Protein arginine N-methyltransferase 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	1-Isoquinolin-6-Yl-3-[2-Oxo-2-(Pyrrolidin-1-Yl)ethyl]urea	IC50	19.0 [1], 91.0 [2], 225.0 [3]
	1-(1,2,3-Benzothiadiazol-6-Yl)-3-[2-(Cyclohex-1-En-1-Yl)ethyl]urea	IC50	1600.0 [1], 2400.0 [2], 2500.0 [3]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-oxo-2-piperidin-1-ylethyl)urea	IC50	134.0 [1], 230.0 [2]
	1-Isoquinolin-6-yl-3-[2-oxo-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethyl]urea	IC50	24.0 [1], 240.0 [2]
	1-[2-(2,5-Dimethylpyrrolidin-1-yl)-2-oxoethyl]-3-isoquinolin-6-ylurea	IC50	22.0 [1], 134.0 [2]
	1-(7-Fluoroisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea	IC50	19.0 [1], 134.0 [2]
	1-[2-(4-Aminocyclohexyl)ethyl]-3-(1,2,3-benzothiadiazol-6-yl)urea	IC50	3600.0 [1], 10000.0 [2]
	CID 71268957	IC50	74000.0 [1]
	CID 46901937	IC50	40000.0 [1]
	N,N,N'-Trimethylethylenediamine	IC50	35000.0 [1]
	CID 44251522	IC50	40000.0 [1]
	C.I. Direct Red 23	IC50	7100.0 [1]
	CID 53315882	IC50	10000.0 [1]
	Bromo-deaza-SAH	IC50	2300.0 [1]
	6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	IC50	100000.0 [1]
	BMS pyrazole inhibitor 7f	IC50	25000.0 [1]
	2-[3-[[[(2S)-2-Aminopropanoyl]amino]methyl]phenyl]-N-benzyl-5-(trifluoromethyl)pyrazole-3-carboxamide	IC50	25000.0 [1]
	Benzo[d]imidazole inhibitors of PRMT4 from BMS	IC50	25000.0 [1]
	CID 53868701	IC50	22000.0 [1]
	MS023	IC50	4.0 [1]
	PRMT5 Inhibitor C17	IC50	100000.0 [1]
	2-[4-[(3-Fluorophenyl)methoxy]piperidin-1-yl]-N-methylethanamine	IC50	28000.0 [1]
	N-Methyl-2-[4-[(3-phenylphenyl)methoxy]piperidin-1-yl]ethanamine	IC50	1970.0 [1]
	1-(2-Oxo-2-piperidin-1-ylethyl)-3-quinazolin-7-ylurea	IC50	967.0 [1]
	1-Isoquinolin-6-yl-3-(2-phenylethyl)urea	IC50	833.0 [1]
	N,N-Diethyl-2-(isoquinolin-6-ylcarbamoylamino)acetamide	IC50	114.0 [1]
	N-Cyclopentyl-2-(isoquinolin-6-ylcarbamoylamino)acetamide	IC50	292.0 [1]
	1-(1-Methylisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea	IC50	194.0 [1]
	1-(8-Chloroisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea	IC50	19.0 [1]
	1-[2-(8-Azabicyclo[3.2.1]octan-8-yl)-2-oxoethyl]-3-isoquinolin-6-ylurea	IC50	22.0 [1]
	1-Isoquinolin-6-yl-1-methyl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea	IC50	50000.0 [1]
	1-Isoquinolin-6-yl-3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]urea	IC50	1900.0 [1]
	3-Isoquinolin-6-yl-1-methyl-1-(2-oxo-2-pyrrolidin-1-ylethyl)urea	IC50	2594.0 [1]
	1-[2-(4,4-Difluoropiperidin-1-yl)-2-oxoethyl]-3-isoquinolin-6-ylurea	IC50	35.0 [1]
	1-(1-Oxo-3H-2-benzofuran-5-yl)-3-(2-oxo-2-piperidin-1-ylethyl)urea	IC50	757.0 [1]
	1-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-3-isoquinolin-6-ylurea	IC50	5000.0 [1]
	2-(Isoquinolin-6-ylcarbamoylamino)-N,N-dimethylacetamide	IC50	150.0 [1]
	1-Isoquinolin-6-yl-3-(2-oxo-2-piperidin-1-ylethyl)urea	IC50	84.0 [1]
	1-[2-(7-Azabicyclo[2.2.1]heptan-7-yl)-2-oxoethyl]-3-isoquinolin-6-ylurea	IC50	46.0 [1]
	N-Cyclopentyl-2-(isoquinolin-6-ylcarbamoylamino)-N-methylacetamide	IC50	87.0 [1]
	1-Isoquinolin-7-yl-3-(2-oxo-2-piperidin-1-ylethyl)urea	IC50	2000.0 [1]
	1-(2-Cyclopentylethyl)-3-isoquinolin-6-ylurea	IC50	295.0 [1]
	N-Cyclohexyl-2-(isoquinolin-6-ylcarbamoylamino)acetamide	IC50	477.0 [1]
	1-(2-Cyclopropylethyl)-3-isoquinolin-6-ylurea	IC50	8000.0 [1]
	1-[2-(Azepan-1-yl)-2-oxoethyl]-3-isoquinolin-6-ylurea	IC50	17.0 [1]
	N-Cyclopropyl-2-(isoquinolin-6-ylcarbamoylamino)acetamide	IC50	158.0 [1]
	1-(3-Fluoroisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea	IC50	10.0 [1]
	1-(7-Methylisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea	IC50	36.0 [1]
	N'-[[2-(2-Chlorophenyl)sulfanylphenyl]methyl]-N'-methylethane-1,2-diamine	IC50	22.0 [1]
	1-[2-(Cyclohexen-1-yl)ethyl]-3-isoquinolin-6-ylurea	IC50	421.0 [1]
	1-[2-(3,3a,4,5,6,6a-Hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-2-oxoethyl]-3-isoquinolin-6-ylurea	IC50	55.0 [1]
	2-(Isoquinolin-6-ylcarbamoylamino)-N-methylacetamide	IC50	1938.0 [1]
	2-(Isoquinolin-6-ylcarbamoylamino)-N-methoxy-N-methylacetamide	IC50	476.0 [1]
	Methyl (2S)-1-[2-(isoquinolin-6-ylcarbamoylamino)acetyl]pyrrolidine-2-carboxylate	IC50	166.0 [1]
	1-[2-(Azetidin-1-yl)-2-oxoethyl]-3-isoquinolin-6-ylurea	IC50	61.0 [1]
	1-(2-Cyclohexylethyl)-3-isoquinolin-6-ylurea	IC50	540.0 [1]
