Pyruvate dehydrogenase kinase isoform 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Dichloroacetic acid	IC50	504000.0 [1], 9000000.0 [2]
	2-[(2,4-Dihydroxyphenyl)sulfonyl]-2,3-Dihydro-1h-Isoindole-4,6-Diol	IC50	456.0 [1], 800.0 [2]
	(3S)-3-Amino-4-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-4-oxobutanamide	IC50	58.0 [1], 81.0 [2]
	Dimorpholinethiuram disulfide	Ki	176.0 [1]
	CID 86280454	IC50	84.0 [1]
	4-[(5-Amino-1,3-dihydroisoindol-2-yl)sulfonyl]benzene-1,3-diol	IC50	1177.0 [1]
	4-[[5-[(1-Benzylpiperidin-4-yl)amino]-1,3-dihydroisoindol-2-yl]sulfonyl]benzene-1,3-diol	IC50	416.0 [1]
	4-[[5-[[1-(2,3-Dihydroxypropyl)piperidin-4-yl]amino]-1,3-dihydroisoindol-2-yl]sulfonyl]benzene-1,3-diol	IC50	154.0 [1]
	[4-[[2-(2,4-Dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-[(3R,5R)-3,4,5-trihydroxycyclohexyl]methanone	IC50	432.0 [1]
	4-({5-[(Piperidin-4-Yl)amino]-1,3-Dihydro-2h-Isoindol-2-Yl}sulfonyl)benzene-1,3-Diol	IC50	195.0 [1]
	4-[[5-(Cyclohexylamino)-1,3-dihydroisoindol-2-yl]sulfonyl]benzene-1,3-diol	IC50	1196.0 [1]
	N-[2-(Ethylamino)-2-oxoethyl]-2,4-dihydroxy-N-(4-methoxyphenyl)benzamide	Ki	2170.0 [1]
	(2S)-2,6-Diamino-1-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]hexan-1-one	IC50	580.0 [1]
	(4S)-4-Amino-5-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-5-oxopentanamide	IC50	72.0 [1]
	(3S)-3-Amino-4-[4-[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]-1,4-diazepan-1-yl]-4-oxobutanamide	IC50	1514.0 [1]
	(3S)-3-Amino-4-[(3S)-3-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]pyrrolidin-1-yl]-4-oxobutanamide	IC50	156.0 [1]
	(2S)-2-Amino-N-[2-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]ethyl]butanediamide	IC50	357.0 [1]
	(2S)-2-Amino-N-[3-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]propyl]butanediamide	IC50	67.0 [1]
	(3S)-3-Amino-4-[(3R)-3-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]pyrrolidin-1-yl]-4-oxobutanamide	IC50	221.0 [1]
	(3S)-3-Amino-4-[3-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]azetidin-1-yl]-4-oxobutanamide	IC50	65.0 [1]
	(3S)-3-Amino-4-[4-[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]piperazin-1-yl]-4-oxobutanamide	IC50	767.0 [1]
	(E)-3-[5-(5-Chloro-2,4-dihydroxyphenyl)-4-(4-hydroxyphenyl)-1,2-oxazol-3-yl]-1-[4-(2-methoxyphenyl)piperazin-1-yl]prop-2-en-1-one	IC50	1126.0 [1]
	3-[4-[[2-(2,4-Dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-3-oxopropanoic acid	IC50	1657.0 [1]
	9-[4-[[2-(2,4-Dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-9-oxononanoic acid	IC50	629.0 [1]
	6-[4-[[2-(2,4-Dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-6-oxohexanoic acid	IC50	1610.0 [1]
	N-[4-(Dimethylcarbamoyl)phenyl]-2,4-dihydroxy-N-methylbenzamide	Ki	150.0 [1]
	4-[(5-Piperazin-1-yl-1,3-dihydroisoindol-2-yl)sulfonyl]benzene-1,3-diol	IC50	1346.0 [1]
	(2S,3S)-2-Amino-1-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-3-hydroxybutan-1-one	IC50	91.0 [1]
	[(3R)-3-(Methoxymethyl)morpholine-4-carbothioyl]sulfanyl (3R)-3-(methoxymethyl)morpholine-4-carbodithioate	Ki	702.0 [1]
	N-[2-(Diethylamino)ethyl]-2,4-dihydroxy-N-(4-methoxyphenyl)benzamide	Ki	1330.0 [1]
	2-[4-[[2-(2,4-Dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidine-1-carbonyl]benzoic acid	IC50	565.0 [1]
	(2S)-2-Amino-1-[4-[[2-(2,4-dihydroxyphenyl)sulfonyl-1,3-dihydroisoindol-5-yl]amino]piperidin-1-yl]-3-hydroxypropan-1-one	IC50	68.0 [1]
	1,4-Oxazepane-4-carbothioylsulfanyl 1,4-oxazepane-4-carbodithioate	Ki	1278.0 [1]
	4-[(5-Piperidin-1-yl-1,3-dihydroisoindol-2-yl)sulfonyl]benzene-1,3-diol	IC50	4371.0 [1]
	3-(4-Bromophenyl)-7-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethoxy)-4H-chromen-4-one	IC50	10900.0 [1]
	3-(3,4-Dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one	IC50	5200.0 [1]
	2,4-Dihydroxy-N-(4-methoxyphenyl)-N-methylbenzamide	Ki	1070.0 [1]
	4-[(5-Hydroxy-1,3-Dihydro-2h-Isoindol-2-Yl)sulfonyl]benzene-1,3-Diol	IC50	570.0 [1]
	2-[4-[(9R)-9-Hydroxy-2-[2-(3-hydroxy-1-adamantyl)ethoxy]-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]acetamide	IC50	5.1 [1]
	(9R)-2-(2-Hydroxy-2-methylpropoxy)-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-9-ol	IC50	7.4 [1]
	(9R)-4-[1-(2-Hydroxyethyl)pyrazol-4-yl]-2-(2-hydroxy-2-methylpropoxy)-9-(trifluoromethyl)fluoren-9-ol	IC50	6.7 [1]
	4-[9-Hydroxy-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-2-yl]oxybutanoic acid	IC50	19.0 [1]
	2-[4-[9-Hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]-2-methylpropane-1,3-diol	IC50	30.0 [1]
	2-(Hydroxymethyl)-2-[4-[9-hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]propane-1,3-diol	IC50	31.0 [1]
	2-Fluoro-4-[1-(2-hydroxyethyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-9-ol	IC50	20.0 [1]
	(+)-3-[4-(9-Hydroxy-2-methyl-9-trifluoromethyl-9H-fluoren-4-yl)-pyrazol-1-yl]-propionic acid	IC50	26.0 [1]
	4-[1-(2-Hydroxyethyl)pyrazol-4-yl]-2-methyl-9-(trifluoromethyl)fluoren-9-ol	IC50	17.0 [1]
	(+)-4-[4-(9-Hydroxy-2-methyl-9-trifluoromethyl-9H-fluoren-4-yl)-pyrazol-1-yl]-butyric acid	IC50	27.0 [1]
	(+)-2-[4-(2-Fluoro-9-hydroxy-9-trifluoromethyl-9H-fluoren-4-yl)-pyrazol-1-yl]-propane-1,3-diol	IC50	22.0 [1]
	2-(Hydroxymethyl)-2-[4-[9-hydroxy-2-methyl-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]propane-1,3-diol	IC50	19.0 [1]
	2-[9-Hydroxy-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-2-yl]oxyacetamide	IC50	18.0 [1]
	4-[9-Hydroxy-4-pyrimidin-5-yl-9-(trifluoromethyl)fluoren-2-yl]oxybutanoic acid	IC50	35.0 [1]
	2-[4-[2-Fluoro-9-hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]-2-(hydroxymethyl)propane-1,3-diol	IC50	20.0 [1]
	2-[4-[9-Hydroxy-2-methyl-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]propane-1,3-diol	IC50	19.0 [1]
	2-[4-[2-Fluoro-9-hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]-2-methylpropane-1,3-diol	IC50	22.0 [1]
	(-)-2-(1-Ethyl-1H-pyrazol-4-yl)-9-hydroxy-9-trifluoromethyl-9H-fluorene-4-carboxamide	IC50	20.0 [1]
	[9-Hydroxy-4-[1-(2-hydroxyethyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-2-yl]-pyrrolidin-1-ylmethanone	IC50	20.0 [1]
	2-[1-(2,2-Dimethylpropyl)pyrazol-4-yl]-4-(hydroxymethyl)-9-(trifluoromethyl)fluoren-9-ol	IC50	17.0 [1]
	2-[4-[2-(3,3-Dimethylbutyl)-9-hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]propane-1,3-diol	IC50	17.0 [1]
	4-(Hydroxymethyl)-2-[1-(2-methylpropyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-9-ol	IC50	37.0 [1]
	2-(5-Hydroxypentoxy)-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-9-ol	IC50	31.0 [1]
	1-[4-[4-Chloro-9-hydroxy-9-(trifluoromethyl)fluoren-2-yl]piperazin-1-yl]-2,2-dimethylpropan-1-one	IC50	56.0 [1]
	2-(5-Hydroxypentoxy)-4-pyrimidin-5-yl-9-(trifluoromethyl)fluoren-9-ol	IC50	25.0 [1]
	4-(Aminomethyl)-9-(trifluoromethyl)fluoren-9-ol	IC50	10000.0 [1]
	2-[4-[9-Hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]acetamide	IC50	39.0 [1]
	[3-(2-Hydroxyethoxy)azetidin-1-yl]-[9-hydroxy-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-2-yl]methanone	IC50	50.0 [1]
	Tert-butyl N-[2-[9-hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxyethyl]-N-methylcarbamate	IC50	203.0 [1]
	1-(Azetidin-1-yl)-2-[9-hydroxy-4-[1-(2-hydroxyethyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-2-yl]oxyethanone	IC50	23.0 [1]
	3-[2-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxyethyl]-1,3-oxazinan-2-one	IC50	168.0 [1]
	3-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxypropanoic acid	IC50	5826.0 [1]
	1-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]-N-methylpiperidine-4-carboxamide	IC50	3607.0 [1]
	2-[1-(Cyclohexylmethyl)pyrazol-4-yl]-9-hydroxy-9-(trifluoromethyl)fluorene-4-carboxamide	IC50	15.0 [1]
	4-(Methylamino)-9-(trifluoromethyl)fluoren-9-ol	IC50	23099.0 [1]
	4-(1-Hydroxyethyl)-2-[1-(2-hydroxyethyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-9-ol	IC50	513.0 [1]
	4-[1-(2-Hydroxyethyl)pyrazol-4-yl]-2-methoxy-9-(trifluoromethyl)fluoren-9-ol	IC50	39.0 [1]
	9-Hydroxy-N-(4-hydroxybutyl)-4-pyrimidin-5-yl-9-(trifluoromethyl)fluorene-2-carboxamide	IC50	617.0 [1]
	3-Methoxy-9-(trifluoromethyl)fluoren-9-ol	IC50	4909.0 [1]
	N-[2-[4-[9-Hydroxy-9-(trifluoromethyl)fluoren-4-yl]pyrazol-1-yl]ethyl]-N-methylacetamide	IC50	197.0 [1]
	4-Fluoro-9-(trifluoromethyl)fluoren-9-ol	IC50	6792.0 [1]
	2-[5-[2-Fluoro-9-hydroxy-9-(trifluoromethyl)fluoren-4-yl]-1,3-oxazol-2-yl]propane-1,3-diol	IC50	79.0 [1]
	Methyl 7-fluoro-9-hydroxy-9-(trifluoromethyl)fluorene-4-carboxylate	IC50	10000.0 [1]
	1-[(2S)-2-(Hydroxymethyl)pyrrolidin-1-yl]-2-[9-hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxyethanone	IC50	1225.0 [1]
	2-[9-Hydroxy-4-[1-(2-hydroxyethyl)pyrazol-4-yl]-9-(trifluoromethyl)fluoren-2-yl]oxyacetamide	IC50	18.0 [1]
	4-(1-Methyltetrazol-5-yl)-9-(trifluoromethyl)fluoren-9-ol	IC50	10000.0 [1]
	4-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]benzamide	IC50	182.0 [1]
	2-Ethyl-9-hydroxy-9-(trifluoromethyl)fluorene-4-carboxamide	IC50	560.0 [1]
	Methyl 9-hydroxy-9-(trifluoromethyl)fluorene-2-carboxylate	IC50	571.0 [1]
	Ethyl 5-[9-hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxypentanoate	IC50	571.0 [1]
	[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]-[3-(methylamino)pyrrolidin-1-yl]methanone	IC50	2192.0 [1]
	N-[2-[9-Hydroxy-4-pyrimidin-5-yl-9-(trifluoromethyl)fluoren-2-yl]oxyethyl]-N-methylacetamide	IC50	23.0 [1]
	4-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]-N,N-dimethylbenzamide	IC50	182.0 [1]
	Azetidin-1-yl-[5-hydroxy-2-methoxy-5-(trifluoromethyl)indeno[1,2-b]pyridin-3-yl]methanone	IC50	803.0 [1]
	2-Morpholin-4-yl-9-(trifluoromethyl)fluoren-9-ol	IC50	2113.0 [1]
	1-[9-Hydroxy-9-(trifluoromethyl)fluorene-2-carbonyl]pyrrolidine-2-carboxylic acid	IC50	10000.0 [1]
	[9-Hydroxy-4-(1-methylpyrazol-4-yl)-9-(trifluoromethyl)fluoren-2-yl]-[3-(hydroxymethyl)pyrrolidin-1-yl]methanone	IC50	58.0 [1]
	2-(4-Chlorophenyl)-9-(trifluoromethyl)fluoren-9-ol	IC50	1340.0 [1]
	1-(2-Hydroxyethyl)-5-[[9-hydroxy-9-(trifluoromethyl)fluoren-2-yl]oxymethyl]pyrrolidin-2-one	IC50	247.0 [1]
	2-(Methylamino)-9-(trifluoromethyl)fluoren-9-ol	IC50	7831.0 [1]
	Methyl 9-hydroxy-4-pyrimidin-5-yl-9-(trifluoromethyl)fluorene-2-carboxylate	IC50	178.0 [1]
	4-[9-Hydroxy-9-(trifluoromethyl)fluoren-2-yl]-N-methylbenzamide	IC50	216.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Pyruvate dehydrogenase kinase isoform 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/pyruvate-dehydrogenase-kinase-isoform-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Pyruvate dehydrogenase kinase isoform 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pyruvate-dehydrogenase-kinase-isoform-2-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan