneIC503900.0 [1], 6000.0 [2], 6700.0 [3]
N-[4-(3,4-Dichlorophenyl)phenyl]-4-hydroxy-1,1-dioxo-2H-1lambda6,2-benzothiazine-3-carboxamideIC5016.0 [1], 16.5 [2], 420.0 [3], 500.0 [4], 5000.0 [5]
2-Chloro-5-{[(2,2-Dimethylpropanoyl)amino]methyl}-N-(1h-Imidazol-2-Yl)benzamideIC500.24 [1], 0.87 [2], 240.0 [3], 740.0 [4], 870.0 [5]
2-(Difluoromethyl)-5-[(2-methylpropanoylamino)methyl]-N-[5-methyl-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]pyridine-3-carboxamideIC500.9 [1], 0.94 [2], 12.0 [3]
2-Chloro-N-(1H-imidazol-2-yl)-5-[(2-methylpropanoylamino)methyl]benzamideIC500.89 [1], 2.77 [2], 792.0 [3], 890.0 [4], 2770.0 [5]
N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamideIC5010000.0 [1], 20000.0 [2]
3-(1-(4-Chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acidIC503.0 [1], 7.0 [2], 12.0 [3], 62.0 [4]
1-(5-Chloro-1,3-benzoxazol-2-yl)-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamideIC5065.0 [1], 340.0 [2]
2-(2-Chloro-6-fluoroanilino)-7,7-dimethyl-N-[4-(trifluoromethyl)phenyl]-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC503.9 [1], 10.0 [2], 275.0 [3]
2-(2-Chloro-6-fluoroanilino)-1,7,7-trimethyl-N-[4-(trifluoromethyl)phenyl]-8H-furo[3,2-e]benzimidazole-5-carboxamideIC502.6 [1], 3.2 [2], 3.3 [3], 897.0 [4]
1-[5-Chloro-6-(trifluoromethyl)-1,3-benzoxazol-2-yl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamideIC5033.0 [1], 174.0 [2]
1-(5-Chloro-6-methyl-1,3-benzoxazol-2-yl)-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]piperidine-4-carboxamideIC5025.0 [1], 338.0 [2], 340.0 [3]
2-(2-Chloro-6-fluoroanilino)-N-[4-fluoro-3-(trifluoromethyl)phenyl]-7,7-dimethyl-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC505.0 [1], 14.0 [2], 208.0 [3], 2320.0 [4]
2-(2-Chloro-6-fluoroanilino)-1,7,7-trimethyl-N-[3-(trifluoromethyl)phenyl]-8H-furo[3,2-e]benzimidazole-5-carboxamideIC503.0 [1], 5.7 [2], 405.0 [3], 3180.0 [4]
Mpges1-IN-3IC508.0 [1], 16.24 [2], 249.9 [3], 1900.0 [4]
2-(2-Chloro-6-fluoroanilino)-N-[2-fluoro-5-(trifluoromethyl)phenyl]-7,7-dimethyl-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC503.0 [1], 9.6 [2], 256.0 [3], 2470.0 [4]
CurcuminIC50200.0 [1], 220.0 [2], 300.0 [3]
CelecoxibIC50425.0 [1], 540.0 [2]
beta-Boswellic acidIC505000.0 [1]
ArzanolIC50400.0 [1]
CID 11526708IC503.0 [1], 23.0 [2], 960.0 [3]
N-(4-Chloro-3-(5-methylbenzo[d]oxazol-2-yl)phenyl)-2-(trifluoromethyl)benzamideIC501300.0 [1]
Ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylateIC506010.0 [1], 9200.0 [2]
1,3,5-Trimethyl-4-dodecanoyl-1H-pyrrole-2-propionic acidIC50670.0 [1], 800.0 [2]
5-[5-Bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[2-[4-(trifluoromethyl)phenyl]ethynyl]pyridineIC500.8 [1], 7.0 [2], 3940.0 [3]
Ethyl 2-[(2-chlorophenyl)methyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylateIC50100.0 [1], 960.0 [2], 20500.0 [3]
5-(4-Tert-Butylphenyl)-1-[4-(Propan-2-Yloxy)phenyl]-1h-Indole-2-Carboxylic AcidIC5062.0 [1], 216.0 [2], 2580.0 [3]
