Protein-glutamine gamma-glutamyltransferase K Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N-(4-Bromophenyl)acrylamide	IC50	10000.0 [1]
	N-[(5S)-6-[4-(6-Methylpyridin-2-yl)piperazin-1-yl]-6-oxo-5-[(2-phenylacetyl)amino]hexyl]prop-2-enamide	IC50	15000.0 [1]
	N-[6-(Imidazo[1,2-d][1,2,4]thiadiazol-3-ylamino)-hexyl]-2-nitro-benzenesulfonamide	IC50	8100.0 [1]
	Benzyl N-[(2S)-1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxo-6-(prop-2-enoylamino)hexan-2-yl]carbamate	IC50	12900.0 [1]
	1-Ethyl-3-(4-methoxyphenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione	IC50	18.0 [1]
	{Imidazo[1,2-d][1,2,4]thiadiazol-3-yl-[6-(2-nitro-benzenesulfonylamino)-hexyl]-amino}-acetic acid	IC50	17000.0 [1]
	2-{Imidazo[1,2-d][1,2,4]thiadiazol-3-yl-[6-(2-nitro-benzenesulfonylamino)-hexyl]-amino}-acetamide	IC50	32000.0 [1]
	N-[6-(Imidazo[1,2-d][1,2,4]thiadiazol-3-yl-methyl-amino)-hexyl]-2-nitro-benzenesulfonamide	IC50	6200.0 [1]
	(5-Bromothiophen-2-yl)(4-methyl-1H-pyrazol-1-yl)methanone	IC50	11000.0 [1]
	(2S)-1-Acetyl-N-[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-6-diazo-1,5-dioxohexan-2-yl]pyrrolidine-2-carboxamide	IC50	45000.0 [1]
	N-[4-(Pyrrolidine-1-sulfonyl)phenyl]prop-2-enamide	IC50	25000.0 [1]
	N-[4-[4-(Adamantane-1-carbonyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	3400.0 [1]
	(2,3-Difluorophenyl)methyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	6700.0 [1]
	Cyclopentyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	2500.0 [1]
	N-[4-[4-(Piperidine-1-carbonyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	4100.0 [1]
	N-[4-[4-(Pyrrolidine-1-carbonyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	5400.0 [1]
	N-[4-[4-(3-Phenylpropyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	15000.0 [1]
	Benzyl 4-[6-(prop-2-enoylamino)pyridin-3-yl]sulfonylpiperazine-1-carboxylate	IC50	6400.0 [1]
	N-[4-[4-(4-Phenylbutyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	22000.0 [1]
	N-[4-[4-(Cyclopropanecarbonyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	6000.0 [1]
	N-[4-[4-(Cyclopentanecarbonyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	5600.0 [1]
	N-[4-[4-(4,4-Difluoropiperidine-1-carbonyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	5400.0 [1]
	Tert-butyl 4-[6-(prop-2-enoylamino)pyridin-3-yl]sulfonylpiperazine-1-carboxylate	IC50	3800.0 [1]
	Benzyl 5-[4-(prop-2-enoylamino)phenyl]sulfonyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-2-carboxylate	IC50	9500.0 [1]
	(3-Phenoxyphenyl)methyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	12000.0 [1]
	Benzyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	3700.0 [1]
	Benzyl 4-[3-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	4100.0 [1]
	Benzyl 4-[4-(prop-2-enoylamino)phenyl]sulfonyl-1,4-diazepane-1-carboxylate	IC50	4600.0 [1]
	4-(4-Acryloylamino-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester	IC50	4900.0 [1]
	4-(4-Acryloylamino-benzenesulfonylamino)-piperidine-1-carboxylic acid benzyl ester	IC50	2700.0 [1]
	[1-(4-Acryloylamino-benzenesulfonyl)-piperidin-4-yl]-carbamic acid benzyl ester	IC50	4600.0 [1]
	4-(4-Acryloylamino-benzenesulfonyl)-piperazine-1-carboxylic acid 2-chloro-benzyl ester	IC50	6100.0 [1]
	Benzyl (3R)-3-[[4-(prop-2-enoylamino)phenyl]sulfonylamino]pyrrolidine-1-carboxylate	IC50	3600.0 [1]
	4-(4-Acryloylamino-2-trifluoromethyl-benzenesulfonyl)-piperazine-1-carboxylic acid benzyl ester	IC50	1400.0 [1]
	Benzyl N-methyl-N-[2-[methyl-[4-(prop-2-enoylamino)phenyl]sulfonylamino]ethyl]carbamate	IC50	8100.0 [1]
	Benzyl 4-[[[4-(prop-2-enoylamino)phenyl]sulfonylamino]methyl]piperidine-1-carboxylate	IC50	1800.0 [1]
	Benzyl N-[[1-[4-(prop-2-enoylamino)phenyl]sulfonylpiperidin-4-yl]methyl]carbamate	IC50	2900.0 [1]
	[2-(Trifluoromethyl)phenyl]methyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	8300.0 [1]
	Benzyl N-[(3R)-1-[4-(prop-2-enoylamino)phenyl]sulfonylpyrrolidin-3-yl]carbamate	IC50	14000.0 [1]
	N-(4-Piperazin-1-ylsulfonylphenyl)prop-2-enamide	IC50	45000.0 [1]
	N-[4-(4-Pyridin-2-ylpiperazin-1-yl)sulfonylphenyl]prop-2-enamide	IC50	4500.0 [1]
	N-[4-[4-(3-Methylpyridin-2-yl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	1700.0 [1]
	N-[4-[4-(6-Methylpyridin-2-yl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	4200.0 [1]
	N-[4-[4-[3-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	5900.0 [1]
	N-[4-[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	18000.0 [1]
	N-[4-(4-Phenylpiperazin-1-yl)sulfonylphenyl]prop-2-enamide	IC50	6100.0 [1]
	N-[4-[4-[2-(Trifluoromethyl)phenyl]piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	57000.0 [1]
	Benzyl (3S)-3-[[4-(prop-2-enoylamino)phenyl]sulfonylamino]pyrrolidine-1-carboxylate	IC50	2900.0 [1]
	Benzyl N-[(3S)-1-[4-(prop-2-enoylamino)phenyl]sulfonylpyrrolidin-3-yl]carbamate	IC50	14000.0 [1]
	(4-Fluorophenyl)methyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	4100.0 [1]
	(3,5-Difluorophenyl)methyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	9800.0 [1]
	(2-Methylphenyl)methyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	5100.0 [1]
	Naphthalen-1-ylmethyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	6800.0 [1]
	Naphthalen-2-ylmethyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	76000.0 [1]
	Methyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	6900.0 [1]
	N-[4-[4-(3,4,4a,5,6,7,8,8a-Octahydro-1H-isoquinoline-2-carbonyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	7200.0 [1]
	N-[4-[4-(3,4,4a,5,6,7,8,8a-Octahydro-2H-quinoline-1-carbonyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	2600.0 [1]
	N-[4-[4-(3-Phenylpropanoyl)piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	10000.0 [1]
	N-[4-[4-[(1S,2S)-2-Phenylcyclopropanecarbonyl]piperazin-1-yl]sulfonylphenyl]prop-2-enamide	IC50	3100.0 [1]
	N-[5-[4-(Cyclopropanecarbonyl)piperazin-1-yl]sulfonylpyridin-2-yl]prop-2-enamide	IC50	3400.0 [1]
	N-[5-[4-(Adamantane-1-carbonyl)piperazin-1-yl]sulfonylpyridin-2-yl]prop-2-enamide	IC50	5600.0 [1]
	Tert-butyl 4-[2-(prop-2-enoylamino)pyrimidin-5-yl]sulfonylpiperazine-1-carboxylate	IC50	1800.0 [1]
	Benzyl 4-[2-(prop-2-enoylamino)pyrimidin-5-yl]sulfonylpiperazine-1-carboxylate	IC50	5100.0 [1]
	N-[5-[4-(Adamantane-1-carbonyl)piperazin-1-yl]sulfonylpyrimidin-2-yl]prop-2-enamide	IC50	3000.0 [1]
	Tert-butyl 4-[4-(2-fluoroprop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	80000.0 [1]
