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Prostanoid EP3 receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
DinoprostoneIC500.94 [1]
DinoprostoneKi0.33 [1], 5.0 [2]
N-(4,5-Dichlorothiophen-2-ylsulfonyl)-2-(3-(naphthalen-2-ylmethyl)-1H-indol-4-yloxy)acetamideIC503.0 [1], 5.0 [2]
(E)-3-[1'-[(2,4-Dichlorophenyl)methyl]-2'-oxospiro[1,3-thiazolidine-2,3'-indole]-7'-yl]-N-(4,5-dichlorothiophen-2-yl)sulfonylprop-2-enamideIC504.9 [1], 880.0 [2]
3-(2-(Naphthalen-2-ylmethyl)phenyl)-N-(thiophen-2-ylsulfonyl)acrylamideKi1.1 [1], 1.3 [2], 263.0 [3], 280.0 [4]
DG-041IC504.6 [1]
Acetic acid, (3-(((1S)-2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-, sodium saltKi1000.0 [1], 6800.0 [2]
N-[5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-yl]-4-ethyl-2,3-dihydro-1,4-benzoxazine-6-carboxamideIC503.1 [1]
N-[5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-yl]-4-ethyl-2,3-dihydro-1,4-benzoxazine-6-carboxamideKi1.26 [1], 4.4 [2]
5-(6-Naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dioneKi5.01 [1], 10.0 [2]
3-(2-(Naphthalen-2-ylmethyl)phenyl)acrylic acidKi20.0 [1], 47.0 [2], 400.0 [3]
2-[[3-(3,4-Dichlorophenyl)sulfanyl-1H-indol-4-yl]oxy]-N-(4,5-dichlorothiophen-2-yl)sulfonylacetamideIC500.3 [1], 1.1 [2], 1.3 [3]
2-[[3-(3,4-Dichlorophenyl)sulfonyl-1H-indol-4-yl]oxy]-N-(4,5-dichlorothiophen-2-yl)sulfonylacetamideIC501.0 [1], 3.6 [2], 4.7 [3]
(E)-3-(1-Benzylindol-7-yl)-N-thiophen-2-ylsulfonylprop-2-enamideIC5098.0 [1], 119.0 [2], 6129.0 [3]
(E)-3-[1-[(2,4-Dichlorophenyl)methyl]indol-7-yl]-N-thiophen-2-ylsulfonylprop-2-enamideIC502.0 [1], 357.0 [2]
2-[3-[(2,4-Dichlorophenyl)methyl]benzimidazol-4-yl]oxy-N-(4,5-dichlorothiophen-2-yl)sulfonylacetamideIC501.1 [1], 79.0 [2]
(E)-N-(4,5-Dichlorothiophen-2-yl)sulfonyl-3-[5-fluoro-3-methyl-1-(naphthalen-2-ylmethyl)indol-7-yl]prop-2-enamideIC507.0 [1], 36.0 [2]
DinoprostIC50110.0 [1], 322.0 [2]
(2E)-N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamideKi0.6 [1], 6.9 [2]
trans-2-(4-(1-Hydroxyhexyl)phenyl)-5-oxocyclopentaneheptanoic acidKi82.0 [1], 5200.0 [2]
2-[(3R)-5-Acetyl-4-[(4-chlorophenyl)methyl]-7-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidKi20000.0 [1]
(E)-3-{2-[(E)-3-(2-Benzyloxy-3-methyl-phenyl)-allyl]-phenyl}-acrylic acidKi7.0 [1]
(E)-3-[2-(3,4-Dichlorophenyl)phenyl]-N-thiophen-2-ylsulfonylprop-2-enamideKi25.0 [1]
2-[(3R)-4-[(4-Chlorophenyl)methyl]-5-(1-hydroxyethyl)-7-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acidKi20000.0 [1]
2-(2-Benzoyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)acetic acidIC5010000.0 [1], 25000.0 [2]
7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acidKi3340.0 [1], 20000.0 [2]
7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)-cyclopentyl]-heptanoic acidIC5010000.0 [1]
7-[(R)-2-((E)-3-Hydroxy-4-phenyl-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acidKi13000.0 [1], 100000.0 [2]
(E)-3-[1-[(3,4-Difluorophenyl)methyl]-3-methyl-2-oxo-3H-indol-7-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC501.4 [1], 10.7 [2]
3-(5-Fluoro-1-(3-methoxybenzyl)-3-methyl-1H-indol-7-yl)-N-(2,4,5-trifluorophenylsulfonyl)acrylamideIC505.7 [1], 261.0 [2]
2-(4-Methyl-3,5-diphenyl-1H-pyrazole-1-yl)-4-thiazolecarboxylic acidKi5000.0 [1]
(E)-3-[2-[(E)-3-Phenylprop-1-enyl]phenyl]prop-2-enoic acid;(E)-3-[2-[(E)-3-phenylprop-2-enyl]phenyl]prop-2-enoic acidKi100.0 [1]
(E)-3-[2-[(E)-3-(4-Methoxyphenyl)prop-1-enyl]phenyl]prop-2-enoic acid;(E)-3-[2-[(E)-3-(4-methoxyphenyl)prop-2-enyl]phenyl]prop-2-enoic acidKi68.0 [1]
(E)-3-(2-Naphthalen-2-yloxyphenyl)-N-thiophen-2-ylsulfonylprop-2-enamideKi153.0 [1], 1500.0 [2]
(E)-3-(2-Naphthalen-2-ylsulfinylphenyl)-N-thiophen-2-ylsulfonylprop-2-enamideKi17.0 [1], 200.0 [2]
