Proto-oncogene tyrosine-protein kinase ROS Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Crizotinib	IC50	7.1 [1]
	Crizotinib	Ki	0.6 [1], 5.8 [2], 330.0 [3]
	Ceritinib	IC50	2.0 [1], 141.8 [2], 2000.0 [3]
	Ceritinib	Ki	0.4 [1], 0.7 [2], 230.0 [3]
	Staurosporine	IC50	0.07 [1], 0.2 [2], 1.0 [3]
	Foretinib	IC50	10.0 [1]
	Foretinib	Ki	8.2 [1], 16.0 [2], 20.0 [3]
	Lorlatinib	Ki	0.02 [1], 0.03 [2], 0.1 [3], 12.0 [4]
	Alectinib	Ki	2000.0 [1], 2400.0 [2], 3000.0 [3]
	Entrectinib	IC50	5.0 [1], 7.0 [2]
	2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-[[(2S)-2-hydroxypropyl]amino]-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile	IC50	1.7 [1], 199.0 [2], 775.0 [3]
	2-[4-[6-(3-Hydroxypropylamino)-2-pyridin-3-ylpyrimidin-4-yl]-3-(3-methoxy-5-methylphenyl)pyrazol-1-yl]acetonitrile	IC50	119.0 [1], 50900.0 [2]
	2-[4-[6-(4-Hydroxybutylamino)-2-pyridin-3-ylpyrimidin-4-yl]-3-(3-methoxy-5-methylphenyl)pyrazol-1-yl]acetonitrile	IC50	56.0 [1], 33900.0 [2]
	2-[3-(3-Methoxy-5-methylphenyl)-4-[6-(2-morpholin-4-ylethylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile	IC50	148.0 [1], 57600.0 [2]
	2-[3-(3-Methoxy-5-methylphenyl)-4-[6-(3-morpholin-4-ylpropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile	IC50	88.0 [1], 28400.0 [2]
	2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(3-hydroxypropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile	IC50	108.0 [1], 73400.0 [2]
	2-[4-[6-(4-Hydroxybutylamino)-2-pyridin-3-ylpyrimidin-4-yl]-3-(3-hydroxy-5-methylphenyl)pyrazol-1-yl]acetonitrile	IC50	24.0 [1], 13600.0 [2]
	2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(2-morpholin-4-ylethylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile	IC50	478.0 [1], 90900.0 [2]
	2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(3-morpholin-4-ylpropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile	IC50	183.0 [1], 55500.0 [2]
	6-Ethyl-5-[(4-hydroxy-4-methylcyclohexyl)amino]-3-[3-methyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]pyrazine-2-carboxamide	IC50	0.78 [1], 0.86 [2]
	Mitoxantrone	IC50	2998.7 [1]
	Staurosporine HCl	IC50	0.25 [1]
	Doramapimod	IC50	30000.0 [1]
	Nvp-tae 684	IC50	2.0 [1]
	Brigatinib	IC50	1.9 [1]
	Alk-IN-1	IC50	1.9 [1]
	Gilteritinib	IC50	1.9 [1]
	Nms-P937 (nms1286937)	IC50	10000.0 [1]
	CID 59604787	IC50	10000.0 [1]
	Unii-76pnd635L1	Ki	0.02 [1]
	6,6-Dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	1000.0 [1]
	5-Chloro-2-N-[2-methoxy-4-[4-[(4-methylpiperazin-1-yl)methyl]triazol-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	IC50	1.1 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	N-[5-Amino-1-[(4-methoxyphenyl)methyl]pyrazol-4-yl]-5-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-2-methylbenzamide	IC50	1.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	3-Methyl-5-[1-methyl-4-(6-morpholin-4-yl-2-pyridin-3-ylpyrimidin-4-yl)pyrazol-3-yl]phenol	IC50	13.6 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-ol	IC50	10000.0 [1]
	4-[6-[3-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]morpholine	IC50	59.1 [1]
	1-[6-[3-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]azetidin-3-ol	IC50	108.0 [1]
	4-[[6-[3-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]amino]butan-1-ol	IC50	63.8 [1]
	(2S)-1-[[6-[3-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]amino]propan-2-ol	IC50	241.0 [1]
	4-[6-[5-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]morpholine	IC50	104.0 [1]
	1-[6-[5-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]azetidin-3-ol	IC50	74.2 [1]
	4-[[6-[5-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]amino]butan-1-ol	IC50	138.0 [1]
	(2S)-1-[[6-[5-(3-Methoxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]amino]propan-2-ol	IC50	283.0 [1]
	1-[6-[3-(3-Hydroxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]azetidin-3-ol	IC50	86.5 [1]
	3-[4-[6-(4-Hydroxybutylamino)-2-pyridin-3-ylpyrimidin-4-yl]-1-methylpyrazol-3-yl]-5-methylphenol	IC50	133.0 [1]
	3-[4-[6-[[(2S)-2-Hydroxypropyl]amino]-2-pyridin-3-ylpyrimidin-4-yl]-1-methylpyrazol-3-yl]-5-methylphenol	IC50	105.0 [1]
	3-Methyl-5-[2-methyl-4-(6-morpholin-4-yl-2-pyridin-3-ylpyrimidin-4-yl)pyrazol-3-yl]phenol	IC50	91.5 [1]
	1-[6-[5-(3-Hydroxy-5-methylphenyl)-1-methylpyrazol-4-yl]-2-pyridin-3-ylpyrimidin-4-yl]azetidin-3-ol	IC50	56.6 [1]
	3-[4-[6-(4-Hydroxybutylamino)-2-pyridin-3-ylpyrimidin-4-yl]-2-methylpyrazol-3-yl]-5-methylphenol	IC50	25.4 [1]
	3-[4-[6-[[(2S)-2-Hydroxypropyl]amino]-2-pyridin-3-ylpyrimidin-4-yl]-2-methylpyrazol-3-yl]-5-methylphenol	IC50	139.0 [1]
	2-[3-(3-Methoxy-5-methylphenyl)-4-[6-(2-methylpropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile	IC50	920.0 [1]
	2-[3-(3-Hydroxy-5-methylphenyl)-4-[6-(2-methylpropylamino)-2-pyridin-3-ylpyrimidin-4-yl]pyrazol-1-yl]acetonitrile	IC50	780.0 [1]
	6-[4-(2-Chloro-4-fluorophenyl)-2-methylpyrimidin-5-yl]-N-(3-methoxypropyl)-2-pyridin-3-ylpyrimidin-4-amine	IC50	1330.0 [1]
	6-[4-(2,4-Dichlorophenyl)-2-methylpyrimidin-5-yl]-N-(3-methoxypropyl)-2-pyridin-3-ylpyrimidin-4-amine	IC50	357.0 [1]
	4-(2-Chloro-4-fluorophenyl)-2-methyl-5-(2-pyridin-3-ylpyridin-4-yl)pyrimidine	IC50	570.0 [1]
	4-(2,4-Dichlorophenyl)-2-methyl-5-(2-pyridin-3-ylpyridin-4-yl)pyrimidine	IC50	330.0 [1]
	4-[5-(3-Methoxy-5-methylphenyl)-1H-pyrazol-4-yl]-2-(4-methoxyphenyl)pyridine	IC50	1250.0 [1]
	N-[4-[4-[1-(Cyanomethyl)-5-(3-methoxy-5-methylphenyl)pyrazol-4-yl]pyridin-2-yl]phenyl]acetamide	IC50	6250.0 [1]
	4-[6-(Benzylamino)imidazo[1,2-B]pyridazin-3-Yl]benzonitrile	IC50	300.0 [1]
	6-[(2r)-2-(3-Fluorophenyl)pyrrolidin-1-Yl]-3-(Pyridin-2-Yl)imidazo[1,2-B]pyridazine	IC50	600.0 [1]
	2-[4-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid	IC50	60.0 [1]
	1-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol	IC50	210.0 [1]
	5-Chloro-2-N-[(E)-(3-methoxyphenyl)methylideneamino]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	IC50	5.8 [1]
	5-Chloro-2-N-[(E)-(4-methoxyphenyl)methylideneamino]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	IC50	2.3 [1]
	5-Chloro-4-N-(2-propan-2-ylsulfonylphenyl)-2-N-[(E)-[4-(trifluoromethyl)phenyl]methylideneamino]pyrimidine-2,4-diamine	IC50	3.4 [1]
	5-Chloro-4-N-(2-propan-2-ylsulfonylphenyl)-2-N-[(E)-[3-(trifluoromethyl)phenyl]methylideneamino]pyrimidine-2,4-diamine	IC50	5.0 [1]
	5-Chloro-2-N-[(E)-1-(4-fluorophenyl)ethylideneamino]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	IC50	2.7 [1]
	5-Chloro-2-N-[(E)-(4-fluorophenyl)methylideneamino]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	IC50	1.8 [1]
	5-Chloro-4-N-(2-propan-2-ylsulfonylphenyl)-2-N-[(E)-[4-(trifluoromethoxy)phenyl]methylideneamino]pyrimidine-2,4-diamine	IC50	5.5 [1]
	5-Chloro-2-N-[(E)-1-(4-methoxyphenyl)ethylideneamino]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	IC50	4.7 [1]
	4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-isoquinolin-6-ylpyridin-2-yl]phenol	IC50	168.5 [1]
	4-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	1000.0 [1]
	5-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	1000.0 [1]
	4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol	IC50	272.9 [1]
	N-[2-[[5-Chloro-2-[[2-methoxy-6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino]pyrimidin-4-yl]amino]phenyl]methanesulfonamide	IC50	2300.0 [1]
	N-[(3,5-Difluorophenyl)methyl]-3-[1-[2-[(1-methylpyrazol-4-yl)amino]pyridin-4-yl]oxyethyl]benzamide	IC50	2400.0 [1]
	N-[(4-Methylphenyl)methyl]-3-[1-[2-[(4-methylpiperazin-1-yl)amino]pyridin-4-yl]oxyethyl]benzamide	IC50	10000.0 [1]
	N-[[4-Chloro-3-(trifluoromethyl)phenyl]methyl]-3-[1-[2-[(4-methylpiperazin-1-yl)amino]pyridin-4-yl]oxyethyl]benzamide	IC50	9100.0 [1]
	3-[1-[2-[(1,3-Dimethylpyrazol-4-yl)amino]pyridin-4-yl]oxyethyl]-N-[(4-methylphenyl)methyl]benzamide	IC50	1400.0 [1]
	N-[(4-Methylphenyl)methyl]-3-[1-[2-(pyrimidin-2-ylamino)pyridin-3-yl]oxyethyl]benzamide	IC50	6200.0 [1]
	N-[[4-Chloro-3-(trifluoromethyl)phenyl]methyl]-3-[1-[2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyridin-4-yl]oxyethyl]benzamide	IC50	2300.0 [1]
	N-[(4-Cyanophenyl)methyl]-3-[1-[2-[(1-methylpyrazol-4-yl)amino]pyridin-4-yl]oxyethyl]benzamide	IC50	1500.0 [1]
	3-[1-[2-[[1-(Cyanomethyl)pyrazol-4-yl]amino]pyridin-3-yl]oxyethyl]-N-[(4-methylphenyl)methyl]benzamide	IC50	8700.0 [1]
	N-[(4-Methylphenyl)methyl]-3-[1-[2-[(5-methyl-1,3-thiazol-2-yl)amino]pyridin-3-yl]oxyethyl]benzamide	IC50	9400.0 [1]
	N-[(3,4-Dimethoxyphenyl)methyl]-3-[1-[2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyridin-4-yl]oxyethyl]benzamide	IC50	570.0 [1]
	N-[(4-Methylphenyl)methyl]-3-[1-[2-[(1-methylpyrazol-4-yl)amino]pyridin-4-yl]oxyethyl]benzamide	IC50	1800.0 [1]
	3-[1-[2-[[1-(2-Hydroxy-2-methylpropyl)pyrazol-4-yl]amino]pyridin-4-yl]oxyethyl]-N-[(4-methylphenyl)methyl]benzamide	IC50	2400.0 [1]
	N-[(3,4-Dimethoxyphenyl)methyl]-3-[1-[2-[(1-piperidin-4-ylpyrazol-4-yl)amino]pyridin-4-yl]oxyethyl]benzamide	IC50	370.0 [1]
	N-[[4-Chloro-3-(trifluoromethyl)phenyl]methyl]-3-[1-[2-[[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]amino]pyridin-4-yl]oxyethyl]benzamide	IC50	8400.0 [1]
	N-[(4-Methylphenyl)methyl]-3-[1-[2-(1,2,4-triazol-4-ylamino)pyridin-3-yl]oxyethyl]benzamide	IC50	10000.0 [1]
	N-[(4-Methylphenyl)methyl]-3-[1-[2-(1,3,4-thiadiazol-2-ylamino)pyridin-3-yl]oxyethyl]benzamide	IC50	10000.0 [1]
	3-[1-[2-(1H-Benzimidazol-2-ylamino)pyridin-4-yl]oxyethyl]-N-[(4-methylphenyl)methyl]benzamide	IC50	10000.0 [1]
	N-[(4-Methylphenyl)methyl]-3-[1-[2-(3,4,5-trimethoxyanilino)pyridin-4-yl]oxyethyl]benzamide	IC50	2400.0 [1]
	N-[(4-Methylphenyl)methyl]-3-[1-[2-(1,3-thiazol-2-ylamino)pyridin-3-yl]oxyethyl]benzamide	IC50	10000.0 [1]
	3-[1-[2-[[1-(2-Hydroxy-2-methylpropyl)pyrazol-4-yl]amino]pyridin-3-yl]oxyethyl]-N-[(4-methylphenyl)methyl]benzamide	IC50	9400.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Proto-oncogene tyrosine-protein kinase ROS Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/proto-oncogene-tyrosine-protein-kinase-ros-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Proto-oncogene tyrosine-protein kinase ROS Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/proto-oncogene-tyrosine-protein-kinase-ros-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan