Receptor-type tyrosine-protein phosphatase alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(Oxalyl-amino)-benzoic acid	Ki	870000.0 [1]
	2-[4-[2-Acetamido-3-[4-(3-hydroxy-2-methoxycarbonylphenoxy)butylamino]-3-oxopropyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	65.0 [1]
	5-Iodo-2-(oxaloamino)benzoic acid	Ki	89000.0 [1]
	6-(Oxalyl-amino)-1H-indole-5-carboxylic acid	Ki	180000.0 [1], 800000.0 [2]
	2-(Oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-C]pyran-3-carboxylic acid	Ki	170000.0 [1]
	2-(Carboxyformamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid	Ki	290000.0 [1]
	1H-Indole-7-carboxylic acid, 6-[(carboxycarbonyl)amino]-	Ki	180000.0 [1], 800000.0 [2]
	2-(Carboxyformamido)thiophene-3-carboxylic acid	Ki	1700000.0 [1]
	3-(Carboxyformamido)thiophene-2-carboxylic acid	Ki	2000000.0 [1]
	CID 5179836	IC50	35000.0 [1], 93000.0 [2]
	5-((2-Hydroxy-1-naphthyl)diazenyl)-2-naphthalenesulfonic acid	IC50	5500.0 [1], 8100.0 [2]
	2-(2,3-Dihydro-1H-pyrrolo[3,4-b]quinolin-3-yl)acetic acid	IC50	5500.0 [1], 8100.0 [2]
	Bhansali	IC50	13000.0 [1], 108000.0 [2]
	4-[(4-Anilino-9,10-dioxo-5,8-dihydroanthracen-1-yl)amino]benzenesulfonic acid	IC50	3600.0 [1], 5500.0 [2]
	Oleanolic acid	IC50	40000.0 [1]
	Ursolic acid	IC50	40000.0 [1]
	Corosolic acid	IC50	40000.0 [1]
	3,5-Dibromotyrosine	IC50	4600.0 [1]
	(3S)-4-[[(2S)-1-Amino-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[[2-[4-[difluoro(phosphono)methyl]phenyl]acetyl]amino]-4-oxobutanoic acid	Ki	24.0 [1]
	2-(Oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-C]pyridine-3-carboxylic acid	Ki	2000000.0 [1]
	(4As,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-(3-carboxy-3-methylbutanoyl)oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid	IC50	40000.0 [1]
	(1-Amino-2-phenylethyl)phosphonic acid	IC50	223000.0 [1]
	Cefsulodin sodium salt	IC50	200000.0 [1]
	6-Hydroxy-1-methyl-3-[1-[3-oxo-3-(4-phenylanilino)propyl]triazol-4-yl]-2-phenylindole-5-carboxylic acid	IC50	50000.0 [1]
	5-(3-(3-(3-Hydroxy-2-(methoxycarbonyl)phenoxy)prop-1-enyl)phenyl)isoxazole-3-carboxylic acid	Ki	202000.0 [1]
	2-[4-[2-Acetamido-3-[[5-[[(1S)-1-carboxy-3-methylsulfanylpropyl]amino]-5-oxopentyl]amino]-3-oxopropyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	380.0 [1]
	Benzoic acid, 2-[(carboxycarbonyl)amino]-3-methyl-	Ki	2000000.0 [1]
	2-[4-[(2S)-3-[4-(3-Hydroxy-2-methoxycarbonylphenoxy)butylamino]-3-oxo-2-(prop-2-enoxycarbonylamino)propyl]-N-oxaloanilino]benzoic acid	Ki	470.0 [1]
	3-(Carboxyformamido)-5-(thiophen-3-yl)thiophene-2-carboxylic acid	Ki	200000.0 [1]
	3-(Carboxyformamido)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid	Ki	150000.0 [1]
	3-(Carboxyformamido)-5-phenylthiophene-2-carboxylic acid	Ki	250000.0 [1]
	2-(Carboxyformamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid	Ki	320000.0 [1]
	2-(Carboxyformamido)-6-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid	Ki	52000.0 [1]
	3-(Carboxyformamido)-5-(3,5-dimethoxyphenyl)thiophene-2-carboxylic acid	Ki	1789000.0 [1]
	3-(Carboxyformamido)isonicotinic acid	Ki	1000000.0 [1]
	2-(Oxaloamino)-6,6-dioxo-5,7-dihydro-4H-thieno[2,3-c]thiopyran-3-carboxylic acid	Ki	322000.0 [1]
	Benzoic acid, 2-[(carboxycarbonyl)methylamino]-	Ki	2000000.0 [1]
	2-[4-[[2-Acetamido-3-[4-(2-carboxy-N-oxaloanilino)-3-ethylphenyl]propanoyl]amino]butoxy]-6-hydroxybenzoic acid	Ki	73.0 [1]
	2-(Oxaloamino)-6-oxo-5,7-dihydro-4H-thieno[2,3-c]thiopyran-3-carboxylic acid	Ki	363000.0 [1]
	3-(Carboxyformamido)-5-(4-(carboxymethoxy)phenyl)thiophene-2-carboxylic acid	Ki	200000.0 [1]
	Benzoic acid, 2-[(carboxycarbonyl)amino]-6-methyl-	Ki	2000000.0 [1]
	3-(Carboxyformamido)-4-methylthiophene-2-carboxylic acid	Ki	2000000.0 [1]
	3-(Carboxyformamido)-5-(4-chlorophenyl)thiophene-2-carboxylic acid	Ki	100000.0 [1]
	2-[4-[2-Acetamido-3-oxo-3-(pentylamino)propyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	900.0 [1]
	2-(Oxalyl-amino)-4,7-dihydro-5h-thieno[2,3-c]thiopyran-3-carboxylic acid	Ki	100000.0 [1]
	5-(3-Butyramidophenyl)isoxazole-3-carboxylic acid	Ki	634000.0 [1]
	2-(Carboxyformamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid	Ki	340000.0 [1]
	2-[[4-[2-Acetamido-3-oxo-3-(pentylamino)propyl]naphthalen-1-yl]-oxaloamino]benzoic acid	Ki	1100.0 [1]
	3-(Carboxyformamido)-5-(3-methoxyphenyl)thiophene-2-carboxylic acid	Ki	530000.0 [1]
	4-(Carboxyformamido)biphenyl-3-carboxylic acid	Ki	280000.0 [1]
	3-(Carboxyformamido)-5-(4-isobutylphenyl)thiophene-2-carboxylic acid	Ki	100000.0 [1]
	3-(Carboxyformamido)-5-(4-hydroxyphenyl)thiophene-2-carboxylic acid	Ki	210000.0 [1]
	3-(Carboxyformamido)-5-(4-fluorophenyl)thiophene-2-carboxylic acid	Ki	210000.0 [1]
	2-(Carboxyformamido)-6-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid	Ki	215000.0 [1]
	3-(Carboxyformamido)-5-(3,4-dimethoxyphenyl)thiophene-2-carboxylic acid	Ki	980000.0 [1]
	3-(Carboxyformamido)-5-(4-phenoxyphenyl)thiophene-2-carboxylic acid	Ki	93000.0 [1]
	3-(Carboxyformamido)-5-(3-nitrophenyl)thiophene-2-carboxylic acid	Ki	700000.0 [1]
	5-(4-(Benzyloxy)phenyl)-3-(carboxyformamido)thiophene-2-carboxylic acid	Ki	65000.0 [1]
	5-(3-Aminophenyl)-3-(carboxyformamido)thiophene-2-carboxylic acid	Ki	250000.0 [1]
	N-(4-Butylphenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide	IC50	50000.0 [1]
	6-Hydroxy-2-phenyl-3-[2-[3-(trifluoromethyl)phenyl]ethynyl]benzofuran-5-carboxylic acid	IC50	10000.0 [1]
	3-[2-(3,5-Difluorophenyl)ethynyl]-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acid	IC50	10000.0 [1]
	6-Hydroxy-2-phenyl-3-[2-[4-(trifluoromethoxy)phenyl]ethynyl]benzofuran-5-carboxylic acid	IC50	10000.0 [1]
	2-(Oxaloamino)-6-(2-phenylethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid	Ki	2100000.0 [1]
	(2R)-2-[2,6-Dibromo-4-(6-bromonaphtho[3,2-b][1]benzofuran-11-yl)phenoxy]-3-phenylpropanoic acid	IC50	13000.0 [1]
	2-[4-[2-Acetamido-3-[4-(5-chloro-3-hydroxy-2-methoxycarbonylphenoxy)butylamino]-3-oxopropyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	230.0 [1]
	3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine	IC50	24000.0 [1]
	3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine	IC50	28000.0 [1]
	2-[2,6-Dibromo-4-(6-bromonaphtho[3,2-b][1]benzothiol-11-yl)phenoxy]acetic acid	IC50	17000.0 [1]
	2-[4-[2-Acetamido-3-oxo-3-(pentylamino)propyl]-N-oxalo-2-propan-2-ylanilino]benzoic acid	Ki	1200.0 [1]
	6-(3,3-Diphenylpropyl)-2-(oxaloamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid	Ki	5800.0 [1]
	2-[4-[2-Acetamido-3-[4-(2-methoxycarbonylphenoxy)butylamino]-3-oxopropyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	860.0 [1]
	2-[4-[2-Acetamido-3-[4-[3-hydroxy-2-(methylcarbamoyl)phenoxy]butylamino]-3-oxopropyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	830.0 [1]
	2-[4-[2-Acetamido-3-[4-(4-bromo-3-hydroxy-2-methoxycarbonylphenoxy)butylamino]-3-oxopropyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	2600.0 [1]
