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Pyruvate dehydrogenase kinase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SodiumIC501000000.0 [1]
(2R)-N-(2-Chloro-4-piperazin-1-ylsulfonylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5055.0 [1], 71.0 [2]
4-[[(R)-2-Hydroxy-2-methyl-3,3,3-trifluoropropionyl]amino]-3-chlorobenzoic acidIC5090.0 [1]
[(2R)-6-(2-Chloro-5-methylpyrimidin-4-yl)-2-pyridin-3-yl-3,4-dihydro-2H-quinolin-1-yl]-(2,4-dihydroxyphenyl)methanoneIC50100.0 [1], 1000.0 [2]
(5-Chloro-2,4-dihydroxyphenyl)-[(2R)-6-(2-chloro-5-methoxypyrimidin-4-yl)-2-pyridin-3-yl-3,4-dihydro-2H-quinolin-1-yl]methanoneIC50100.0 [1], 1000.0 [2]
NandroloneIC50120000.0 [1]
Dichloroacetic acidIC502000000.0 [1]
Abietic acidIC5020000.0 [1]
(2S)-N-(4-Benzoylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC509300.0 [1]
DehydroabietylamineIC509500.0 [1]
Norethisterone-3-oximeIC505800.0 [1]
Abietyl alcoholIC5010000.0 [1]
(2R)-4-[(R)-2-Methyl-2-hydroxy-3,3,3-trifluoropropionyl]-2-methyl-1-(4-cyanobenzoyl)piperazineIC5079.0 [1]
N-(4-Benzoylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC509300.0 [1]
4-[(2R,5S)-2,5-Dimethyl-4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]piperazine-1-carbonyl]benzonitrileIC5016.5 [1]
Benzyl (2R)-2-methyl-4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]piperazine-1-carboxylateIC5021.0 [1]
(2S)-N-Cyclohexyl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50200000.0 [1]
4-[4-[(R)-2-Methyl-2-hydroxy-3,3,3-trifluoropropionyl]piperazinocarbonyl]benzonitrileIC506700.0 [1]
(2R)-N-(2-Chlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50300.0 [1]
(2R)-N-Cyclohexyl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC506200.0 [1]
(2S)-N-(2-Chlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC509800.0 [1]
(2R,5S)-4-[(R)-2-Methyl-2-hydroxy-3,3,3-trifluoropropionyl]-2,5-dimethyl-1-benzylpiperazineIC5082.0 [1]
N-(4-Chlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5017300.0 [1]
Propanamide, 3,3,3-trifluoro-2-hydroxy-2-methyl-N-phenyl-IC5032000.0 [1]
N-(4-Benzoyl-2-chlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50113.0 [1]
(2R)-N-[2-Chloro-4-(morpholine-4-carbonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50130.0 [1]
N-[2-Chloro-4-(decylsulfamoyl)phenyl]-2-hydroxy-2-methylpropanamideIC504730.0 [1]
(2R)-N-[2-Chloro-4-(pyridin-2-ylmethylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5020.0 [1]
3-Chloro-N-(3-hydroxypropyl)-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzamideIC5087.0 [1]
Methyl (2S)-2-[[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoyl]-methylamino]-3-(1H-indol-3-yl)propanoateIC50110.0 [1]
Methyl 3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoateIC50120.0 [1]
N-[2-Chloro-4-(2-methylpropylsulfamoyl)phenyl]-2-hydroxy-2-methylpropanamideIC5098.0 [1]
(2R)-N-(4-Benzoyl-2-chlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50110.0 [1]
(2R)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(4-piperidin-1-ylsulfonylphenyl)propanamideIC509300.0 [1]
(2R)-N-[2-Chloro-4-(4-pyridin-2-ylpiperazine-1-carbonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50110.0 [1]
N-[2-Chloro-4-[(3,4,5-trimethoxyphenyl)methylsulfamoyl]phenyl]-2-hydroxy-2-methylpropanamideIC501800.0 [1]
(2R)-N-[2-Chloro-4-[(3,4,5-trimethoxyphenyl)methylsulfamoyl]phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50130.0 [1]
(2R)-N-[2-Chloro-4-[2-(dimethylamino)ethylsulfamoyl]phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5032.0 [1]
(2R)-N-[2-Chloro-4-[3-(2-oxopyrrolidin-1-yl)propylsulfamoyl]phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5016.0 [1]
(2R)-N-[2-Chloro-4-(cyclododecylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50380.0 [1]
(2R)-N-[2-Chloro-4-(prop-2-enylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC508.0 [1]
(2R)-N-[2-Chloro-4-(3-hydroxypropylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5029.0 [1]
(2R)-N-[2-Chloro-4-(3-ethoxypropylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5019.0 [1]
(2R)-N-[2-Chloro-4-(piperidine-1-carbonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC501500.0 [1]
(2R)-N-[4-[(3-Aminocyclohexyl)sulfamoyl]-2-chlorophenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC508.4 [1]
(2R)-N-(2-Chloro-4-methylsulfonylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5070.0 [1]
(2R)-N-[2-Chloro-4-(decylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC501300.0 [1]
(2R)-N-[4-[(1-Benzylpiperidin-4-yl)sulfamoyl]-2-chlorophenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50230.0 [1]
(2R)-N-[2-Chloro-4-(pyridin-3-ylmethylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50140.0 [1]
(2R)-N-[2-Chloro-4-(4-pyridin-2-ylpiperazin-1-yl)sulfonylphenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5073.0 [1]
(2R)-N-[2-Chloro-4-(diethylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5061.0 [1]
(2R)-N-[2-Chloro-4-[2-(4-fluorophenyl)ethylsulfamoyl]phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5035.0 [1]
(2R)-N-[2-Chloro-4-(2-pyrrolidin-1-ylethylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50920.0 [1]
(2S)-2-[[3-Chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoyl]amino]-4-phenylbutanoic acidIC5015.0 [1]
(2R)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-phenylpropanamideIC5035000.0 [1]
3-Chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzenesulfonyl fluorideIC5077.0 [1]
N-(2-Chloro-4-piperazin-1-ylsulfonylphenyl)-2-hydroxy-2-methylpropanamideIC501490.0 [1]
3-Chloro-N-(3-hydroxypropyl)-N-methyl-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzamideIC5047.0 [1]
(2R)-N-[2-Chloro-4-(2-morpholin-4-ylethylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5010.0 [1]
(2R)-N-[2-Chloro-4-[3-(diethylamino)propylsulfamoyl]phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5066.0 [1]
(2R)-N-[2-Chloro-4-(cyclopropylmethylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC507.1 [1]
(2R)-N-[2-Chloro-4-(3,3-dimethylbutylsulfamoyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5020.0 [1]
3-Chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]-N-(3,4,5-trimethoxyphenyl)benzamideIC50160.0 [1]
(2S)-2-[[3-Chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoyl]amino]-3-(4-phenylphenyl)propanoic acidIC5077.0 [1]
(2,4-Dihydroxyphenyl)-[(2S)-2-methyl-6-(3-methylquinolin-2-yl)-3,4-dihydro-2H-quinolin-1-yl]methanoneIC501000.0 [1]
[(2S)-6-(2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]-(2,4-dihydroxyphenyl)methanoneIC501000.0 [1]
(2S)-1-(2,4-Dihydroxybenzoyl)-N,2-dimethyl-N-(quinoxalin-6-ylmethyl)-3,4-dihydro-2H-quinoline-6-carboxamideIC501000.0 [1]
[(2S)-6-(2-Chlorothieno[3,2-d]pyrimidin-4-yl)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]-(2,4-dihydroxyphenyl)methanoneIC501000.0 [1]
(3E,5R,8R,9S,10S,13S,14S,17S)-3-Hydroxyimino-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-olIC5036000.0 [1]
3,3,3-Trifluoro-2-hydroxy-N-(4-methoxyphenyl)-2-methylpropanamideIC5022600.0 [1]
3-Chloro-N-(oxolan-2-ylmethyl)-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzamideIC50240.0 [1]
N-(2-Benzoylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50203000.0 [1]
N-[2-Chloro-4-(piperidine-1-carbonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC501500.0 [1]
3-Chloro-4-[(3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)amino]benzenesulfonyl fluorideIC5077.0 [1]
N-(2-Acetylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC502000.0 [1]
3,3,3-Trifluoro-2-hydroxy-N-(2-methoxyphenyl)-2-methylpropanamideIC5061500.0 [1]
N-(2-Chlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC501200.0 [1]
N-(2-Bromophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC501000.0 [1]
3,3,3-Trifluoro-N-(2-fluorophenyl)-2-hydroxy-2-methylpropanamideIC504150.0 [1]
N-(2,4-Dichlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC502000.0 [1]
N-(2-Cyanophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5016100.0 [1]
N-(2,3-Dichlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50300.0 [1]
Sodium;(2S)-2-[[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoyl]amino]-3-phenylpropanoateIC5034.0 [1]
Sodium;(2S)-2-[[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoyl]-methylamino]propanoateIC50150.0 [1]
Sodium;(2S)-2-[[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoyl]-methylamino]-3-methylbutanoateIC50140.0 [1]
(3E,8R,9S,10R,13S,14S,17S)-3-Hydroxyimino-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-olIC505400.0 [1]
2-[[(8R,9S,10R,13S,14S,17S)-17-Hydroxy-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ylidene]amino]acetic acidIC5056000.0 [1]
(1R,4Ar,4bR,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxamideIC506700.0 [1]
CID 44311223IC50840.0 [1]
N-(3-Benzoylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC503000.0 [1]
N-(2-Chloro-4-cyanophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50150.0 [1]
(2R)-N-[4-[[4-(2-Aminoethyl)phenyl]sulfonylsulfamoyl]-2-chlorophenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5016.0 [1]
N-(2-Chloro-4-hydroxyphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50560.0 [1]
3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(2-methylphenyl)propanamideIC5016900.0 [1]
3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(4-phenoxyphenyl)propanamideIC5042100.0 [1]
N-(2,5-Dichlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC502400.0 [1]
N-(3-Acetylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC50170000.0 [1]
N-(3-Cyanophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideIC5021800.0 [1]
3,3,3-Trifluoro-2-hydroxy-N-(3-methoxyphenyl)-2-methylpropanamideIC5047400.0 [1]
N-Hexyl-3-(2-hydroxy-2-methyl-3,3,3-trifluoropropionylamino)-2-chlorobenzamideIC503660.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Pyruvate dehydrogenase kinase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/pyruvate-dehydrogenase-kinase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Pyruvate dehydrogenase kinase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pyruvate-dehydrogenase-kinase-inhibitors-ic50-ki.
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