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Protein kinase C zeta Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
StaurosporineIC50216.8 [1], 1500.0 [2], 10000.0 [3]
BalanolIC503500.0 [1], 7400.0 [2]
Balanol analog 4IC50150.0 [1], 6800.0 [2]
Balanol analog 5IC5022000.0 [1]
3-(3,4-Dichlorophenyl)-4-(6-iodo-1H-benzimidazol-2-yl)butanoic acidIC5012000.0 [1], 15900.0 [2], 18000.0 [3]
4-[1-(4-Chlorophenyl)-3-tert-butyl-4,5-dihydro-1H-pyrazole-5-yl]phenolIC503200.0 [1], 10700.0 [2], 26700.0 [3]
4-[5-Tert-butyl-2-(4-chlorophenyl)-3,4-dihydropyrazol-3-yl]-2-chlorophenolIC50700.0 [1], 2900.0 [2], 14800.0 [3]
4-[2-(3-Chlorophenyl)-3-(3-fluoro-4-hydroxyphenyl)-3,4-dihydropyrazol-5-yl]benzene-1,3-diolIC50100.0 [1], 1100.0 [2]
Isopropyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylateIC506000.0 [1], 20000.0 [2], 35000.0 [3]
4-[1-(4-Bromophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-5-yl]phenolIC50500.0 [1], 1000.0 [2]
4-[5-Tert-butyl-2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-3-yl]phenolIC502700.0 [1]
4-[5-Tert-butyl-2-(3-chloro-4-fluorophenyl)-3,4-dihydropyrazol-3-yl]phenolIC50900.0 [1], 1900.0 [2]
4-[5-Tert-butyl-2-(3,4-difluorophenyl)-3,4-dihydropyrazol-3-yl]phenolIC50500.0 [1], 900.0 [2]
4-[5-Tert-butyl-2-(2,3,4-trifluorophenyl)-3,4-dihydropyrazol-3-yl]phenolIC50700.0 [1], 3100.0 [2]
3-[5-Tert-butyl-2-(4-chlorophenyl)-3,4-dihydropyrazol-3-yl]phenolIC502000.0 [1], 5300.0 [2]
4-[5-Tert-butyl-2-(4-chlorophenyl)-3,4-dihydropyrazol-3-yl]-2-fluorophenolIC503700.0 [1], 3800.0 [2]
5-[5-Tert-butyl-2-(3-chlorophenyl)-3,4-dihydropyrazol-3-yl]-2-fluorophenolIC50300.0 [1], 2500.0 [2]
2-[2-(4-Chlorophenyl)-3-(4-hydroxyphenyl)-3,4-dihydropyrazol-5-yl]phenolIC501500.0 [1], 3100.0 [2]
4-[2-(3-Chlorophenyl)-5-(2-hydroxyphenyl)-3,4-dihydropyrazol-3-yl]-2,6-difluorophenolIC502500.0 [1], 11100.0 [2]
4-[2-(3-Chlorophenyl)-5-(2-hydroxyphenyl)-3,4-dihydropyrazol-3-yl]-2-fluorophenolIC502900.0 [1]
4-[2-(3-Chlorophenyl)-5-(2-hydroxyphenyl)-3,4-dihydropyrazol-3-yl]-2,3-difluorophenolIC501400.0 [1], 6600.0 [2]
4-[5-Tert-butyl-2-(4-chlorophenyl)pyrazol-3-yl]-2-chlorophenolIC503000.0 [1], 17400.0 [2]
Ethyl 2-amino-4-(benzo[d][1,3]dioxol-5-yl)thiophene-3-carboxylateIC502000.0 [1]
2-[2,6-Dihydroxy-4-[[2-[(4-hydroxybenzoyl)amino]-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC5050000.0 [1]
3-(4-Chlorophenyl)-4-(6-iodo-1H-benzimidazol-2-yl)butanoic acidIC5033000.0 [1], 38000.0 [2]
3-(4-Chlorophenyl)-4-(4,6-dichloro-1H-benzimidazol-2-yl)butanoic acidIC5014000.0 [1], 38000.0 [2]
4-(6-Chloro-4-methyl-1H-benzimidazol-2-yl)-3-(4-chlorophenyl)butanoic acidIC5030000.0 [1], 55000.0 [2]
4-(6-Chloro-1H-benzimidazol-2-yl)-3-(3,4-dichlorophenyl)butanoic acidIC5032000.0 [1], 39000.0 [2]
4-(6-Iodo-1H-benzimidazol-2-yl)-3-(4-propylphenyl)butanoic acidIC5014000.0 [1], 33000.0 [2]
2-[2,6-Dihydroxy-4-[(1R,2R)-2-[(4-hydroxybenzoyl)amino]cycloheptyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50150000.0 [1]
Balanol analog 3IC50150000.0 [1]
4-(6-Chloro-1H-benzimidazol-2-yl)-3-[4-chloro-3-(trifluoromethyl)phenyl]butanoic acidIC5028000.0 [1], 43000.0 [2]
3-(4-Tert-butylphenyl)-4-(6-iodo-1H-benzimidazol-2-yl)butanoic acidIC5013000.0 [1], 23000.0 [2]
Ethyl 2-amino-4-(4-aminophenyl)thiophene-3-carboxylateIC502000.0 [1]
Ethyl 2-amino-4-[4-(dimethylamino)phenyl]thiophene-3-carboxylateIC50800.0 [1], 1000.0 [2]
Benzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylateIC506000.0 [1]
(3-Methoxyphenyl)methyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylateIC502000.0 [1], 5000.0 [2]
Ethyl 2-amino-4-(2-fluoro-4-methoxyphenyl)thiophene-3-carboxylateIC504000.0 [1]
4-[1-[4-(Trifluoromethyl)phenyl]-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-5-yl]phenolIC50400.0 [1], 2900.0 [2]
4-[2,3-Bis(4-chlorophenyl)-3,4-dihydropyrazol-5-yl]benzene-1,3-diolIC504300.0 [1], 9700.0 [2]
4-[2,3-Bis(3-chlorophenyl)-3,4-dihydropyrazol-5-yl]phenolIC50400.0 [1], 4100.0 [2]
4-[2,3-Bis(4-chlorophenyl)-3,4-dihydropyrazol-5-yl]benzene-1,2-diolIC50100.0 [1], 800.0 [2]
4-[2,3-Bis(4-chlorophenyl)-3,4-dihydropyrazol-5-yl]phenolIC506200.0 [1], 20800.0 [2]
DasatinibIC5050000.0 [1]
Bisindolylmaleimide iIC505800.0 [1]
EnzastaurinIC508000.0 [1]
Chir-99021IC5010000.0 [1]
RuboxistaurinIC50100000.0 [1]
SotrastaurinIC505400.0 [1]
Purvalanol BIC50100000.0 [1]
Purvalanol AIC50100000.0 [1]
Cfms Receptor Tyrosine Kinase InhibitorIC5024000.0 [1]
Rac-syn-BalanolIC503500.0 [1]
4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenolIC50100000.0 [1]
CID 59604787IC5010000.0 [1]
Methyl 2-amino-4-phenylthiophene-3-carboxylateIC5062000.0 [1]
(2R)-2-[(2S)-4-[3-Chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi5000.0 [1]
CID 9957049IC5010000.0 [1]
N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamideIC5040000.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi8300.0 [1]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrileIC5050000.0 [1]
4-(4-Methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrileIC50100000.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi8333.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
2,2-Dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-1-[(1R)-1-phenylethyl]-3H-quinazolin-4-oneIC501000.0 [1]
Meridianin EIC504000.0 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi8000.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi8000.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
3-(1-Methyl-1H-indol-3-yl)-4-(1-piperidin-4-yl-1H-indol-3-yl)-pyrrole-2,5-dioneIC504000.0 [1]
2-Methoxy-4-[3-[4-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl]phenolIC502.26 [1]
2-[2,6-Dihydroxy-4-[3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC503500.0 [1]
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC5050000.0 [1]
Unii-7N5LJ2Z26CIC50200.0 [1]
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC5050000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
4-(Cyclopentylamino)-2-[(2-methoxyphenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamideIC5030000.0 [1]
3-[1-(1-Benzylpiperidin-4-yl)indol-3-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dioneIC50100000.0 [1]
2-[2,6-Dihydroxy-4-[(3R,4R)-3-[(4-hydroxybenzoyl)amino]oxepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50150000.0 [1]
3-[(6-Benzoyl-5-Methylpyrrolo[2,1-F][1,2,4]triazin-4-Yl)amino]-N-Cyclopropyl-4-MethylbenzamideIC5025000.0 [1]
2-[2,6-Dihydroxy-4-[(3S,4R)-3-[(4-hydroxybenzoyl)amino]thiepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50121000.0 [1]
2-[2,6-Dihydroxy-4-[[(3R,4R)-3-[(4-hydroxybenzoyl)amino]-1-azabicyclo[3.2.2]nonan-4-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC5022500.0 [1]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-naphthalen-1-ylindol-3-yl)pyrrole-2,5-dioneIC5010000.0 [1]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-pyridin-3-ylindol-3-yl)pyrrole-2,5-dioneIC504400.0 [1]
3-[1-(1-Benzothiophen-3-yl)indol-3-yl]-4-[1-[3-(dimethylamino)propyl]indazol-3-yl]pyrrole-2,5-dioneIC5010000.0 [1]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-naphthalen-2-ylindol-3-yl)pyrrole-2,5-dioneIC506200.0 [1]
3-[1-[3-(Dimethylamino)propyl]indazol-3-yl]-4-(1-quinolin-3-ylindol-3-yl)pyrrole-2,5-dioneIC505700.0 [1]
2-[4-[(1R,2R,4S)-4-(Aminomethyl)-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acidIC502800.0 [1]
(18S)-18-(Hydroxymethyl)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dioneIC508700.0 [1]
2-[2,6-Dihydroxy-4-[(1R,2R,4S)-2-[(4-hydroxybenzoyl)amino]-4-(hydroxymethyl)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5039000.0 [1]
2-[4-[(1R,2R,4R)-4-Amino-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acidIC501200.0 [1]
2-[2,6-Dihydroxy-4-[(1R,2R,4R)-4-hydroxy-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5013000.0 [1]
(18S)-18-(Aminomethyl)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dioneIC5044000.0 [1]
2-[2,6-Dihydroxy-4-[(1R,2R,4R)-2-[(4-hydroxybenzoyl)amino]-4-(hydroxymethyl)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5034000.0 [1]
2-[2,6-Dihydroxy-4-[(3S,4S)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50150000.0 [1]
2-[2,6-Dihydroxy-4-[(3S,4R)-3-[(4-hydroxybenzoyl)amino]-1,1-dioxothiepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50150000.0 [1]
N-[[(18S)-3,5-Dioxo-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaen-18-yl]methyl]benzenesulfonamideIC505000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Protein kinase C zeta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/protein-kinase-c-zeta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Protein kinase C zeta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/protein-kinase-c-zeta-inhibitors-ic50-ki.
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