	2-[4-[2-Acetamido-3-[4-(3-hydroxy-2-nitrophenoxy)butylamino]-3-oxopropyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	120.0 [1]
	2-[4-[2-Acetamido-3-[4-(3-hydroxy-2-methoxycarbonyl-4-phenylphenoxy)butylamino]-3-oxopropyl]-2-ethyl-N-oxaloanilino]benzoic acid	Ki	840.0 [1]
	2-[4-[[2-(4-Iodoanilino)-2-oxoacetyl]amino]anilino]-2-oxo-1-phenylethanesulfonic acid	IC50	50000.0 [1]
	2-Oxo-2-[4-[[2-oxo-2-(4-phenylanilino)acetyl]amino]anilino]-1-phenylethanesulfonic acid	IC50	50000.0 [1]
	2-Oxo-2-[4-[[2-oxo-2-(4-propan-2-ylanilino)acetyl]amino]anilino]-1-phenylethanesulfonic acid	IC50	50000.0 [1]
	N'-[1-[4-(4-Fluorophenyl)piperazin-1-yl]-1-thiophen-2-ylpropan-2-yl]-N-(pyridin-3-ylmethyl)oxamide	IC50	50000.0 [1]
	N-(Furan-2-ylmethyl)-N'-[1-[4-(4-methoxyphenyl)piperazin-1-yl]-1-thiophen-2-ylpropan-2-yl]oxamide	IC50	50000.0 [1]
	2-Hydroxy-3-(pyridin-2-yl)propanoic acid	IC50	88000.0 [1]
	2-[4-[2-Acetamido-3-oxo-3-(pentylamino)propyl]-N-oxaloanilino]benzoic acid	Ki	10900.0 [1]
	2-[4-[2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-oxo-3-(pentylamino)propyl]-N-oxaloanilino]benzoic acid	Ki	13000.0 [1]
	2-[4-[2-Amino-3-oxo-3-(pentylamino)propyl]-N-oxaloanilino]benzoic acid	Ki	100000.0 [1]
	6-(1,3-Dioxolan-2-yl)-2-(oxaloamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid	Ki	150000.0 [1]
	N-[(3beta)-3-Hydroxy-28-oxoolean-12-en-28-yl]-L-phenylalanine	IC50	40000.0 [1]
	3-[(4Ar,6aR,6aS,6bR,8aR,10S,12aR,14bR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-4a-yl]propanoic acid	IC50	40000.0 [1]
	5-[(4Ar,6aR,6aS,6bR,8aR,10S,12aR,14bR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-4a-yl]pentanoic acid	IC50	40000.0 [1]
	(2S)-2-[5-[(4Ar,6aR,6aS,6bR,8aR,10S,12aR,14bR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-4a-yl]pentanoylamino]-3-phenylpropanoic acid	IC50	40000.0 [1]
	2-[5-[(4Ar,6aR,6aS,6bR,8aR,10S,12aR,14bR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-4a-yl]pentanoylamino]-3-(1,3-benzodioxol-5-yl)propanoic acid	IC50	40000.0 [1]
	(4As,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(4-carboxyphenyl)methoxy]-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid	IC50	40000.0 [1]
	4-[[(3S,4Ar,6aR,6bS,8aR,12aR,14aR,14bR)-8a-[5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentyl]-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxymethyl]benzoic acid	IC50	40000.0 [1]
	(7S)-7-[(1,1-Dioxo-1,2-benzothiazol-3-yl)oxymethyl]-2-(oxaloamino)-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid	Ki	500000.0 [1]
	2-(3-(Dihydroxymethyl)naphthalen-2-ylamino)-2-oxoacetic acid	Ki	190000.0 [1]
	8-Phenyl-1-thia-4,8-diazaspiro[4.5]decane-3-carboxylic acid	IC50	4000.0 [1]
	2-Amino-3-(6-nitro-1H-indol-3-yl)propanoic acid	IC50	51000.0 [1]
	2-[2-[(E)-3-Amino-3-oxoprop-1-enyl]-4-[2-(methanesulfonamido)-3-oxo-3-(pentylamino)propyl]-N-oxaloanilino]benzoic acid	Ki	160.0 [1]
	(2E)-2-Hydroxyimino-3-quinolin-4-ylpropanoic acid	IC50	72000.0 [1]
	{4-[2-Benzyl-3-methoxy-2-(methoxycarbonyl)-3-oxopropyl]phenyl}sulfamic acid	IC50	900.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Receptor-type tyrosine-protein phosphatase alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/receptor-type-tyrosine-protein-phosphatase-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Receptor-type tyrosine-protein phosphatase alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/receptor-type-tyrosine-protein-phosphatase-alpha-inhibitors-ic50-ki.
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