Receptor tyrosine-protein kinase erbB-3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Erlotinib	IC50	10.0 [1]
	Osimertinib	IC50	2.1 [1]
	Rociletinib	IC50	46.0 [1]
	Sapitinib	IC50	4.0 [1]
	4-Fluoro-N-[6-(4-morpholinyl)-4-pyrimidinyl]benzamide	IC50	96.0 [1]
	Unii-5IE92SK9EB	IC50	21.0 [1]
	N-[(3R,4R)-4-Fluoro-1-[6-[(1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide	IC50	2.0 [1]
	N-[(3R,4R)-1-[6-[(1,3-Dimethylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide	IC50	9.0 [1]
	N-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide	IC50	1.0 [1]
	Mavelertinib	IC50	4.0 [1]
	4-N-(2,5-Dimethoxyphenyl)-6-N-(4-fluorophenyl)pyrimidine-4,6-diamine	IC50	230.0 [1]
	4-N-(3-Chlorophenyl)-6-N-(3-methoxyphenyl)pyrimidine-4,6-diamine	IC50	1573.0 [1]
	6-N-(4-Chlorophenyl)-4-N-(3,4,5-trimethoxyphenyl)pyrimidine-4,6-diamine	IC50	10000.0 [1]
	4-N-(2,5-Dimethoxyphenyl)-6-N-(3-methoxyphenyl)pyrimidine-4,6-diamine	IC50	18.0 [1]
	Ethyl 4-[[6-(3-methoxyanilino)pyrimidin-4-yl]amino]benzoate	IC50	1745.0 [1]
	N-[(3R,4R)-4-Fluoro-1-[6-[(3-methoxy-1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide	IC50	2.0 [1]
	N-[4-(4-Methylpiperazin-1-yl)phenyl]-9-(oxan-4-yl)-8-phenylsulfanylpurin-2-amine	IC50	2.0 [1]
	N-[4-[2-(Dimethylamino)ethoxy]phenyl]-9-(oxan-4-yl)-8-phenylsulfanylpurin-2-amine	IC50	1.7 [1]
	N-[4-[2-(Dimethylamino)ethoxy]phenyl]-8-(4-fluorophenyl)sulfanyl-9-(oxan-4-yl)purin-2-amine	IC50	1.2 [1]
	N-[4-[4-(Dimethylamino)piperidin-1-yl]phenyl]-9-(oxan-4-yl)-8-phenylsulfanylpurin-2-amine	IC50	1.9 [1]
	8-(Benzenesulfinyl)-N-[4-[2-(dimethylamino)ethoxy]phenyl]-9-(oxan-4-yl)purin-2-amine	IC50	2.6 [1]
	N-[4-[2-(Dimethylamino)ethoxy]phenyl]-8-(3-fluorophenyl)sulfanyl-9-(oxan-4-yl)purin-2-amine	IC50	5.8 [1]
	5-(4-Methylphenyl)-3-naphthalen-2-yl-2-phenyl-3,4-dihydropyrazole	IC50	45300.0 [1]
	8-(Benzenesulfinyl)-9-cyclopentyl-N-[4-(4-methylpiperazin-1-yl)phenyl]purin-2-amine	IC50	4.2 [1]
	4-[2-[4-(4-Methylpiperazin-1-yl)anilino]-8-phenylsulfanylpurin-9-yl]cyclohexan-1-ol	IC50	2.4 [1]
	9-Cyclopentyl-N-[4-(4-methylpiperazin-1-yl)phenyl]-8-phenylsulfanylpurin-2-amine	IC50	4.2 [1]
	N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methoxy-5-[[2-(1-methylindol-3-yl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide	IC50	36.0 [1]
	4-N-(2,5-Dimethoxyphenyl)-6-N-(2-thiophen-2-ylethyl)pyrimidine-4,6-diamine	IC50	167.0 [1]
	N-[6-(4-Chloroanilino)pyrimidin-4-yl]-4-fluorobenzamide	IC50	1608.0 [1]
	5-[[6-(3-Chloroanilino)pyrimidin-4-yl]amino]-5-oxopentanoic acid	IC50	21.0 [1]
	Ethyl 5-[[6-(3-chloroanilino)pyrimidin-4-yl]amino]-5-oxopentanoate	IC50	10000.0 [1]
	5-[(6-Anilinopyrimidin-4-yl)amino]-5-oxopentanoic acid	IC50	183.0 [1]
	5-[[6-(2,5-Dimethoxyanilino)pyrimidin-4-yl]amino]-5-oxopentanoic acid	IC50	10000.0 [1]
	4-[[6-(2,5-Dimethoxyanilino)pyrimidin-4-yl]amino]benzenesulfonamide	IC50	619.0 [1]
	N-[6-(4-Ethoxyanilino)pyrimidin-4-yl]benzamide	IC50	1209.0 [1]
	5-[[6-(4-Chloroanilino)pyrimidin-4-yl]amino]-5-oxopentanoic acid	IC50	1322.0 [1]
	5-[[6-(4-Ethoxycarbonylanilino)pyrimidin-4-yl]amino]-5-oxopentanoic acid	IC50	69.0 [1]
	4-N-(2,5-Dimethoxyphenyl)-6-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrimidine-4,6-diamine	IC50	167.0 [1]
	6-N-(4-Chlorophenyl)-4-N-(6-chloropyridin-2-yl)pyrimidine-4,6-diamine	IC50	236.0 [1]
	N-[6-(4-Methoxyanilino)pyrimidin-4-yl]benzamide	IC50	60.0 [1]
	4-[[6-(3-Methoxyanilino)pyrimidin-4-yl]amino]benzenesulfonamide	IC50	1847.0 [1]
	5-[[6-(3-Bromoanilino)pyrimidin-4-yl]amino]-5-oxopentanoic acid	IC50	10000.0 [1]
	4-[[6-(4-Chloroanilino)pyrimidin-4-yl]amino]-4-oxobutanoic acid	IC50	825.0 [1]
	5-[(6-Morpholin-4-ylpyrimidin-4-yl)amino]-5-oxopentanoic acid	IC50	27.0 [1]
	Ethyl 4-[[6-(3-bromoanilino)pyrimidin-4-yl]amino]-4-oxobutanoate	IC50	1345.0 [1]
	5-[[6-(3-Methoxyanilino)pyrimidin-4-yl]amino]-5-oxopentanoic acid	IC50	31.0 [1]
	4-N-(3-Chlorophenyl)-6-N-ethylpyrimidine-4,6-diamine	IC50	10000.0 [1]
	3-(4-Methoxyphenyl)-5-(1-naphthyl)-2-pyrazoline-1-carbothioamide	IC50	55600.0 [1]
	5-(4-Methoxyphenyl)-3-naphthalen-1-yl-2-phenyl-3,4-dihydropyrazole	IC50	40200.0 [1]
	5-(4-Methylphenyl)-3-naphthalen-2-yl-3,4-dihydropyrazole-2-carbothioamide	IC50	63200.0 [1]
	5-(3,4-Dichlorophenyl)-3-naphthalen-2-yl-3,4-dihydropyrazole-2-carbothioamide	IC50	51700.0 [1]
	1-Phenyl-3-(3,4-dichlorophenyl)-5-(2-naphthyl)-2-pyrazoline	IC50	35900.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 52 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Receptor tyrosine-protein kinase erbB-3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/receptor-tyrosine-protein-kinase-erbb-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Receptor tyrosine-protein kinase erbB-3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/receptor-tyrosine-protein-kinase-erbb-3-inhibitors-ic50-ki.
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