1-Benzyl-1-(biphenyl-3-ylmethyl)-3-isopropylureaIC501700.0 [1], 11900.0 [2]
1-(3-(Cyclopropylethynyl)benzyl)-3-isopropyl-1-(3-(phenylethynyl)benzyl)ureaIC501.0 [1], 160.0 [2]
N-(4-Chloro-2-fluorophenyl)-2-[2,6-dichloro-3-[(2,2-dimethylpropanoylamino)methyl]anilino]-6-(2,2-difluoroethoxy)-1-methylbenzimidazole-5-carboxamideIC503.0 [1], 4.0 [2]
(4S)-N-[(2S,4S)-2-(Hydroxymethyl)oxan-4-yl]-3,3-dimethyl-1-(8-methylquinolin-2-yl)piperidine-4-carboxamideIC502.0 [1], 5.0 [2], 7.0 [3]
(4S)-3,3-Dimethyl-1-(8-methylquinolin-2-yl)-N-[(3S)-oxan-3-yl]piperidine-4-carboxamideIC507.0 [1], 36.0 [2], 72.0 [3]
(4S)-3,3-Dimethyl-N-[(2R)-3-methylbutan-2-yl]-1-(8-methylquinolin-2-yl)piperidine-4-carboxamideIC5012.0 [1], 77.0 [2], 89.0 [3]
(4S)-N-[4-(Hydroxymethyl)cyclohexyl]-3,3-dimethyl-1-(8-methylquinolin-2-yl)piperidine-4-carboxamideIC501.0 [1], 2.0 [2]
(4S)-1-(8-Chloroquinolin-2-yl)-N-[4-(hydroxymethyl)cyclohexyl]-3,3-dimethylpiperidine-4-carboxamideIC504.0 [1], 23.0 [2], 30.0 [3]
(4S)-N-[(1S,3S)-3-(Hydroxymethyl)cyclohexyl]-3,3-dimethyl-1-[4-(trifluoromethyl)phenyl]piperidine-4-carboxamideIC503.0 [1], 5.0 [2], 11.0 [3]
(4S)-N-[(1S,3S)-3-(Hydroxymethyl)cyclohexyl]-3,3-dimethyl-1-(8-methylquinolin-2-yl)piperidine-4-carboxamideIC501.0 [1], 3.0 [2]
(4S)-3,3-Dimethyl-1-(8-methylquinolin-2-yl)-N-[(3S)-oxolan-3-yl]piperidine-4-carboxamideIC506.0 [1], 23.0 [2], 51.0 [3]
N-[[4-Chloro-3-[4-oxo-7-[4-(trifluoromethyl)phenyl]-3H-quinazolin-2-yl]phenyl]methyl]-2-methylpropanamideIC507.0 [1], 10.0 [2], 234.0 [3]
Unii-K399UL8ovbIC505.0 [1], 376.0 [2]
N-[[4-Chloro-3-[4-oxo-7-[4-(trifluoromethyl)phenyl]-3H-pyrido[2,3-d]pyrimidin-2-yl]phenyl]methyl]-2-methylpropanamideIC5010.0 [1], 11.0 [2], 328.0 [3]
2-(2-Chloro-6-fluoroanilino)-N-[6-(difluoromethyl)pyridin-3-yl]-7,7-dimethyl-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC5020.0 [1], 33.0 [2], 1335.0 [3]
1-[[3-[2-(4-Chlorophenyl)ethynyl]phenyl]methyl]-3-propan-2-yl-1-[[3-(2-pyridin-4-ylethynyl)phenyl]methyl]ureaIC502.0 [1], 340.0 [2], 2100.0 [3]
3-Propan-2-yl-1-[[3-(2-pyridin-3-ylethynyl)phenyl]methyl]-1-[[3-[2-[4-(trifluoromethyl)phenyl]ethynyl]phenyl]methyl]ureaIC503.0 [1], 330.0 [2], 7700.0 [3]
1-[[3-[2-(4-Chlorophenyl)ethynyl]phenyl]methyl]-3-propan-2-yl-1-[[3-(2-pyridin-2-ylethynyl)phenyl]methyl]ureaIC501.0 [1], 480.0 [2], 6700.0 [3]
1-[[3-[2-(4-Chlorophenyl)ethynyl]phenyl]methyl]-3-propan-2-yl-1-[[3-(2-pyridin-3-ylethynyl)phenyl]methyl]ureaIC501.0 [1], 240.0 [2], 9700.0 [3]
2-[(3,5-Dichloropyridin-4-yl)amino]-7,7-dimethyl-N-[4-(trifluoromethyl)phenyl]-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC505.8 [1], 7.2 [2], 164.0 [3]
2-(2,6-Dichloroanilino)-7,7-dimethyl-N-[2-(trifluoromethyl)phenyl]-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC504.9 [1], 5.2 [2], 506.0 [3]
2-(2,6-Dichloroanilino)-N-(2,6-difluorophenyl)-7,7-dimethyl-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC506.4 [1], 15.0 [2], 661.0 [3]
2-(2,6-Dichloroanilino)-7,7-dimethyl-N-[5-(trifluoromethyl)pyridin-2-yl]-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC504.1 [1], 8.4 [2], 261.0 [3]
2-(2-Chloro-6-methylanilino)-N-[2-fluoro-5-(trifluoromethyl)phenyl]-7,7-dimethyl-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC503.3 [1], 30.0 [2], 222.0 [3]
2-(2-Chloro-6-fluoroanilino)-7,7-dimethyl-N-[2-methyl-4-(trifluoromethyl)phenyl]-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC506.0 [1], 6.1 [2], 270.0 [3]
2-(2-Chloro-6-fluoroanilino)-N-(5-cyclopropyl-2-fluorophenyl)-7,7-dimethyl-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC503.6 [1], 6.0 [2], 1377.0 [3]
2-(2-Chloro-6-fluoroanilino)-N-(2-fluoro-4-methylphenyl)-1,7,7-trimethyl-8H-furo[3,2-e]benzimidazole-5-carboxamideIC503.1 [1], 16.0 [2], 177.0 [3]
N-(5-Cyclopropyl-2-fluorophenyl)-2-(2,6-dichloroanilino)-7,7-dimethyl-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC503.2 [1], 16.0 [2], 197.0 [3]
2-(2-Chloro-6-methylanilino)-7,7-dimethyl-N-[4-(trifluoromethyl)phenyl]-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC5011.0 [1], 14.0 [2], 337.0 [3]
2-(2-Chloro-6-fluoroanilino)-1,7,7-trimethyl-N-[5-(trifluoromethyl)pyridin-2-yl]-8H-furo[3,2-e]benzimidazole-5-carboxamideIC504.0 [1], 12.0 [2], 673.0 [3]
2-(2-Chloro-6-fluoroanilino)-N-(4-cyclopropylphenyl)-1,7,7-trimethyl-8H-furo[3,2-e]benzimidazole-5-carboxamideIC504.3 [1], 4.9 [2], 350.0 [3]
2-(2-Chloro-6-fluoroanilino)-N-[5-(difluoromethyl)-2-fluorophenyl]-7,7-dimethyl-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC506.3 [1], 9.2 [2], 336.0 [3]
2-(2-Chloro-6-fluoroanilino)-7,7-dimethyl-N-[5-(trifluoromethyl)pyridin-2-yl]-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC5014.0 [1], 25.0 [2], 955.0 [3]
2-(2-Chloro-6-methylanilino)-N-[4-fluoro-3-(trifluoromethyl)phenyl]-7,7-dimethyl-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC505.4 [1], 10.0 [2], 876.0 [3]
2-(2,6-Dichloroanilino)-7-methyl-N-[3-(trifluoromethyl)phenyl]-3H-furo[3,2-e]benzimidazole-5-carboxamideIC504.6 [1], 18.0 [2], 1890.0 [3]
2-(2,6-Dichloroanilino)-7,7-dimethyl-N-[4-(trifluoromethyl)phenyl]-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC503.7 [1], 4.4 [2], 234.0 [3]
2-(2-Chloro-6-fluoroanilino)-7,7-dimethyl-N-[2-(trifluoromethyl)phenyl]-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC505.1 [1], 9.7 [2], 536.0 [3]
N-(3-Chloro-2-methylphenyl)-6-[[2-chloro-6-(trifluoromethyl)benzoyl]amino]-2-(methoxymethyl)-1H-benzimidazole-4-carboxamideIC500.1 [1], 1.2 [2]
1-(5-Chloro-6-methyl-1,3-benzoxazol-2-yl)-N-(4-hydroxy-4-methylcyclohexyl)piperidine-4-carboxamideIC50610.0 [1], 4200.0 [2], 7400.0 [3]
2-(2-Chloro-6-fluoroanilino)-N-[4-fluoro-3-(trifluoromethyl)phenyl]-7,8-dihydro-3H-[1,4]dioxino[2,3-e]benzimidazole-5-carboxamideIC509.09 [1], 35.07 [2], 1127.0 [3]
2-(2-Chloro-6-fluoroanilino)-N-[3-fluoro-5-(trifluoromethyl)phenyl]-7,8-dihydro-3H-[1,4]dioxino[2,3-e]benzimidazole-5-carboxamideIC5011.04 [1], 14.34 [2], 632.5 [3]
