 | N2-(2-Chlorobenzyl)-N4-((4-(aminomethyl)cyclohexyl)methyl)-5-nitropyrimidine-2,4-diamine | IC50 | 18.0 [1], 29.0 [2], 46.0 [3], 290.0 [4], 630.0 [5] |
 | Sotrastaurin | IC50 | 1.0 [1], 81.0 [2] |
 | Indolactam V | Ki | 8.7 [1] |
 | 5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrile | IC50 | 70.0 [1], 150.0 [2] |
| 5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrile | Ki | 79.0 [1] |
 | 4-[(3-Bromophenyl)amino]-5-(3,4-dimethoxyphenyl)nicotinonitrile | IC50 | 150.0 [1], 4600.0 [2] |
| 4-[(3-Bromophenyl)amino]-5-(3,4-dimethoxyphenyl)nicotinonitrile | Ki | 4900.0 [1] |
 | 2-[3-[(Dimethylamino)methyl]phenyl]-4-[(4-methyl-1H-indol-5-yl)amino]thieno[2,3-b]pyridine-5-carbonitrile | IC50 | 7.5 [1], 230.0 [2] |
| 2-[3-[(Dimethylamino)methyl]phenyl]-4-[(4-methyl-1H-indol-5-yl)amino]thieno[2,3-b]pyridine-5-carbonitrile | Ki | 9.0 [1] |
 | (2R)-2-[(2S)-4-[3-Chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol | IC50 | 11.0 [1] |
| (2R)-2-[(2S)-4-[3-Chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol | Ki | 0.08 [1] |
 | CID 76285722 | IC50 | 23.0 [1] |
 | 8-Octyl-benzolactam-V9 | Ki | 290.0 [1] |
 | 4-(4-Methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrile | IC50 | 7.4 [1] |
 | (1S,3R,5R,9R,13R)-9-(Hydroxymethyl)-3-[4-(3-hydroxyphenyl)butyl]-16,16-dimethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dione | Ki | 4.0 [1] |
 | N'-(3-Pyridin-4-yl-2,6-naphthyridin-1-yl)ethane-1,2-diamine | IC50 | 77.0 [1] |
 | 2,2-Dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-1-[(1R)-1-phenylethyl]-3H-quinazolin-4-one | IC50 | 0.25 [1], 11.0 [2] |
 | 8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-one | Ki | 1097.0 [1], 1100.0 [2] |
 | 5-(3,4-Dimethoxyphenyl)-4-(1H-indol-6-ylamino)pyridine-3-carbonitrile | IC50 | 2000.0 [1], 2300.0 [2] |
 | 5-(3,4-Dimethoxyphenyl)-4-(1H-indol-4-ylamino)pyridine-3-carbonitrile | IC50 | 13.0 [1] |
 | (2-Aminopyridine-3-yl)(6-(1,4-diazepan-1-yl)pyridine-2-yl)methanone | Ki | 164.0 [1] |
 | 2-Methyl-N~1~-[3-(Pyridin-4-Yl)-2,6-Naphthyridin-1-Yl]propane-1,2-Diamine | IC50 | 141.0 [1] |
 | 3,5-Dihydro[1,2,4]triazino[3,4-C][1,4]benzoxazin-2(1h)-One | IC50 | 19000.0 [1], 453000.0 [2] |
 | 3-(1H-Indol-3-yl)-4-[3-(4-methylpiperazin-1-yl)naphthalen-1-yl]pyrrole-2,5-dione | IC50 | 4.8 [1] |
 | 4-(1H-Indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile | IC50 | 52.0 [1], 460.0 [2] |
 | 4-(4-Methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)styryl)nicotinonitrile | IC50 | 3.6 [1] |
 | (2-Aminopyridin-3-yl)-(6-piperazin-1-ylpyridin-2-yl)methanone | Ki | 32.0 [1] |
 | 3-(2-Chloro-6-dimethylaminomethyl-naphthalen-1-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione | IC50 | 19.0 [1], 185.0 [2] |
 | 3-[2-Chloro-7-[(dimethylamino)methyl]naphthalen-1-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione | IC50 | 216.0 [1], 708.0 [2] |
 | 3-[2-Chloro-6-[(dimethylamino)methyl]naphthalen-1-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione | IC50 | 12.0 [1], 156.0 [2] |
 | 1-Benzyl-2,2-dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-3H-quinazolin-4-one | IC50 | 0.46 [1], 16.0 [2] |
 | 1-(Cyclopropylmethyl)-2,2-dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-3H-quinazolin-4-one | IC50 | 170.0 [1], 1000.0 [2] |
 | 1-Ethyl-2,2-dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-3H-quinazolin-4-one | IC50 | 260.0 [1], 1000.0 [2] |
 | 2,2-Dimethyl-1-(2-methylpropyl)-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-3H-quinazolin-4-one | IC50 | 45.0 [1], 1000.0 [2] |
