Pyroglutamylated RFamide peptide receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N-(4,6,7-Trimethylquinazolin-2-yl)guanidine	IC50	2511.89 [1], 5011.87 [2]
	(5-Bromo-1-methylpyrrolo[2,3-c]pyridin-2-yl)-[6-[(dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]methanone	IC50	240.0 [1], 280.0 [2]
	(5-Chloro-1-methylindol-2-yl)-[6-[(dimethylamino)methyl]-7-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone	IC50	40.0 [1], 46.0 [2]
	(6R)-N-(5-Chloro-2-methoxyphenyl)-6-(dimethylamino)-4-methoxy-5,6,7,8-tetrahydronaphthalene-1-sulfonamide	IC50	79.43 [1]
	(5-Chloro-1-methylindol-2-yl)-[6-[(dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]methanone	IC50	70.0 [1]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]benzenecarboximidamide	IC50	19.95 [1], 25.12 [2]
	N-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]pyridin-2-amine	IC50	12589.25 [1], 31622.78 [2]
	3-(Cyclopentylsulfanylmethyl)-4-methoxy-N'-phenylbenzenecarboximidamide	IC50	1000.0 [1], 3981.07 [2]
	N'-[3-(Cyclopentylsulfanylmethyl)phenyl]thiophene-2-carboximidamide	IC50	794.33 [1], 2511.89 [2]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-methylphenyl]thiophene-2-carboximidamide	IC50	1584.89 [1], 10000.0 [2]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-fluorophenyl]thiophene-2-carboximidamide	IC50	501.19 [1], 1258.93 [2]
	N'-[4-Chloro-3-(cyclopentylsulfanylmethyl)phenyl]thiophene-2-carboximidamide	IC50	1000.0 [1], 3981.07 [2]
	N'-[3-(Cyclopentyloxymethyl)-4-methoxyphenyl]thiophene-2-carboximidamide	IC50	2511.89 [1], 10000.0 [2]
	N'-[3-(2-Cyclopentylethyl)-4-methoxyphenyl]benzenecarboximidamide	IC50	199.53 [1], 316.23 [2]
	N'-[4-Methoxy-3-(phenylsulfanylmethyl)phenyl]benzenecarboximidamide	IC50	1584.89 [1], 7943.28 [2]
	N-[[5-[[Amino(phenyl)methylidene]amino]-2-methoxyphenyl]methyl]cyclopentanecarboxamide	IC50	2511.89 [1], 7943.28 [2]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]thiophene-2-carboximidamide	IC50	50.12 [1], 158.49 [2]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]thiophene-3-carboximidamide	IC50	100.0 [1], 125.89 [2]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]-4-methylthiophene-2-carboximidamide	IC50	63.1 [1], 100.0 [2]
	5-Bromo-N'-[3-(cyclopentylsulfanylmethyl)-4-methoxyphenyl]thiophene-2-carboximidamide	IC50	19.95 [1], 125.89 [2]
	4-Chloro-N'-[3-(cyclopentylsulfanylmethyl)-4-methoxyphenyl]benzenecarboximidamide	IC50	12.59 [1], 39.81 [2]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]-1,3-thiazole-2-carboximidamide	IC50	2511.89 [1], 25118.86 [2]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]pyridine-3-carboximidamide	IC50	251.19 [1], 501.19 [2]
	N-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]thiophene-2-carboxamide	IC50	7943.28 [1], 31622.78 [2]
	N-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]-N'-methylthiophene-2-carboximidamide	IC50	251.19 [1], 630.96 [2]
	(5-Bromo-1-methylpyrrolo[2,3-c]pyridin-2-yl)-[6-[(dimethylamino)methyl]-4-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone	IC50	110.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide	IC50	8730.0 [1]
	CID 56659503	IC50	1.26 [1]
	(5-Chloro-1-methylpyrrolo[2,3-c]pyridin-2-yl)-[6-[(dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]methanone	IC50	570.0 [1]
	[6-[(Dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-(1-methylpyrrolo[2,3-c]pyridin-2-yl)methanone	IC50	2900.0 [1]
	[6-[(Dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-(1,5-dimethylpyrrolo[2,3-c]pyridin-2-yl)methanone	IC50	18900.0 [1]
	[6-[(Dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-(5-iodo-1-methylpyrrolo[2,3-c]pyridin-2-yl)methanone	IC50	130.0 [1]
	[6-[(Dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-(5-ethynyl-1-methylpyrrolo[2,3-c]pyridin-2-yl)methanone	IC50	6000.0 [1]
	[6-[(Dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-[1-methyl-5-(trifluoromethyl)pyrrolo[2,3-c]pyridin-2-yl]methanone	IC50	3300.0 [1]
	[6-[(Dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-(1-methyl-5-phenylpyrrolo[2,3-c]pyridin-2-yl)methanone	IC50	41000.0 [1]
	(5-Chloro-1-methylpyrrolo[2,3-c]pyridin-2-yl)-[6-[(dimethylamino)methyl]-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone	IC50	500.0 [1]
	(5-Chloro-1-methylpyrrolo[2,3-c]pyridin-2-yl)-[6-[(dimethylamino)methyl]-3-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone	IC50	710.0 [1]
	(5-Chloro-1-methylpyrrolo[2,3-c]pyridin-2-yl)-[6-[1-(dimethylamino)ethyl]-3,4-dihydro-1H-isoquinolin-2-yl]methanone	IC50	460.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-[[amino(diethylamino)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-5-[[amino(dimethylamino)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]pentanamide	IC50	6060.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-[[amino(ethylamino)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-[(N,N,N'-trimethylcarbamimidoyl)amino]pentanamide	IC50	8250.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-6-[[amino(dimethylamino)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-[[amino(azetidin-1-yl)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-6-[[amino(ethylamino)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-6-[[amino(diethylamino)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-5-[[amino(diethylamino)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]pentanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-6-[(N'-methylcarbamimidoyl)amino]hexanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-6-[(N,N,N'-trimethylcarbamimidoyl)amino]hexanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-4-[(N,N,N'-trimethylcarbamimidoyl)amino]butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-5-[[amino-[ethyl(methyl)amino]methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]pentanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-4-[(N'-propylcarbamimidoyl)amino]butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-4-[(N,N'-dimethylcarbamimidoyl)amino]butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-[[amino(dimethylamino)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-6-[[amino-[ethyl(methyl)amino]methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-6-[[amino(azetidin-1-yl)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-[[amino-[ethyl(methyl)amino]methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-4-[[N'-(2-methylpropyl)carbamimidoyl]amino]butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-4-[(N'-methylcarbamimidoyl)amino]butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-4-(diaminomethylideneamino)butanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-5-[[amino(azetidin-1-yl)methylidene]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]pentanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-6-[(N,N'-dimethylcarbamimidoyl)amino]hexanamide	IC50	100000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-6-[(N'-propylcarbamimidoyl)amino]hexanamide	IC50	100000.0 [1]
	(2S)-2-[[2-[[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-benzylamino]acetyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide	IC50	10000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[2-(2-Aminoacetyl)hydrazinyl]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide	IC50	2987.0 [1]
	(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[2-(2-amino-2-oxoethyl)-2-benzylhydrazinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-3-phenylpropanamide	IC50	10000.0 [1]
	(2S)-2-[[2-[[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-[3-(diaminomethylideneamino)propyl]amino]acetyl]amino]-3-phenylpropanamide	IC50	10000.0 [1]
	(2S)-2-[[(2S)-2-[[2-[[[(2S)-2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-propylamino]acetyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide	IC50	10000.0 [1]
	(2S)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[[(2S)-2-[[2-[2,3-dihydroxypropyl-[[(2S)-3-phenyl-2-[(2-piperazin-1-ylacetyl)amino]propanoyl]amino]amino]acetyl]amino]-3-phenylpropanoyl]amino]pentanamide	IC50	1994.0 [1]
	4-Bromo-N'-[3-(cyclopentylsulfanylmethyl)-4-methoxyphenyl]thiophene-2-carboximidamide	IC50	158.49 [1]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]-2-phenylethanimidamide	IC50	6309.57 [1]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]propanimidamide	IC50	39810.72 [1]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]pyridine-4-carboximidamide	IC50	1584.89 [1]
	N-[3-(Cyclopentylsulfanylmethyl)-4-methoxyphenyl]-N,N'-dimethylthiophene-2-carboximidamide	IC50	39810.72 [1]
	N'-[3-(Cyclopentylsulfanylmethyl)-4-(trifluoromethoxy)phenyl]thiophene-2-carboximidamide	IC50	1995.26 [1]
	N'-[3-(Cyclopentylsulfinylmethyl)-4-methoxyphenyl]benzenecarboximidamide	IC50	39810.72 [1]
	N'-[3-(Cyclopentylsulfonylmethyl)-4-methoxyphenyl]benzenecarboximidamide	IC50	31622.78 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 78 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Pyroglutamylated RFamide peptide receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/pyroglutamylated-rfamide-peptide-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Pyroglutamylated RFamide peptide receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pyroglutamylated-rfamide-peptide-receptor-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan