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Prostanoid EP4 receptor Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
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▼
DinoprostoneIC500.7 [1]
DinoprostoneKi0.79 [1], 3.1 [2]
GrapiprantIC5011.7 [1]
GrapiprantKi13.0 [1], 448.0 [2], 449.0 [3]
1-(2,6-Dichlorophenyl)sulfonyl-3-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]ureaIC503.0 [1], 14.0 [2], 78.0 [3]
1-(2,6-Dichlorophenyl)sulfonyl-3-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]ureaKi0.3 [1], 3.1 [2]
4-[(1S)-1-[[(2R)-1-(2-Phenoxyethyl)piperidine-2-carbonyl]amino]ethyl]benzoic acidIC505.62 [1], 6.9 [2], 123.0 [3], 126.0 [4]
4-[(1S)-1-[[(2R)-1-(2-Phenoxyethyl)piperidine-2-carbonyl]amino]ethyl]benzoic acidKi40.6 [1], 54.0 [2]
CID 24952929IC502.5 [1], 2.9 [2], 11.0 [3]
CID 24952929Ki0.5 [1], 0.56 [2], 0.97 [3]
3-[[3-(3-Chlorophenyl)naphthalene-1-carbonyl]amino]-2,4-dimethylbenzoic acidIC503.62 [1], 243.0 [2]
3-[[3-(3-Chlorophenyl)naphthalene-1-carbonyl]amino]-2,4-dimethylbenzoic acidKi3.49 [1]
3-[[3-[3-(Hydroxymethyl)phenyl]naphthalene-1-carbonyl]amino]-2,4-dimethylbenzoic acidIC502.42 [1], 6.2 [2]
3-[[3-[3-(Hydroxymethyl)phenyl]naphthalene-1-carbonyl]amino]-2,4-dimethylbenzoic acidKi1.98 [1]
Unii-86KF5vsv88IC501.3 [1], 1.8 [2], 9.5 [3]
Unii-86KF5vsv88Ki0.23 [1], 0.34 [2]
1-(2-Chlorophenyl)sulfonyl-3-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]ureaIC502.4 [1], 33.0 [2], 423.0 [3]
1-(2-Chlorophenyl)sulfonyl-3-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]ureaKi0.16 [1], 2.3 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(2-methoxyphenyl)sulfonylureaIC503.8 [1], 23.0 [2], 162.0 [3]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(2-methoxyphenyl)sulfonylureaKi0.17 [1], 3.0 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(2,6-dimethoxyphenyl)sulfonylureaIC503.3 [1], 21.0 [2], 102.0 [3]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(2,6-dimethoxyphenyl)sulfonylureaKi0.34 [1], 1.6 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(2,6-dimethylphenyl)sulfonylureaIC503.2 [1], 19.0 [2], 77.0 [3]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(2,6-dimethylphenyl)sulfonylureaKi0.4 [1], 1.6 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(4-methylphenyl)sulfonylureaIC501.5 [1], 17.0 [2], 613.0 [3]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(4-methylphenyl)sulfonylureaKi0.11 [1], 10.0 [2]
CID 91810751IC502.36 [1], 38.7 [2]
(S)-4-(1-(1-(3-Chlorobenzyl)-1H-indole-7-carboxamido)ethyl)benzoic acidIC505.9 [1], 6.0 [2]
(S)-4-(1-(1-(3-Chlorobenzyl)-1H-indole-7-carboxamido)ethyl)benzoic acidKi2.7 [1]
1-(2-Chlorophenyl)sulfonyl-3-[1-[[3-methyl-4-[6-oxo-5,9-bis(2,2,2-trifluoroethoxy)-8H-pyrrolo[3,4-g]quinolin-7-yl]phenyl]methyl]cyclopropyl]ureaIC503.0 [1], 48.0 [2]
1-(2-Chlorophenyl)sulfonyl-3-[1-[[3-methyl-4-[6-oxo-5,9-bis(2,2,2-trifluoroethoxy)-8H-pyrrolo[3,4-g]quinolin-7-yl]phenyl]methyl]cyclopropyl]ureaKi0.48 [1], 14.0 [2]
1-[1-[[3-Methyl-4-[6-oxo-5,9-bis(2,2,2-trifluoroethoxy)-8H-pyrrolo[3,4-g]quinolin-7-yl]phenyl]methyl]cyclopropyl]-3-naphthalen-2-ylsulfonylureaIC508.9 [1], 103.0 [2]
1-[1-[[3-Methyl-4-[6-oxo-5,9-bis(2,2,2-trifluoroethoxy)-8H-pyrrolo[3,4-g]quinolin-7-yl]phenyl]methyl]cyclopropyl]-3-naphthalen-2-ylsulfonylureaKi1.2 [1], 21.0 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-[2-(trifluoromethyl)phenyl]sulfonylureaIC503.3 [1], 28.0 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-[2-(trifluoromethyl)phenyl]sulfonylureaKi0.39 [1], 8.9 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(2-methylphenyl)sulfonylureaIC503.3 [1], 14.0 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(2-methylphenyl)sulfonylureaKi0.23 [1], 3.0 [2]
1-(2-Bromophenyl)sulfonyl-3-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]ureaIC502.2 [1], 22.0 [2]
1-(2-Bromophenyl)sulfonyl-3-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]ureaKi0.49 [1], 7.5 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-naphthalen-2-ylsulfonylureaIC502.5 [1], 37.0 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-naphthalen-2-ylsulfonylureaKi0.52 [1], 6.3 [2]
1-(2,3-Dichlorophenyl)sulfonyl-3-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]ureaIC502.0 [1], 28.0 [2]
1-(2,3-Dichlorophenyl)sulfonyl-3-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]ureaKi0.4 [1], 64.0 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(4-fluorophenyl)sulfonylureaIC504.6 [1], 80.0 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-(4-fluorophenyl)sulfonylureaKi0.48 [1], 21.0 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-[4-(trifluoromethoxy)phenyl]sulfonylureaIC508.3 [1], 370.0 [2]
1-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-[4-(trifluoromethoxy)phenyl]sulfonylureaKi0.66 [1], 57.0 [2]
N,N,5,7-Tetramethyl-3-[4-[2-[(4-methylphenyl)sulfonylcarbamoylamino]ethyl]phenyl]-1-benzothiophene-2-carboxamideIC501.2 [1]
N,N,5,7-Tetramethyl-3-[4-[2-[(4-methylphenyl)sulfonylcarbamoylamino]ethyl]phenyl]-1-benzothiophene-2-carboxamideKi0.54 [1], 1.4 [2], 2.6 [3]
3-[4-[2-[[2-(2-Methoxyphenyl)acetyl]amino]ethyl]phenyl]-N,N,5,7-tetramethyl-1-benzothiophene-2-carboxamideIC502.4 [1]
3-[4-[2-[[2-(2-Methoxyphenyl)acetyl]amino]ethyl]phenyl]-N,N,5,7-tetramethyl-1-benzothiophene-2-carboxamideKi0.2 [1], 3.4 [2], 17.0 [3]
2-(2-Chlorophenyl)-N-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]acetamideIC506.0 [1], 35.1 [2]
2-(2-Chlorophenyl)-N-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]acetamideKi0.32 [1], 1.3 [2]
N-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-2-(2-methoxyphenyl)acetamideIC504.6 [1], 16.0 [2]
N-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-2-(2-methoxyphenyl)acetamideKi0.2 [1], 0.68 [2]
2-(2,4-Dichlorophenyl)-N-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]acetamideIC502.1 [1], 10.2 [2]
2-(2,4-Dichlorophenyl)-N-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]acetamideKi0.34 [1], 0.53 [2]
3-[2-[[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]amino]-2-oxoethyl]-4-methoxybenzoic acidIC503.8 [1], 60.6 [2]
3-[2-[[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]amino]-2-oxoethyl]-4-methoxybenzoic acidKi0.18 [1], 6.2 [2]
N-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-2-(3-methoxypyridin-2-yl)acetamideIC504.9 [1], 23.6 [2]
N-[1-[[4-(4,9-Diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-2-(3-methoxypyridin-2-yl)acetamideKi0.16 [1], 1.44 [2]
4-[[6-(4-Hydroxy-1-piperidyl)-3-methyl-pyridine-2-carbonyl]amino]-3,5-dimethyl-benzoic acidIC505.62 [1], 123.0 [2]
4-[[6-(4-Hydroxy-1-piperidyl)-3-methyl-pyridine-2-carbonyl]amino]-3,5-dimethyl-benzoic acidKi58.0 [1], 76.0 [2]
ButaprostKi10000.0 [1]
(S)-4-(1-(5-Chloro-2-(4-fluorophenoxy)benzamido)ethyl)benzoic acidIC506.59 [1], 10.0 [2], 13.0 [3]
Acetic acid, (3-(((1S)-2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-, sodium saltKi1020.0 [1]
2-(2-Benzoyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)acetic acidIC5010000.0 [1]
CID 118174952IC5011.2 [1], 1980.0 [2]
CID 118174952Ki39.2 [1]
4-[[2-[3-(Hydroxymethyl)phenyl]quinoline-4-carbonyl]amino]-3,5-dimethylbenzoic acidIC503.08 [1], 501.0 [2]
4-[[2-[3-(Hydroxymethyl)phenyl]quinoline-4-carbonyl]amino]-3,5-dimethylbenzoic acidKi52.3 [1]
4-[[3-[3-(Hydroxymethyl)phenyl]naphthalene-1-carbonyl]amino]-3,5-dimethylbenzoic acidIC501.11 [1], 136.0 [2]
4-[[3-[3-(Hydroxymethyl)phenyl]naphthalene-1-carbonyl]amino]-3,5-dimethylbenzoic acidKi3.54 [1]
3,5-Dimethyl-4-[(3-phenylnaphthalene-1-carbonyl)amino]benzoic acidIC503.48 [1], 623.0 [2]
3,5-Dimethyl-4-[(3-phenylnaphthalene-1-carbonyl)amino]benzoic acidKi8.04 [1]
2,4-Dimethyl-3-[(3-phenylnaphthalene-1-carbonyl)amino]benzoic acidIC505.65 [1], 577.0 [2]
2,4-Dimethyl-3-[(3-phenylnaphthalene-1-carbonyl)amino]benzoic acidKi6.72 [1]
3-[[2-[3-(Hydroxymethyl)phenyl]quinoline-4-carbonyl]amino]-2,4-dimethylbenzoic acidIC505.2 [1], 312.0 [2]
3-[[2-[3-(Hydroxymethyl)phenyl]quinoline-4-carbonyl]amino]-2,4-dimethylbenzoic acidKi17.0 [1]
4-[4-[(2,6-Dimethylphenyl)carbamoyl]quinolin-2-yl]benzoic acidIC5025000.0 [1], 30000.0 [2]
4-[4-[(2,6-Dimethylphenyl)carbamoyl]quinolin-2-yl]benzoic acidKi19200.0 [1]
N-(2,6-Dimethylphenyl)-2-phenylquinoline-4-carboxamideIC50128.0 [1], 30000.0 [2]
N-(2,6-Dimethylphenyl)-2-phenylquinoline-4-carboxamideKi512.0 [1]
4-[(1S)-1-({[4-(3-Chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]-benzoic AcidIC5012.0 [1]
4-[(1S)-1-({[4-(3-Chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]-benzoic AcidKi6.4 [1], 7.9 [2]
4-[(1S)-1-({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]carbonyl}-amino)ethyl]benzoic AcidIC503.6 [1]
4-[(1S)-1-({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]carbonyl}-amino)ethyl]benzoic AcidKi1.3 [1]
4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]ethyl}benzoic acidIC504.5 [1]
4-{(1S)-1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]ethyl}benzoic acidKi1.4 [1]
2,5-Dimethyl-N-[1-[4-(2H-tetrazol-5-yl)phenyl]cyclopropyl]-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carboxamideIC502.3 [1]
2,5-Dimethyl-N-[1-[4-(2H-tetrazol-5-yl)phenyl]cyclopropyl]-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carboxamideKi0.6 [1], 0.63 [2]
4-[(1R)-1-({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoic acidIC501.8 [1]
4-[(1R)-1-({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoic acidKi0.87 [1], 0.9 [2]
4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)methyl]benzoic acidIC501.6 [1]
4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)methyl]benzoic acidKi0.72 [1], 0.9 [2]
4-[(1S)-1-({[4-(3-Chlorobenzyl)-2,5-dimethyl-3-thienyl]carbonyl}-amino)ethyl]benzoic AcidIC508.6 [1]
4-[(1S)-1-({[4-(3-Chlorobenzyl)-2,5-dimethyl-3-thienyl]carbonyl}-amino)ethyl]benzoic AcidKi3.1 [1]
4-{(1S)-1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]ethyl}benzoic AcidIC504.7 [1]
4-{(1S)-1-[({2,5-Dimethyl-4-[3-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]ethyl}benzoic AcidKi2.4 [1], 2.5 [2]
4-[(1S)-1-[[4-[(4-Chlorophenyl)methyl]-2,5-dimethylthiophene-3-carbonyl]amino]ethyl]benzoic acidIC505.4 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Prostanoid EP4 receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/prostanoid-ep4-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Prostanoid EP4 receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/prostanoid-ep4-receptor-inhibitors-ic50-ki.
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