 | 2,2-Dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-1-(2-phenylethyl)-3H-quinazolin-4-one | IC50 | 300.0 [1], 1000.0 [2] |
 | 1-(Cyclopentylmethyl)-2,2-dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-3H-quinazolin-4-one | IC50 | 4.3 [1], 170.0 [2] |
 | 5-Fluoro-2-[(3S)-3-[(2R)-2-hydroxy-3-methylbutan-2-yl]piperazin-1-yl]-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-3-ol | IC50 | 4.0 [1] |
| 5-Fluoro-2-[(3S)-3-[(2R)-2-hydroxy-3-methylbutan-2-yl]piperazin-1-yl]-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-3-ol | Ki | 0.1 [1] |
 | 3-[2-Chloro-7-[[cyclopropyl(methyl)amino]methyl]naphthalen-1-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione | IC50 | 316.0 [1], 3555.0 [2] |
 | (2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanone | IC50 | 165.0 [1] |
| (2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanone | Ki | 3.0 [1] |
 | (2-Aminopyridin-3-yl)-[3-cyclopropyl-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanone | IC50 | 2600.0 [1] |
| (2-Aminopyridin-3-yl)-[3-cyclopropyl-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanone | Ki | 28.0 [1] |
 | (S)-(2-Aminopyridin-3-yl)(6-(3-isobutylpiperazin-1-yl)-3-(trifluoromethyl)pyridin-2-yl)methanone | IC50 | 52.0 [1] |
| (S)-(2-Aminopyridin-3-yl)(6-(3-isobutylpiperazin-1-yl)-3-(trifluoromethyl)pyridin-2-yl)methanone | Ki | 3.0 [1] |
 | (2-Aminopyridin-3-yl)-[3-chloro-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanone | IC50 | 58.0 [1] |
| (2-Aminopyridin-3-yl)-[3-chloro-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanone | Ki | 2.0 [1] |
 | (2R)-2-[(2S)-4-[3,5-Difluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol | IC50 | 2.0 [1] |
| (2R)-2-[(2S)-4-[3,5-Difluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol | Ki | 0.1 [1] |
 | 5-Fluoro-2-[(3S)-3-[(2R)-2-hydroxy-3-methylbutan-2-yl]piperazin-1-yl]-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridine-3-carbonitrile | IC50 | 120.0 [1] |
| 5-Fluoro-2-[(3S)-3-[(2R)-2-hydroxy-3-methylbutan-2-yl]piperazin-1-yl]-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridine-3-carbonitrile | Ki | 1.0 [1] |
 | (2R)-2-[(2S)-4-[5-Fluoro-3-(hydroxymethyl)-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol | IC50 | 1.0 [1] |
| (2R)-2-[(2S)-4-[5-Fluoro-3-(hydroxymethyl)-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol | Ki | 0.1 [1] |
 | 3-(2-Chloro-7-dimethylaminomethyl-naphthalen-1-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione | IC50 | 263.0 [1], 402.0 [2] |
 | (2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]-3-propylpyridin-2-yl]methanone | IC50 | 410.0 [1] |
| (2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]-3-propylpyridin-2-yl]methanone | Ki | 20.0 [1] |
 | (2-Aminopyridin-3-yl)-[3-(difluoromethoxy)-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanone | IC50 | 229.0 [1] |
| (2-Aminopyridin-3-yl)-[3-(difluoromethoxy)-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanone | Ki | 7.0 [1] |
 | (2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]-3-phenylpyridin-2-yl]methanone | IC50 | 5.0 [1] |
| (2-Aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]-3-phenylpyridin-2-yl]methanone | Ki | 0.6 [1] |
 | 4-[[(3R,5S)-4-Amino-1-adamantyl]methylamino]-2-[[2-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonitrile | IC50 | 1.3 [1], 22.0 [2] |
 | 4-[[(3R,5S)-4-Amino-1-adamantyl]methylamino]-2-(3-bromoanilino)pyrimidine-5-carbonitrile | IC50 | 3.9 [1], 100.0 [2] |
 | 4-[[(3R,5S)-4-Amino-1-adamantyl]methylamino]-2-anilinopyrimidine-5-carbonitrile | IC50 | 28.0 [1], 660.0 [2] |
 | 2-[[(1R,3S)-5-[[[5-Cyano-2-[[2-(trifluoromethoxy)phenyl]methylamino]pyrimidin-4-yl]amino]methyl]-2-adamantyl]amino]acetamide | IC50 | 1.9 [1], 41.0 [2] |
 | 4-[[(3R,5S)-4-(2-Hydroxyethylamino)-1-adamantyl]methylamino]-2-[[2-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonitrile | IC50 | 0.7 [1], 6.3 [2] |
 | 4-[[(3R,5S)-4-Amino-1-adamantyl]methylamino]-2-[(2-bromophenyl)methylamino]pyrimidine-5-carbonitrile | IC50 | 5.9 [1], 31.0 [2] |
 | (2-Aminopyridin-3-yl)-[4-methyl-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanone | IC50 | 410.0 [1] |
| (2-Aminopyridin-3-yl)-[4-methyl-6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]pyridin-2-yl]methanone | Ki | 24.0 [1] |
 | (2R)-2-[(2S)-4-[5-Fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol | IC50 | 6.0 [1] |
| (2R)-2-[(2S)-4-[5-Fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol | Ki | 0.2 [1] |
 | (2R)-2-[(2S)-4-[5-Chloro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol | IC50 | 170.0 [1] |
| (2R)-2-[(2S)-4-[5-Chloro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol | Ki | 21.0 [1] |
 | (2R)-3-Methyl-2-[(2S)-4-[6-(2H-pyrazolo[3,4-b]pyridin-3-yl)-5-(trifluoromethyl)pyridin-2-yl]piperazin-2-yl]butan-2-ol | IC50 | 420.0 [1] |
| (2R)-3-Methyl-2-[(2S)-4-[6-(2H-pyrazolo[3,4-b]pyridin-3-yl)-5-(trifluoromethyl)pyridin-2-yl]piperazin-2-yl]butan-2-ol | Ki | 20.0 [1] |
 | Phorbol 12,13-dibutyrate | Ki | 1.54 [1] |
 | Bisindolylmaleimide i | IC50 | 6.7 [1] |
 | Xanthohumol | IC50 | 100000.0 [1] |
 | Doramapimod | IC50 | 30000.0 [1] |
 | Aplysiatoxin | Ki | 0.16 [1] |
 | Isoxanthohumol | IC50 | 31600.0 [1] |
 | Gsk-690693 | IC50 | 2.0 [1] |
 | Debromoaplysiatoxin | Ki | 0.11 [1] |
 | Tak-285 | IC50 | 10000.0 [1] |
 | CID 46209401 | IC50 | 10000.0 [1] |
 | CID 59604787 | IC50 | 10000.0 [1] |
 | 1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea | IC50 | 10000.0 [1] |
 | 3-[5-[4-(2-Hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione | IC50 | 68.0 [1] |
 | CID 44814409 | IC50 | 4100.0 [1] |
 | 17,20,23-Trioxa-4,12,14,26,28-pentazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8(13),9,11,27(32),28,30-nonaene-3,5-dione | IC50 | 10000.0 [1] |
 | Indolylylmaleimide 1 | IC50 | 835.0 [1] |
 | 4-[(4-Methyl-1H-indol-5-yl)amino]-2-phenylthieno[2,3-b]pyridine-5-carbonitrile | IC50 | 52.0 [1] |
 | 8-Bromo-4-(3-chloro-4-fluoroanilino)-6-[(1-methylimidazol-4-yl)methylamino]quinoline-3-carbonitrile | IC50 | 50000.0 [1] |
 | Khk-IN-1 | IC50 | 40000.0 [1] |
 | cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenol | IC50 | 230.0 [1] |
 | Indolylylmaleimide 2 | IC50 | 65.0 [1] |
 | (2S,5S)-8-Decyl-5-(hydroxymethyl)-1-methyl-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-3-one | Ki | 13.2 [1] |
 | Methyl 6-bromo-2-[(4-methylsulfonylphenyl)methyl]-1-oxo-4-phenylisoquinoline-3-carboxylate | IC50 | 11000.0 [1] |
 | 17,20,23,26-Tetraoxa-4,12,14,29,31-pentazahexacyclo[27.6.1.17,14.02,6.08,13.030,35]heptatriaconta-1(36),2(6),7(37),8(13),9,11,30(35),31,33-nonaene-3,5-dione | IC50 | 10000.0 [1] |
 | (2,6-Dimethylphenyl) N-[2-[3,5-dimethoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]anilino]pyrimidin-4-yl]-N-(2,4-dimethoxyphenyl)carbamate | IC50 | 5000.0 [1] |
 | 3-(1H-Indol-3-yl)-4-(2-piperazin-1-ylquinazolin-4-yl)pyrrole-2,5-dione | IC50 | 0.5 [1] |
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