Receptor-interacting serine/threonine-protein kinase 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	CID 77108121	IC50	1.0 [1]
	CID 77108121	Ki	0.98 [1]
	5-Benzyl-N-[(3S)-4-oxo-3,5-dihydro-2H-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	16.0 [1], 200.0 [2]
	5-Benzyl-N-[(3s)-5-Methyl-4-Oxo-2,3,4,5-Tetrahydro-1,5-Benzoxazepin-3-Yl]-1,2-Oxazole-3-Carboxamide	IC50	1.6 [1], 2.8 [2], 10.0 [3]
	5-Benzyl-N-[(3s)-5-Methyl-4-Oxo-2,3,4,5-Tetrahydro-1,5-Benzoxazepin-3-Yl]-1,2-Oxazole-3-Carboxamide	Ki	0.8 [1]
	1-[4-(1-Aminoisoquinolin-5-Yl)phenyl]-3-(5-Tert-Butyl-1,2-Oxazol-3-Yl)urea	IC50	10.0 [1], 16.0 [2], 25.0 [3], 500.0 [4], 630.0 [5]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	13.0 [1], 63.0 [2], 250.0 [3]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea	Ki	2.04 [1]
	5-Benzyl-N-[(3R)-4-oxo-3,5-dihydro-2H-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	10000.0 [1]
	CID 76332060	IC50	1.3 [1], 16.0 [2], 32.0 [3]
	(5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione	IC50	200.0 [1], 320.0 [2], 630.0 [3]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[3,5-bis(trifluoromethyl)phenyl]urea	IC50	32.0 [1], 320.0 [2], 7900.0 [3]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[3-(trifluoromethyl)phenyl]urea	IC50	10.0 [1], 20.0 [2], 1000.0 [3]
	5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1H-1,5-benzodiazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	0.79 [1], 40.0 [2]
	5-Benzyl-N-[(3S)-1-methyl-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	0.2 [1], 6.3 [2]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-chloro-5-(trifluoromethyl)phenyl]urea	IC50	2500.0 [1], 10000.0 [2]
	1-Phenyl-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea	IC50	400.0 [1], 600.0 [2], 1300.0 [3]
	5-Benzyl-N-[(3R)-5-methyl-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	0.06 [1], 0.94 [2], 2.0 [3]
	1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-chlorophenyl)urea	IC50	160.0 [1], 200.0 [2], 7900.0 [3]
	N-[(3S)-4-Oxo-3,5-dihydro-2H-1,5-benzoxazepin-3-yl]-3-phenoxybenzamide	IC50	7.9 [1], 40.0 [2], 400.0 [3]
	1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	13.0 [1], 130.0 [2], 630.0 [3]
	1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea	IC50	20.0 [1], 25.0 [2], 630.0 [3]
	1-(3-Nitrophenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea	IC50	16.0 [1], 320.0 [2]
	1-[3-(5-Phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea	IC50	32.0 [1], 79.0 [2]
	1-[3-[5-(4-Ethylsulfonylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	3.2 [1], 10.0 [2], 25.0 [3]
	1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[3-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea	IC50	4.0 [1], 6.3 [2], 7.9 [3]
	1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]urea	IC50	160.0 [1], 500.0 [2], 1300.0 [3]
	3-[3-[3-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]benzamide	IC50	10.0 [1], 16.0 [2], 63.0 [3]
	1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-3-(trifluoromethyl)phenyl]urea	IC50	200.0 [1], 250.0 [2], 10000.0 [3]
	1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea	IC50	40.0 [1], 160.0 [2], 2000.0 [3]
	1-(3-Acetylphenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea	IC50	10.0 [1], 13.0 [2], 320.0 [3]
	1-[3-[5-(4-Aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	16.0 [1], 32.0 [2], 50.0 [3]
	1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[2-fluoro-3-(trifluoromethyl)phenyl]urea	IC50	4000.0 [1], 10000.0 [2]
	1-Cyclopentyl-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea	IC50	500.0 [1], 2000.0 [2], 7900.0 [3]
	1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[3-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	63.0 [1], 130.0 [2], 5000.0 [3]
	1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea	IC50	32.0 [1], 160.0 [2], 1300.0 [3]
	1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-ethylphenyl)urea	IC50	10.0 [1], 25.0 [2], 250.0 [3]
	1-(3-Methylphenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea	IC50	13.0 [1], 20.0 [2], 160.0 [3]
	1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]urea	IC50	10.0 [1], 320.0 [2], 2500.0 [3]
	1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[3-[5-(3-methylsulfonylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]urea	IC50	10.0 [1], 50.0 [2], 63.0 [3]
	1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[3-[5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]urea	IC50	6.0 [1], 16.0 [2], 63.0 [3]
	1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[3-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	25.0 [1], 160.0 [2], 2500.0 [3]
	1-[4-(1-Aminoisoquinolin-5-yl)phenyl]-3-[2-chloro-5-(trifluoromethyl)phenyl]urea	IC50	630.0 [1], 3200.0 [2], 10000.0 [3]
	1-(3-Methoxyphenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea	IC50	6.3 [1], 32.0 [2], 400.0 [3]
	1-[4-(4-Aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea	IC50	16.0 [1], 32.0 [2], 200.0 [3]
	1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea	IC50	80.0 [1], 160.0 [2], 200.0 [3]
	5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone	IC50	182.0 [1], 760.0 [2]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-naphthalen-2-ylurea	IC50	100.0 [1], 790.0 [2]
	5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,3,4-oxadiazole-2-carboxamide	IC50	0.79 [1], 7.9 [2]
	N-[(3S)-5-Methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(2-methylpropyl)-1,2-oxazole-3-carboxamide	IC50	1600.0 [1], 6310.0 [2]
	1-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]imidazole-4-carboxamide	IC50	0.4 [1], 6.3 [2]
	N-[(3S)-4-Oxo-3,5-dihydro-2H-1,5-benzoxazepin-3-yl]-5-pentyl-1H-pyrazole-3-carboxamide	IC50	320.0 [1], 1600.0 [2]
	1-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2,4-triazole-3-carboxamide	IC50	0.63 [1], 1.6 [2]
	2-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]tetrazole-5-carboxamide	IC50	0.08 [1], 2.5 [2]
	1-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]pyrazole-4-carboxamide	IC50	63.0 [1], 631.0 [2]
	1-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]triazole-4-carboxamide	IC50	1.0 [1], 25.0 [2]
	5-Benzyl-N-[(3S)-5-methyl-4-oxo-7-(1H-pyrazol-5-yl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	1.0 [1], 6.3 [2]
	5-Benzyl-N-[(3S)-5-methyl-4-oxo-7-(2-oxo-3H-1,3,4-oxadiazol-5-yl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	0.5 [1], 3.2 [2]
	2-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,3-oxazole-4-carboxamide	IC50	794.0 [1], 2512.0 [2]
	5-Benzyl-N-[(4S)-5-oxo-2,3,4,6-tetrahydro-1,6-benzoxazocin-4-yl]-1,2-oxazole-3-carboxamide	IC50	200.0 [1], 631.0 [2]
	5-Benzyl-N-[(3S)-1,5-dimethyl-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	5.0 [1], 20.0 [2]
	Methyl N-[(3S)-3-[(5-benzyl-1,2-oxazole-3-carbonyl)amino]-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-7-yl]carbamate	IC50	0.32 [1], 10.0 [2]
	5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,3-thiazole-2-carboxamide	IC50	631.0 [1], 794.0 [2]
	5-Benzyl-N-[(3S)-5-ethyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	3162.0 [1], 7943.0 [2]
	RIP1 kinase inhibitor 1	IC50	1.3 [1]
	RIP1 kinase inhibitor 1	Ki	0.91 [1]
	5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,3-oxazole-2-carboxamide	IC50	0.05 [1], 1.0 [2]
	5-Benzyl-N-[(3R)-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	10000.0 [1]
	5-Benzyl-N-[(6S)-5-oxo-1,4-oxazepan-6-yl]-1,2-oxazole-3-carboxamide	IC50	10000.0 [1]
	N-[(3S)-5-Methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-pentyl-1,2-oxazole-3-carboxamide	IC50	100.0 [1], 126.0 [2]
	5-Benzyl-1-methyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]pyrazole-3-carboxamide	IC50	0.4 [1], 10.0 [2]
	4-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]pyridine-2-carboxamide	IC50	2.0 [1], 40.0 [2]
	5-(Cyclohexylmethyl)-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	251.0 [1], 501.0 [2]
	5-Benzyl-N-[(3S)-5-cyclopropyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	10000.0 [1]
	5-Benzyl-N-[(3S)-7-(methanesulfonamido)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	0.63 [1], 13.0 [2]
	5-Benzyl-N-(2-oxo-3,4-dihydro-1H-quinolin-3-yl)-1,2-oxazole-3-carboxamide	IC50	10000.0 [1]
	5-Benzyl-N-[(3S)-3-methyl-4-oxo-2,5-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	10000.0 [1]
	N-[(3S)-5-Methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(piperidin-1-ylmethyl)-1,2-oxazole-3-carboxamide	IC50	10000.0 [1]
	5-Benzyl-N-methyl-N-[(3S)-4-oxo-3,5-dihydro-2H-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	10000.0 [1]
	2-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-imidazole-5-carboxamide	IC50	1259.0 [1], 1995.0 [2]
	3-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]benzamide	IC50	251.0 [1], 398.0 [2]
	N-[(3S)-7-Acetamido-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-benzyl-1,2-oxazole-3-carboxamide	IC50	0.32 [1], 7.9 [2]
	5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2,4-oxadiazole-3-carboxamide	IC50	0.5 [1], 5.0 [2]
	Tozasertib	IC50	208.0 [1]
	Necrostatin 2 racemate	IC50	754.0 [1]
	CID 121439991	IC50	13.0 [1]
	Ripk1-IN-7	IC50	11.0 [1]
	5-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-pyrazole-3-carboxamide	IC50	0.4 [1]
	5-Benzyl-N-[(3R)-1,1,4-trioxo-3,5-dihydro-2H-1lambda6,5-benzothiazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	79.0 [1]
	5-Benzyl-N-[(3S)-4-oxo-1,2,3,5-tetrahydro-1,5-benzodiazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	3.2 [1]
	N-[(3S)-5-Methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-[[3-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methyl]-1H-pyrazole-3-carboxamide	IC50	35.0 [1]
	5-Benzyl-N-[(3S)-1-methyl-2-oxo-7-[3-(trifluoromethyl)diazirin-3-yl]-4,5-dihydro-3H-1-benzazepin-3-yl]-1,2-oxazole-3-carboxamide	IC50	210.0 [1]
	(3S)-3-(2-Benzyl-3-chloro-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl)-N,5-dimethyl-4-oxo-2,3-dihydro-1,5-benzoxazepine-8-carboxamide	Ki	0.91 [1]
	(3S)-3-[2-[(2-Fluorophenyl)methyl]-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl]-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-one	Ki	1.74 [1]
	(3S)-3-[2-(Cyclobutylmethyl)-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl]-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-one	Ki	13.8 [1]
	(3S)-3-(2-Benzyl-4-oxo-6,7-dihydropyrazolo[4,3-c]pyridin-5-yl)-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-one	Ki	251.19 [1]
	(3S)-3-[2-[(2,6-Difluorophenyl)methyl]-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl]-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepine-8-carbonitrile	Ki	1.78 [1]
	(3S)-3-(2-Benzyl-3-methyl-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl)-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-one	Ki	2.57 [1]
	(3S)-3-[2-[(1,1-Dioxothian-4-yl)methyl]-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl]-5-methyl-2,3-dihydro-1,5-benzoxazepin-4-one	Ki	6918.31 [1]
	2-Benzyl-6-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide	Ki	2.51 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Receptor-interacting serine/threonine-protein kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/receptor-interacting-serine-threonine-protein-kinase-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Receptor-interacting serine/threonine-protein kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/receptor-interacting-serine-threonine-protein-kinase-1-inhibitors-ic50-ki.
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