Receptor protein-tyrosine kinase erbB-4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Canertinib	IC50	10.0 [1], 14.0 [2], 27.0 [3], 31.0 [4]
	Ibrutinib	IC50	0.1 [1], 1.8 [2]
	Staurosporine	IC50	28.3 [1], 282.0 [2]
	Dacomitinib	IC50	74.0 [1], 83.67 [2]
	2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]-	IC50	3.2 [1]
	Gefitinib	IC50	476.0 [1]
	Erlotinib	IC50	1130.0 [1]
	Lapatinib	IC50	1000.0 [1]
	Doramapimod	IC50	30000.0 [1]
	Dacomitinib monohydrate	IC50	74.0 [1]
	Nvp-aew541	IC50	1700.0 [1]
	4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline	IC50	12.0 [1]
	Cfms Receptor Tyrosine Kinase Inhibitor	IC50	24000.0 [1]
	N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)but-2-ynamide	IC50	12.0 [1]
	N6,N6-Dimethyl-N4-[1-(phenylmethyl)-5-indazolyl]pyrido[3,4-d]pyrimidine-4,6-diamine	IC50	20.0 [1]
	Tak-285	IC50	260.0 [1]
	Bms-599626	IC50	190.0 [1]
	N-(2,6-Difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamide	IC50	25000.0 [1]
	PD-153035 hydrochloride	IC50	49.0 [1]
	1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one	IC50	25200.0 [1]
	Evobrutinib	IC50	37.9 [1]
	EGFR Inhibitor	IC50	7640.0 [1]
	EGFR/ErbB-2/ErbB-4 Inhibitor	IC50	0.5 [1]
	4-Tert-Butyl-N-[6-(1h-Imidazol-1-Yl)imidazo[1,2-A]pyridin-2-Yl]benzamide	IC50	19952.62 [1]
	N~3~-Cyclopropyl-N~4~'-(Cyclopropylmethyl)-6-Methylbiphenyl-3,4'-Dicarboxamide	IC50	25000.0 [1]
	CID 44814409	IC50	10000.0 [1]
	2-(4-Fluorophenyl)-3-(4-pyridinyl)pyrazolo[1,5-a]pyridine	IC50	10000.0 [1]
	2-Methyl-N-[2-[3-[[2-(prop-2-enoylamino)acetyl]amino]anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide	IC50	3.3 [1]
	6,6-Dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	213.0 [1]
	JAK3 covalent inhibitor-1	IC50	10000.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	3800.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	3750.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	2-Methyl-N-[2-[3-(prop-2-enoylamino)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide	IC50	5.5 [1]
	7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrile	Ki	10000.0 [1]
	7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrile	Ki	10000.0 [1]
	N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamide	Ki	10000.0 [1]
	[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	IC50	50000.0 [1]
	5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine	IC50	10000.0 [1]
	N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide	IC50	18.0 [1]
	CID 46927672	IC50	10.0 [1]
	N-[[2-[4-Amino-6-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]pyrimidin-5-yl]-1,3-oxazol-4-yl]methyl]prop-2-enamide	IC50	4.0 [1]
	1-(4-Fluorophenyl)-N-[3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yl)oxyphenyl]-2-oxopyridine-3-carboxamide	IC50	10000.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	9-Cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine	IC50	30.0 [1]
	(E)-4-(Dimethylamino)-N-[7-fluoro-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide	IC50	43.7 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	6-(6-Fluoroindol-1-yl)-2-[2-[7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyethyl]pyridazin-3-one	IC50	1000.0 [1]
	N-Cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide	IC50	25000.0 [1]
	N-[4-Methyl-3-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]phenyl]-2-pyrrolidin-1-ylpyridine-4-carboxamide	IC50	25000.0 [1]
	N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-[di(propan-2-yl)amino]but-2-ynamide	IC50	538.0 [1]
	N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-4-morpholin-4-ylbut-2-ynamide	IC50	229.0 [1]
	N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-5-(4-methylpiperazin-1-yl)pent-2-ynamide	IC50	1.2 [1]
	N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-4-(dibutylamino)but-2-ynamide	IC50	624.0 [1]
	N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]hept-2-ynamide	IC50	7.1 [1]
	N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-5-(diethylamino)pent-2-ynamide	IC50	16.0 [1]
	N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-morpholin-4-ylbut-2-ynamide	IC50	6.2 [1]
	N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-4-(diethylamino)but-2-ynamide	IC50	310.0 [1]
	N-[4-[(3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-5-(4-morpholinyl)-2-pentynamide	IC50	1.0 [1]
	N-[4-[(3-Chloro-4-fluorophenyl)amino]-6-quinazolinyl]-5-(4-morpholinyl)-2-pentynamide	IC50	4.3 [1]
	N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-4-hydroxybut-2-ynamide	IC50	7.3 [1]
	N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-5-piperidin-1-ylpent-2-ynamide	IC50	1.8 [1]
	N-[4-(3-Bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-5-(4-methylpiperazin-1-yl)pent-2-ynamide	IC50	0.8 [1]
	N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]hex-2-ynamide	IC50	2.4 [1]
	N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dibutylamino)but-2-ynamide	IC50	73.0 [1]
	6,7-Diethoxy-N-(3-iodophenyl)quinazolin-4-amine;hydrochloride	IC50	59.0 [1]
	6,7-Diethoxy-N-[(4-fluorophenyl)methyl]quinazolin-4-amine	IC50	100.0 [1]
	N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(diethylamino)but-2-ynamide	IC50	644.0 [1]
	N-[4-(3-Bromo-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-5-morpholin-4-ylpent-2-ynamide	IC50	1.0 [1]
	N-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-4-[di(propan-2-yl)amino]but-2-ynamide	IC50	11.0 [1]
	2,3-Dimethyl-4-[2-methyl-3-(prop-2-enoylamino)phenyl]-1H-indole-7-carboxamide	IC50	240.0 [1]
	4-[3-(Ethenylsulfonylamino)-2-methylphenyl]-2,3-dimethyl-1H-indole-7-carboxamide	IC50	10.0 [1]
	6-[4-[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-N-[3-(dimethylamino)propyl]imidazo[2,1-b][1,3]thiazole-3-carboxamide	IC50	10000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-6-(1-methylpyrazol-4-yl)quinazolin-4-amine	IC50	801.0 [1]
	6-(1-Piperidin-4-ylpyrazol-4-yl)-N-quinolin-6-ylquinazolin-4-amine	IC50	1100.0 [1]
	6-(1-Methylpyrazol-4-yl)-N-quinolin-6-ylquinazolin-4-amine	IC50	930.0 [1]
	N-(3-Ethynylphenyl)-6-(1-methylpyrazol-4-yl)quinazolin-4-amine	IC50	782.0 [1]
	N-(3-Chloro-4-fluorophenyl)-6-(1-piperidin-4-ylpyrazol-4-yl)quinazolin-4-amine	IC50	1603.0 [1]
	Chmfl-egfr-202	IC50	3.2 [1]
	7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(prop-2-enoylamino)phenyl]-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide	IC50	150.0 [1]
	(E)-N-[4-[(1-Benzylindazol-5-yl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide	IC50	2.0 [1]
	(E)-N-[4-[(1-Benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-morpholin-4-ylbut-2-enamide	IC50	6.0 [1]
	(E)-N-[4-(4-Phenoxyanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide	IC50	2.0 [1]
	(E)-N-[4-[[1-(Benzenesulfonyl)indol-5-yl]amino]-7-ethoxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide	IC50	10.0 [1]
	(E)-N-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]pyrido[3,4-d]pyrimidin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide	IC50	5.0 [1]
	N-[4-[(1-Benzyl-2,3-dihydroindol-5-yl)amino]-7-methoxyquinazolin-6-yl]propanamide	IC50	82.0 [1]
	(E)-N-[4-[[1-(Benzenesulfonyl)indol-5-yl]amino]-7-ethoxyquinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide	IC50	11.0 [1]
	(E)-N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-piperidin-1-ylbut-2-enamide	IC50	7.0 [1]
	N-[7-Methoxy-4-(4-phenylmethoxyanilino)quinazolin-6-yl]propanamide	IC50	460.0 [1]
	(E)-N-[7-Methoxy-4-[4-(pyridin-2-ylmethyl)anilino]quinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide	IC50	13.0 [1]
	(E)-N-[4-[(1-Benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide	IC50	3.0 [1]
	(E)-N-[4-[[1-(Benzenesulfonyl)indol-5-yl]amino]-7-ethoxyquinazolin-6-yl]-4-morpholin-4-ylbut-2-enamide	IC50	27.0 [1]
	N-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]propanamide	IC50	376.0 [1]
	N-[7-Methoxy-4-[[1-(pyridin-2-ylmethyl)indazol-5-yl]amino]quinazolin-6-yl]propanamide	IC50	15.0 [1]
	(E)-4-(4-Methylpiperazin-1-yl)-N-[4-[4-(pyridin-2-ylmethyl)anilino]pyrido[3,4-d]pyrimidin-6-yl]but-2-enamide	IC50	94.0 [1]
	(E)-N-[7-Ethoxy-4-[4-(pyridin-2-ylmethoxy)anilino]quinazolin-6-yl]-4-(4-methylpiperazin-1-yl)but-2-enamide	IC50	94.0 [1]
	(E)-N-[4-[(1-Benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-(4-methylpiperazin-1-yl)but-2-enamide	IC50	4.0 [1]
	(E)-N-[4-(3-Chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(4-methylpiperazin-1-yl)but-2-enamide	IC50	302.0 [1]
	(E)-N-[4-[(1-Benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide	IC50	4.0 [1]
	N-[7-Methoxy-4-[[1-(pyridin-4-ylmethyl)indol-5-yl]amino]quinazolin-6-yl]propanamide	IC50	213.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Receptor protein-tyrosine kinase erbB-4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/receptor-protein-tyrosine-kinase-erbb-4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Receptor protein-tyrosine kinase erbB-4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/receptor-protein-tyrosine-kinase-erbb-4-inhibitors-ic50-ki.
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