2-(2-Chloro-6-fluoroanilino)-N-(4,4-dimethylcyclohexyl)-1-methyl-7,8-dihydro-[1,4]dioxino[2,3-e]benzimidazole-5-carboxamideIC507.2 [1], 30.62 [2], 835.0 [3]
2-(2-Chloro-6-fluoroanilino)-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-7,8-dihydro-[1,4]dioxino[2,3-e]benzimidazole-5-carboxamideIC507.99 [1], 26.69 [2], 1388.0 [3]
2-(2-Chloro-6-fluoroanilino)-1-methyl-N-[4-(trifluoromethyl)cyclohexyl]-7,8-dihydro-[1,4]dioxino[2,3-e]benzimidazole-5-carboxamideIC5015.25 [1], 65.0 [2], 541.9 [3]
2-(2-Chloro-6-methylanilino)-N-[3-fluoro-5-(trifluoromethyl)phenyl]-7,8-dihydro-3H-[1,4]dioxino[2,3-e]benzimidazole-5-carboxamideIC5010.41 [1], 27.82 [2], 959.6 [3]
2-(2-Chloro-6-fluoroanilino)-N-[4-(2-cyclopropylethynyl)-3-fluorophenyl]-7,8-dihydro-3H-[1,4]dioxino[2,3-e]benzimidazole-5-carboxamideIC503.56 [1], 16.21 [2], 277.3 [3]
2-(2-Chloro-6-fluoroanilino)-N-[2-fluoro-4-(trifluoromethyl)phenyl]-7,7-dimethyl-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC503.1 [1], 9.6 [2], 570.0 [3]
2-(2,6-Dichloroanilino)-7,7-dimethyl-N-(2,2,3,3,3-pentafluoropropyl)-3,8-dihydrofuro[3,2-e]benzimidazole-5-carboxamideIC506.2 [1], 12.0 [2], 302.0 [3]
Carnosic acidIC505000.0 [1]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-oneIC50600.0 [1], 1200.0 [2]
CarnosolIC505000.0 [1]
Acetyl-11-keto-beta-boswellic acidIC503000.0 [1]
11-Keto-beta-boswellic acidIC503000.0 [1], 10000.0 [2]
3-Acetyl-beta-boswellic acidIC503000.0 [1], 30000.0 [2]
2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoic acidIC503400.0 [1], 3900.0 [2]
Olivetoric acidIC50400.0 [1], 1150.0 [2]
CID 1232170IC501200.0 [1], 160000.0 [2]
2-[(3-Chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl esterIC50600.0 [1]
2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyl-2-naphthalen-1-ylacetic acidIC505100.0 [1]
CID 16730275IC501.0 [1]
2-[4-Chloro-6-[(4-phenylphenyl)methylamino]pyrimidin-2-yl]sulfanyloctanoic acidIC50650.0 [1], 1300.0 [2]
4-(3-Chlorobenzyl)-2,6-bis-(4-trifluoromethoxyphenyl)thieno[3,2-b]pyrrole-5-carboxylic AcidIC50390.0 [1]
2-(6-Chloro-9-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrileIC500.7 [1], 1.0 [2]
2-[4-Chloro-6-(4-phenylanilino)pyrimidin-2-yl]sulfanyloctanoic acidIC501600.0 [1]
Ethyl 2-[(3-bromophenyl)methyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylateIC50200.0 [1]
Ethyl 5-hydroxy-2-[(3-methoxyphenyl)methyl]-1H-benzo[g]indole-3-carboxylateIC50600.0 [1]
Ethyl 2-[(3-chlorophenyl)methyl]-5-hydroxy-7,8-dimethoxy-1H-benzo[g]indole-3-carboxylateIC501700.0 [1]
(2E)-2-[[2,5-Bis[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylidene]hexanoic acidIC5010000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Prostaglandin E synthase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/prostaglandin-e-synthase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Prostaglandin E synthase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/prostaglandin-e-synthase-inhibitors-ic50-ki.
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