	2-(4-Benzylpiperidin-1-yl)ethanamine	IC50	19000.0 [1]
	N-Methyl-2-(4-methylpiperidin-1-yl)ethanamine	IC50	500000.0 [1]
	N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide	IC50	54000.0 [1]
	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide	IC50	100000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-Yl)-3-(2-Oxo-2-Phenylethyl)urea	IC50	480.0 [1]
	(2Z)-1-Ethyl-2-[(E)-3-(1-ethylbenzo[cd]indol-1-ium-2-yl)prop-2-enylidene]benzo[cd]indole;iodide	IC50	8300.0 [1]
	(2R)-2-Amino-N-ethylpropanamide	IC50	1000000.0 [1]
	1-(2H-Benzotriazol-5-yl)-3-(2-cyclohexylethyl)urea	IC50	100000.0 [1]
	1-(2-Cyclohexylethyl)-3-(1H-indazol-6-yl)urea	IC50	100000.0 [1]
	1-(2-Cyclohexylethyl)-3-(1H-indazol-5-yl)urea	IC50	100000.0 [1]
	1-(2-Cyclohexylethyl)-3-(2-oxo-3H-1,3-benzoxazol-6-yl)urea	IC50	100000.0 [1]
	3-(1,2,3-Benzothiadiazol-6-ylamino)-4-(2-cyclohexylethylamino)cyclobut-3-ene-1,2-dione	IC50	100000.0 [1]
	3-(1,2,3-Benzothiadiazol-6-ylamino)-4-(phenacylamino)cyclobut-3-ene-1,2-dione	IC50	100000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-cyano-2-(2-cyclohexylethyl)guanidine	IC50	100000.0 [1]
	N-[5-(2-Cyclohexylethyl)-1H-1,2,4-triazol-3-yl]-1,2,3-benzothiadiazol-6-amine	IC50	100000.0 [1]
	1-(2-Amino-2-phenylethyl)-3-(1,2,3-benzothiadiazol-6-yl)urea	IC50	5900.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-hydroxy-2-phenylethyl)urea	IC50	1900.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(2,2-difluoro-2-phenylethyl)urea	IC50	5000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[2-(4-fluorophenyl)-2-hydroxyethyl]urea	IC50	4400.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[2-(2-fluorophenyl)-2-hydroxyethyl]urea	IC50	3300.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-cyclohexyl-2-hydroxyethyl)urea	IC50	490.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-cyclohexyl-2-oxoethyl)urea	IC50	840.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[2-(4-fluorophenyl)-2-oxoethyl]urea	IC50	360.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[2-(oxan-4-yl)ethyl]urea	IC50	3600.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-piperidin-1-ylethyl)urea	IC50	5200.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-morpholin-4-ylethyl)urea	IC50	10000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(3-morpholin-4-ylpropyl)urea	IC50	7200.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-pyrrolidin-1-ylethyl)urea	IC50	10000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(cyclohexylmethyl)urea	IC50	50000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-ethylurea	IC50	15000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(3,3-dimethylbutyl)urea	IC50	10000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(pyridin-2-ylmethyl)urea	IC50	15000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(pyridin-3-ylmethyl)urea	IC50	15000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(pyridin-4-ylmethyl)urea	IC50	10000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[[4-(dimethylamino)phenyl]methyl]urea	IC50	15000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[(4-methoxyphenyl)methyl]urea	IC50	10000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[(4-nitrophenyl)methyl]urea	IC50	300.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[(4-methylsulfonylphenyl)methyl]urea	IC50	850.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[(4-cyanophenyl)methyl]urea	IC50	1800.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]urea	IC50	3100.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[(4-fluorophenyl)methyl]urea	IC50	4000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea	IC50	25000.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-[3-(4-fluorophenyl)propyl]urea	IC50	2200.0 [1]
	1-(1,2,3-Benzothiadiazol-6-yl)-3-(2-piperidin-4-ylethyl)urea	IC50	2700.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Protein arginine N-methyltransferase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/protein-arginine-n-methyltransferase-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Protein arginine N-methyltransferase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-arginine-n-methyltransferase-3-inhibitors-ic50-ki.
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