(E)-3-(2-Naphthalen-2-ylsulfanylphenyl)-N-thiophen-2-ylsulfonylprop-2-enamideKi6.7 [1], 356.0 [2]
(E)-3-[2-[(6-Phenylmethoxynaphthalen-2-yl)methyl]phenyl]-N-thiophen-2-ylsulfonylprop-2-enamideKi0.6 [1], 2.4 [2]
6-(1-Ethyl-4-methylindazol-6-yl)-3-[(3R)-3-methyl-2-oxopyrrolidin-3-yl]-1H-pyridin-2-oneKi31.6 [1]
6-(4-Chloro-1-methylindazol-6-yl)-3-[(3R)-3-methyl-2-oxopiperidin-3-yl]-1H-pyridin-2-oneKi3.6 [1]
6-(7-Chloro-1-methylbenzimidazol-5-yl)-3-[(3R)-3-methyl-2-oxopiperidin-3-yl]-1H-pyridin-2-oneKi7.8 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-4-ethyl-2,3-dihydro-1,4-benzoxazine-6-carboxamideIC5074.3 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-4-ethyl-2,3-dihydro-1,4-benzoxazine-6-carboxamideKi77.0 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-methylindazole-6-carboxamideIC501679.0 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-methylindazole-6-carboxamideKi1066.0 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-methylindazole-5-carboxamideIC506700.0 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-methylindazole-5-carboxamideKi5890.0 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-ethylindazole-6-carboxamideIC50362.0 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-ethylindazole-6-carboxamideKi310.0 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-propan-2-ylindazole-6-carboxamideIC502850.0 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-propan-2-ylindazole-6-carboxamideKi584.0 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-methylpyrazolo[4,3-b]pyridine-6-carboxamideIC5010000.0 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-methylpyrazolo[4,3-b]pyridine-6-carboxamideKi9650.0 [1]
4-Chloro-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-1-ethylindazole-6-carboxamideIC5018.1 [1]
4-Chloro-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-1-ethylindazole-6-carboxamideKi14.1 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-ethyl-4-fluoroindazole-6-carboxamideIC5061.7 [1]
N-(5-Cyclopropyl-1,3,4-thiadiazol-2-yl)-1-ethyl-4-fluoroindazole-6-carboxamideKi38.3 [1]
2-[5-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidIC505000.0 [1]
2-[5-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acidKi5000.0 [1]
(E)-N-(5-Bromo-2-methoxyphenyl)sulfonyl-3-[2-[(6-phenylmethoxynaphthalen-2-yl)methyl]phenyl]prop-2-enamideKi0.7 [1], 0.9 [2]
N-(5-(Pentan-3-yl)-1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamideKi79.43 [1], 100.0 [2]
3-(2-((6-(Benzyloxy)naphthalen-2-yl)methyl)phenyl)acrylic acidKi3.2 [1], 46.0 [2]
(E)-3-[1-[(3,4-Difluorophenyl)methyl]-3a-methyl-2-oxo-3,4,5,6-tetrahydroindol-7-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC503.5 [1], 7.7 [2]
(E)-3-(1-Methyl-4-naphthalen-2-yloxyindol-3-yl)-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC509.2 [1], 28.0 [2]
(E)-N-(3,4-Difluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC507.4 [1], 15.9 [2]
(E)-3-[4-(3,4-Dichlorophenoxy)-1-methylindol-3-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamideIC5012.4 [1], 50.8 [2]
(E)-N-(3-Chlorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC5015.7 [1], 35.0 [2]
(E)-N-(4,5-Dichlorothiophen-2-yl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC504.6 [1], 89.6 [2]
(E)-N-(4-Fluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC509.4 [1], 182.3 [2]
(E)-N-(2-Chlorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC5018.4 [1], 1682.0 [2]
(E)-N-(3,4-Dichlorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC5011.8 [1], 92.9 [2]
(E)-N-(2,4-Dichlorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC5054.1 [1], 1542.0 [2]
(E)-N-(3,5-Dichlorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC508.7 [1], 321.3 [2]
(E)-N-(2,4-Difluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC503.5 [1], 115.3 [2]
(E)-N-(2,5-Difluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC506.5 [1], 156.7 [2]
(E)-N-(2,6-Difluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC505.9 [1], 709.6 [2]
(E)-N-(3,5-Difluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC5044.9 [1], 156.7 [2]
(E)-N-(3-Fluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC5017.5 [1], 115.5 [2]
(E)-N-(2-Fluorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC5011.9 [1], 646.4 [2]
(E)-N-(4-Chlorophenyl)sulfonyl-3-(1-methyl-4-naphthalen-2-yloxyindol-3-yl)prop-2-enamideIC5021.9 [1], 1100.0 [2]
(E)-3-[4-(2,4-Dichlorophenoxy)-1-methylindol-3-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamideIC5011.8 [1], 23.7 [2]
(E)-3-[4-(4-Chlorophenoxy)-1-methylindol-3-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamideIC5027.3 [1], 776.2 [2]
(E)-3-[4-(3,4-Difluorophenoxy)-1-methylindol-3-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamideIC504.7 [1], 195.9 [2]
(E)-3-[4-(4-Chloro-3-fluorophenoxy)-1-methylindol-3-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamideIC5023.4 [1], 612.4 [2]
(E)-3-[4-(4-Chloro-2-fluorophenoxy)-1-methylindol-3-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamideIC507.2 [1], 124.0 [2]
(E)-3-[4-(2-Chloro-4-fluorophenoxy)-1-methylindol-3-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamideIC5013.8 [1], 145.8 [2]
(E)-N-(3,4-Difluorophenyl)sulfonyl-3-(1-methyl-4-quinolin-6-yloxyindol-3-yl)prop-2-enamideIC501.9 [1], 129.8 [2]
(E)-N-(3,4-Difluorophenyl)sulfonyl-3-(1-methyl-4-quinoxalin-2-yloxyindol-3-yl)prop-2-enamideIC506.1 [1], 216.5 [2]
(E)-3-[4-(3,4-Dichlorophenoxy)-1-methylindol-3-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC502.6 [1], 45.2 [2]
(E)-3-[4-(2,4-Dichlorophenoxy)-1-methylindol-3-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC503.2 [1], 16.7 [2]
(E)-3-[4-(4-Chlorophenoxy)-1-methylindol-3-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC503.0 [1], 392.9 [2]
(E)-3-[4-(3,4-Difluorophenoxy)-1-methylindol-3-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC503.8 [1], 209.5 [2]
(E)-3-[4-(3-Chloro-4-fluorophenoxy)-1-methylindol-3-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC509.7 [1], 61.1 [2]
(E)-3-[4-(4-Chloro-3-fluorophenoxy)-1-methylindol-3-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC506.7 [1], 53.9 [2]
(E)-3-[4-(4-Chloro-2-fluorophenoxy)-1-methylindol-3-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC504.4 [1], 155.7 [2]
(E)-3-[4-(2-Chloro-4-fluorophenoxy)-1-methylindol-3-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC5018.1 [1], 316.3 [2]
(E)-3-(1-Methyl-4-quinolin-6-yloxyindol-3-yl)-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC508.5 [1], 167.8 [2]
(E)-3-(1-Methyl-4-quinoxalin-2-yloxyindol-3-yl)-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamideIC507.2 [1], 128.2 [2]
(E)-3-[4-(3-Chloro-4-fluorophenoxy)-1-methylindol-3-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamideIC5026.9 [1], 81.5 [2]
N-(4,5-Dichlorothiophen-2-yl)sulfonyl-2-[[3-(2,5-dimethoxyphenyl)sulfonyl-1H-indol-4-yl]oxy]acetamideIC506.1 [1], 7.9 [2]
2-[[3-(1,3-Benzothiazol-2-ylsulfonyl)-1H-indol-4-yl]oxy]-N-(4,5-dichlorothiophen-2-yl)sulfonylacetamideIC507.6 [1], 44.0 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Prostanoid EP3 receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/prostanoid-ep3-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Prostanoid EP3 receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/prostanoid-ep3-receptor-inhibitors-ic50-ki.
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