Rap guanine nucleotide exchange factor 4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	CID 6077765	IC50	4400.0 [1], 7000.0 [2], 9000.0 [3]
	Cyclic AMP	IC50	40000.0 [1], 48000.0 [2]
	Mesityl P-tolyl sulfone	IC50	400.0 [1], 500.0 [2]
	(2R)-5,7-Dibromo-6-fluoro-2-methyl-3,4-dihydro-2H-quinoline-1-carbaldehyde	IC50	17000.0 [1], 22300.0 [2]
	(E)-3-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)prop-2-enoic acid	IC50	3800.0 [1]
	2,4-Dimethyl-1-(2,4,6-trimethyl-benzenesulfonyl)-1H-pyrrole	IC50	300.0 [1]
	1-(2,4,6-Trimethylphenyl)sulfonylindole	IC50	1200.0 [1]
	Benzenesulfonic acid, 5-amino-2-[(4-aminophenyl)amino]-	IC50	18000.0 [1]
	5-((2-Hydroxy-1-naphthyl)diazenyl)-2-naphthalenesulfonic acid	IC50	1700.0 [1]
	4-Cyclohexyl-2-[(2,5-dimethylphenyl)methylsulfanyl]-6-oxo-1H-pyrimidine-5-carbonitrile	IC50	8400.0 [1]
	N-(5-Cyano-15,22-dioxo-13-oxa-3-thiapentacyclo[12.8.0.02,6.07,12.016,21]docosa-1(14),2(6),4,7,9,11,16,18,20-nonaen-4-yl)-2,2,2-trifluoroacetamide	IC50	7900.0 [1]
	N-(3,5-Dimethylphenyl)-2,4,6-trimethylaniline	IC50	1700.0 [1]
	3-N-(2,4,6-Trimethylphenyl)benzene-1,3-diamine	IC50	34000.0 [1]
	2,4,6-Trimethyl-N-(4-methylphenyl)aniline	IC50	3800.0 [1]
	N-(4-Bromophenyl)-2,4,6-trimethylaniline	IC50	1600.0 [1]
	N-(2,4-Dimethylphenyl)-2,4,6-trimethylaniline	IC50	2200.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2,4,6-trimethylaniline	IC50	2900.0 [1]
	N-[3-Chloro-5-(trifluoromethyl)phenyl]-2,4,6-trimethylaniline	IC50	500.0 [1]
	N-(3,5-Difluorophenyl)-2,4,6-trimethylaniline	IC50	5700.0 [1]
	N-(3,4-Difluorophenyl)-2,4,6-trimethylaniline	IC50	8700.0 [1]
	N-(5-Chloro-2-methylphenyl)-2,4,6-trimethylaniline	IC50	1400.0 [1]
	N-(2,4-Dichloro-6-methylphenyl)-2,4,6-trimethylaniline	IC50	700.0 [1]
	N-(3-Fluorophenyl)-2,4,6-trimethylaniline	IC50	5800.0 [1]
	N-(3-Bromophenyl)-2,4,6-trimethylaniline	IC50	1500.0 [1]
	2,4,6-Trimethyl-N-(3,4,5-trichlorophenyl)aniline	IC50	1100.0 [1]
	2,4,6-Trimethyl-N-(2,4,6-trifluorophenyl)aniline	IC50	2700.0 [1]
	N-(2,3-Dimethylphenyl)-2,4,6-trimethylaniline	IC50	1000.0 [1]
	N-(3-Chloro-5-fluorophenyl)-2,4,6-trimethylaniline	IC50	2900.0 [1]
	N-(3,4-Dichlorophenyl)-2,4,6-trimethylaniline	IC50	1100.0 [1]
	N-(4-Chloro-3-fluorophenyl)-2,4,6-trimethylaniline	IC50	3300.0 [1]
	N-(2,4,6-Trimethylphenyl)-2,3-dihydro-1H-inden-5-amine	IC50	1800.0 [1]
	N-(3-Ethylphenyl)-2,4,6-trimethylaniline	IC50	1800.0 [1]
	2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]aniline	IC50	2000.0 [1]
	2,4,6-Trimethyl-N-[3-[2-(2,4,6-trimethylphenyl)ethynyl]phenyl]aniline	IC50	300000.0 [1]
	2,4,6-Trimethyl-N-(3,4,5-trifluorophenyl)aniline	IC50	3000.0 [1]
	3-(2,4,6-Trimethylanilino)phenol	IC50	46000.0 [1]
	N-(3-Chloro-4-methylphenyl)-2,4,6-trimethylaniline	IC50	1800.0 [1]
	(1E)-2-(4-Tert-butylphenyl)-N-(3,5-dichloroanilino)-2-oxoethanimidoyl cyanide	IC50	2500.0 [1]
	(1E)-N-(3,5-Dichloroanilino)-2-naphthalen-2-yl-2-oxoethanimidoyl cyanide	IC50	2500.0 [1]
	(1E)-2-(4-Tert-butylphenyl)-N-(3-chloro-5-fluoroanilino)-2-oxoethanimidoyl cyanide	IC50	3400.0 [1]
	(1E)-2-(4-Tert-butylphenyl)-N-[4-chloro-3-(trifluoromethyl)anilino]-2-oxoethanimidoyl cyanide	IC50	12400.0 [1]
	(1E)-2-(4-Tert-butylphenyl)-2-oxo-N-(3,4,5-trifluoroanilino)ethanimidoyl cyanide	IC50	15800.0 [1]
	(1E)-2-(4-Tert-butylphenyl)-N-[3-chloro-5-(trifluoromethyl)anilino]-2-oxoethanimidoyl cyanide	IC50	5400.0 [1]
	(1E)-2-(4-Tert-butylphenyl)-2-oxo-N-(3,4,5-trichloroanilino)ethanimidoyl cyanide	IC50	3000.0 [1]
	2-Benzylsulfanyl-4-cyclohexyl-6-hydroxy-pyrimidine-5-carbonitrile	IC50	30500.0 [1]
	2-[(5-Cyano-4-cyclohexyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(4-methylphenyl)acetamide	IC50	300000.0 [1]
	2-[(2,5-Dimethylphenyl)methylsulfanyl]-6-oxo-4-propan-2-yl-1H-pyrimidine-5-carbonitrile	IC50	12700.0 [1]
	4-Cyclohexyl-2-[(2,4-dimethylphenyl)methylsulfanyl]-6-oxo-1H-pyrimidine-5-carbonitrile	IC50	15700.0 [1]
	2-[(5-Cyano-4-cyclohexyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetic acid	IC50	300000.0 [1]
	4-Cyclohexyl-6-oxo-2-[(2,4,6-trimethylphenyl)methylsulfanyl]-1H-pyrimidine-5-carbonitrile	IC50	11600.0 [1]
	2-[(2,5-Dimethylphenyl)methylsulfanyl]-4-(1-methylpiperidin-4-yl)-6-oxo-1H-pyrimidine-5-carbonitrile	IC50	127000.0 [1]
	2-Anilino-4-cyclohexyl-6-oxo-1H-pyrimidine-5-carbonitrile	IC50	300000.0 [1]
	4-Cyclohexyl-2-[(3,5-dimethylphenyl)methylsulfanyl]-6-oxo-1H-pyrimidine-5-carbonitrile	IC50	7000.0 [1]
	4-Cyclopropyl-2-[(2,5-dimethylphenyl)methylsulfanyl]-6-oxo-1H-pyrimidine-5-carbonitrile	IC50	4000.0 [1]
	4-Cyclopentyl-2-[(2,5-dimethylphenyl)methylsulfanyl]-6-oxo-1H-pyrimidine-5-carbonitrile	IC50	5900.0 [1]
	4-Cyclohexyl-2-[(4-methylphenyl)methylsulfanyl]-6-oxo-1H-pyrimidine-5-carbonitrile	IC50	38700.0 [1]
	2-(4-Chloroanilino)-4-cyclohexyl-6-oxo-1H-pyrimidine-5-carbonitrile	IC50	300000.0 [1]
	2-[(5-Cyano-4-cyclohexyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(2,4,6-trimethylphenyl)acetamide	IC50	300000.0 [1]
	2-[(2,5-Dimethylphenyl)methylsulfanyl]-6-oxo-4-piperidin-4-yl-1H-pyrimidine-5-carbonitrile	IC50	300000.0 [1]
	2-[(5-Cyano-4-cyclohexyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-phenylacetamide	IC50	300000.0 [1]
	N-(3-Methoxyphenyl)-2,4,6-trimethylaniline	IC50	10700.0 [1]
	5-Cyano-6-cyclohexyl-2-thiouracil	IC50	300000.0 [1]
	2-(4-Methoxyphenyl)sulfonyl-1,3,5-trimethyl-benzene	IC50	1900.0 [1]
	N-(2,5-Dimethylphenyl)-2,4,6-trimethylaniline	IC50	1800.0 [1]
	4-(2,4,6-Trimethylbenzenesulfonyl)Phenol	IC50	13500.0 [1]
	2-Fluoro-5-[4-(2,4,6-trimethylphenyl)sulfonylphenyl]pyridine	IC50	300000.0 [1]
	4,5-Dimethyl-N-(2,4,6-trimethylphenyl)-1,3-thiazol-2-amine	IC50	300000.0 [1]
	1,3,5-Trimethyl-2-(2,4,5-trimethylphenyl)sulfonylbenzene	IC50	700.0 [1]
	1,3,5-Trimethyl-2-(4-pentylphenyl)sulfonylbenzene	IC50	300000.0 [1]
	2-(4-Cyclohexylphenyl)sulfonyl-1,3,5-trimethylbenzene	IC50	300000.0 [1]
	2-(4-Cyclohexyloxyphenyl)sulfonyl-1,3,5-trimethylbenzene	IC50	300000.0 [1]
	Tert-butyl 4-[4-(2,4,6-trimethylphenyl)sulfonylphenoxy]piperidine-1-carboxylate	IC50	300000.0 [1]
	4-[4-(2,4,6-Trimethylphenyl)sulfonylphenoxy]piperidine	IC50	300000.0 [1]
	2-[4-(2,4,6-Trimethylphenyl)sulfonylphenoxy]ethanamine	IC50	300000.0 [1]
	N-(3,5-Dichlorophenyl)-2,4,6-trimethylaniline	IC50	900.0 [1]
	(2,5-Dichlorophenyl)-(2,4,6-trimethylphenyl)-amine	IC50	400.0 [1]
	2-Ethyl-1-(2,4,6-trimethylphenyl)sulfonylpyrrole	IC50	500.0 [1]
	2-Ethyl-1-(4-methylphenyl)sulfonylpyrrole	IC50	4000.0 [1]
	2-Ethyl-1-(4-methoxyphenyl)sulfonylpyrrole	IC50	8000.0 [1]
	1-(4-Chloro-benzenesulfonyl)-2-ethyl-1H-pyrrole	IC50	8000.0 [1]
	2-Ethyl-1-[4-(trifluoromethyl)phenyl]sulfonylpyrrole	IC50	300000.0 [1]
	2-Ethyl-1-(2-methylphenyl)sulfonylpyrrole	IC50	5300.0 [1]
	1-(3,5-Dimethylphenyl)sulfonyl-2-ethylpyrrole	IC50	4700.0 [1]
	1-(2,4-Dimethylphenyl)sulfonyl-2-ethylpyrrole	IC50	1300.0 [1]
	Methyl 1-(2,4,6-trimethylphenyl)sulfonylindole-5-carboxylate	IC50	300000.0 [1]
	1-(2,4,6-Trimethylphenyl)sulfonylindole-5-carboxylic acid	IC50	10800.0 [1]
	1-(2,4,6-Trimethylphenyl)sulfonylpyrrolo[3,2-b]pyridine	IC50	3800.0 [1]
	1-(2,4,6-Trimethylphenyl)sulfonylpyrrolo[3,2-c]pyridine	IC50	8900.0 [1]
	1-(2,4,6-Trimethylphenyl)sulfonylpyrrolo[2,3-c]pyridine	IC50	12600.0 [1]
	1-(2,4,6-Trimethylphenyl)sulfonylpyrrolo[2,3-b]pyridine	IC50	2400.0 [1]
	2-(4-Iodophenyl)sulfonyl-1,3,5-trimethylbenzene	IC50	4000.0 [1]
	(2S)-5,7-Dibromo-6-fluoro-2-methyl-3,4-dihydro-2H-quinoline-1-carbaldehyde	IC50	17100.0 [1]
	2-(Mesitylamino)-3-(3-methoxypropyl)-4-methylthiazole-3-ium	IC50	600.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 93 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Rap guanine nucleotide exchange factor 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/rap-guanine-nucleotide-exchange-factor-4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Rap guanine nucleotide exchange factor 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/rap-guanine-nucleotide-exchange-factor-4-inhibitors-ic50-ki.
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