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Protein kinase C alpha Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
StaurosporineIC502.4 [1]
Indolactam VKi126.9 [1], 4000.0 [2]
BalanolIC5030.0 [1], 67.0 [2], 70.0 [3], 74.0 [4]
(E)-2-(2-(Hydroxymethyl)-4-(3-isobutyl-5-methylhexylidene)-5-oxo-tetrahydrofuran-2-yl)ethyl pivalateKi3.25 [1]
Balanol analog 5IC5040.0 [1]
8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-oneKi14.7 [1], 15.0 [2], 23.0 [3]
[(4Z)-2-(Hydroxymethyl)-4-(4-methyl-3-propan-2-ylpentylidene)-5-oxooxolan-2-yl]methyl 4-methyl-3-propan-2-ylpentanoateKi2.89 [1], 2.9 [2]
Balanol analog 4IC5022.0 [1]
Phorbol 12,13-dibutyrateKi0.2 [1], 0.78 [2], 1.55 [3], 17.2 [4]
(Z)-(2-(Hydroxymethyl)-4-(3-isobutyl-5-methylhexylidene)-5-oxo-tetrahydrofuran-2-yl)methyl pivalateKi2.9 [1]
CID 25053598Ki12.9 [1], 16.2 [2], 29.7 [3], 31.7 [4]
8-Octyl-benzolactam-V9Ki10000.0 [1]
8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi10000.0 [1]
2-[2,6-Dihydroxy-4-[3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5030.0 [1], 67.0 [2], 70.0 [3], 370.0 [4]
Go-6976IC502.0 [1], 2.3 [2], 3.7 [3]
RuboxistaurinIC50360.0 [1]
SotrastaurinIC502.1 [1]
Benzolactam-V8Ki334.0 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-tetradecylideneoxolan-2-yl]methyl acetateKi77.9 [1], 78.0 [2]
5-(Hydroxymethyl)-5-(tetradecanoyloxymethyl)tetrahydrofuran-2-oneKi138.0 [1]
[(4Z)-2-(Hydroxymethyl)-4-(4-methyl-3-propan-2-ylpentylidene)-5-oxooxolan-2-yl]methyl decanoateKi2.3 [1]
4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC50100000.0 [1]
(2S,5S)-8-Decyl-5-(hydroxymethyl)-1-methyl-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-3-oneKi46.6 [1], 322.5 [2], 4690.0 [3]
N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC501200.0 [1]
Phenyl-acetic acid 2-hydroxymethyl-4-nonylidene-5-oxo-tetrahydro-furan-2-ylmethyl esterKi43.3 [1], 45.0 [2], 145.0 [3]
2-[2,6-Dihydroxy-4-[2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5040.0 [1]
Benzoic acid 4-decylidene-2-hydroxymethyl-5-oxo-tetrahydro-furan-2-ylmethyl esterKi9.0 [1], 20.3 [2], 37.0 [3]
Phorbol 12-myristate 13-acetateKi2.5 [1], 6.4 [2]
ImatinibIC50100000.0 [1]
Bisindolylmaleimide iIC502.3 [1], 10.0 [2]
Bisindolylmaleimide IXIC5033.0 [1]
1,2-Dioctanoyl-sn-glycerolKi33.0 [1], 40.1 [2]
EnzastaurinIC5039.0 [1], 800.0 [2]
RebeccamycinIC50100000.0 [1]
CercosporamideIC501000.0 [1], 1020.0 [2]
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC5072000.0 [1]
PKCbeta InhibitorIC50331.0 [1]
3-[(2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dioneIC50100000.0 [1]
3-Isopropyl-4-methyl-pentanoic acid 3-hydroxy-2-(3-isopropyl-4-methyl-pentanoyloxy)-propyl esterKi28.6 [1]
3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol;hydrochlorideIC503400.0 [1], 466000.0 [2]
(1S,3R,5R,9R,13R)-9-(Hydroxymethyl)-3-[4-(3-hydroxyphenyl)butyl]-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dioneKi63.0 [1]
N'-(3-Pyridin-4-yl-2,6-naphthyridin-1-yl)ethane-1,2-diamineIC50900.0 [1]
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamineIC50100000.0 [1], 240000.0 [2]
N-Hydroxy-N-[[(4E)-2-(hydroxymethyl)-4-[5-methyl-3-(2-methylpropyl)hexylidene]-5-oxooxolan-2-yl]methyl]-2,2-dimethylpropanamideKi4.81 [1], 6790.0 [2]
Acetic acid 2-hydroxymethyl-5-oxo-4-tetradecylidene-tetrahydro-furan-2-ylmethyl esterKi35.0 [1]
(Z)-9-Octadecenoic acid 2-(hydroxymethyl)-5-oxotetrahydrofuran-2-ylmethyl esterKi96.0 [1]
[(4E)-2-(Hydroxymethyl)-4-[5-methyl-3-(2-methylpropyl)hexylidene]-5-oxooxolan-2-yl]methyl 4-methyl-3-propan-2-ylpentanoateKi4.46 [1]
[(4Z)-2-(Hydroxymethyl)-4-[5-methyl-3-(2-methylpropyl)hexylidene]-5-oxooxolan-2-yl]methyl 4-methyl-3-propan-2-ylpentanoateKi6.87 [1]
[(4E)-2-(Hydroxymethyl)-4-[(Z)-octadec-9-enylidene]-5-oxooxolan-2-yl]methyl acetateKi24.0 [1], 28.0 [2]
8-Chloro-4-(3-chloro-4-fluoroanilino)-6-(1H-imidazol-5-ylmethylamino)-3-quinolinecarbonitrileIC5023400.0 [1], 100000.0 [2]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-methoxybenzoateKi212.0 [1], 446.0 [2]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoateKi174.0 [1], 186.0 [2]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoateKi1020.0 [1], 1480.0 [2]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi1130.0 [1], 1188.0 [2]
3-(1H-Indol-3-yl)-4-[3-(4-methylpiperazin-1-yl)naphthalen-1-yl]pyrrole-2,5-dioneIC500.9 [1]
N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-acetamideIC50100000.0 [1], 500000.0 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 5-methyl-3-(2-methylpropyl)hexanoateKi4.74 [1], 57.0 [2]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-methyl-2-(2-methylpropyl)pentanoateKi14.8 [1], 39.0 [2]
1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridineIC501000.0 [1]
6,6-Dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC5050000.0 [1]
[(4Z)-4-Decylidene-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-methyl-3-propan-2-ylpentanoateKi13.0 [1]
[(4E)-2-(Hydroxymethyl)-4-(4-methyl-3-propan-2-ylpentylidene)-5-oxooxolan-2-yl]methyl 4-methyl-3-propan-2-ylpentanoateKi2.7 [1]
[(4E)-2-(Hydroxymethyl)-4-(4-methyl-3-propan-2-ylpentylidene)-5-oxooxolan-2-yl]methyl decanoateKi6.6 [1]
N-Hydroxy-N-[[(4Z)-2-(hydroxymethyl)-4-[5-methyl-3-(2-methylpropyl)hexylidene]-5-oxooxolan-2-yl]methyl]-2,2-dimethylpropanamideKi5.42 [1], 6980.0 [2]
Acetic acid 2-hydroxymethyl-4-octadec-9-enylidene-5-oxo-tetrahydro-furan-2-ylmethyl esterKi24.0 [1]
2-Methoxy-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC5080000.0 [1], 100000.0 [2]
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]naphthalene-2-carboxamideIC50100000.0 [1]
5-Hydroxymethyl-2-isopropyl-1-undecyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi4580.0 [1], 10000.0 [2]
(10S,13S)-13-(Hydroxymethyl)-9-methyl-10-propan-2-yl-3,9,12-triazatricyclo[6.6.1.04,15]pentadeca-1,4(15),5,7-tetraene-11-thioneKi261.5 [1], 2140.0 [2]
7-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi870.0 [1], 10000.0 [2]
9-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-oneKi412.0 [1], 4050.0 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl (9E,12E)-octadeca-9,12-dienoateKi7.05 [1], 26.2 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl (9E,12E)-octadeca-9,12-dienoateKi4.33 [1], 24.7 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoateKi15.4 [1], 44.0 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoateKi10.2 [1], 60.0 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 8-[3-[(3-pentyloxiran-2-yl)methyl]oxiran-2-yl]octanoateKi16.5 [1], 103.0 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 8-[3-[(3-pentyloxiran-2-yl)methyl]oxiran-2-yl]octanoateKi13.2 [1], 116.0 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadecanoateKi43.9 [1], 106.0 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadecanoateKi30.8 [1], 99.0 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl 5-methyl-3-(2-methylpropyl)hexanoateKi2.78 [1], 15.4 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadec-9-ynoateKi12.6 [1], 38.7 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadec-9-ynoateKi8.7 [1], 43.8 [2]
[(4Z)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadeca-9,11-diynoateKi9.8 [1], 44.8 [2]
[(4E)-2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxooxolan-2-yl]methyl octadeca-9,11-diynoateKi8.31 [1], 60.8 [2]
[(4Z)-2-(Hydroxymethyl)-4-[(9Z,12Z)-octadeca-9,12-dienylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi7.2 [1], 31.1 [2]
[(4E)-2-(Hydroxymethyl)-4-[(9Z,12Z)-octadeca-9,12-dienylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi8.26 [1], 25.7 [2]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-[8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octylidene]oxolan-2-yl]methyl 2,2-dimethylpropanoateKi33.1 [1], 73.0 [2]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-[8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octylidene]oxolan-2-yl]methyl 2,2-dimethylpropanoateKi26.7 [1], 110.3 [2]
[(3E)-2-(Hydroxymethyl)-3-octadecylidene-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi31.6 [1], 84.1 [2]
[(3Z)-2-(Hydroxymethyl)-3-octadecylidene-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi24.5 [1], 117.0 [2]
1-Hexylindolactam-VKi5.8 [1], 43.0 [2]
2-[2,6-Dihydroxy-4-[[2-[(4-hydroxybenzoyl)amino]-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC5034000.0 [1]
(3S,6S)-11-Hexyl-6-(hydroxymethyl)-2-methyl-3-propan-2-yl-2,5,11-triazatricyclo[7.6.1.012,16]hexadeca-1(15),9,12(16),13-tetraen-4-oneKi6700.0 [1], 10000.0 [2]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 3-[4-[2-(4-methylphenyl)ethynyl]phenoxy]propanoateKi20.8 [1], 143.0 [2]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 2-[4-[2-(4-methylphenyl)ethynyl]phenoxy]acetateKi38.0 [1], 165.1 [2]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 4-[4-[2-(4-methylphenyl)ethynyl]phenoxy]butanoateKi19.5 [1], 76.0 [2]
[2-(Hydroxymethyl)-5-oxo-4-propan-2-ylideneoxolan-2-yl]methyl 4-[2-(4-methylphenyl)ethynyl]benzoateKi6.0 [1], 15.8 [2]
(2R,3R,4R)-2-Hydroxymethyl-5-oxo-4-tetradecyl-tetrahydro-furan-3-carboxylic acid methyl esterKi500.0 [1]
[2-[(4-Hydroxyphenyl)methyl]cyclopentyl] 3,5-dihydroxy-4-(2-hydroxy-6-methoxycarbonylbenzoyl)benzoateIC501400.0 [1]
2-[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5022.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein kinase C alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/protein-kinase-c-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Protein kinase C alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-kinase-c-alpha-inhibitors-ic50-ki.
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