	Tert-butyl 4-[4-(2-methylprop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	80000.0 [1]
	Tert-butyl 4-[4-[[(Z)-but-2-enoyl]amino]phenyl]sulfonylpiperazine-1-carboxylate	IC50	80000.0 [1]
	Tert-butyl 4-[4-[[(E)-but-2-enoyl]amino]phenyl]sulfonylpiperazine-1-carboxylate	IC50	80000.0 [1]
	Tert-butyl 4-[4-[[(E)-2-methylbut-2-enoyl]amino]phenyl]sulfonylpiperazine-1-carboxylate	IC50	80000.0 [1]
	Tert-butyl 4-[4-[[(Z)-3-chloroprop-2-enoyl]amino]phenyl]sulfonylpiperazine-1-carboxylate	IC50	8800.0 [1]
	4-[4-(1-Oxo-but-2-ynylamino)-benzenesulfonyl]-piperazine-1-carboxylic acid tert-butyl ester	IC50	80000.0 [1]
	Benzyl 4-[4-[(E)-4-ethoxy-4-oxobut-2-enyl]phenyl]sulfonylpiperazine-1-carboxylate	IC50	8900.0 [1]
	Benzyl 4-[3-[methyl(2-methylpropyl)amino]-4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	14000.0 [1]
	Benzyl 4-[3-fluoro-4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	20000.0 [1]
	4-(4-Acryloylamino-2-methoxy-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester	IC50	19000.0 [1]
	Tert-butyl 4-[2-methyl-4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	6500.0 [1]
	Tert-butyl 4-[2-fluoro-4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	2400.0 [1]
	Tert-butyl 4-[2-chloro-4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	950.0 [1]
	Ethyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	5000.0 [1]
	Methyl (2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[(E,2S)-6-methylsulfonyl-2-(phenylmethoxycarbonylamino)hex-5-enoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoate	IC50	250.0 [1]
	Tert-butyl 4-(4-cyanophenyl)sulfonylpiperazine-1-carboxylate	IC50	80000.0 [1]
	Tert-butyl 5-[4-(prop-2-enoylamino)phenyl]sulfonyl-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate	IC50	14000.0 [1]
	(2-Phenoxyphenyl)methyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	10000.0 [1]
	(4-Phenoxyphenyl)methyl 4-[4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	IC50	7700.0 [1]
	N-[[4-(Aminomethyl)phenyl]methyl]-3-[5-[[[(E)-2-phenylethenyl]sulfonyl-(pyridin-2-ylmethyl)amino]methyl]-1,2,4-oxadiazol-3-yl]benzamide	IC50	80000.0 [1]
	[4-(4-Acryloylamino-piperidine-1-sulfonyl)-phenyl]carbamic acid benzyl ester	IC50	910.0 [1]
	Tert-butyl 2-[[(2S)-2-(phenylmethoxycarbonylamino)-6-(prop-2-enoylamino)hexanoyl]amino]acetate	IC50	80000.0 [1]
	Benzyl N-[(2S)-1-oxo-1-(4-phenylpiperidin-1-yl)-6-(prop-2-enoylamino)hexan-2-yl]carbamate	IC50	9300.0 [1]
	N-[2-(4-Methoxyphenyl)ethyl]-4-[4-(prop-2-enoylamino)piperidin-1-yl]sulfonylbenzamide	IC50	1200.0 [1]
	Benzyl 4-[4-(4-diazo-3-oxobutyl)phenyl]sulfonylpiperazine-1-carboxylate	IC50	6400.0 [1]
	1-[(5-Methyl-[1,3]thiazolo[2,3-b][1,3,4]thiadiazol-4-ium-2-yl)sulfanyl]propan-2-one	IC50	250.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 91 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Protein-glutamine gamma-glutamyltransferase K Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/protein-glutamine-gamma-glutamyltransferase-k-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Protein-glutamine gamma-glutamyltransferase K Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-glutamine-gamma-glutamyltransferase-k-inhibitors-ic50-ki.
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