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RAS guanyl releasing protein 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 25053598Ki0.18 [1], 0.33 [2], 0.84 [3]
[(4E)-2-(Hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoateKi3.8 [1]
[(4E)-4-[[4-(Dimethylamino)phenyl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoateKi4.68 [1], 26.8 [2]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-methoxybenzoateKi3.3 [1], 26.5 [2]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoateKi3.7 [1], 18.2 [2]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoateKi23.8 [1], 271.0 [2]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi35.8 [1], 89.7 [2]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-methyl-2-(2-methylpropyl)pentanoateKi0.7 [1], 5.07 [2]
(4-(4-Nitrobenzylidene)-2-(hydroxymethyl)-5-oxo-tetrahydrofuran-2-yl)methyl 4-methoxybenzoateKi6.7 [1]
[(4E)-4-[[4-(Dimethylamino)phenyl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-methoxybenzoateKi7.48 [1]
[(4E)-2-(Hydroxymethyl)-4-[(4-methoxyphenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoateKi7.0 [1]
[(4E)-2-(Hydroxymethyl)-4-[(4-methoxyphenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-methoxybenzoateKi4.17 [1]
[(2Z,4E)-6-[(3S,4R,5S,6R,7Z,10S)-4,10-Dihydroxy-6-(3-hydroxypropyl)-10-methyl-7-(1-oxopropan-2-ylidene)spiro[4.5]decan-3-yl]-2-(4-methylpent-3-enyl)hepta-2,4,6-trienyl] acetateKi41.7 [1]
Chembl4169454Ki1.75 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl (E)-3-pyridin-2-ylprop-2-enoateKi149.0 [1]
[(4E)-4-[(4-Chlorophenyl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-chlorobenzoateKi2.69 [1]
[(4E)-2-(Hydroxymethyl)-4-[(4-methoxyphenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-chlorobenzoateKi1.54 [1]
[(4E)-4-(1-Benzothiophen-3-ylmethylidene)-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi1.67 [1]
[(4E)-2-(Hydroxymethyl)-4-[(5-methoxy-1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi4.76 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 2,2-dimethylpropanoateKi192.0 [1]
[(4E)-4-[(4-Chlorophenyl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoateKi2.73 [1]
[(4Z)-4-(1-Benzothiophen-3-ylmethylidene)-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi4.26 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-chlorobenzoateKi11.2 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl heptanoateKi5.3 [1]
[(4E)-4-[[4-(Dimethylamino)phenyl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-chlorobenzoateKi1.81 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methyl-5-nitroindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi3490.0 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl (E)-3-(1-methylindol-3-yl)prop-2-enoateKi15.7 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindazol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi7.22 [1]
[(4E)-2-(Hydroxymethyl)-4-[[1-(2-methylpropyl)indol-3-yl]methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi3.03 [1]
[(4E)-4-[(1-Butylindol-3-yl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi1.87 [1]
[(4Z)-4-(1-Benzofuran-3-ylmethylidene)-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi11.67 [1]
[(4E)-4-[[4-(Dimethylamino)phenyl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi1.07 [1]
[(4E)-4-[(5-Chloro-1-methylindol-3-yl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi1.01 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl (E)-3-phenylprop-2-enoateKi25.0 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl cyclohexanecarboxylateKi2.86 [1]
[(4E)-2-(Hydroxymethyl)-4-[(4-methoxyphenyl)methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi1.09 [1]
[(4Z)-4-[(5-Chloro-1-methylindol-3-yl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi4.32 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 4-tert-butylcyclohexane-1-carboxylateKi2.15 [1]
[(4Z)-2-(Hydroxymethyl)-4-[(1-methyl-5-nitroindol-3-yl)methylidene]-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi1390.0 [1]
[(4E)-4-(1-Benzofuran-3-ylmethylidene)-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi2.8 [1]
[(4E)-4-[(4-Chlorophenyl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 4-methoxybenzoateKi2.25 [1]
[(4E)-4-[[1-(Cyclopropylmethyl)indol-3-yl]methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi3.58 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-chlorobenzoateKi29.0 [1]
[(4E)-4-[(4-Chlorophenyl)methylidene]-2-(hydroxymethyl)-5-oxooxolan-2-yl]methyl 2,2-dimethylpropanoateKi0.53 [1]
[(4E)-2-(Hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 3-(dimethylamino)benzoateKi2.3 [1]
[(4E)-2-(Hydroxymethyl)-4-[(3-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoateKi8.0 [1]
[(4E)-2-(Hydroxymethyl)-4-[(3-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 3-(dimethylamino)benzoateKi5.3 [1]
[(4E)-2-(Hydroxymethyl)-4-[(2-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-(dimethylamino)benzoateKi14.4 [1]
[(4E)-2-(Hydroxymethyl)-4-[(2-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 3-(dimethylamino)benzoateKi16.4 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoateKi0.72 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoateKi83.0 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoateKi1.6 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoateKi670.0 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoateKi13.8 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoateKi1.7 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoateKi4.6 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoateKi32.2 [1]
[(4E)-2-(Hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 4-nitrobenzoateKi2.22 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoateKi59.0 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoateKi54.0 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoateKi2360.0 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoateKi2040.0 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoateKi137.0 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi2470.0 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi81.0 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi5500.0 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi54.2 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi1390.0 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi17.4 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi907.0 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoateKi1970.0 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoateKi1410.0 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi3660.0 [1]
[(4E)-2-(Hydroxymethyl)-4-[(4-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 2-(dimethylamino)benzoateKi1.8 [1]
[(4E)-2-(Hydroxymethyl)-4-[(3-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 2-(dimethylamino)benzoateKi3.9 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 4-(dimethylamino)benzoateKi11.0 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoateKi8.2 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoateKi0.52 [1]
[(4E)-2-(Hydroxymethyl)-4-[(2-nitrophenyl)methylidene]-5-oxooxolan-2-yl]methyl 2-(dimethylamino)benzoateKi9.4 [1]
[(4Z)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-4-ylmethylidene)oxolan-2-yl]methyl 2-propylpentanoateKi44.0 [1]
(2Z)-2-[(2R,3S,4S)-4-Hydroxy-3-(hydroxymethyl)-2-(3-hydroxypropyl)-4-methyl-3-[(3Z,5E)-4-methyl-6-[(1R,5S)-2,5,6,6-tetramethylcyclohex-2-en-1-yl]hexa-3,5-dienyl]cyclohexylidene]propanalKi15.5 [1]
[(4E)-2-(Hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylidene)oxolan-2-yl]methyl 4-methyl-2-(2-methylpropyl)pentanoateKi0.2 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-6-yl)methylidene]-5-oxooxolan-2-yl]methyl 2-propylpentanoateKi1.22 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-4-yl)methylidene]-5-oxooxolan-2-yl]methyl 2-propylpentanoateKi1.63 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-5-yl)methylidene]-5-oxooxolan-2-yl]methyl 2-propylpentanoateKi0.34 [1]
[(4E)-2-(Hydroxymethyl)-4-[(1-methylindol-7-yl)methylidene]-5-oxooxolan-2-yl]methyl 2-propylpentanoateKi1.12 [1]
Items per page: 1 - 10 of 86
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References

This online tool may be cited as follows

MLA

"Quest Database™ RAS guanyl releasing protein 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/ras-guanyl-releasing-protein-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ RAS guanyl releasing protein 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ras-guanyl-releasing-protein-3-inhibitors-ic50-ki.
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