 | Dinoprostone | IC50 | 2.2 [1], 2.6 [2], 3.3 [3], 37.7 [4] |
| Dinoprostone | Ki | 4.9 [1], 38.0 [2] |
 | Butaprost | Ki | 110.0 [1], 2400.0 [2] |
 | Acetic acid, (3-(((1S)-2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-, sodium salt | Ki | 1000.0 [1] |
 | 5-[[(2R)-1-(4-Tert-butylphenyl)-5-oxopyrrolidin-2-yl]methoxymethyl]furan-2-carboxylic acid | Ki | 189.0 [1], 4000.0 [2] |
 | 5-[[(2R)-1-(4-Tert-butylphenyl)-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acid | Ki | 27.0 [1], 501.0 [2] |
 | 4-[(1S)-1-[[(2R)-1-(2-Phenoxyethyl)piperidine-2-carbonyl]amino]ethyl]benzoic acid | Ki | 1210.0 [1], 1550.0 [2] |
 | Dinoprost | IC50 | 10000.0 [1], 100000.0 [2] |
 | 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid | Ki | 1150.0 [1] |
 | (S)-4-(1-(5-Chloro-2-(4-fluorophenoxy)benzamido)ethyl)benzoic acid | IC50 | 709.0 [1], 1000.0 [2] |
 | trans-2-(4-(1-Hydroxyhexyl)phenyl)-5-oxocyclopentaneheptanoic acid | Ki | 240.0 [1], 871.0 [2] |
 | 4-(2-((R)-2-((S)-3-Hydroxyoct-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoate | Ki | 120.0 [1], 130.0 [2] |
 | 2-[(3R)-5-Acetyl-4-[(4-chlorophenyl)methyl]-7-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid | Ki | 230.0 [1] |
 | (E)-3-{2-[(E)-3-(2-Benzyloxy-3-methyl-phenyl)-allyl]-phenyl}-acrylic acid | Ki | 8100.0 [1] |
 | (E)-3-[2-(3,4-Dichlorophenyl)phenyl]-N-thiophen-2-ylsulfonylprop-2-enamide | Ki | 10000.0 [1], 27000.0 [2] |
 | 2-[(3R)-4-[(4-Chlorophenyl)methyl]-5-(1-hydroxyethyl)-7-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid | Ki | 390.0 [1] |
 | 2-(2-Benzoyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)acetic acid | IC50 | 10000.0 [1] |
 | 7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid | Ki | 13000.0 [1], 164000.0 [2] |
 | 3-(2-((E)-3-(4-(Benzyloxy)-3-methoxyphenyl)prop-1-enyl)phenyl)-N-(thiophen-2-ylsulfonyl)acrylamide | Ki | 2415.0 [1], 8700.0 [2] |
 | N-[5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-yl]-4-ethyl-2,3-dihydro-1,4-benzoxazine-6-carboxamide | Ki | 10000.0 [1] |
 | 7-[(R)-2-((E)-3-Hydroxy-4-phenyl-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid | Ki | 13000.0 [1], 31000.0 [2] |
 | 4-(2-((R)-2-((S)-3-Hydroxyhept-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoate | Ki | 125.5 [1], 425.0 [2] |
 | 2-(4-Methyl-3,5-diphenyl-1H-pyrazole-1-yl)-4-thiazolecarboxylic acid | Ki | 8000.0 [1], 8700.0 [2] |
 | (E)-3-[2-[(E)-3-Phenylprop-1-enyl]phenyl]prop-2-enoic acid;(E)-3-[2-[(E)-3-phenylprop-2-enyl]phenyl]prop-2-enoic acid | Ki | 1400.0 [1] |
 | (E)-3-[2-[(E)-3-(4-Methoxyphenyl)prop-1-enyl]phenyl]prop-2-enoic acid;(E)-3-[2-[(E)-3-(4-methoxyphenyl)prop-2-enyl]phenyl]prop-2-enoic acid | Ki | 2500.0 [1] |
 | (Z)-7-[(1R,2R,3R,5R)-5-Chloro-2-[(E,4S)-4-(1-ethylcyclobutyl)-4-hydroxybut-1-enyl]-3-hydroxycyclopentyl]hept-5-enoic acid | Ki | 0.74 [1], 3.3 [2] |
 | 3-(2-(Naphthalen-2-ylmethyl)phenyl)acrylic acid | Ki | 12000.0 [1] |
 | 7-(1-Benzothiophen-3-yl)-9-ethoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 14000.0 [1], 30000.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-9-methoxy-4-(pyrimidin-5-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 20.0 [1], 80.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-9-methoxy-4-[(2-methoxypyridin-3-yl)methyl]-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 200.0 [1], 1100.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-9-methoxy-4-[(6-methoxypyridin-3-yl)methyl]-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 100.0 [1], 1500.0 [2] |
 | 5-[[7-(1-Benzothiophen-3-yl)-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]-1H-pyridin-2-one | IC50 | 200.0 [1], 500.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-4-benzyl-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 10000.0 [1], 30000.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-4-[(4-chlorophenyl)methyl]-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 30000.0 [1] |
 | 7-(1-Benzothiophen-3-yl)-9-methoxy-4-[(4-methylphenyl)methyl]-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 30000.0 [1] |
 | 7-(1-Benzothiophen-3-yl)-9-methoxy-4-[(4-methoxyphenyl)methyl]-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 1800.0 [1], 30000.0 [2] |
 | Methyl 4-[[7-(1-benzothiophen-3-yl)-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]benzoate | IC50 | 600.0 [1], 30000.0 [2] |
 | 4-[[7-(1-Benzothiophen-3-yl)-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]benzonitrile | IC50 | 600.0 [1], 30000.0 [2] |
 | 3-[[7-(1-Benzothiophen-3-yl)-9-methoxy-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]benzonitrile | IC50 | 100.0 [1], 1000.0 [2] |
 | 9-Methoxy-4-(pyridin-3-ylmethyl)-7-thiophen-3-yl-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 30000.0 [1] |
 | 7-(1-Benzothiophen-2-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 2800.0 [1], 4800.0 [2] |
 | 9-Methoxy-7-phenyl-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 15000.0 [1], 30000.0 [2] |
 | 9-Methoxy-7-naphthalen-1-yl-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 300.0 [1], 2500.0 [2] |
 | 9-Methoxy-7-(2-methylphenyl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 30000.0 [1] |
 | 9-Methoxy-7-(3-methylphenyl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 13000.0 [1], 15000.0 [2] |
 | 9-Methoxy-7-(4-methylphenyl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 30000.0 [1] |
 | 7-(2-Chlorophenyl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 12000.0 [1], 30000.0 [2] |
 | 7-(3-Chlorophenyl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 700.0 [1], 1900.0 [2] |
 | 7-(4-Chlorophenyl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 10000.0 [1], 30000.0 [2] |
 | 7-(1,2-Benzothiazol-3-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 400.0 [1], 600.0 [2] |
 | 7-(Benzimidazol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 6400.0 [1], 15000.0 [2] |
 | 7-Indol-1-yl-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 300.0 [1], 1000.0 [2] |
 | 7-(1H-Indol-3-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 2700.0 [1], 3000.0 [2] |
 | 9-Methoxy-7-(1-methylindol-3-yl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 1100.0 [1], 2500.0 [2] |
 | 7-(3-Chloroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 60.0 [1], 900.0 [2] |
 | 7-(4-Chloroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 400.0 [1], 3300.0 [2] |
 | 7-(5-Chloroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 80.0 [1], 700.0 [2] |
 | 7-(6-Chloroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 800.0 [1], 4000.0 [2] |
 | 7-(7-Chloroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 5600.0 [1], 30000.0 [2] |
 | 1-[9-Methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepin-7-yl]indole-5-carbonitrile | IC50 | 100.0 [1], 200.0 [2] |
 | 7-(5-Fluoroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 40.0 [1], 90.0 [2] |
 | 7-(5-Chloro-2,3-dihydroindol-1-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 30.0 [1], 60.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 1100.0 [1], 30000.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepin-9-ol | IC50 | 1500.0 [1], 3800.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-9-propan-2-yloxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 30000.0 [1] |
 | 7-(1-Benzothiophen-3-yl)-9-methyl-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 200.0 [1], 1000.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-9-chloro-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 80.0 [1], 2500.0 [2] |
 | 8-(1-Benzothiophen-3-yl)-2-(pyridin-3-ylmethyl)-1,3,4,5-tetrahydro-2-benzazepine | IC50 | 1600.0 [1], 30000.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-4-(pyridin-3-ylmethyl)-1,2,3,5-tetrahydro-1,4-benzodiazepine | IC50 | 6000.0 [1], 30000.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-1-methyl-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzodiazepine | IC50 | 4000.0 [1], 30000.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-5H-1,4-benzoxazepin-3-one | IC50 | 13000.0 [1], 30000.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-2,3-dihydro-1,4-benzoxazepin-5-one | IC50 | 30000.0 [1] |
 | 4-[[7-(1-Benzothiophen-3-yl)-9-chloro-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]-1H-pyridin-2-one | IC50 | 20.0 [1], 200.0 [2] |
 | 4-[[(3R)-7-(1-Benzothiophen-3-yl)-9-chloro-3-methyl-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]-1H-pyridin-2-one | IC50 | 8.0 [1], 200.0 [2] |
 | 4-[[(3R)-9-Chloro-7-(5-fluoroindol-1-yl)-3-methyl-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]-1H-pyridin-2-one | IC50 | 2.0 [1], 10.0 [2] |
 | 2-[5-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid | IC50 | 8000.0 [1] |
| 2-[5-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid | Ki | 8000.0 [1] |
 | 7-(1-Benzothiophen-3-yl)-9-methoxy-4-(pyridin-3-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 70.0 [1], 600.0 [2] |
 | 7-(1-Benzothiophen-3-yl)-9-methoxy-4-(pyridin-4-ylmethyl)-3,5-dihydro-2H-1,4-benzoxazepine | IC50 | 200.0 [1], 900.0 [2] |
 | 4-(2-Pyridyl)methyl-7-(1-benzothiophene-3-yl)-9-methoxy-2,3,4,5-tetrahydro-1,4-benzooxazepine | IC50 | 700.0 [1], 3000.0 [2] |
 | 4-[[9-Chloro-7-(5-fluoroindol-1-yl)-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]methyl]-1H-pyridin-2-one | IC50 | 8.0 [1], 50.0 [2] |
 | 5-[[(2R)-1-[4-(1-Hydroxyhexyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acid | Ki | 115.0 [1] |
 | 7-[(2S)-1-(4-Tert-butylphenyl)-5-oxopyrrolidin-2-yl]heptanoic acid | Ki | 10000.0 [1] |
 | 5-[[(2R)-1-[4-(1-Hydroxy-2-methylpropyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]furan-2-carboxylic acid | Ki | 10000.0 [1] |
 | 5-[[(2R)-1-[4-(1-Hydroxy-2-phenylethyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]furan-2-carboxylic acid | Ki | 2293.0 [1] |
 | 5-[[(2R)-1-[4-(1-Hydroxypentyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acid | Ki | 387.0 [1] |
 | 5-[[(2R)-1-[4-(1-Hydroxyheptyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acid | Ki | 10.0 [1], 190.0 [2] |
 | 5-[[(2R)-1-[4-(1-Hydroxybutyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acid | Ki | 1639.0 [1] |
 | 5-[[(2R)-1-[4-(1-Hydroxypropyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acid | Ki | 5731.0 [1] |
 | 5-(3-{(S)-1-[4-(1-Hydroxyhexyl)-phenyl]-5-oxo-pyrrolidin-2-yl}-propyl)-thiophene-2-carboxylic acid | Ki | 15.0 [1] |
 | 5-[3-[(2S)-1-(4-Hexanoylphenyl)-5-oxopyrrolidin-2-yl]propyl]thiophene-2-carboxylic acid | Ki | 31.0 [1] |
 | 5-[[(2R)-1-(4-Hexanoylphenyl)-5-oxopyrrolidin-2-yl]methoxymethyl]thiophene-2-carboxylic acid | Ki | 163.0 [1] |
 | 5-[3-[(2S)-1-[4-(1-Hydroxyheptyl)phenyl]-5-oxopyrrolidin-2-yl]propyl]thiophene-2-carboxylic acid | Ki | 8.0 [1] |
 | 4-[[(2R)-1-[4-(1-Hydroxyhexyl)phenyl]-5-oxopyrrolidin-2-yl]methoxy]benzoic acid | Ki | 22726.0 [1] |
 | (E)-3-[2-[(Z)-3-(3-Methoxy-4-phenylmethoxyphenyl)prop-2-enyl]phenyl]prop-2-enoic acid | Ki | 750.0 [1] |
 | 5-[[(2R)-1-[4-(1-Hydroxyhexyl)phenyl]-5-oxopyrrolidin-2-yl]methoxymethyl]furan-2-carboxylic acid | Ki | 2028.0 [1] |
 | Cloprostenol | IC50 | 3700.0 [1] |
 | Laropiprant | Ki | 136.0 [1] |
 | Grapiprant | Ki | 5000.0 [1] |
 | Ono-AE1-259 | Ki | 1.7 [1] |
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